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Q8IYL3

- CA174_HUMAN

UniProt

Q8IYL3 - CA174_HUMAN

Protein

UPF0688 protein C1orf174

Gene

C1orf174

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 2 (10 Jul 2007)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UPF0688 protein C1orf174
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:27915. C1orf174.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA143485318.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 243243UPF0688 protein C1orf174PRO_0000294244Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei148 – 1481Phosphoserine1 Publication
    Modified residuei189 – 1891Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8IYL3.
    PaxDbiQ8IYL3.
    PRIDEiQ8IYL3.

    PTM databases

    PhosphoSiteiQ8IYL3.

    Expressioni

    Gene expression databases

    BgeeiQ8IYL3.
    CleanExiHS_C1orf174.
    GenevestigatoriQ8IYL3.

    Organism-specific databases

    HPAiHPA008270.

    Interactioni

    Protein-protein interaction databases

    BioGridi130884. 7 interactions.
    IntActiQ8IYL3. 6 interactions.
    MINTiMINT-1387024.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IYL3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi232 – 2409Poly-Asp

    Sequence similaritiesi

    Belongs to the UPF0688 family.Curated

    Phylogenomic databases

    eggNOGiNOG79905.
    HOGENOMiHOG000111263.
    HOVERGENiHBG097321.
    InParanoidiQ8IYL3.
    OMAiSKKFKYD.
    OrthoDBiEOG76MKBC.
    PhylomeDBiQ8IYL3.
    TreeFamiTF336079.

    Sequencei

    Sequence statusi: Complete.

    Q8IYL3-1 [UniParc]FASTAAdd to Basket

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    MRSRKLTGAV RSSARLKARS CSAARLASAQ EVAGSTSAKT ACLTSSSHKA    50
    TDTRTSKKFK CDKGHLVKSE LQKLVPKNDS ASLPKVTPET PCENEFAEGS 100
    ALLPGSEAGV SVQQGAASLP LGGCRVVSDS RLAKTRDGLS VPKHSAGSGA 150
    EESNSSSTVQ KQNEPGLQTE DVQKPPLQMD NSVFLDDDSN QPMPVSRFFG 200
    NVELMQDLPP ASSSCPSMSR REFRKMHFRA KDDDDDDDDD AEM 243
    Length:243
    Mass (Da):25,977
    Last modified:July 10, 2007 - v2
    Checksum:i80DF42E5FD907454
    GO

    Sequence cautioni

    The sequence AAH35643.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti53 – 531T → R.3 Publications
    Corresponds to variant rs4274008 [ dbSNP | Ensembl ].
    VAR_033152
    Natural varianti101 – 1011A → S.
    Corresponds to variant rs10909820 [ dbSNP | Ensembl ].
    VAR_033153
    Natural varianti165 – 1651P → A.
    Corresponds to variant rs12036962 [ dbSNP | Ensembl ].
    VAR_057829

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK289493 mRNA. Translation: BAF82182.1.
    BX005110, AL691523 Genomic DNA. Translation: CAI17266.1.
    AL691523, BX005110 Genomic DNA. Translation: CAI17365.1.
    CH471130 Genomic DNA. Translation: EAW71492.1.
    BC035643 mRNA. Translation: AAH35643.1. Different initiation.
    BC067302 mRNA. Translation: AAH67302.1.
    CCDSiCCDS53.1.
    RefSeqiNP_997239.2. NM_207356.2.
    UniGeneiHs.103939.

    Genome annotation databases

    EnsembliENST00000361605; ENSP00000355306; ENSG00000198912.
    GeneIDi339448.
    KEGGihsa:339448.
    UCSCiuc001alf.3. human.

    Polymorphism databases

    DMDMi152013372.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK289493 mRNA. Translation: BAF82182.1 .
    BX005110 , AL691523 Genomic DNA. Translation: CAI17266.1 .
    AL691523 , BX005110 Genomic DNA. Translation: CAI17365.1 .
    CH471130 Genomic DNA. Translation: EAW71492.1 .
    BC035643 mRNA. Translation: AAH35643.1 . Different initiation.
    BC067302 mRNA. Translation: AAH67302.1 .
    CCDSi CCDS53.1.
    RefSeqi NP_997239.2. NM_207356.2.
    UniGenei Hs.103939.

    3D structure databases

    ProteinModelPortali Q8IYL3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 130884. 7 interactions.
    IntActi Q8IYL3. 6 interactions.
    MINTi MINT-1387024.

    PTM databases

    PhosphoSitei Q8IYL3.

    Polymorphism databases

    DMDMi 152013372.

    Proteomic databases

    MaxQBi Q8IYL3.
    PaxDbi Q8IYL3.
    PRIDEi Q8IYL3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000361605 ; ENSP00000355306 ; ENSG00000198912 .
    GeneIDi 339448.
    KEGGi hsa:339448.
    UCSCi uc001alf.3. human.

    Organism-specific databases

    CTDi 339448.
    GeneCardsi GC01M003805.
    H-InvDB HIX0023581.
    HGNCi HGNC:27915. C1orf174.
    HPAi HPA008270.
    neXtProti NX_Q8IYL3.
    PharmGKBi PA143485318.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG79905.
    HOGENOMi HOG000111263.
    HOVERGENi HBG097321.
    InParanoidi Q8IYL3.
    OMAi SKKFKYD.
    OrthoDBi EOG76MKBC.
    PhylomeDBi Q8IYL3.
    TreeFami TF336079.

    Miscellaneous databases

    ChiTaRSi C1orf174. human.
    GenomeRNAii 339448.
    NextBioi 97395.

    Gene expression databases

    Bgeei Q8IYL3.
    CleanExi HS_C1orf174.
    Genevestigatori Q8IYL3.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-53.
      Tissue: Cerebellum.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-53.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-53.
      Tissue: Brain and Skin.
    5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-189, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-148, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy."
      Stadler C., Hjelmare M., Neumann B., Jonasson K., Pepperkok R., Uhlen M., Lundberg E.
      J. Proteomics 75:2236-2251(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiCA174_HUMAN
    AccessioniPrimary (citable) accession number: Q8IYL3
    Secondary accession number(s): A8K0C8
    , A8MUG9, Q5SR20, Q6NX36
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 79 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families
    5. Uncharacterized protein families (UPF)
      List of uncharacterized protein family (UPF) entries

    External Data

    Dasty 3