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Q8IYL3

- CA174_HUMAN

UniProt

Q8IYL3 - CA174_HUMAN

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Protein
UPF0688 protein C1orf174
Gene
C1orf174
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0688 protein C1orf174
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:27915. C1orf174.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485318.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 243243UPF0688 protein C1orf174
PRO_0000294244Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei148 – 1481Phosphoserine1 Publication
Modified residuei189 – 1891Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8IYL3.
PaxDbiQ8IYL3.
PRIDEiQ8IYL3.

PTM databases

PhosphoSiteiQ8IYL3.

Expressioni

Gene expression databases

BgeeiQ8IYL3.
CleanExiHS_C1orf174.
GenevestigatoriQ8IYL3.

Organism-specific databases

HPAiHPA008270.

Interactioni

Protein-protein interaction databases

BioGridi130884. 7 interactions.
IntActiQ8IYL3. 6 interactions.
MINTiMINT-1387024.

Structurei

3D structure databases

ProteinModelPortaliQ8IYL3.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi232 – 2409Poly-Asp

Sequence similaritiesi

Belongs to the UPF0688 family.

Phylogenomic databases

eggNOGiNOG79905.
HOGENOMiHOG000111263.
HOVERGENiHBG097321.
InParanoidiQ8IYL3.
OMAiSKKFKYD.
OrthoDBiEOG76MKBC.
PhylomeDBiQ8IYL3.
TreeFamiTF336079.

Sequencei

Sequence statusi: Complete.

Q8IYL3-1 [UniParc]FASTAAdd to Basket

« Hide

MRSRKLTGAV RSSARLKARS CSAARLASAQ EVAGSTSAKT ACLTSSSHKA    50
TDTRTSKKFK CDKGHLVKSE LQKLVPKNDS ASLPKVTPET PCENEFAEGS 100
ALLPGSEAGV SVQQGAASLP LGGCRVVSDS RLAKTRDGLS VPKHSAGSGA 150
EESNSSSTVQ KQNEPGLQTE DVQKPPLQMD NSVFLDDDSN QPMPVSRFFG 200
NVELMQDLPP ASSSCPSMSR REFRKMHFRA KDDDDDDDDD AEM 243
Length:243
Mass (Da):25,977
Last modified:July 10, 2007 - v2
Checksum:i80DF42E5FD907454
GO

Sequence cautioni

The sequence AAH35643.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti53 – 531T → R.3 Publications
Corresponds to variant rs4274008 [ dbSNP | Ensembl ].
VAR_033152
Natural varianti101 – 1011A → S.
Corresponds to variant rs10909820 [ dbSNP | Ensembl ].
VAR_033153
Natural varianti165 – 1651P → A.
Corresponds to variant rs12036962 [ dbSNP | Ensembl ].
VAR_057829

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK289493 mRNA. Translation: BAF82182.1.
BX005110, AL691523 Genomic DNA. Translation: CAI17266.1.
AL691523, BX005110 Genomic DNA. Translation: CAI17365.1.
CH471130 Genomic DNA. Translation: EAW71492.1.
BC035643 mRNA. Translation: AAH35643.1. Different initiation.
BC067302 mRNA. Translation: AAH67302.1.
CCDSiCCDS53.1.
RefSeqiNP_997239.2. NM_207356.2.
UniGeneiHs.103939.

Genome annotation databases

EnsembliENST00000361605; ENSP00000355306; ENSG00000198912.
GeneIDi339448.
KEGGihsa:339448.
UCSCiuc001alf.3. human.

Polymorphism databases

DMDMi152013372.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK289493 mRNA. Translation: BAF82182.1 .
BX005110 , AL691523 Genomic DNA. Translation: CAI17266.1 .
AL691523 , BX005110 Genomic DNA. Translation: CAI17365.1 .
CH471130 Genomic DNA. Translation: EAW71492.1 .
BC035643 mRNA. Translation: AAH35643.1 . Different initiation.
BC067302 mRNA. Translation: AAH67302.1 .
CCDSi CCDS53.1.
RefSeqi NP_997239.2. NM_207356.2.
UniGenei Hs.103939.

3D structure databases

ProteinModelPortali Q8IYL3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 130884. 7 interactions.
IntActi Q8IYL3. 6 interactions.
MINTi MINT-1387024.

PTM databases

PhosphoSitei Q8IYL3.

Polymorphism databases

DMDMi 152013372.

Proteomic databases

MaxQBi Q8IYL3.
PaxDbi Q8IYL3.
PRIDEi Q8IYL3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000361605 ; ENSP00000355306 ; ENSG00000198912 .
GeneIDi 339448.
KEGGi hsa:339448.
UCSCi uc001alf.3. human.

Organism-specific databases

CTDi 339448.
GeneCardsi GC01M003805.
H-InvDB HIX0023581.
HGNCi HGNC:27915. C1orf174.
HPAi HPA008270.
neXtProti NX_Q8IYL3.
PharmGKBi PA143485318.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG79905.
HOGENOMi HOG000111263.
HOVERGENi HBG097321.
InParanoidi Q8IYL3.
OMAi SKKFKYD.
OrthoDBi EOG76MKBC.
PhylomeDBi Q8IYL3.
TreeFami TF336079.

Miscellaneous databases

ChiTaRSi C1orf174. human.
GenomeRNAii 339448.
NextBioi 97395.

Gene expression databases

Bgeei Q8IYL3.
CleanExi HS_C1orf174.
Genevestigatori Q8IYL3.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-53.
    Tissue: Cerebellum.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-53.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-53.
    Tissue: Brain and Skin.
  5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-189, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-148, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy."
    Stadler C., Hjelmare M., Neumann B., Jonasson K., Pepperkok R., Uhlen M., Lundberg E.
    J. Proteomics 75:2236-2251(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiCA174_HUMAN
AccessioniPrimary (citable) accession number: Q8IYL3
Secondary accession number(s): A8K0C8
, A8MUG9, Q5SR20, Q6NX36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: July 9, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3

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