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Protein

UPF0688 protein C1orf174

Gene

C1orf174

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-31100-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0688 protein C1orf174
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:27915. C1orf174.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi339448.
OpenTargetsiENSG00000198912.
PharmGKBiPA143485318.

Polymorphism and mutation databases

BioMutaiC1orf174.
DMDMi152013372.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002942441 – 243UPF0688 protein C1orf174Add BLAST243

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei148PhosphoserineCombined sources1
Modified residuei189PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IYL3.
MaxQBiQ8IYL3.
PaxDbiQ8IYL3.
PeptideAtlasiQ8IYL3.
PRIDEiQ8IYL3.

PTM databases

iPTMnetiQ8IYL3.
PhosphoSitePlusiQ8IYL3.

Expressioni

Gene expression databases

BgeeiENSG00000198912.
CleanExiHS_C1orf174.
GenevisibleiQ8IYL3. HS.

Organism-specific databases

HPAiHPA008270.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
IKZF1Q134223EBI-715898,EBI-745305
PDIK1LQ8N1659EBI-715898,EBI-6423298
TERF2IPQ9NYB02EBI-715898,EBI-750109

Protein-protein interaction databases

BioGridi130884. 11 interactors.
IntActiQ8IYL3. 11 interactors.
MINTiMINT-1387024.
STRINGi9606.ENSP00000355306.

Structurei

3D structure databases

ProteinModelPortaliQ8IYL3.
SMRiQ8IYL3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi232 – 240Poly-Asp9

Sequence similaritiesi

Belongs to the UPF0688 family.Curated

Phylogenomic databases

eggNOGiENOG410IXWN. Eukaryota.
ENOG410XZ19. LUCA.
GeneTreeiENSGT00390000016496.
HOGENOMiHOG000111263.
HOVERGENiHBG097321.
InParanoidiQ8IYL3.
OMAiKFKCDKG.
OrthoDBiEOG091G0N6K.
PhylomeDBiQ8IYL3.
TreeFamiTF336079.

Family and domain databases

InterProiIPR031530. UPF0688.
[Graphical view]
PfamiPF15772. UPF0688. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IYL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSRKLTGAV RSSARLKARS CSAARLASAQ EVAGSTSAKT ACLTSSSHKA
60 70 80 90 100
TDTRTSKKFK CDKGHLVKSE LQKLVPKNDS ASLPKVTPET PCENEFAEGS
110 120 130 140 150
ALLPGSEAGV SVQQGAASLP LGGCRVVSDS RLAKTRDGLS VPKHSAGSGA
160 170 180 190 200
EESNSSSTVQ KQNEPGLQTE DVQKPPLQMD NSVFLDDDSN QPMPVSRFFG
210 220 230 240
NVELMQDLPP ASSSCPSMSR REFRKMHFRA KDDDDDDDDD AEM
Length:243
Mass (Da):25,977
Last modified:July 10, 2007 - v2
Checksum:i80DF42E5FD907454
GO

Sequence cautioni

The sequence AAH35643 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03315253T → R.3 PublicationsCorresponds to variant rs4274008dbSNPEnsembl.1
Natural variantiVAR_033153101A → S.Corresponds to variant rs10909820dbSNPEnsembl.1
Natural variantiVAR_057829165P → A.Corresponds to variant rs12036962dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289493 mRNA. Translation: BAF82182.1.
BX005110, AL691523 Genomic DNA. Translation: CAI17266.1.
AL691523, BX005110 Genomic DNA. Translation: CAI17365.1.
CH471130 Genomic DNA. Translation: EAW71492.1.
BC035643 mRNA. Translation: AAH35643.1. Different initiation.
BC067302 mRNA. Translation: AAH67302.1.
CCDSiCCDS53.1.
RefSeqiNP_997239.2. NM_207356.2.
UniGeneiHs.103939.

Genome annotation databases

EnsembliENST00000361605; ENSP00000355306; ENSG00000198912.
GeneIDi339448.
KEGGihsa:339448.
UCSCiuc001alf.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289493 mRNA. Translation: BAF82182.1.
BX005110, AL691523 Genomic DNA. Translation: CAI17266.1.
AL691523, BX005110 Genomic DNA. Translation: CAI17365.1.
CH471130 Genomic DNA. Translation: EAW71492.1.
BC035643 mRNA. Translation: AAH35643.1. Different initiation.
BC067302 mRNA. Translation: AAH67302.1.
CCDSiCCDS53.1.
RefSeqiNP_997239.2. NM_207356.2.
UniGeneiHs.103939.

3D structure databases

ProteinModelPortaliQ8IYL3.
SMRiQ8IYL3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130884. 11 interactors.
IntActiQ8IYL3. 11 interactors.
MINTiMINT-1387024.
STRINGi9606.ENSP00000355306.

PTM databases

iPTMnetiQ8IYL3.
PhosphoSitePlusiQ8IYL3.

Polymorphism and mutation databases

BioMutaiC1orf174.
DMDMi152013372.

Proteomic databases

EPDiQ8IYL3.
MaxQBiQ8IYL3.
PaxDbiQ8IYL3.
PeptideAtlasiQ8IYL3.
PRIDEiQ8IYL3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361605; ENSP00000355306; ENSG00000198912.
GeneIDi339448.
KEGGihsa:339448.
UCSCiuc001alf.4. human.

Organism-specific databases

CTDi339448.
DisGeNETi339448.
GeneCardsiC1orf174.
H-InvDBHIX0023581.
HGNCiHGNC:27915. C1orf174.
HPAiHPA008270.
neXtProtiNX_Q8IYL3.
OpenTargetsiENSG00000198912.
PharmGKBiPA143485318.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXWN. Eukaryota.
ENOG410XZ19. LUCA.
GeneTreeiENSGT00390000016496.
HOGENOMiHOG000111263.
HOVERGENiHBG097321.
InParanoidiQ8IYL3.
OMAiKFKCDKG.
OrthoDBiEOG091G0N6K.
PhylomeDBiQ8IYL3.
TreeFamiTF336079.

Enzyme and pathway databases

BioCyciZFISH:G66-31100-MONOMER.

Miscellaneous databases

ChiTaRSiC1orf174. human.
GenomeRNAii339448.
PROiQ8IYL3.

Gene expression databases

BgeeiENSG00000198912.
CleanExiHS_C1orf174.
GenevisibleiQ8IYL3. HS.

Family and domain databases

InterProiIPR031530. UPF0688.
[Graphical view]
PfamiPF15772. UPF0688. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCA174_HUMAN
AccessioniPrimary (citable) accession number: Q8IYL3
Secondary accession number(s): A8K0C8
, A8MUG9, Q5SR20, Q6NX36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: November 30, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.