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Protein

Probable tRNA (uracil-O(2)-)-methyltransferase

Gene

TRMT44

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.By similarity

Catalytic activityi

S-adenosyl-L-methionine + uridine(44) in tRNA(Ser) = S-adenosyl-L-homocysteine + 2'-O-methyluridine(44) in tRNA(Ser).

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri713 – 74331C3H1-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

Metal-binding, S-adenosyl-L-methionine, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-6782315. tRNA modification in the nucleus and cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable tRNA (uracil-O(2)-)-methyltransferase (EC:2.1.1.211)
Alternative name(s):
Methyltransferase-like protein 19
Gene namesi
Name:TRMT44
Synonyms:C4orf23, METTL19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:26653. TRMT44.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145008869.

Polymorphism and mutation databases

BioMutaiTRMT44.
DMDMi115311883.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 757757Probable tRNA (uracil-O(2)-)-methyltransferasePRO_0000249894Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei78 – 781PhosphoserineCombined sources
Modified residuei533 – 5331PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IYL2.
MaxQBiQ8IYL2.
PaxDbiQ8IYL2.
PeptideAtlasiQ8IYL2.
PRIDEiQ8IYL2.

PTM databases

iPTMnetiQ8IYL2.
PhosphoSiteiQ8IYL2.

Expressioni

Gene expression databases

BgeeiENSG00000155275.
CleanExiHS_C4orf23.
ExpressionAtlasiQ8IYL2. baseline and differential.
GenevisibleiQ8IYL2. HS.

Organism-specific databases

HPAiHPA045461.

Interactioni

Protein-protein interaction databases

BioGridi127475. 16 interactions.
STRINGi9606.ENSP00000374387.

Structurei

3D structure databases

ProteinModelPortaliQ8IYL2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TRM44 family.Curated
Contains 1 C3H1-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri713 – 74331C3H1-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3790. Eukaryota.
ENOG410YQ45. LUCA.
GeneTreeiENSGT00390000000645.
HOGENOMiHOG000004858.
HOVERGENiHBG072662.
InParanoidiQ8IYL2.
KOiK15447.
OMAiSNVYQIQ.
OrthoDBiEOG091G05XY.
PhylomeDBiQ8IYL2.
TreeFamiTF106127.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR029063. SAM-dependent_MTases.
IPR011671. tRNA_uracil_MeTrfase.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF07757. AdoMet_MTase. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS50103. ZF_C3H1. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IYL2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEVGRTGIS YPGALLPQGF WAAVEVWLER PQVANKRLCG ARLEARWSAA
60 70 80 90 100
LPCAEARGPG TSAGSEQKER GPGPGQGSPG GGPGPRSLSG PEQGTACCEL
110 120 130 140 150
EEAQGQCQQE EAQREAASVP LRDSGHPGHA EGREGDFPAA DLDSLWEDFS
160 170 180 190 200
QSLARGNSEL LAFLTSSGAG SQPEAQRELD VVLRTVIPKT SPHCPLTTPR
210 220 230 240 250
REIVVQDVLN GTITFLPLEE DDEGNLKVKM SNVYQIQLSH SKEEWFISVL
260 270 280 290 300
IFCPERWHSD GIVYPKPTWL GEELLAKLAK WSVENKKSDF KSTLSLISIM
310 320 330 340 350
KYSKAYQELK EKYKEMVKVW PEVTDPEKFV YEDVAIAAYL LILWEEERAE
360 370 380 390 400
RRLTARQSFV DLGCGNGLLV HILSSEGHPG RGIDVRRRKI WDMYGPQTQL
410 420 430 440 450
EEDAITPNDK TLFPDVDWLI GNHSDELTPW IPVIAARSSY NCRFFVLPCC
460 470 480 490 500
FFDFIGRYSR RQSKKTQYRE YLDFIKEVGF TCGFHVDEDC LRIPSTKRVC
510 520 530 540 550
LVGKSRTYPS SREASVDEKR TQYIKSRRGC PVSPPGWELS PSPRWVAAGS
560 570 580 590 600
AGHCDGQQAL DARVGCVTRA WAAEHGAGPQ AEGPWLPGFH PREKAERVRN
610 620 630 640 650
CAALPRDFID QVVLQVANLL LGGKQLNTRS SRNGSLKTWN GGESLSLAEV
660 670 680 690 700
ANELDTETLR RLKRECGGLQ TLLRNSHQVF QVVNGRVHIR DWREETLWKT
710 720 730 740 750
KQPEAKQRLL SEACKTRLCW FFMHHPDGCA LSTDCCPFAH GPAELRPPRT

TPRKKIS
Length:757
Mass (Da):84,629
Last modified:September 19, 2006 - v2
Checksum:i71E5E4614D6718DC
GO
Isoform 2 (identifier: Q8IYL2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-241: Missing.
     242-254: KEEWFISVLIFCP → MCIKFSSVIAKKN
     643-652: ESLSLAEVAN → GKLSTILGRG
     653-757: Missing.

Note: No experimental confirmation available.
Show »
Length:411
Mass (Da):46,592
Checksum:i85DA290CC8BBC78D
GO
Isoform 3 (identifier: Q8IYL2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-392: Missing.

Show »
Length:365
Mass (Da):41,327
Checksum:iFD7F525D425F08EC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti300 – 3001M → L.1 Publication
Corresponds to variant rs73211375 [ dbSNP | Ensembl ].
VAR_066601
Natural varianti352 – 3521R → G.
Corresponds to variant rs1880024 [ dbSNP | Ensembl ].
VAR_027515
Natural varianti455 – 4551I → V.1 Publication
Corresponds to variant rs34873641 [ dbSNP | Ensembl ].
VAR_066602
Natural varianti641 – 6411G → A.1 Publication
Corresponds to variant rs150441746 [ dbSNP | Ensembl ].
VAR_066603

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 392392Missing in isoform 3. 1 PublicationVSP_039538Add
BLAST
Alternative sequencei1 – 241241Missing in isoform 2. 1 PublicationVSP_020589Add
BLAST
Alternative sequencei242 – 25413KEEWF…LIFCP → MCIKFSSVIAKKN in isoform 2. 1 PublicationVSP_020590Add
BLAST
Alternative sequencei643 – 65210ESLSLAEVAN → GKLSTILGRG in isoform 2. 1 PublicationVSP_020591
Alternative sequencei653 – 757105Missing in isoform 2. 1 PublicationVSP_020592Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093044 mRNA. Translation: BAC04031.1.
AC104825 Genomic DNA. No translation available.
AC105345 Genomic DNA. No translation available.
CH471131 Genomic DNA. Translation: EAW82337.1.
BC035655 mRNA. Translation: AAH35655.1.
CCDSiCCDS3402.2. [Q8IYL2-1]
RefSeqiNP_689757.2. NM_152544.2. [Q8IYL2-1]
UniGeneiHs.566191.
Hs.734761.

Genome annotation databases

EnsembliENST00000389737; ENSP00000374387; ENSG00000155275. [Q8IYL2-1]
ENST00000513449; ENSP00000424643; ENSG00000155275. [Q8IYL2-2]
GeneIDi152992.
KEGGihsa:152992.
UCSCiuc003glf.2. human. [Q8IYL2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093044 mRNA. Translation: BAC04031.1.
AC104825 Genomic DNA. No translation available.
AC105345 Genomic DNA. No translation available.
CH471131 Genomic DNA. Translation: EAW82337.1.
BC035655 mRNA. Translation: AAH35655.1.
CCDSiCCDS3402.2. [Q8IYL2-1]
RefSeqiNP_689757.2. NM_152544.2. [Q8IYL2-1]
UniGeneiHs.566191.
Hs.734761.

3D structure databases

ProteinModelPortaliQ8IYL2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127475. 16 interactions.
STRINGi9606.ENSP00000374387.

PTM databases

iPTMnetiQ8IYL2.
PhosphoSiteiQ8IYL2.

Polymorphism and mutation databases

BioMutaiTRMT44.
DMDMi115311883.

Proteomic databases

EPDiQ8IYL2.
MaxQBiQ8IYL2.
PaxDbiQ8IYL2.
PeptideAtlasiQ8IYL2.
PRIDEiQ8IYL2.

Protocols and materials databases

DNASUi152992.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389737; ENSP00000374387; ENSG00000155275. [Q8IYL2-1]
ENST00000513449; ENSP00000424643; ENSG00000155275. [Q8IYL2-2]
GeneIDi152992.
KEGGihsa:152992.
UCSCiuc003glf.2. human. [Q8IYL2-1]

Organism-specific databases

CTDi152992.
GeneCardsiTRMT44.
HGNCiHGNC:26653. TRMT44.
HPAiHPA045461.
MIMi614309. gene.
neXtProtiNX_Q8IYL2.
PharmGKBiPA145008869.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3790. Eukaryota.
ENOG410YQ45. LUCA.
GeneTreeiENSGT00390000000645.
HOGENOMiHOG000004858.
HOVERGENiHBG072662.
InParanoidiQ8IYL2.
KOiK15447.
OMAiSNVYQIQ.
OrthoDBiEOG091G05XY.
PhylomeDBiQ8IYL2.
TreeFamiTF106127.

Enzyme and pathway databases

ReactomeiR-HSA-6782315. tRNA modification in the nucleus and cytosol.

Miscellaneous databases

GenomeRNAii152992.
PROiQ8IYL2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000155275.
CleanExiHS_C4orf23.
ExpressionAtlasiQ8IYL2. baseline and differential.
GenevisibleiQ8IYL2. HS.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR029063. SAM-dependent_MTases.
IPR011671. tRNA_uracil_MeTrfase.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF07757. AdoMet_MTase. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS50103. ZF_C3H1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRM44_HUMAN
AccessioniPrimary (citable) accession number: Q8IYL2
Secondary accession number(s): Q8NA95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: September 19, 2006
Last modified: September 7, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.