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Protein

GTP-binding protein REM 2

Gene

REM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi121 – 1288GTP1 Publication
Nucleotide bindingi229 – 2324GTP1 Publication
Nucleotide bindingi260 – 2612GTP1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.4.23.15. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein REM 2
Alternative name(s):
Rad and Gem-like GTP-binding protein 2
Gene namesi
Name:REM2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:20248. REM2.

Subcellular locationi

  • Cell membrane By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134916581.

Polymorphism and mutation databases

BioMutaiREM2.
DMDMi290457655.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 340340GTP-binding protein REM 2PRO_0000122483Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei27 – 271PhosphoserineBy similarity
Modified residuei295 – 2951PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8IYK8.
PRIDEiQ8IYK8.

PTM databases

iPTMnetiQ8IYK8.
PhosphoSiteiQ8IYK8.

Expressioni

Gene expression databases

BgeeiQ8IYK8.
CleanExiHS_REM2.
GenevisibleiQ8IYK8. HS.

Interactioni

Protein-protein interaction databases

BioGridi127778. 1 interaction.
IntActiQ8IYK8. 1 interaction.
STRINGi9606.ENSP00000267396.

Structurei

Secondary structure

1
340
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi114 – 1207Combined sources
Helixi127 – 1337Combined sources
Helixi141 – 1433Combined sources
Turni144 – 1463Combined sources
Beta strandi151 – 1588Combined sources
Beta strandi161 – 1688Combined sources
Helixi175 – 1773Combined sources
Helixi178 – 18710Combined sources
Beta strandi189 – 1968Combined sources
Helixi200 – 2045Combined sources
Helixi206 – 21611Combined sources
Beta strandi224 – 2296Combined sources
Turni234 – 2363Combined sources
Helixi241 – 25010Combined sources
Beta strandi254 – 2596Combined sources
Turni260 – 2634Combined sources
Helixi266 – 27813Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3CBQX-ray1.82A110-286[»]
ProteinModelPortaliQ8IYK8.
SMRiQ8IYK8. Positions 113-281.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8IYK8.

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. RGK family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121849.
HOGENOMiHOG000246961.
HOVERGENiHBG104899.
InParanoidiQ8IYK8.
KOiK07848.
OMAiCEFLEVS.
OrthoDBiEOG7Q8CP8.
PhylomeDBiQ8IYK8.
TreeFamiTF314379.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IYK8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHTDLDTDMD MDTETTALCP SGSRRASPPG TPTPEADATL LKKSEKLLAE
60 70 80 90 100
LDRSGLPSAP GAPRRRGSMP VPYKHQLRRA QAVDELDWPP QASSSGSSDS
110 120 130 140 150
LGSGEAAPAQ KDGIFKVMLV GESGVGKSTL AGTFGGLQGD SAHEPENPED
160 170 180 190 200
TYERRIMVDK EEVTLVVYDI WEQGDAGGWL RDHCLQTGDA FLIVFSVTDR
210 220 230 240 250
RSFSKVPETL LRLRAGRPHH DLPVILVGNK SDLARSREVS LEEGRHLAGT
260 270 280 290 300
LSCKHIETSA ALHHNTRELF EGAVRQIRLR RGRNHAGGQR PDPGSPEGPA
310 320 330 340
PPARRESLTK KAKRFLANLV PRNAKFFKQR SRSCHDLSVL
Length:340
Mass (Da):37,139
Last modified:March 2, 2010 - v2
Checksum:i7043E32471EA18DA
GO
Isoform 2 (identifier: Q8IYK8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     149-221: EDTYERRIMV...RLRAGRPHHD → GGCRRVAAGP...PGGITGGCVS
     222-340: Missing.

Note: No experimental confirmation available.
Show »
Length:221
Mass (Da):23,295
Checksum:i8234E026BA80174C
GO

Sequence cautioni

The sequence AAH35663.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC04746.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti96 – 961G → A.
Corresponds to variant rs8014119 [ dbSNP | Ensembl ].
VAR_055938

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei149 – 22173EDTYE…RPHHD → GGCRRVAAGPLPSDRGRLSH RLLSHRPTEFLQSSRDPTSA PGWEAAPRPTRYPRWKQERL GPLPGGITGGCVS in isoform 2. 1 PublicationVSP_056922Add
BLAST
Alternative sequencei222 – 340119Missing in isoform 2. 1 PublicationVSP_056923Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096283 mRNA. Translation: BAC04746.1. Different initiation.
AK299238 mRNA. Translation: BAH12977.1.
AL135998 Genomic DNA. No translation available.
BC035663 mRNA. Translation: AAH35663.1. Different initiation.
CCDSiCCDS45082.1. [Q8IYK8-1]
RefSeqiNP_775798.2. NM_173527.2. [Q8IYK8-1]
UniGeneiHs.444911.

Genome annotation databases

EnsembliENST00000267396; ENSP00000267396; ENSG00000139890. [Q8IYK8-1]
ENST00000536884; ENSP00000442774; ENSG00000139890. [Q8IYK8-2]
GeneIDi161253.
KEGGihsa:161253.
UCSCiuc001whf.2. human. [Q8IYK8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096283 mRNA. Translation: BAC04746.1. Different initiation.
AK299238 mRNA. Translation: BAH12977.1.
AL135998 Genomic DNA. No translation available.
BC035663 mRNA. Translation: AAH35663.1. Different initiation.
CCDSiCCDS45082.1. [Q8IYK8-1]
RefSeqiNP_775798.2. NM_173527.2. [Q8IYK8-1]
UniGeneiHs.444911.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3CBQX-ray1.82A110-286[»]
ProteinModelPortaliQ8IYK8.
SMRiQ8IYK8. Positions 113-281.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127778. 1 interaction.
IntActiQ8IYK8. 1 interaction.
STRINGi9606.ENSP00000267396.

PTM databases

iPTMnetiQ8IYK8.
PhosphoSiteiQ8IYK8.

Polymorphism and mutation databases

BioMutaiREM2.
DMDMi290457655.

Proteomic databases

PaxDbiQ8IYK8.
PRIDEiQ8IYK8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267396; ENSP00000267396; ENSG00000139890. [Q8IYK8-1]
ENST00000536884; ENSP00000442774; ENSG00000139890. [Q8IYK8-2]
GeneIDi161253.
KEGGihsa:161253.
UCSCiuc001whf.2. human. [Q8IYK8-1]

Organism-specific databases

CTDi161253.
GeneCardsiREM2.
HGNCiHGNC:20248. REM2.
neXtProtiNX_Q8IYK8.
PharmGKBiPA134916581.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121849.
HOGENOMiHOG000246961.
HOVERGENiHBG104899.
InParanoidiQ8IYK8.
KOiK07848.
OMAiCEFLEVS.
OrthoDBiEOG7Q8CP8.
PhylomeDBiQ8IYK8.
TreeFamiTF314379.

Enzyme and pathway databases

BRENDAi3.4.23.15. 2681.

Miscellaneous databases

EvolutionaryTraceiQ8IYK8.
GenomeRNAii161253.
PROiQ8IYK8.

Gene expression databases

BgeeiQ8IYK8.
CleanExiHS_REM2.
GenevisibleiQ8IYK8. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
  2. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Ovary.
  4. "Crystal structure of the human rem2 GTPase with bound GDP."
    Structural genomics consortium (SGC)
    Submitted (FEB-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.82 ANGSTROMS) OF 110-286 IN COMPLEX WITH GDP.

Entry informationi

Entry nameiREM2_HUMAN
AccessioniPrimary (citable) accession number: Q8IYK8
Secondary accession number(s): B7Z5P1, Q8N8R8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: March 2, 2010
Last modified: June 8, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.