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Protein

GTP-binding protein REM 2

Gene

REM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi121 – 128GTP1 Publication8
Nucleotide bindingi229 – 232GTP1 Publication4
Nucleotide bindingi260 – 261GTP1 Publication2

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.4.23.15. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein REM 2
Alternative name(s):
Rad and Gem-like GTP-binding protein 2
Gene namesi
Name:REM2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:20248. REM2.

Subcellular locationi

  • Cell membrane By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi161253.
OpenTargetsiENSG00000139890.
PharmGKBiPA134916581.

Polymorphism and mutation databases

BioMutaiREM2.
DMDMi290457655.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001224831 – 340GTP-binding protein REM 2Add BLAST340

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei27PhosphoserineBy similarity1
Modified residuei295PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IYK8.
PaxDbiQ8IYK8.
PeptideAtlasiQ8IYK8.
PRIDEiQ8IYK8.

PTM databases

iPTMnetiQ8IYK8.
PhosphoSitePlusiQ8IYK8.

Expressioni

Gene expression databases

BgeeiENSG00000139890.
CleanExiHS_REM2.
GenevisibleiQ8IYK8. HS.

Interactioni

Protein-protein interaction databases

BioGridi127778. 1 interactor.
IntActiQ8IYK8. 3 interactors.
STRINGi9606.ENSP00000267396.

Structurei

Secondary structure

1340
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi114 – 120Combined sources7
Helixi127 – 133Combined sources7
Helixi141 – 143Combined sources3
Turni144 – 146Combined sources3
Beta strandi151 – 158Combined sources8
Beta strandi161 – 168Combined sources8
Helixi175 – 177Combined sources3
Helixi178 – 187Combined sources10
Beta strandi189 – 196Combined sources8
Helixi200 – 204Combined sources5
Helixi206 – 216Combined sources11
Beta strandi224 – 229Combined sources6
Turni234 – 236Combined sources3
Helixi241 – 250Combined sources10
Beta strandi254 – 259Combined sources6
Turni260 – 263Combined sources4
Helixi266 – 278Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3CBQX-ray1.82A110-286[»]
ProteinModelPortaliQ8IYK8.
SMRiQ8IYK8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8IYK8.

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. RGK family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000133672.
HOGENOMiHOG000246961.
HOVERGENiHBG104899.
InParanoidiQ8IYK8.
KOiK07848.
OMAiCEFLEVS.
OrthoDBiEOG091G0OCN.
PhylomeDBiQ8IYK8.
TreeFamiTF314379.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IYK8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHTDLDTDMD MDTETTALCP SGSRRASPPG TPTPEADATL LKKSEKLLAE
60 70 80 90 100
LDRSGLPSAP GAPRRRGSMP VPYKHQLRRA QAVDELDWPP QASSSGSSDS
110 120 130 140 150
LGSGEAAPAQ KDGIFKVMLV GESGVGKSTL AGTFGGLQGD SAHEPENPED
160 170 180 190 200
TYERRIMVDK EEVTLVVYDI WEQGDAGGWL RDHCLQTGDA FLIVFSVTDR
210 220 230 240 250
RSFSKVPETL LRLRAGRPHH DLPVILVGNK SDLARSREVS LEEGRHLAGT
260 270 280 290 300
LSCKHIETSA ALHHNTRELF EGAVRQIRLR RGRNHAGGQR PDPGSPEGPA
310 320 330 340
PPARRESLTK KAKRFLANLV PRNAKFFKQR SRSCHDLSVL
Length:340
Mass (Da):37,139
Last modified:March 2, 2010 - v2
Checksum:i7043E32471EA18DA
GO
Isoform 2 (identifier: Q8IYK8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     149-221: EDTYERRIMV...RLRAGRPHHD → GGCRRVAAGP...PGGITGGCVS
     222-340: Missing.

Note: No experimental confirmation available.
Show »
Length:221
Mass (Da):23,295
Checksum:i8234E026BA80174C
GO

Sequence cautioni

The sequence AAH35663 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC04746 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05593896G → A.Corresponds to variant rs8014119dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056922149 – 221EDTYE…RPHHD → GGCRRVAAGPLPSDRGRLSH RLLSHRPTEFLQSSRDPTSA PGWEAAPRPTRYPRWKQERL GPLPGGITGGCVS in isoform 2. 1 PublicationAdd BLAST73
Alternative sequenceiVSP_056923222 – 340Missing in isoform 2. 1 PublicationAdd BLAST119

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096283 mRNA. Translation: BAC04746.1. Different initiation.
AK299238 mRNA. Translation: BAH12977.1.
AL135998 Genomic DNA. No translation available.
BC035663 mRNA. Translation: AAH35663.1. Different initiation.
CCDSiCCDS45082.1. [Q8IYK8-1]
RefSeqiNP_775798.2. NM_173527.2. [Q8IYK8-1]
UniGeneiHs.444911.

Genome annotation databases

EnsembliENST00000267396; ENSP00000267396; ENSG00000139890. [Q8IYK8-1]
ENST00000536884; ENSP00000442774; ENSG00000139890. [Q8IYK8-2]
GeneIDi161253.
KEGGihsa:161253.
UCSCiuc001whf.2. human. [Q8IYK8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096283 mRNA. Translation: BAC04746.1. Different initiation.
AK299238 mRNA. Translation: BAH12977.1.
AL135998 Genomic DNA. No translation available.
BC035663 mRNA. Translation: AAH35663.1. Different initiation.
CCDSiCCDS45082.1. [Q8IYK8-1]
RefSeqiNP_775798.2. NM_173527.2. [Q8IYK8-1]
UniGeneiHs.444911.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3CBQX-ray1.82A110-286[»]
ProteinModelPortaliQ8IYK8.
SMRiQ8IYK8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127778. 1 interactor.
IntActiQ8IYK8. 3 interactors.
STRINGi9606.ENSP00000267396.

PTM databases

iPTMnetiQ8IYK8.
PhosphoSitePlusiQ8IYK8.

Polymorphism and mutation databases

BioMutaiREM2.
DMDMi290457655.

Proteomic databases

EPDiQ8IYK8.
PaxDbiQ8IYK8.
PeptideAtlasiQ8IYK8.
PRIDEiQ8IYK8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267396; ENSP00000267396; ENSG00000139890. [Q8IYK8-1]
ENST00000536884; ENSP00000442774; ENSG00000139890. [Q8IYK8-2]
GeneIDi161253.
KEGGihsa:161253.
UCSCiuc001whf.2. human. [Q8IYK8-1]

Organism-specific databases

CTDi161253.
DisGeNETi161253.
GeneCardsiREM2.
HGNCiHGNC:20248. REM2.
neXtProtiNX_Q8IYK8.
OpenTargetsiENSG00000139890.
PharmGKBiPA134916581.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000133672.
HOGENOMiHOG000246961.
HOVERGENiHBG104899.
InParanoidiQ8IYK8.
KOiK07848.
OMAiCEFLEVS.
OrthoDBiEOG091G0OCN.
PhylomeDBiQ8IYK8.
TreeFamiTF314379.

Enzyme and pathway databases

BRENDAi3.4.23.15. 2681.

Miscellaneous databases

EvolutionaryTraceiQ8IYK8.
GenomeRNAii161253.
PROiQ8IYK8.

Gene expression databases

BgeeiENSG00000139890.
CleanExiHS_REM2.
GenevisibleiQ8IYK8. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiREM2_HUMAN
AccessioniPrimary (citable) accession number: Q8IYK8
Secondary accession number(s): B7Z5P1, Q8N8R8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: March 2, 2010
Last modified: November 30, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.