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Reviewed, UniProtKB/Swiss-Prot Q8IYK8 (REM2_HUMAN)

Last modified June 16, 2009. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    GTP-binding protein REM 2
Alternative name(s):
    Rad and Gem-like GTP-binding protein 2
Gene names
Name: REM2
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length330 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis By similarity.

Subcellular location

Cell membrane By similarity.

Sequence similarities

Belongs to the small GTPase superfamily. RGK family.

Caution

It is uncertain whether Met-1 or Met-59 is the initiator.

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Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   LigandGTP-binding
Nucleotide-binding
   Technical term3D-structure
Gene Ontology (GO)
   Biological processsmall GTPase mediated signal transduction

Inferred from electronic annotation. Source: InterPro

   Cellular componentplasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 330330GTP-binding protein REM 2
PRO_0000122483

Regions

Nucleotide binding111 – 1188GTP By similarity
Nucleotide binding219 – 2224GTP By similarity

Natural variations

Natural variant861G → A: dbSNP rs8014119.
VAR_055938

Secondary structure

1 ................................ 330
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
Q8IYK8-1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: C9F16FC730892216

FASTA33035,964
        10         20         30         40         50         60 
MDTETTALCP SGSRRASPPG TPTPEADATL LKKSEKLLAE LDRSGLPSAP GAPRRRGSMP 

        70         80         90        100        110        120 
VPYKHQLRRA QAVDELDWPP QASSSGSSDS LGSGEAAPAQ KDGIFKVMLV GESGVGKSTL 

       130        140        150        160        170        180 
AGTFGGLQGD SAHEPENPED TYERRIMVDK EEVTLVVYDI WEQGDAGGWL RDHCLQTGDA 

       190        200        210        220        230        240 
FLIVFSVTDR RSFSKVPETL LRLRAGRPHH DLPVILVGNK SDLARSREVS LEEGRHLAGT 

       250        260        270        280        290        300 
LSCKHIETSA ALHHNTRELF EGAVRQIRLR RGRNHAGGQR PDPGSPEGPA PPARRESLTK 

       310        320        330 
KAKRFLANLV PRNAKFFKQR SRSCHDLSVL

« Hide

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References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Ovary.
+Additional computationally mapped references.

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Cross-references

Sequence databases

AK096283 mRNA. Translation: BAC04746.1. Different initiation.
BC035663 mRNA. Translation: AAH35663.1.
IPIIPI00793200.
RefSeqNP_775798.2.
UniGeneHs.444911

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
3CBQX-ray1.82A100-276[»]
ModBaseSearch...

PTM databases

PhosphoSiteQ8IYK8.

Genome annotation databases

EnsemblENSG00000139890. Homo sapiens. [Contig view]
GeneID161253.
KEGGhsa:161253.

Organism-specific databases

GeneCardsGC14P022423.
H-InvDBHIX0011522.
HGNCHGNC:20248. REM2.
PharmGKBPA134930862.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ8IYK8.
HOVERGENQ8IYK8.
OMAQ8IYK8. AAPAQKD.

Enzyme and pathway databases

BRENDA3.4.23.15. 247.

Gene expression databases

ArrayExpressQ8IYK8.
BgeeQ8IYK8.
CleanExHS_REM2.
GermOnlineENSG00000139890. Homo sapiens.

Family and domain databases

InterProIPR017358. GTP-binding_GEM/REM/Rad.
IPR013753. Ras.
IPR001806. Ras_GTPase.
IPR005225. Small_GTP_bd.
[Graphical view]
PfamPF00071. Ras. 1 hit.
[Graphical view]
PIRSFPIRSF038017. GTP-binding_GEM. 1 hit.
PRINTSPR00449. RASTRNSFRMNG.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio88040.

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Entry information

Entry nameREM2_HUMAN
AccessionPrimary (citable) accession number: Q8IYK8
Secondary accession number(s): Q8N8R8
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: March 1, 2003
Last modified: June 16, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents