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Protein

Synaptotagmin-like protein 1

Gene

SYTL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in vesicle trafficking (By similarity). Binds phosphatidylinositol 3,4,5-trisphosphate. Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes (By similarity).By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Exocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-like protein 1
Alternative name(s):
Exophilin-7
Protein JFC1
Gene namesi
Name:SYTL1
Synonyms:SLP1
ORF Names:SB146
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:15584. SYTL1.

Subcellular locationi

GO - Cellular componenti

  • exocytic vesicle Source: GO_Central
  • extracellular exosome Source: UniProtKB
  • extrinsic component of plasma membrane Source: UniProtKB
  • melanosome Source: UniProtKB
  • plasma membrane Source: UniProtKB
  • presynapse Source: GOC
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134921815.

Polymorphism and mutation databases

BioMutaiSYTL1.
DMDMi33301659.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 562562Synaptotagmin-like protein 1PRO_0000190211Add
BLAST

Proteomic databases

EPDiQ8IYJ3.
MaxQBiQ8IYJ3.
PaxDbiQ8IYJ3.
PRIDEiQ8IYJ3.
TopDownProteomicsiQ8IYJ3-2. [Q8IYJ3-2]

PTM databases

iPTMnetiQ8IYJ3.
PhosphoSiteiQ8IYJ3.

Expressioni

Tissue specificityi

Highly expressed in bone marrow and lymphoid tissues. Detected at lower levels in cerebellum, occipital lobe, prostate, stomach, kidney, appendix, lung and trachea. Expressed in cytotoxic T-lymphocytes (CTL).2 Publications

Gene expression databases

BgeeiQ8IYJ3.
CleanExiHS_SYTL1.
ExpressionAtlasiQ8IYJ3. baseline and differential.
GenevisibleiQ8IYJ3. HS.

Organism-specific databases

HPAiHPA037825.

Interactioni

Subunit structurei

Monomer. Binds NRXN1. Binds RAB27A that has been activated by GTP-binding via its N-terminus (By similarity). Binds NCF2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi124389. 5 interactions.
IntActiQ8IYJ3. 2 interactions.
STRINGi9606.ENSP00000440704.

Structurei

3D structure databases

ProteinModelPortaliQ8IYJ3.
SMRiQ8IYJ3. Positions 266-544.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 8757RabBDPROSITE-ProRule annotationAdd
BLAST
Domaini268 – 368101C2 1PROSITE-ProRule annotationAdd
BLAST
Domaini409 – 511103C2 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi237 – 25822Ser-richAdd
BLAST

Sequence similaritiesi

Contains 2 C2 domains.PROSITE-ProRule annotation
Contains 1 RabBD (Rab-binding) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IT3I. Eukaryota.
ENOG41107B6. LUCA.
GeneTreeiENSGT00810000125376.
HOGENOMiHOG000231332.
HOVERGENiHBG057965.
InParanoidiQ8IYJ3.
KOiK17598.
OMAiTWDWDSE.
OrthoDBiEOG7JMGDC.
PhylomeDBiQ8IYJ3.
TreeFamiTF341184.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR000008. C2_dom.
IPR010911. Rab_BD.
IPR028378. Sytl1.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR10024:SF11. PTHR10024:SF11. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 2 hits.
PS50916. RABBD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IYJ3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPQRGHPSQE GLWALPSLPM AHGPKPETEG LLDLSFLTEE EQEAIAGVLQ
60 70 80 90 100
RDARLRQLEE GRVSKLRASV ADPGQLKILT GDWFQEARSQ RHHNAHFGSD
110 120 130 140 150
LVRASMRRKK STRGDQAPGH DREAEAAVKE KEEGPEPRLT IDEAPQERLR
160 170 180 190 200
ETEGPDFPSP SVPLKASDPE EASQAQEDPG QGDQQVCAEE ADPELEPASG
210 220 230 240 250
GEQEPRPQQA QTKAASQILE NGEEAPGPDP SLDRMLSSSS SVSSLNSSTL
260 270 280 290 300
SGSQMSLSGD AEAVQVRGSV HFALHYEPGA AELRVHVIQC QGLAAARRRR
310 320 330 340 350
SDPYVKSYLL PDKQSKRKTA VKKRNLNPVF NETLRYSVPQ AELQGRVLSL
360 370 380 390 400
SVWHRESLGR NIFLGEVEVP LDTWDWGSEP TWLPLQPRVP PSPDDLPSRG
410 420 430 440 450
LLALSLKYVP AGSEGAGLPP SGELHFWVKE ARDLLPLRAG SLDTYVQCFV
460 470 480 490 500
LPDDSQASRQ RTRVVRRSLS PVFNHTMVYD GFGPADLRQA CAELSLWDHG
510 520 530 540 550
ALANRQLGGT RLSLGTGSSY GLQVPWMDST PEEKQLWQAL LEQPCEWVDG
560
LLPLRTNLAP RT
Length:562
Mass (Da):61,857
Last modified:March 1, 2003 - v1
Checksum:i056BE1F16723EE19
GO
Isoform 2 (identifier: Q8IYJ3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     154-165: Missing.

Note: No experimental confirmation available.
Show »
Length:550
Mass (Da):60,635
Checksum:i9FE6477065A8F01A
GO

Sequence cautioni

The sequence AAH15764.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti111 – 1111S → N in AAK67636 (Ref. 1) Curated
Sequence conflicti162 – 1621V → A in AAH15764 (PubMed:15489334).Curated
Sequence conflicti456 – 4561Q → R in AAK67636 (Ref. 1) Curated
Sequence conflicti456 – 4561Q → R in AAH09224 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei154 – 16512Missing in isoform 2. 1 PublicationVSP_007883Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY037157 mRNA. Translation: AAK67636.1.
AK027902 mRNA. Translation: BAB55444.1.
FO393419 Genomic DNA. No translation available.
BC009224 mRNA. Translation: AAH09224.2.
BC015764 mRNA. Translation: AAH15764.1. Different initiation.
BC035725 mRNA. Translation: AAH35725.1.
CCDSiCCDS298.1. [Q8IYJ3-2]
CCDS53286.1. [Q8IYJ3-1]
RefSeqiNP_001180237.1. NM_001193308.1. [Q8IYJ3-1]
NP_116261.1. NM_032872.2. [Q8IYJ3-2]
UniGeneiHs.469175.

Genome annotation databases

EnsembliENST00000318074; ENSP00000316464; ENSG00000142765. [Q8IYJ3-2]
ENST00000543823; ENSP00000440704; ENSG00000142765. [Q8IYJ3-1]
ENST00000616558; ENSP00000481032; ENSG00000142765. [Q8IYJ3-1]
GeneIDi84958.
KEGGihsa:84958.
UCSCiuc001bnv.3. human. [Q8IYJ3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY037157 mRNA. Translation: AAK67636.1.
AK027902 mRNA. Translation: BAB55444.1.
FO393419 Genomic DNA. No translation available.
BC009224 mRNA. Translation: AAH09224.2.
BC015764 mRNA. Translation: AAH15764.1. Different initiation.
BC035725 mRNA. Translation: AAH35725.1.
CCDSiCCDS298.1. [Q8IYJ3-2]
CCDS53286.1. [Q8IYJ3-1]
RefSeqiNP_001180237.1. NM_001193308.1. [Q8IYJ3-1]
NP_116261.1. NM_032872.2. [Q8IYJ3-2]
UniGeneiHs.469175.

3D structure databases

ProteinModelPortaliQ8IYJ3.
SMRiQ8IYJ3. Positions 266-544.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124389. 5 interactions.
IntActiQ8IYJ3. 2 interactions.
STRINGi9606.ENSP00000440704.

PTM databases

iPTMnetiQ8IYJ3.
PhosphoSiteiQ8IYJ3.

Polymorphism and mutation databases

BioMutaiSYTL1.
DMDMi33301659.

Proteomic databases

EPDiQ8IYJ3.
MaxQBiQ8IYJ3.
PaxDbiQ8IYJ3.
PRIDEiQ8IYJ3.
TopDownProteomicsiQ8IYJ3-2. [Q8IYJ3-2]

Protocols and materials databases

DNASUi84958.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318074; ENSP00000316464; ENSG00000142765. [Q8IYJ3-2]
ENST00000543823; ENSP00000440704; ENSG00000142765. [Q8IYJ3-1]
ENST00000616558; ENSP00000481032; ENSG00000142765. [Q8IYJ3-1]
GeneIDi84958.
KEGGihsa:84958.
UCSCiuc001bnv.3. human. [Q8IYJ3-1]

Organism-specific databases

CTDi84958.
GeneCardsiSYTL1.
HGNCiHGNC:15584. SYTL1.
HPAiHPA037825.
MIMi608042. gene.
neXtProtiNX_Q8IYJ3.
PharmGKBiPA134921815.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IT3I. Eukaryota.
ENOG41107B6. LUCA.
GeneTreeiENSGT00810000125376.
HOGENOMiHOG000231332.
HOVERGENiHBG057965.
InParanoidiQ8IYJ3.
KOiK17598.
OMAiTWDWDSE.
OrthoDBiEOG7JMGDC.
PhylomeDBiQ8IYJ3.
TreeFamiTF341184.

Miscellaneous databases

ChiTaRSiSYTL1. human.
GeneWikiiSYTL1.
GenomeRNAii84958.
PROiQ8IYJ3.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IYJ3.
CleanExiHS_SYTL1.
ExpressionAtlasiQ8IYJ3. baseline and differential.
GenevisibleiQ8IYJ3. HS.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR000008. C2_dom.
IPR010911. Rab_BD.
IPR028378. Sytl1.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR10024:SF11. PTHR10024:SF11. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 2 hits.
PS50916. RABBD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Li N., Wan T., Zhang M., Zhang W., Cao X.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: B-cell, Lung and Ovary.
  5. "JFC1, a novel tandem C2 domain-containing protein associated with the leukocyte NADPH oxidase."
    McAdara Berkowitz J.K., Catz S.D., Johnson J.L., Ruedi J.M., Thon V., Babior B.M.
    J. Biol. Chem. 276:18855-18862(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH NCF2.
    Tissue: Peripheral blood leukocyte.
  6. "Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse."
    Holt O., Kanno E., Bossi G., Booth S., Daniele T., Santoro A., Arico M., Saegusa C., Fukuda M., Griffiths G.M.
    Traffic 9:446-457(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiSYTL1_HUMAN
AccessioniPrimary (citable) accession number: Q8IYJ3
Secondary accession number(s): Q5SSC9
, Q96BB6, Q96GU6, Q96S89, Q96SI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.