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Protein

PILR alpha-associated neural protein

Gene

PIANP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as a ligand for PILRA in neural tissues, where it may be involved in immune regulation.1 Publication

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Names & Taxonomyi

Protein namesi
Recommended name:
PILR alpha-associated neural protein
Alternative name(s):
PILR-associating neural protein
Paired immunoglobin-like type 2 receptor-associating neural protein
Gene namesi
Name:PIANP
Synonyms:C12orf53, PANP
ORF Names:UNQ828/PRO1755
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000139200.13
HGNCiHGNC:25338 PIANP
MIMi616065 gene
neXtProtiNX_Q8IYJ0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 178ExtracellularSequence analysisAdd BLAST147
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Topological domaini200 – 282CytoplasmicSequence analysisAdd BLAST83

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000139200
PharmGKBiPA143485382

Polymorphism and mutation databases

BioMutaiPIANP
DMDMi74728342

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000028596432 – 282PILR alpha-associated neural proteinAdd BLAST251

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi140O-linked (GalNAc...) threonineBy similarity1

Post-translational modificationi

O-glycosylation at Thr-140 is essential for recognition by PILRA.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8IYJ0
PeptideAtlasiQ8IYJ0
PRIDEiQ8IYJ0
ProteomicsDBi71182
71183 [Q8IYJ0-2]

PTM databases

PhosphoSitePlusiQ8IYJ0

Expressioni

Tissue specificityi

Mainly expressed in adult brain and cerebellum. Weaker expression in fetal brain and virtually no expression in spleen, heart, kidney, liver and dorsal ganglion relative to brain.1 Publication

Gene expression databases

BgeeiENSG00000139200
CleanExiHS_C12orf53
ExpressionAtlasiQ8IYJ0 baseline and differential
GenevisibleiQ8IYJ0 HS

Organism-specific databases

HPAiHPA010631

Interactioni

Protein-protein interaction databases

BioGridi128215, 11 interactors
IntActiQ8IYJ0, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ8IYJ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVS4 Eukaryota
ENOG411268B LUCA
GeneTreeiENSGT00510000049460
HOGENOMiHOG000013006
HOVERGENiHBG101687
InParanoidiQ8IYJ0
OMAiFLPLDYG
OrthoDBiEOG091G0LBJ
PhylomeDBiQ8IYJ0
TreeFamiTF336539

Family and domain databases

InterProiView protein in InterPro
IPR029198 AJAP1_PANP_C
PfamiView protein in Pfam
PF15298 AJAP1_PANP_C, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IYJ0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESRMWPALL LSHLLPLWPL LLLPLPPPAQ GSSSSPRTPP APARPPCARG
60 70 80 90 100
GPSAPRHVCV WERAPPPSRS PRVPRSRRQV LPGTAPPATP SGFEEGPPSS
110 120 130 140 150
QYPWAIVWGP TVSREDGGDP NSANPGFLDY GFAAPHGLAT PHPNSDSMRG
160 170 180 190 200
DGDGLILGEA PATLRPFLFG GRGEGVDPQL YVTITISIII VLVATGIIFK
210 220 230 240 250
FCWDRSQKRR RPSGQQGALR QEESQQPLTD LSPAGVTVLG AFGDSPTPTP
260 270 280
DHEEPRGGPR PGMPHPKGAP AFQLNRIPLV NL
Length:282
Mass (Da):30,076
Last modified:March 1, 2003 - v1
Checksum:i772F37069CE472C8
GO
Isoform 2 (identifier: Q8IYJ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     277-282: Missing.

Show »
Length:276
Mass (Da):29,426
Checksum:i72C81C7DF9B7CB89
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22L → S in BAG52398 (PubMed:14702039).Curated1
Sequence conflicti41 – 43APA → VPT in BAG51669 (PubMed:14702039).Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_024939277 – 282Missing in isoform 2. 2 Publications6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358534 mRNA Translation: AAQ88898.1
AK056295 mRNA Translation: BAG51669.1
AK091656 mRNA Translation: BAG52398.1
AK095854 mRNA Translation: BAG53145.1
AK289648 mRNA Translation: BAF82337.1
CH471116 Genomic DNA Translation: EAW88750.1
CH471116 Genomic DNA Translation: EAW88751.1
BC035736 mRNA Translation: AAH35736.1
CCDSiCCDS44818.1 [Q8IYJ0-1]
CCDS58205.1 [Q8IYJ0-2]
RefSeqiNP_001230943.1, NM_001244014.1 [Q8IYJ0-2]
NP_001230944.1, NM_001244015.1 [Q8IYJ0-1]
NP_710152.1, NM_153685.3 [Q8IYJ0-1]
UniGeneiHs.44067
Hs.740050

Genome annotation databases

EnsembliENST00000320591; ENSP00000317818; ENSG00000139200 [Q8IYJ0-1]
ENST00000534837; ENSP00000443919; ENSG00000139200 [Q8IYJ0-2]
ENST00000540656; ENSP00000442157; ENSG00000139200 [Q8IYJ0-1]
GeneIDi196500
KEGGihsa:196500
UCSCiuc001qqf.3 human [Q8IYJ0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPIANP_HUMAN
AccessioniPrimary (citable) accession number: Q8IYJ0
Secondary accession number(s): A8K0T3
, B3KPF7, B3KRI6, Q6UX35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 1, 2003
Last modified: June 20, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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