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Protein

PILR alpha-associated neural protein

Gene

PIANP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a ligand for PILRA in neural tissues, where it may be involved in immune regulation.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
PILR alpha-associated neural protein
Alternative name(s):
PILR-associating neural protein
Paired immunoglobin-like type 2 receptor-associating neural protein
Gene namesi
Name:PIANP
Synonyms:C12orf53, PANP
ORF Names:UNQ828/PRO1755
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:25338. PIANP.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini32 – 178147ExtracellularSequence analysisAdd
BLAST
Transmembranei179 – 19921HelicalSequence analysisAdd
BLAST
Topological domaini200 – 28283CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485382.

Polymorphism and mutation databases

BioMutaiPIANP.
DMDMi74728342.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence analysisAdd
BLAST
Chaini32 – 282251PILR alpha-associated neural proteinPRO_0000285964Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi140 – 1401O-linked (GalNAc...)By similarity

Post-translational modificationi

O-glycosylation at Thr-140 is essential for recognition by PILRA.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8IYJ0.
PeptideAtlasiQ8IYJ0.
PRIDEiQ8IYJ0.

PTM databases

PhosphoSiteiQ8IYJ0.

Expressioni

Tissue specificityi

Mainly expressed in adult brain and cerebellum. Weaker expression in fetal brain and virtually no expression in spleen, heart, kidney, liver and dorsal ganglion relative to brain.1 Publication

Gene expression databases

BgeeiENSG00000139200.
CleanExiHS_C12orf53.
ExpressionAtlasiQ8IYJ0. baseline and differential.
GenevisibleiQ8IYJ0. HS.

Organism-specific databases

HPAiHPA010631.

Interactioni

Protein-protein interaction databases

BioGridi128215. 11 interactions.
STRINGi9606.ENSP00000317818.

Structurei

3D structure databases

ProteinModelPortaliQ8IYJ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVS4. Eukaryota.
ENOG411268B. LUCA.
GeneTreeiENSGT00510000049460.
HOGENOMiHOG000013006.
HOVERGENiHBG101687.
InParanoidiQ8IYJ0.
OMAiMPQPKGA.
OrthoDBiEOG091G0LBJ.
PhylomeDBiQ8IYJ0.
TreeFamiTF336539.

Family and domain databases

InterProiIPR029198. AJAP1_PANP_C.
[Graphical view]
PfamiPF15298. AJAP1_PANP_C. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IYJ0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESRMWPALL LSHLLPLWPL LLLPLPPPAQ GSSSSPRTPP APARPPCARG
60 70 80 90 100
GPSAPRHVCV WERAPPPSRS PRVPRSRRQV LPGTAPPATP SGFEEGPPSS
110 120 130 140 150
QYPWAIVWGP TVSREDGGDP NSANPGFLDY GFAAPHGLAT PHPNSDSMRG
160 170 180 190 200
DGDGLILGEA PATLRPFLFG GRGEGVDPQL YVTITISIII VLVATGIIFK
210 220 230 240 250
FCWDRSQKRR RPSGQQGALR QEESQQPLTD LSPAGVTVLG AFGDSPTPTP
260 270 280
DHEEPRGGPR PGMPHPKGAP AFQLNRIPLV NL
Length:282
Mass (Da):30,076
Last modified:March 1, 2003 - v1
Checksum:i772F37069CE472C8
GO
Isoform 2 (identifier: Q8IYJ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     277-282: Missing.

Show »
Length:276
Mass (Da):29,426
Checksum:i72C81C7DF9B7CB89
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti22 – 221L → S in BAG52398 (PubMed:14702039).Curated
Sequence conflicti41 – 433APA → VPT in BAG51669 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei277 – 2826Missing in isoform 2. 2 PublicationsVSP_024939

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358534 mRNA. Translation: AAQ88898.1.
AK056295 mRNA. Translation: BAG51669.1.
AK091656 mRNA. Translation: BAG52398.1.
AK095854 mRNA. Translation: BAG53145.1.
AK289648 mRNA. Translation: BAF82337.1.
CH471116 Genomic DNA. Translation: EAW88750.1.
CH471116 Genomic DNA. Translation: EAW88751.1.
BC035736 mRNA. Translation: AAH35736.1.
CCDSiCCDS44818.1. [Q8IYJ0-1]
CCDS58205.1. [Q8IYJ0-2]
RefSeqiNP_001230943.1. NM_001244014.1. [Q8IYJ0-2]
NP_001230944.1. NM_001244015.1. [Q8IYJ0-1]
NP_710152.1. NM_153685.3. [Q8IYJ0-1]
UniGeneiHs.44067.
Hs.740050.

Genome annotation databases

EnsembliENST00000320591; ENSP00000317818; ENSG00000139200. [Q8IYJ0-1]
ENST00000534837; ENSP00000443919; ENSG00000139200. [Q8IYJ0-2]
ENST00000540656; ENSP00000442157; ENSG00000139200. [Q8IYJ0-1]
GeneIDi196500.
KEGGihsa:196500.
UCSCiuc001qqf.3. human. [Q8IYJ0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358534 mRNA. Translation: AAQ88898.1.
AK056295 mRNA. Translation: BAG51669.1.
AK091656 mRNA. Translation: BAG52398.1.
AK095854 mRNA. Translation: BAG53145.1.
AK289648 mRNA. Translation: BAF82337.1.
CH471116 Genomic DNA. Translation: EAW88750.1.
CH471116 Genomic DNA. Translation: EAW88751.1.
BC035736 mRNA. Translation: AAH35736.1.
CCDSiCCDS44818.1. [Q8IYJ0-1]
CCDS58205.1. [Q8IYJ0-2]
RefSeqiNP_001230943.1. NM_001244014.1. [Q8IYJ0-2]
NP_001230944.1. NM_001244015.1. [Q8IYJ0-1]
NP_710152.1. NM_153685.3. [Q8IYJ0-1]
UniGeneiHs.44067.
Hs.740050.

3D structure databases

ProteinModelPortaliQ8IYJ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128215. 11 interactions.
STRINGi9606.ENSP00000317818.

PTM databases

PhosphoSiteiQ8IYJ0.

Polymorphism and mutation databases

BioMutaiPIANP.
DMDMi74728342.

Proteomic databases

PaxDbiQ8IYJ0.
PeptideAtlasiQ8IYJ0.
PRIDEiQ8IYJ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320591; ENSP00000317818; ENSG00000139200. [Q8IYJ0-1]
ENST00000534837; ENSP00000443919; ENSG00000139200. [Q8IYJ0-2]
ENST00000540656; ENSP00000442157; ENSG00000139200. [Q8IYJ0-1]
GeneIDi196500.
KEGGihsa:196500.
UCSCiuc001qqf.3. human. [Q8IYJ0-1]

Organism-specific databases

CTDi196500.
GeneCardsiPIANP.
H-InvDBHIX0201843.
HGNCiHGNC:25338. PIANP.
HPAiHPA010631.
MIMi616065. gene.
neXtProtiNX_Q8IYJ0.
PharmGKBiPA143485382.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVS4. Eukaryota.
ENOG411268B. LUCA.
GeneTreeiENSGT00510000049460.
HOGENOMiHOG000013006.
HOVERGENiHBG101687.
InParanoidiQ8IYJ0.
OMAiMPQPKGA.
OrthoDBiEOG091G0LBJ.
PhylomeDBiQ8IYJ0.
TreeFamiTF336539.

Miscellaneous databases

GenomeRNAii196500.
PROiQ8IYJ0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000139200.
CleanExiHS_C12orf53.
ExpressionAtlasiQ8IYJ0. baseline and differential.
GenevisibleiQ8IYJ0. HS.

Family and domain databases

InterProiIPR029198. AJAP1_PANP_C.
[Graphical view]
PfamiPF15298. AJAP1_PANP_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPIANP_HUMAN
AccessioniPrimary (citable) accession number: Q8IYJ0
Secondary accession number(s): A8K0T3
, B3KPF7, B3KRI6, Q6UX35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.