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Protein

Zinc finger protein 440

Gene

ZNF440

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri144 – 166C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri172 – 194C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri200 – 222C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 334C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri340 – 362C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri368 – 390C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri396 – 418C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri424 – 448C2H2-type 11PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri458 – 480C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 440
Gene namesi
Name:ZNF440
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:20874. ZNF440.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi126070.
OpenTargetsiENSG00000171295.
PharmGKBiPA134917447.

Polymorphism and mutation databases

BioMutaiZNF440.
DMDMi30580626.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475891 – 595Zinc finger protein 440Add BLAST595

Proteomic databases

EPDiQ8IYI8.
MaxQBiQ8IYI8.
PaxDbiQ8IYI8.
PeptideAtlasiQ8IYI8.
PRIDEiQ8IYI8.

PTM databases

iPTMnetiQ8IYI8.
PhosphoSitePlusiQ8IYI8.

Expressioni

Gene expression databases

BgeeiENSG00000171295.
CleanExiHS_ZNF440.
ExpressionAtlasiQ8IYI8. baseline and differential.
GenevisibleiQ8IYI8. HS.

Organism-specific databases

HPAiHPA047845.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-9P604113EBI-726439,EBI-10172052
MDFIQ997509EBI-726439,EBI-724076
MID2Q9UJV3-25EBI-726439,EBI-10172526
MTUS2Q5JR593EBI-726439,EBI-742948
NOTCH2NLQ7Z3S95EBI-726439,EBI-945833
TRAF1Q130776EBI-726439,EBI-359224

Protein-protein interaction databases

BioGridi125953. 12 interactors.
IntActiQ8IYI8. 22 interactors.
MINTiMINT-1384085.
STRINGi9606.ENSP00000305373.

Structurei

3D structure databases

ProteinModelPortaliQ8IYI8.
SMRiQ8IYI8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 86KRABPROSITE-ProRule annotationAdd BLAST83

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri144 – 166C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri172 – 194C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri200 – 222C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 334C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri340 – 362C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri368 – 390C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri396 – 418C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri424 – 448C2H2-type 11PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri458 – 480C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8IYI8.
KOiK09228.
OMAiMKGHKHT.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8IYI8.
TreeFamiTF338854.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IYI8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPVAFKDVA VNFTQEEWAL LDISQRKLYR EVMLETFRNL TSLGKRWKDQ
60 70 80 90 100
NIEYEHQNPR RNFRSLIEEK VNEIKDDSHC GETFTPVPDD RLNFQEKKAS
110 120 130 140 150
PEVKSCESFV CGEVGLGNSS FNMNIRGDIG HKAYEYQEYG PKPCKCQQPK
160 170 180 190 200
KAFRYRPSFR TQERDHTGEK PNACKVCGKT FISHSSVRRH MVMHSGDGPY
210 220 230 240 250
KCKFCGKAFH CLRLYLIHER IHTGEKPCEC KQCGKSFSYS ATHRIHKRTH
260 270 280 290 300
TGEKPYEYQE CGKAFHSPRS YRRHERIHMG EKAYQCKECG KAFTCPRYVR
310 320 330 340 350
IHERTHSRKN LYECKQCGKA LSSLTSFQTH VRLHSGERPY ECKICGKDFC
360 370 380 390 400
SVNSFQRHEK IHSGEKPYKC KQCGKAFPHS SSLRYHERTH TGEKPYECKQ
410 420 430 440 450
CGKAFRSASH LRVHGRTHTG EKPYECKECG KAFRYVNNLQ SHERTQTHIR
460 470 480 490 500
IHSGERRYKC KICGKGFYCP KSFQRHEKTH TGEKLYECKQ RSVVPSVVPV
510 520 530 540 550
PFDIMKGLTL ERSPINASNV GKPSELCQSF ECMVGLTLKR NPMSVSNDGK
560 570 580 590
PSDLPHTFEY VVGHTMERSP MHVRNVGNPS DLPRTFEFMK GHKHT
Length:595
Mass (Da):69,106
Last modified:March 1, 2003 - v1
Checksum:i7DCCDFB698E40661
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40L → M in BAC04510 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05991543L → I.Corresponds to variant rs424132dbSNPEnsembl.1
Natural variantiVAR_05282888P → R.Corresponds to variant rs448446dbSNPEnsembl.1
Natural variantiVAR_059916124N → S.Corresponds to variant rs427880dbSNPEnsembl.1
Natural variantiVAR_052829569S → N.1 PublicationCorresponds to variant rs400106dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC035760 mRNA. Translation: AAH35760.1.
AK095252 mRNA. Translation: BAC04510.1.
CCDSiCCDS42503.1.
RefSeqiNP_689570.2. NM_152357.2.
UniGeneiHs.418192.

Genome annotation databases

EnsembliENST00000304060; ENSP00000305373; ENSG00000171295.
GeneIDi126070.
KEGGihsa:126070.
UCSCiuc002msp.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC035760 mRNA. Translation: AAH35760.1.
AK095252 mRNA. Translation: BAC04510.1.
CCDSiCCDS42503.1.
RefSeqiNP_689570.2. NM_152357.2.
UniGeneiHs.418192.

3D structure databases

ProteinModelPortaliQ8IYI8.
SMRiQ8IYI8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125953. 12 interactors.
IntActiQ8IYI8. 22 interactors.
MINTiMINT-1384085.
STRINGi9606.ENSP00000305373.

PTM databases

iPTMnetiQ8IYI8.
PhosphoSitePlusiQ8IYI8.

Polymorphism and mutation databases

BioMutaiZNF440.
DMDMi30580626.

Proteomic databases

EPDiQ8IYI8.
MaxQBiQ8IYI8.
PaxDbiQ8IYI8.
PeptideAtlasiQ8IYI8.
PRIDEiQ8IYI8.

Protocols and materials databases

DNASUi126070.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304060; ENSP00000305373; ENSG00000171295.
GeneIDi126070.
KEGGihsa:126070.
UCSCiuc002msp.2. human.

Organism-specific databases

CTDi126070.
DisGeNETi126070.
GeneCardsiZNF440.
HGNCiHGNC:20874. ZNF440.
HPAiHPA047845.
neXtProtiNX_Q8IYI8.
OpenTargetsiENSG00000171295.
PharmGKBiPA134917447.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119089.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8IYI8.
KOiK09228.
OMAiMKGHKHT.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8IYI8.
TreeFamiTF338854.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii126070.
PROiQ8IYI8.

Gene expression databases

BgeeiENSG00000171295.
CleanExiHS_ZNF440.
ExpressionAtlasiQ8IYI8. baseline and differential.
GenevisibleiQ8IYI8. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN440_HUMAN
AccessioniPrimary (citable) accession number: Q8IYI8
Secondary accession number(s): Q8N1R9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.