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Q8IYI6

- EXOC8_HUMAN

UniProt

Q8IYI6 - EXOC8_HUMAN

Protein

Exocyst complex component 8

Gene

EXOC8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 2 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. cellular protein localization Source: Ensembl
    2. cellular protein metabolic process Source: Reactome
    3. exocytosis Source: UniProtKB-KW
    4. membrane organization Source: Reactome
    5. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    Exocytosis, Protein transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_147867. Translocation of GLUT4 to the plasma membrane.
    REACT_15550. Insulin processing.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Exocyst complex component 8
    Alternative name(s):
    Exocyst complex 84 kDa subunit
    Gene namesi
    Name:EXOC8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:24659. EXOC8.

    Subcellular locationi

    Cytoplasm. Cell projectiongrowth cone By similarity
    Note: Redistributes to growing neurites and growth cones during cell differentiation By similarity. Binds lipids with phosphatidylinositol 3,4,5-trisphosphate groups.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. exocyst Source: Ensembl
    3. growth cone Source: UniProtKB-SubCell
    4. membrane Source: UniProtKB
    5. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell projection, Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134991382.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 725725Exocyst complex component 8PRO_0000227550Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei142 – 1421Phosphothreonine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8IYI6.
    PaxDbiQ8IYI6.
    PRIDEiQ8IYI6.

    PTM databases

    PhosphoSiteiQ8IYI6.

    Expressioni

    Gene expression databases

    BgeeiQ8IYI6.
    CleanExiHS_EXOC8.
    GenevestigatoriQ8IYI6.

    Organism-specific databases

    HPAiHPA027438.

    Interactioni

    Subunit structurei

    The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with the GTP-bound forms of RALA and RALB via its PH domain.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    BECN1Q144574EBI-742102,EBI-949378
    USHBP1Q8N6Y02EBI-742102,EBI-739895
    WASH1A8K0Z33EBI-742102,EBI-6160405

    Protein-protein interaction databases

    BioGridi127206. 32 interactions.
    IntActiQ8IYI6. 22 interactions.
    MINTiMINT-1449731.
    STRINGi9606.ENSP00000353564.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IYI6.
    SMRiQ8IYI6. Positions 180-292.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini182 – 282101PHPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi108 – 11710Poly-Ala
    Compositional biasi316 – 3194Poly-Glu

    Sequence similaritiesi

    Belongs to the EXO84 family.Curated
    Contains 1 PH domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG331886.
    HOGENOMiHOG000006737.
    HOVERGENiHBG081489.
    InParanoidiQ8IYI6.
    OMAiRNFEQYT.
    OrthoDBiEOG7NSB1Q.
    PhylomeDBiQ8IYI6.
    TreeFamiTF105819.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    InterProiIPR016159. Cullin_repeat-like_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view]
    SMARTiSM00233. PH. 1 hit.
    [Graphical view]
    SUPFAMiSSF74788. SSF74788. 1 hit.
    PROSITEiPS50003. PH_DOMAIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8IYI6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAMAMSDSGA SRLRRQLESG GFEARLYVKQ LSQQSDGDRD LQEHRQRIQA    50
    LAEETAQNLK RNVYQNYRQF IETAREISYL ESEMYQLSHL LTEQKSSLES 100
    IPLTLLPAAA AAGAAAASGG EEGVGGAGGR DHLRGQAGFF STPGGASRDG 150
    SGPGEEGKQR TLTTLLEKVE GCRHLLETPG QYLVYNGDLV EYDADHMAQL 200
    QRVHGFLMND CLLVATWLPQ RRGMYRYNAL YSLDGLAVVN VKDNPPMKDM 250
    FKLLMFPESR IFQAENAKIK REWLEVLEDT KRALSEKRRR EQEEAAAPRG 300
    PPQVTSKATN PFEDDEEEEP AVPEVEEEKV DLSMEWIQEL PEDLDVCIAQ 350
    RDFEGAVDLL DKLNHYLEDK PSPPPVKELR AKVEERVRQL TEVLVFELSP 400
    DRSLRGGPKA TRRAVSQLIR LGQCTKACEL FLRNRAAAVH TAIRQLRIEG 450
    ATLLYIHKLC HVFFTSLLET AREFEIDFAG TDSGCYSAFV VWARSAMGMF 500
    VDAFSKQVFD SKESLSTAAE CVKVAKEHCQ QLGDIGLDLT FIIHALLVKD 550
    IQGALHSYKE IIIEATKHRN SEEMWRRMNL MTPEALGKLK EEMKSCGVSN 600
    FEQYTGDDCW VNLSYTVVAF TKQTMGFLEE ALKLYFPELH MVLLESLVEI 650
    ILVAVQHVDY SLRCEQDPEK KAFIRQNASF LYETVLPVVE KRFEEGVGKP 700
    AKQLQDLRNA SRLIRVNPES TTSVV 725
    Length:725
    Mass (Da):81,799
    Last modified:July 5, 2004 - v2
    Checksum:iF4E5E344EF24FDCA
    GO

    Sequence cautioni

    The sequence CAI23095.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK096460 mRNA. Translation: BAG53295.1.
    AL117352 Genomic DNA. Translation: CAI23095.1. Different initiation.
    CH471098 Genomic DNA. Translation: EAW69955.1.
    BC035763 mRNA. Translation: AAH35763.2.
    CCDSiCCDS1593.1.
    RefSeqiNP_787072.2. NM_175876.3.
    UniGeneiHs.356198.

    Genome annotation databases

    EnsembliENST00000360394; ENSP00000353564; ENSG00000116903.
    GeneIDi149371.
    KEGGihsa:149371.
    UCSCiuc001huq.3. human.

    Polymorphism databases

    DMDMi74750763.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK096460 mRNA. Translation: BAG53295.1 .
    AL117352 Genomic DNA. Translation: CAI23095.1 . Different initiation.
    CH471098 Genomic DNA. Translation: EAW69955.1 .
    BC035763 mRNA. Translation: AAH35763.2 .
    CCDSi CCDS1593.1.
    RefSeqi NP_787072.2. NM_175876.3.
    UniGenei Hs.356198.

    3D structure databases

    ProteinModelPortali Q8IYI6.
    SMRi Q8IYI6. Positions 180-292.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127206. 32 interactions.
    IntActi Q8IYI6. 22 interactions.
    MINTi MINT-1449731.
    STRINGi 9606.ENSP00000353564.

    PTM databases

    PhosphoSitei Q8IYI6.

    Polymorphism databases

    DMDMi 74750763.

    Proteomic databases

    MaxQBi Q8IYI6.
    PaxDbi Q8IYI6.
    PRIDEi Q8IYI6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000360394 ; ENSP00000353564 ; ENSG00000116903 .
    GeneIDi 149371.
    KEGGi hsa:149371.
    UCSCi uc001huq.3. human.

    Organism-specific databases

    CTDi 149371.
    GeneCardsi GC01M231469.
    HGNCi HGNC:24659. EXOC8.
    HPAi HPA027438.
    MIMi 615283. gene.
    neXtProti NX_Q8IYI6.
    PharmGKBi PA134991382.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG331886.
    HOGENOMi HOG000006737.
    HOVERGENi HBG081489.
    InParanoidi Q8IYI6.
    OMAi RNFEQYT.
    OrthoDBi EOG7NSB1Q.
    PhylomeDBi Q8IYI6.
    TreeFami TF105819.

    Enzyme and pathway databases

    Reactomei REACT_147867. Translocation of GLUT4 to the plasma membrane.
    REACT_15550. Insulin processing.

    Miscellaneous databases

    GeneWikii EXOC8.
    GenomeRNAii 149371.
    NextBioi 86129.
    PROi Q8IYI6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8IYI6.
    CleanExi HS_EXOC8.
    Genevestigatori Q8IYI6.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    InterProi IPR016159. Cullin_repeat-like_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view ]
    SMARTi SM00233. PH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF74788. SSF74788. 1 hit.
    PROSITEi PS50003. PH_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Tongue.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lymph.
    5. "Ral GTPases regulate exocyst assembly through dual subunit interactions."
      Moskalenko S., Tong C., Rosse C., Mirey G., Formstecher E., Daviet L., Camonis J., White M.A.
      J. Biol. Chem. 278:51743-51748(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH EXOC2; RALA AND RALB.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-142, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiEXOC8_HUMAN
    AccessioniPrimary (citable) accession number: Q8IYI6
    Secondary accession number(s): B3KU33, Q5TE82
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 101 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3