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Q8IYI0

- CT196_HUMAN

UniProt

Q8IYI0 - CT196_HUMAN

Protein

Uncharacterized protein C20orf196

Gene

C20orf196

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uncharacterized protein C20orf196
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:26318. C20orf196.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA145149476.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 205205Uncharacterized protein C20orf196PRO_0000286612Add
    BLAST

    Proteomic databases

    PaxDbiQ8IYI0.
    PRIDEiQ8IYI0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8IYI0.
    BgeeiQ8IYI0.
    CleanExiHS_C20orf196.
    GenevestigatoriQ8IYI0.

    Organism-specific databases

    HPAiHPA040749.

    Interactioni

    Protein-protein interaction databases

    BioGridi127244. 3 interactions.
    IntActiQ8IYI0. 2 interactions.
    MINTiMINT-8417631.
    STRINGi9606.ENSP00000305875.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IYI0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG44092.
    HOGENOMiHOG000013194.
    HOVERGENiHBG096587.
    InParanoidiQ8IYI0.
    OMAiIIHFLLQ.
    PhylomeDBiQ8IYI0.
    TreeFamiTF336046.

    Family and domain databases

    InterProiIPR027821. DUF4521.
    [Graphical view]
    PfamiPF15021. DUF4521. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8IYI0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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    MAARDATSGS LSEESSALDL PSACDIRDYV LQGPSQEANS EAFSSLEFHS    50
    FPYSSDVDPD TSNLNIEQNN SWTAENFWLD PAVKGQSEKE EDDGLRKSLD 100
    RFYEMFGHPQ PGSANSLSAS VCKCLSQKIT QLRGQESQKY ALRSFQMARV 150
    IFNRDGCSVL QRHSRDTHFY PLEEGSTSLD DEKPNPGLSK DITHFLLQQN 200
    VMKDL 205
    Length:205
    Mass (Da):22,938
    Last modified:March 1, 2003 - v1
    Checksum:i4AF85DA351FF5FAF
    GO
    Isoform 2 (identifier: Q8IYI0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         142-195: Missing.

    Show »
    Length:151
    Mass (Da):16,706
    Checksum:i48EE73BEA8B6F3E0
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti23 – 231A → V.
    Corresponds to variant rs237422 [ dbSNP | Ensembl ].
    VAR_032144

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei142 – 19554Missing in isoform 2. 1 PublicationVSP_025125Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK057796 mRNA. Translation: BAB71578.1.
    AK292708 mRNA. Translation: BAF85397.1.
    AL390028, AL035249 Genomic DNA. Translation: CAI22784.1.
    AL390028, AL035249 Genomic DNA. Translation: CAI22786.1.
    AL035249, AL390028 Genomic DNA. Translation: CAI19011.1.
    AL035249, AL390028 Genomic DNA. Translation: CAI19013.1.
    CH471133 Genomic DNA. Translation: EAX10412.1.
    BC035800 mRNA. Translation: AAH35800.1.
    CCDSiCCDS13091.1. [Q8IYI0-1]
    RefSeqiNP_689717.2. NM_152504.2. [Q8IYI0-1]
    UniGeneiHs.529340.

    Genome annotation databases

    EnsembliENST00000303142; ENSP00000305875; ENSG00000171984. [Q8IYI0-1]
    GeneIDi149840.
    KEGGihsa:149840.
    UCSCiuc002wmf.3. human. [Q8IYI0-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK057796 mRNA. Translation: BAB71578.1 .
    AK292708 mRNA. Translation: BAF85397.1 .
    AL390028 , AL035249 Genomic DNA. Translation: CAI22784.1 .
    AL390028 , AL035249 Genomic DNA. Translation: CAI22786.1 .
    AL035249 , AL390028 Genomic DNA. Translation: CAI19011.1 .
    AL035249 , AL390028 Genomic DNA. Translation: CAI19013.1 .
    CH471133 Genomic DNA. Translation: EAX10412.1 .
    BC035800 mRNA. Translation: AAH35800.1 .
    CCDSi CCDS13091.1. [Q8IYI0-1 ]
    RefSeqi NP_689717.2. NM_152504.2. [Q8IYI0-1 ]
    UniGenei Hs.529340.

    3D structure databases

    ProteinModelPortali Q8IYI0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127244. 3 interactions.
    IntActi Q8IYI0. 2 interactions.
    MINTi MINT-8417631.
    STRINGi 9606.ENSP00000305875.

    Proteomic databases

    PaxDbi Q8IYI0.
    PRIDEi Q8IYI0.

    Protocols and materials databases

    DNASUi 149840.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000303142 ; ENSP00000305875 ; ENSG00000171984 . [Q8IYI0-1 ]
    GeneIDi 149840.
    KEGGi hsa:149840.
    UCSCi uc002wmf.3. human. [Q8IYI0-1 ]

    Organism-specific databases

    CTDi 149840.
    GeneCardsi GC20P005680.
    HGNCi HGNC:26318. C20orf196.
    HPAi HPA040749.
    neXtProti NX_Q8IYI0.
    PharmGKBi PA145149476.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44092.
    HOGENOMi HOG000013194.
    HOVERGENi HBG096587.
    InParanoidi Q8IYI0.
    OMAi IIHFLLQ.
    PhylomeDBi Q8IYI0.
    TreeFami TF336046.

    Miscellaneous databases

    GenomeRNAii 149840.
    NextBioi 86262.

    Gene expression databases

    ArrayExpressi Q8IYI0.
    Bgeei Q8IYI0.
    CleanExi HS_C20orf196.
    Genevestigatori Q8IYI0.

    Family and domain databases

    InterProi IPR027821. DUF4521.
    [Graphical view ]
    Pfami PF15021. DUF4521. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Cerebellum and Thymus.
    2. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.

    Entry informationi

    Entry nameiCT196_HUMAN
    AccessioniPrimary (citable) accession number: Q8IYI0
    Secondary accession number(s): A8K9J3, Q5TGA9, Q96LU1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations

    External Data

    Dasty 3