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Q8IYI0

- CT196_HUMAN

UniProt

Q8IYI0 - CT196_HUMAN

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Protein
Uncharacterized protein C20orf196
Gene
C20orf196
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C20orf196
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:26318. C20orf196.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145149476.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 205205Uncharacterized protein C20orf196
PRO_0000286612Add
BLAST

Proteomic databases

PaxDbiQ8IYI0.
PRIDEiQ8IYI0.

Expressioni

Gene expression databases

ArrayExpressiQ8IYI0.
BgeeiQ8IYI0.
CleanExiHS_C20orf196.
GenevestigatoriQ8IYI0.

Organism-specific databases

HPAiHPA040749.

Interactioni

Protein-protein interaction databases

BioGridi127244. 3 interactions.
IntActiQ8IYI0. 2 interactions.
MINTiMINT-8417631.
STRINGi9606.ENSP00000305875.

Structurei

3D structure databases

ProteinModelPortaliQ8IYI0.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG44092.
HOGENOMiHOG000013194.
HOVERGENiHBG096587.
InParanoidiQ8IYI0.
OMAiIIHFLLQ.
PhylomeDBiQ8IYI0.
TreeFamiTF336046.

Family and domain databases

InterProiIPR027821. DUF4521.
[Graphical view]
PfamiPF15021. DUF4521. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IYI0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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MAARDATSGS LSEESSALDL PSACDIRDYV LQGPSQEANS EAFSSLEFHS    50
FPYSSDVDPD TSNLNIEQNN SWTAENFWLD PAVKGQSEKE EDDGLRKSLD 100
RFYEMFGHPQ PGSANSLSAS VCKCLSQKIT QLRGQESQKY ALRSFQMARV 150
IFNRDGCSVL QRHSRDTHFY PLEEGSTSLD DEKPNPGLSK DITHFLLQQN 200
VMKDL 205
Length:205
Mass (Da):22,938
Last modified:March 1, 2003 - v1
Checksum:i4AF85DA351FF5FAF
GO
Isoform 2 (identifier: Q8IYI0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     142-195: Missing.

Show »
Length:151
Mass (Da):16,706
Checksum:i48EE73BEA8B6F3E0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti23 – 231A → V.
Corresponds to variant rs237422 [ dbSNP | Ensembl ].
VAR_032144

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei142 – 19554Missing in isoform 2.
VSP_025125Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK057796 mRNA. Translation: BAB71578.1.
AK292708 mRNA. Translation: BAF85397.1.
AL390028, AL035249 Genomic DNA. Translation: CAI22784.1.
AL390028, AL035249 Genomic DNA. Translation: CAI22786.1.
AL035249, AL390028 Genomic DNA. Translation: CAI19011.1.
AL035249, AL390028 Genomic DNA. Translation: CAI19013.1.
CH471133 Genomic DNA. Translation: EAX10412.1.
BC035800 mRNA. Translation: AAH35800.1.
CCDSiCCDS13091.1. [Q8IYI0-1]
RefSeqiNP_689717.2. NM_152504.2. [Q8IYI0-1]
UniGeneiHs.529340.

Genome annotation databases

EnsembliENST00000303142; ENSP00000305875; ENSG00000171984. [Q8IYI0-1]
GeneIDi149840.
KEGGihsa:149840.
UCSCiuc002wmf.3. human. [Q8IYI0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK057796 mRNA. Translation: BAB71578.1 .
AK292708 mRNA. Translation: BAF85397.1 .
AL390028 , AL035249 Genomic DNA. Translation: CAI22784.1 .
AL390028 , AL035249 Genomic DNA. Translation: CAI22786.1 .
AL035249 , AL390028 Genomic DNA. Translation: CAI19011.1 .
AL035249 , AL390028 Genomic DNA. Translation: CAI19013.1 .
CH471133 Genomic DNA. Translation: EAX10412.1 .
BC035800 mRNA. Translation: AAH35800.1 .
CCDSi CCDS13091.1. [Q8IYI0-1 ]
RefSeqi NP_689717.2. NM_152504.2. [Q8IYI0-1 ]
UniGenei Hs.529340.

3D structure databases

ProteinModelPortali Q8IYI0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127244. 3 interactions.
IntActi Q8IYI0. 2 interactions.
MINTi MINT-8417631.
STRINGi 9606.ENSP00000305875.

Proteomic databases

PaxDbi Q8IYI0.
PRIDEi Q8IYI0.

Protocols and materials databases

DNASUi 149840.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000303142 ; ENSP00000305875 ; ENSG00000171984 . [Q8IYI0-1 ]
GeneIDi 149840.
KEGGi hsa:149840.
UCSCi uc002wmf.3. human. [Q8IYI0-1 ]

Organism-specific databases

CTDi 149840.
GeneCardsi GC20P005680.
HGNCi HGNC:26318. C20orf196.
HPAi HPA040749.
neXtProti NX_Q8IYI0.
PharmGKBi PA145149476.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44092.
HOGENOMi HOG000013194.
HOVERGENi HBG096587.
InParanoidi Q8IYI0.
OMAi IIHFLLQ.
PhylomeDBi Q8IYI0.
TreeFami TF336046.

Miscellaneous databases

GenomeRNAii 149840.
NextBioi 86262.

Gene expression databases

ArrayExpressi Q8IYI0.
Bgeei Q8IYI0.
CleanExi HS_C20orf196.
Genevestigatori Q8IYI0.

Family and domain databases

InterProi IPR027821. DUF4521.
[Graphical view ]
Pfami PF15021. DUF4521. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Cerebellum and Thymus.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiCT196_HUMAN
AccessioniPrimary (citable) accession number: Q8IYI0
Secondary accession number(s): A8K9J3, Q5TGA9, Q96LU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

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