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Protein

ZZ-type zinc finger-containing protein 3

Gene

ZZZ3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi680 – 703H-T-H motifPROSITE-ProRule annotationAdd BLAST24
Zinc fingeri817 – 867ZZ-typePROSITE-ProRule annotationAdd BLAST51

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-3214847. HATs acetylate histones.

Names & Taxonomyi

Protein namesi
Recommended name:
ZZ-type zinc finger-containing protein 3
Gene namesi
Name:ZZZ3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:24523. ZZZ3.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi26009.
OpenTargetsiENSG00000036549.
PharmGKBiPA134873184.

Polymorphism and mutation databases

BioMutaiZZZ3.
DMDMi74762495.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002874951 – 903ZZ-type zinc finger-containing protein 3Add BLAST903

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei82PhosphoserineCombined sources1
Modified residuei89PhosphoserineCombined sources1
Modified residuei113PhosphoserineCombined sources1
Modified residuei130PhosphoserineCombined sources1
Modified residuei131PhosphoserineCombined sources1
Modified residuei135PhosphoserineCombined sources1
Modified residuei394N6-acetyllysineBy similarity1
Modified residuei606PhosphoserineCombined sources1
Cross-linki647Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei701N6-acetyllysineCombined sources1
Cross-linki708Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8IYH5.
MaxQBiQ8IYH5.
PaxDbiQ8IYH5.
PeptideAtlasiQ8IYH5.
PRIDEiQ8IYH5.

PTM databases

iPTMnetiQ8IYH5.
PhosphoSitePlusiQ8IYH5.

Expressioni

Gene expression databases

BgeeiENSG00000036549.
CleanExiHS_ZZZ3.
ExpressionAtlasiQ8IYH5. baseline and differential.
GenevisibleiQ8IYH5. HS.

Organism-specific databases

HPAiHPA053663.
HPA054913.
HPA066197.

Interactioni

Subunit structurei

Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FAM124AQ86V423EBI-2795524,EBI-744506
Hoxa1P090223EBI-2795524,EBI-3957603From a different organism.
KAT2AQ928302EBI-2795524,EBI-477622

Protein-protein interaction databases

BioGridi117482. 40 interactors.
DIPiDIP-47289N.
IntActiQ8IYH5. 21 interactors.
MINTiMINT-7032149.
STRINGi9606.ENSP00000359837.

Structurei

Secondary structure

1903
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi657 – 669Combined sources13
Helixi676 – 687Combined sources12
Beta strandi688 – 690Combined sources3
Helixi692 – 703Combined sources12
Helixi704 – 706Combined sources3
Beta strandi807 – 809Combined sources3
Beta strandi817 – 820Combined sources4
Beta strandi824 – 826Combined sources3
Beta strandi829 – 833Combined sources5
Beta strandi835 – 841Combined sources7
Beta strandi843 – 845Combined sources3
Beta strandi848 – 850Combined sources3
Helixi851 – 853Combined sources3
Beta strandi865 – 867Combined sources3
Beta strandi869 – 872Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FC7NMR-A807-886[»]
2YUMNMR-A652-713[»]
ProteinModelPortaliQ8IYH5.
SMRiQ8IYH5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8IYH5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini647 – 707HTH myb-typePROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Contains 1 HTH myb-type DNA-binding domain.PROSITE-ProRule annotation
Contains 1 ZZ-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri817 – 867ZZ-typePROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IHEM. Eukaryota.
ENOG410ZINA. LUCA.
GeneTreeiENSGT00390000005307.
HOVERGENiHBG062668.
InParanoidiQ8IYH5.
OMAiKLEDHKI.
OrthoDBiEOG091G0H07.
PhylomeDBiQ8IYH5.
TreeFamiTF106396.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR017930. Myb_dom.
IPR001005. SANT/Myb.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF00249. Myb_DNA-binding. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view]
SMARTiSM00717. SANT. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51294. HTH_MYB. 1 hit.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IYH5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASRSTRVT RSTVGLNGLD ESFCGRTLRN RSIAHPEEIS SNSQVRSRSP
60 70 80 90 100
KKRPEPVPIQ KGNNNGRTTD LKQQSTRESW VSPRKRGLSS SEKDNIERQA
110 120 130 140 150
IENCERRQTE PVSPVLKRIK RCLRSEAPNS SEEDSPIKSD KESVEQRSTV
160 170 180 190 200
VDNDADFQGT KRACRCLILD DCEKREIKKV NVSEEGPLNS AVVEEITGYL
210 220 230 240 250
AVNGVDDSDS AVINCDDCQP DGNTKQNSIG SYVLQEKSVA ENGDTDTQTS
260 270 280 290 300
MFLDSRKEDS YIDHKVPCTD SQVQVKLEDH KIVTACLPVE HVNQLTTEPA
310 320 330 340 350
TGPFSETQSS LRDSEEEVDV VGDSSASKEQ CKENTNNELD TSLESMPASG
360 370 380 390 400
EPEPSPVLDC VSAQMMSLSE PQEHRYTLRT SPRRAAPTRG SPTKNSSPYR
410 420 430 440 450
ENGQFEENNL SPNETNATVS DNVSQSPTNP GEISQNEKGI CCDSQNNGSE
460 470 480 490 500
GVSKPPSEAR LNIGHLPSAK ESASQHITEE EDDDPDVYYF ESDHVALKHN
510 520 530 540 550
KDYQRLLQTI AVLEAQRSQA VQDLESLGRH QREALKNPIG FVEKLQKKAD
560 570 580 590 600
IGLPYPQRVV QLPEIVWDQY THSLGNFERE FKNRKRHTRR VKLVFDKVGL
610 620 630 640 650
PARPKSPLDP KKDGESLSYS MLPLSDGPEG SSSRPQMIRG RLCDDTKPET
660 670 680 690 700
FNQLWTVEEQ KKLEQLLIKY PPEEVESRRW QKIADELGNR TAKQVASRVQ
710 720 730 740 750
KYFIKLTKAG IPVPGRTPNL YIYSKKSSTS RRQHPLNKHL FKPSTFMTSH
760 770 780 790 800
EPPVYMDEDD DRSCFHSHMN TAVEDASDDE SIPIMYRNLP EYKELLQFKK
810 820 830 840 850
LKKQKLQQMQ AESGFVQHVG FKCDNCGIEP IQGVRWHCQD CPPEMSLDFC
860 870 880 890 900
DSCSDCLHET DIHKEDHQLE PIYRSETFLD RDYCVSQGTS YNYLDPNYFP

ANR
Length:903
Mass (Da):102,023
Last modified:March 1, 2003 - v1
Checksum:i16ED137C0A8202EA
GO
Isoform 2 (identifier: Q8IYH5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     598-598: Missing.

Show »
Length:902
Mass (Da):101,924
Checksum:iB7E306C19A1011D8
GO
Isoform 3 (identifier: Q8IYH5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-494: Missing.
     495-502: VALKHNKD → MIDLWLYS

Note: No experimental confirmation available.
Show »
Length:409
Mass (Da):47,716
Checksum:iE0ADB97A8D186009
GO
Isoform 4 (identifier: Q8IYH5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     661-683: KKLEQLLIKYPPEEVESRRWQKI → VINISKSCRLKKTSKQLTSESVL
     684-903: Missing.

Note: No experimental confirmation available.
Show »
Length:683
Mass (Da):76,126
Checksum:i50C9B12134DB1D66
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti596D → G in AAH35079 (PubMed:15489334).Curated1
Sequence conflicti655W → G in CAB45694 (PubMed:17974005).Curated1
Sequence conflicti698R → Q in AAH35079 (PubMed:15489334).Curated1
Sequence conflicti721Y → C in AAH35079 (PubMed:15489334).Curated1
Sequence conflicti807Q → R in CAE45800 (PubMed:17974005).Curated1
Sequence conflicti877T → A in CAE45870 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035718456P → S in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0255091 – 494Missing in isoform 3. 1 PublicationAdd BLAST494
Alternative sequenceiVSP_025510495 – 502VALKHNKD → MIDLWLYS in isoform 3. 1 Publication8
Alternative sequenceiVSP_025511598Missing in isoform 2. 2 Publications1
Alternative sequenceiVSP_025512661 – 683KKLEQ…RWQKI → VINISKSCRLKKTSKQLTSE SVL in isoform 4. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_025513684 – 903Missing in isoform 4. 1 PublicationAdd BLAST220

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL080063 mRNA. Translation: CAB45694.1.
BX641001 mRNA. Translation: CAE46004.1.
BX640658 mRNA. Translation: CAE45800.1.
BX640766 mRNA. Translation: CAE45870.1.
AC093575 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX06376.1.
BC035397 mRNA. Translation: AAH35397.1.
BC035079 mRNA. Translation: AAH35079.1.
BC035818 mRNA. Translation: AAH35818.1.
AK074119 mRNA. Translation: BAB84945.1.
CCDSiCCDS677.1. [Q8IYH5-1]
CCDS76172.1. [Q8IYH5-3]
PIRiT12463.
RefSeqiNP_001295166.1. NM_001308237.1. [Q8IYH5-3]
NP_056349.1. NM_015534.5. [Q8IYH5-1]
XP_005270782.1. XM_005270725.3. [Q8IYH5-1]
XP_005270783.1. XM_005270726.3. [Q8IYH5-1]
XP_005270784.1. XM_005270727.3. [Q8IYH5-2]
XP_005270786.1. XM_005270729.4. [Q8IYH5-3]
XP_016856459.1. XM_017000970.1. [Q8IYH5-2]
UniGeneiHs.480506.

Genome annotation databases

EnsembliENST00000370798; ENSP00000359834; ENSG00000036549. [Q8IYH5-3]
ENST00000370801; ENSP00000359837; ENSG00000036549. [Q8IYH5-1]
GeneIDi26009.
KEGGihsa:26009.
UCSCiuc001dhq.4. human. [Q8IYH5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL080063 mRNA. Translation: CAB45694.1.
BX641001 mRNA. Translation: CAE46004.1.
BX640658 mRNA. Translation: CAE45800.1.
BX640766 mRNA. Translation: CAE45870.1.
AC093575 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX06376.1.
BC035397 mRNA. Translation: AAH35397.1.
BC035079 mRNA. Translation: AAH35079.1.
BC035818 mRNA. Translation: AAH35818.1.
AK074119 mRNA. Translation: BAB84945.1.
CCDSiCCDS677.1. [Q8IYH5-1]
CCDS76172.1. [Q8IYH5-3]
PIRiT12463.
RefSeqiNP_001295166.1. NM_001308237.1. [Q8IYH5-3]
NP_056349.1. NM_015534.5. [Q8IYH5-1]
XP_005270782.1. XM_005270725.3. [Q8IYH5-1]
XP_005270783.1. XM_005270726.3. [Q8IYH5-1]
XP_005270784.1. XM_005270727.3. [Q8IYH5-2]
XP_005270786.1. XM_005270729.4. [Q8IYH5-3]
XP_016856459.1. XM_017000970.1. [Q8IYH5-2]
UniGeneiHs.480506.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FC7NMR-A807-886[»]
2YUMNMR-A652-713[»]
ProteinModelPortaliQ8IYH5.
SMRiQ8IYH5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117482. 40 interactors.
DIPiDIP-47289N.
IntActiQ8IYH5. 21 interactors.
MINTiMINT-7032149.
STRINGi9606.ENSP00000359837.

PTM databases

iPTMnetiQ8IYH5.
PhosphoSitePlusiQ8IYH5.

Polymorphism and mutation databases

BioMutaiZZZ3.
DMDMi74762495.

Proteomic databases

EPDiQ8IYH5.
MaxQBiQ8IYH5.
PaxDbiQ8IYH5.
PeptideAtlasiQ8IYH5.
PRIDEiQ8IYH5.

Protocols and materials databases

DNASUi26009.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370798; ENSP00000359834; ENSG00000036549. [Q8IYH5-3]
ENST00000370801; ENSP00000359837; ENSG00000036549. [Q8IYH5-1]
GeneIDi26009.
KEGGihsa:26009.
UCSCiuc001dhq.4. human. [Q8IYH5-1]

Organism-specific databases

CTDi26009.
DisGeNETi26009.
GeneCardsiZZZ3.
HGNCiHGNC:24523. ZZZ3.
HPAiHPA053663.
HPA054913.
HPA066197.
neXtProtiNX_Q8IYH5.
OpenTargetsiENSG00000036549.
PharmGKBiPA134873184.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHEM. Eukaryota.
ENOG410ZINA. LUCA.
GeneTreeiENSGT00390000005307.
HOVERGENiHBG062668.
InParanoidiQ8IYH5.
OMAiKLEDHKI.
OrthoDBiEOG091G0H07.
PhylomeDBiQ8IYH5.
TreeFamiTF106396.

Enzyme and pathway databases

ReactomeiR-HSA-3214847. HATs acetylate histones.

Miscellaneous databases

ChiTaRSiZZZ3. human.
EvolutionaryTraceiQ8IYH5.
GeneWikiiZZZ3.
GenomeRNAii26009.
PROiQ8IYH5.

Gene expression databases

BgeeiENSG00000036549.
CleanExiHS_ZZZ3.
ExpressionAtlasiQ8IYH5. baseline and differential.
GenevisibleiQ8IYH5. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR017930. Myb_dom.
IPR001005. SANT/Myb.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF00249. Myb_DNA-binding. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view]
SMARTiSM00717. SANT. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51294. HTH_MYB. 1 hit.
PS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZZZ3_HUMAN
AccessioniPrimary (citable) accession number: Q8IYH5
Secondary accession number(s): B7WPC6
, Q6N004, Q6N070, Q8IYP0, Q8IYR1, Q8TEK4, Q9Y4U0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.