ID TEX11_HUMAN Reviewed; 940 AA. AC Q8IYF3; A8K8V6; Q5JQQ8; Q96LZ4; Q96M47; Q9BXU6; DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot. DT 24-JUL-2007, sequence version 3. DT 24-JAN-2024, entry version 169. DE RecName: Full=Testis-expressed protein 11; DE AltName: Full=Protein ZIP4 homolog {ECO:0000250|UniProtKB:Q14AT2}; DE Short=ZIP4H; GN Name=TEX11; Synonyms=ZIP4 {ECO:0000250|UniProtKB:Q14AT2}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3). RC TISSUE=Testis; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15772651; DOI=10.1038/nature03440; RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C., RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., RA Rogers J., Bentley D.R.; RT "The DNA sequence of the human X chromosome."; RL Nature 434:325-337(2005). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND VARIANT LYS-451. RC TISSUE=Testis; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] RP NUCLEOTIDE SEQUENCE [MRNA] OF 20-940 (ISOFORM 3). RC TISSUE=Testis; RX PubMed=11279525; DOI=10.1038/86927; RA Wang P.J., McCarrey J.R., Yang F., Page D.C.; RT "An abundance of X-linked genes expressed in spermatogonia."; RL Nat. Genet. 27:422-426(2001). RN [6] RP TISSUE SPECIFICITY. RX PubMed=18369460; DOI=10.1371/journal.pgen.1000042; RA Adelman C.A., Petrini J.H.; RT "ZIP4H (TEX11) deficiency in the mouse impairs meiotic double strand break RT repair and the regulation of crossing over."; RL PLoS Genet. 4:E1000042-E1000042(2008). RN [7] RP INVOLVEMENT IN SPGFX2, AND VARIANTS SPGFX2 VAL-171 AND THR-698. RX PubMed=25970010; DOI=10.1056/nejmoa1406192; RA Yatsenko A.N., Georgiadis A.P., Roepke A., Berman A.J., Jaffe T., RA Olszewska M., Westernstroeer B., Sanfilippo J., Kurpisz M., Rajkovic A., RA Yatsenko S.A., Kliesch S., Schlatt S., Tuettelmann F.; RT "X-linked TEX11 mutations, meiotic arrest, and azoospermia in infertile RT men."; RL N. Engl. J. Med. 372:2097-2107(2015). RN [8] RP INTERACTION WITH SHOC1. RX PubMed=29742103; DOI=10.1371/journal.pgen.1007381; RA Guiraldelli M.F., Felberg A., Almeida L.P., Parikh A., de Castro R.O., RA Pezza R.J.; RT "SHOC1 is a ERCC4-(HhH)2-like protein, integral to the formation of RT crossover recombination intermediates during mammalian meiosis."; RL PLoS Genet. 14:E1007381-E1007381(2018). RN [9] RP VARIANT SPGFX2 VAL-171. RX PubMed=28718531; DOI=10.1111/andr.12378; RA Nakamura S., Miyado M., Saito K., Katsumi M., Nakamura A., Kobori Y., RA Tanaka Y., Ishikawa H., Yoshida A., Okada H., Hata K., Nakabayashi K., RA Okamura K., Ogata H., Matsubara Y., Ogata T., Nakai H., Fukami M.; RT "Next-generation sequencing for patients with non-obstructive azoospermia: RT implications for significant roles of monogenic/oligogenic mutations."; RL Andrology 5:824-831(2017). RN [10] RP INVOLVEMENT IN SPGFX2. RX PubMed=32741963; DOI=10.1038/s41436-020-0907-1; RA Krausz C., Riera-Escamilla A., Moreno-Mendoza D., Holleman K., Cioppi F., RA Algaba F., Pybus M., Friedrich C., Wyrwoll M.J., Casamonti E., RA Pietroforte S., Nagirnaja L., Lopes A.M., Kliesch S., Pilatz A., RA Carrell D.T., Conrad D.F., Ars E., Ruiz-Castane E., Aston K.I., RA Baarends W.M., Tuettelmann F.; RT "Genetic dissection of spermatogenic arrest through exome analysis: RT clinical implications for the management of azoospermic men."; RL Genet. Med. 22:1956-1966(2020). CC -!- FUNCTION: Regulator of crossing-over during meiosis. Involved in CC initiation and/or maintenance of chromosome synapsis and formation of CC crossovers. {ECO:0000250|UniProtKB:Q14AT2}. CC -!- SUBUNIT: Interacts with SYCP2. Interacts with PBXIP1; may prevent CC interaction between PBXIP1 and ESR2 (By similarity). Interacts with CC SHOC1 (PubMed:29742103). Interacts with REDIC1. CC {ECO:0000250|UniProtKB:Q14AT2, ECO:0000269|PubMed:29742103}. CC -!- INTERACTION: CC Q8IYF3; Q9HBH7: BEX1; NbExp=3; IntAct=EBI-742397, EBI-7162175; CC Q8IYF3; Q96FH0: BORCS8; NbExp=5; IntAct=EBI-742397, EBI-744076; CC Q8IYF3; Q5I0X4: C6orf226; NbExp=3; IntAct=EBI-742397, EBI-10244057; CC Q8IYF3; Q8NA61: CBY2; NbExp=3; IntAct=EBI-742397, EBI-741724; CC Q8IYF3; Q9NVL8: CCDC198; NbExp=3; IntAct=EBI-742397, EBI-10238351; CC Q8IYF3; P38936: CDKN1A; NbExp=4; IntAct=EBI-742397, EBI-375077; CC Q8IYF3; Q6IPU0: CENPP; NbExp=3; IntAct=EBI-742397, EBI-10250303; CC Q8IYF3; Q9P218-2: COL20A1; NbExp=3; IntAct=EBI-742397, EBI-10318410; CC Q8IYF3; O95715: CXCL14; NbExp=3; IntAct=EBI-742397, EBI-2798068; CC Q8IYF3; Q9H596: DUSP21; NbExp=3; IntAct=EBI-742397, EBI-7357329; CC Q8IYF3; Q8NDB6: FAM156A; NbExp=3; IntAct=EBI-742397, EBI-749727; CC Q8IYF3; Q8TES7-6: FBF1; NbExp=3; IntAct=EBI-742397, EBI-10244131; CC Q8IYF3; Q8WXI9: GATAD2B; NbExp=3; IntAct=EBI-742397, EBI-923440; CC Q8IYF3; Q5T013: HYI; NbExp=4; IntAct=EBI-742397, EBI-749235; CC Q8IYF3; A0A0C4DG38: ING3; NbExp=3; IntAct=EBI-742397, EBI-10263367; CC Q8IYF3; Q96GY3: LIN37; NbExp=2; IntAct=EBI-742397, EBI-748884; CC Q8IYF3; P45984: MAPK9; NbExp=3; IntAct=EBI-742397, EBI-713568; CC Q8IYF3; O60336: MAPKBP1; NbExp=3; IntAct=EBI-742397, EBI-947402; CC Q8IYF3; Q9P2K5-2: MYEF2; NbExp=3; IntAct=EBI-742397, EBI-10318831; CC Q8IYF3; I6L9F6: NEFL; NbExp=4; IntAct=EBI-742397, EBI-10178578; CC Q8IYF3; Q96HA1: POM121; NbExp=4; IntAct=EBI-742397, EBI-739990; CC Q8IYF3; Q6NYC8: PPP1R18; NbExp=3; IntAct=EBI-742397, EBI-2557469; CC Q8IYF3; Q8IX06: REXO1L1P; NbExp=3; IntAct=EBI-742397, EBI-10262361; CC Q8IYF3; Q8N443: RIBC1; NbExp=3; IntAct=EBI-742397, EBI-10265323; CC Q8IYF3; Q8WYJ6: SEPTIN1; NbExp=3; IntAct=EBI-742397, EBI-693002; CC Q8IYF3; Q13573: SNW1; NbExp=3; IntAct=EBI-742397, EBI-632715; CC Q8IYF3; Q9UNH6: SNX7; NbExp=4; IntAct=EBI-742397, EBI-751422; CC Q8IYF3; Q93045: STMN2; NbExp=5; IntAct=EBI-742397, EBI-714194; CC Q8IYF3; Q9NU19: TBC1D22B; NbExp=3; IntAct=EBI-742397, EBI-8787464; CC Q8IYF3; Q9BVW5: TIPIN; NbExp=3; IntAct=EBI-742397, EBI-2515360; CC Q8IYF3; Q8IV54: TSC22D4; NbExp=3; IntAct=EBI-742397, EBI-10261521; CC Q8IYF3; Q08E77: UTP14C; NbExp=3; IntAct=EBI-742397, EBI-10225961; CC Q8IYF3-3; P54252: ATXN3; NbExp=6; IntAct=EBI-11523345, EBI-946046; CC Q8IYF3-3; Q92843: BCL2L2; NbExp=3; IntAct=EBI-11523345, EBI-707714; CC Q8IYF3-3; Q96FH0: BORCS8; NbExp=5; IntAct=EBI-11523345, EBI-744076; CC Q8IYF3-3; Q5PSV4: BRMS1L; NbExp=3; IntAct=EBI-11523345, EBI-5666615; CC Q8IYF3-3; Q8NA61-2: CBY2; NbExp=3; IntAct=EBI-11523345, EBI-11524851; CC Q8IYF3-3; E9PSE9: CCDC198; NbExp=4; IntAct=EBI-11523345, EBI-11748295; CC Q8IYF3-3; P04233-2: CD74; NbExp=3; IntAct=EBI-11523345, EBI-12222807; CC Q8IYF3-3; Q5SZL2-5: CEP85L; NbExp=3; IntAct=EBI-11523345, EBI-12344751; CC Q8IYF3-3; Q08495: DMTN; NbExp=3; IntAct=EBI-11523345, EBI-715275; CC Q8IYF3-3; Q9H596: DUSP21; NbExp=3; IntAct=EBI-11523345, EBI-7357329; CC Q8IYF3-3; Q5JVL4: EFHC1; NbExp=6; IntAct=EBI-11523345, EBI-743105; CC Q8IYF3-3; Q6NZ36-4: FAAP20; NbExp=3; IntAct=EBI-11523345, EBI-12013806; CC Q8IYF3-3; Q96MY7: FAM161B; NbExp=3; IntAct=EBI-11523345, EBI-7225287; CC Q8IYF3-3; Q8IXS0: FAM217A; NbExp=3; IntAct=EBI-11523345, EBI-10694567; CC Q8IYF3-3; Q9Y4H4: GPSM3; NbExp=3; IntAct=EBI-11523345, EBI-347538; CC Q8IYF3-3; A8MXD5: GRXCR1; NbExp=3; IntAct=EBI-11523345, EBI-5235612; CC Q8IYF3-3; P09067: HOXB5; NbExp=3; IntAct=EBI-11523345, EBI-3893317; CC Q8IYF3-3; A0A0C4DG38: ING3; NbExp=3; IntAct=EBI-11523345, EBI-10263367; CC Q8IYF3-3; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-11523345, EBI-2556193; CC Q8IYF3-3; Q9H3F6: KCTD10; NbExp=3; IntAct=EBI-11523345, EBI-2505886; CC Q8IYF3-3; P04259: KRT6B; NbExp=3; IntAct=EBI-11523345, EBI-740907; CC Q8IYF3-3; Q5VUJ6-2: LRCH2; NbExp=3; IntAct=EBI-11523345, EBI-12287681; CC Q8IYF3-3; Q1X8D7: LRRC36; NbExp=3; IntAct=EBI-11523345, EBI-12218159; CC Q8IYF3-3; P45984: MAPK9; NbExp=3; IntAct=EBI-11523345, EBI-713568; CC Q8IYF3-3; O60336: MAPKBP1; NbExp=3; IntAct=EBI-11523345, EBI-947402; CC Q8IYF3-3; Q9Y605: MRFAP1; NbExp=3; IntAct=EBI-11523345, EBI-995714; CC Q8IYF3-3; Q7Z6G3-2: NECAB2; NbExp=3; IntAct=EBI-11523345, EBI-10172876; CC Q8IYF3-3; I6L9F6: NEFL; NbExp=3; IntAct=EBI-11523345, EBI-10178578; CC Q8IYF3-3; Q6NYC8: PPP1R18; NbExp=3; IntAct=EBI-11523345, EBI-2557469; CC Q8IYF3-3; O60256: PRPSAP2; NbExp=3; IntAct=EBI-11523345, EBI-724960; CC Q8IYF3-3; A2A3K4: PTPDC1; NbExp=3; IntAct=EBI-11523345, EBI-11603375; CC Q8IYF3-3; Q9UPN6: SCAF8; NbExp=3; IntAct=EBI-11523345, EBI-7954236; CC Q8IYF3-3; Q9UNH7: SNX6; NbExp=3; IntAct=EBI-11523345, EBI-949294; CC Q8IYF3-3; P35711-4: SOX5; NbExp=3; IntAct=EBI-11523345, EBI-11954419; CC Q8IYF3-3; Q93045: STMN2; NbExp=3; IntAct=EBI-11523345, EBI-714194; CC Q8IYF3-3; Q9Y4E8-2: USP15; NbExp=3; IntAct=EBI-11523345, EBI-12041225; CC Q8IYF3-3; Q5TAP6: UTP14C; NbExp=3; IntAct=EBI-11523345, EBI-11737646; CC Q8IYF3-3; Q96IQ9: ZNF414; NbExp=3; IntAct=EBI-11523345, EBI-744257; CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q14AT2}. CC Note=Forms arrays of discrete foci along synaptonemal complexes in CC spermatocytes and fetal oocytes. {ECO:0000250|UniProtKB:Q14AT2}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=Q8IYF3-1; Sequence=Displayed; CC Name=2; CC IsoId=Q8IYF3-2; Sequence=VSP_027260; CC Name=3; CC IsoId=Q8IYF3-3; Sequence=VSP_027261; CC -!- TISSUE SPECIFICITY: Testis-specific. Not expressed in adult ovaries. CC {ECO:0000269|PubMed:18369460}. CC -!- DISEASE: Spermatogenic failure, X-linked, 2 (SPGFX2) [MIM:309120]: An CC infertility disorder caused by spermatogenesis defects. It is CC characterized by mixed testicular atrophy and azoospermia with meiotic CC arrest. {ECO:0000269|PubMed:25970010, ECO:0000269|PubMed:28718531, CC ECO:0000269|PubMed:32741963}. Note=The disease is caused by variants CC affecting the gene represented in this entry. CC -!- SIMILARITY: Belongs to the SPO22 family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAK31973.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK057391; BAB71465.1; -; mRNA. DR EMBL; AK057523; BAB71520.1; -; mRNA. DR EMBL; AK292471; BAF85160.1; -; mRNA. DR EMBL; AL139109; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL627071; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL627390; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471132; EAX05331.1; -; Genomic_DNA. DR EMBL; BC036016; AAH36016.2; -; mRNA. DR EMBL; AF285594; AAK31973.1; ALT_INIT; mRNA. DR CCDS; CCDS35323.1; -. [Q8IYF3-1] DR CCDS; CCDS43968.1; -. [Q8IYF3-3] DR RefSeq; NP_001003811.1; NM_001003811.1. [Q8IYF3-1] DR RefSeq; NP_112566.2; NM_031276.2. [Q8IYF3-3] DR RefSeq; XP_011529298.1; XM_011530996.1. DR AlphaFoldDB; Q8IYF3; -. DR SMR; Q8IYF3; -. DR BioGRID; 121093; 104. DR IntAct; Q8IYF3; 76. DR MINT; Q8IYF3; -. DR STRING; 9606.ENSP00000379226; -. DR iPTMnet; Q8IYF3; -. DR PhosphoSitePlus; Q8IYF3; -. DR BioMuta; TEX11; -. DR DMDM; 156637425; -. DR EPD; Q8IYF3; -. DR MassIVE; Q8IYF3; -. DR PaxDb; 9606-ENSP00000379226; -. DR PeptideAtlas; Q8IYF3; -. DR ProteomicsDB; 71166; -. [Q8IYF3-1] DR ProteomicsDB; 71167; -. [Q8IYF3-2] DR ProteomicsDB; 71168; -. [Q8IYF3-3] DR Antibodypedia; 508; 99 antibodies from 26 providers. DR DNASU; 56159; -. DR Ensembl; ENST00000344304.3; ENSP00000340995.3; ENSG00000120498.14. [Q8IYF3-1] DR Ensembl; ENST00000374320.6; ENSP00000363440.2; ENSG00000120498.14. [Q8IYF3-2] DR Ensembl; ENST00000374333.7; ENSP00000363453.2; ENSG00000120498.14. [Q8IYF3-3] DR Ensembl; ENST00000395889.6; ENSP00000379226.2; ENSG00000120498.14. [Q8IYF3-1] DR GeneID; 56159; -. DR KEGG; hsa:56159; -. DR MANE-Select; ENST00000374333.7; ENSP00000363453.2; NM_031276.3; NP_112566.2. [Q8IYF3-3] DR UCSC; uc004dyk.4; human. [Q8IYF3-1] DR AGR; HGNC:11733; -. DR CTD; 56159; -. DR DisGeNET; 56159; -. DR GeneCards; TEX11; -. DR HGNC; HGNC:11733; TEX11. DR HPA; ENSG00000120498; Tissue enriched (pancreas). DR MalaCards; TEX11; -. DR MIM; 300311; gene. DR MIM; 309120; phenotype. DR neXtProt; NX_Q8IYF3; -. DR OpenTargets; ENSG00000120498; -. DR Orphanet; 399805; Male infertility with azoospermia or oligozoospermia due to single gene mutation. DR PharmGKB; PA36450; -. DR VEuPathDB; HostDB:ENSG00000120498; -. DR eggNOG; KOG4814; Eukaryota. DR GeneTree; ENSGT00390000006492; -. DR HOGENOM; CLU_018086_0_0_1; -. DR InParanoid; Q8IYF3; -. DR OMA; INEAHWF; -. DR OrthoDB; 2947287at2759; -. DR PhylomeDB; Q8IYF3; -. DR TreeFam; TF333356; -. DR PathwayCommons; Q8IYF3; -. DR SignaLink; Q8IYF3; -. DR BioGRID-ORCS; 56159; 12 hits in 777 CRISPR screens. DR ChiTaRS; TEX11; human. DR GenomeRNAi; 56159; -. DR Pharos; Q8IYF3; Tbio. DR PRO; PR:Q8IYF3; -. DR Proteomes; UP000005640; Chromosome X. DR RNAct; Q8IYF3; Protein. DR Bgee; ENSG00000120498; Expressed in sperm and 61 other cell types or tissues. DR GO; GO:0000801; C:central element; IBA:GO_Central. DR GO; GO:0005694; C:chromosome; ISS:UniProtKB. DR GO; GO:0006915; P:apoptotic process; IEA:Ensembl. DR GO; GO:0051026; P:chiasma assembly; IEA:Ensembl. DR GO; GO:0035234; P:ectopic germ cell programmed cell death; IEA:Ensembl. DR GO; GO:0009566; P:fertilization; IEA:Ensembl. DR GO; GO:0008584; P:male gonad development; IEA:Ensembl. DR GO; GO:0007060; P:male meiosis chromosome segregation; IBA:GO_Central. DR GO; GO:0006311; P:meiotic gene conversion; ISS:UniProtKB. DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl. DR GO; GO:0051093; P:negative regulation of developmental process; IEA:Ensembl. DR GO; GO:2000242; P:negative regulation of reproductive process; IEA:Ensembl. DR GO; GO:0007131; P:reciprocal meiotic recombination; ISS:UniProtKB. DR GO; GO:0000712; P:resolution of meiotic recombination intermediates; IEA:Ensembl. DR GO; GO:0007130; P:synaptonemal complex assembly; IBA:GO_Central. DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1. DR InterPro; IPR013940; Spo22/ZIP4/TEX11. DR InterPro; IPR042861; TEX11. DR InterPro; IPR011990; TPR-like_helical_dom_sf. DR InterPro; IPR019734; TPR_repeat. DR PANTHER; PTHR47083; TESTIS-EXPRESSED PROTEIN 11; 1. DR PANTHER; PTHR47083:SF1; TESTIS-EXPRESSED PROTEIN 11; 1. DR Pfam; PF08631; SPO22; 1. DR SMART; SM00028; TPR; 2. DR SUPFAM; SSF48452; TPR-like; 1. DR Genevisible; Q8IYF3; HS. PE 1: Evidence at protein level; KW Alternative splicing; Chromosome; Disease variant; Meiosis; KW Reference proteome. FT CHAIN 1..940 FT /note="Testis-expressed protein 11" FT /id="PRO_0000296955" FT VAR_SEQ 1..325 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_027260" FT VAR_SEQ 1..27 FT /note="MISAHCNLRLLCSSDSSASASQVAGTT -> MDNDDFFSMDFK (in FT isoform 3)" FT /evidence="ECO:0000303|PubMed:11279525, FT ECO:0000303|PubMed:14702039, ECO:0000303|PubMed:15489334" FT /id="VSP_027261" FT VARIANT 130 FT /note="K -> R (in dbSNP:rs6525433)" FT /id="VAR_034635" FT VARIANT 171 FT /note="M -> V (in SPGFX2; dbSNP:rs143246552)" FT /evidence="ECO:0000269|PubMed:25970010, FT ECO:0000269|PubMed:28718531" FT /id="VAR_073889" FT VARIANT 451 FT /note="E -> K (in dbSNP:rs4844247)" FT /evidence="ECO:0000269|PubMed:15489334" FT /id="VAR_034636" FT VARIANT 698 FT /note="A -> T (in SPGFX2; dbSNP:rs140984555)" FT /evidence="ECO:0000269|PubMed:25970010" FT /id="VAR_073890" FT CONFLICT 65 FT /note="T -> A (in Ref. 1; BAB71520)" FT /evidence="ECO:0000305" FT CONFLICT 600 FT /note="K -> E (in Ref. 1; BAB71465)" FT /evidence="ECO:0000305" SQ SEQUENCE 940 AA; 107889 MW; 20A3B0BF58B82EF9 CRC64; MISAHCNLRL LCSSDSSASA SQVAGTTEVV ENLVTNDNSP NIPEAIDRLF SDIANINRES MAEITDIQIE EMAVNLWNWA LTIGGGWLVN EEQKIRLHYV ACKLLSMCEA SFASEQSIQR LIMMNMRIGK EWLDAGNFLI ADECFQAAVA SLEQLYVKLI QRSSPEADLT MEKITVESDH FRVLSYQAES AVAQGDFQRA SMCVLQCKDM LMRLPQMTSS LHHLCYNFGV ETQKNNKYEE SSFWLSQSYD IGKMDKKSTG PEMLAKVLRL LATNYLDWDD TKYYDKALNA VNLANKEHLS SPGLFLKMKI LLKGETSNEE LLEAVMEILH LDMPLDFCLN IAKLLMDHER ESVGFHFLTI IHERFKSSEN IGKVLILHTD MLLQRKEELL AKEKIEEIFL AHQTGRQLTA ESMNWLHNIL WRQAASSFEV QNYTDALQWY YYSLRFYSTD EMDLDFTKLQ RNMACCYLNL QQLDKAKEAV AEAERHDPRN VFTQFYIFKI AVIEGNSERA LQAIITLENI LTDEESEDND LVAERGSPTM LLSLAAQFAL ENGQQIVAEK ALEYLAQHSE DQEQVLTAVK CLLRFLLPKI AEMPESEDKK KEMDRLLTCL NRAFVKLSQP FGEEALSLES RANEAQWFRK TAWNLAVQCD KDPVMMREFF ILSYKMSQFC PSDQVILIAR KTCLLMAVAV DLEQGRKAST AFEQTMFLSR ALEEIQTCND IHNFLKQTGT FSNDSCEKLL LLYEFEVRAK LNDPLLESFL ESVWELPHLE TKTFETIAII AMEKPAHYPL IALKALKKAL LLYKKEEPID ISQYSKCMHN LVNLSVPDGA SNVELCPLEE VWGYFEDALS HISRTKDYPE MEILWLMVKS WNTGVLMFSR SKYASAEKWC GLALRFLNHL TSFKESYETQ MNMLYSQLVE ALSNNKGPVF HEHGYWSKSD //