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Protein

Testis-expressed protein 11

Gene

TEX11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processMeiosis

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-expressed protein 11
Gene namesi
Name:TEX11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000120498.13
HGNCiHGNC:11733 TEX11
MIMi300311 gene
neXtProtiNX_Q8IYF3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome

Pathology & Biotechi

Involvement in diseasei

Spermatogenic failure, X-linked, 2 (SPGFX2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn infertility disorder caused by spermatogenesis defects. It is characterized by mixed testicular atrophy and azoospermia with meiotic arrest.
See also OMIM:309120
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_073889171M → V in SPGFX2. 1 PublicationCorresponds to variant dbSNP:rs143246552Ensembl.1
Natural variantiVAR_073890698A → T in SPGFX2. 1 PublicationCorresponds to variant dbSNP:rs140984555Ensembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi56159
MalaCardsiTEX11
MIMi309120 phenotype
OpenTargetsiENSG00000120498
PharmGKBiPA36450

Polymorphism and mutation databases

BioMutaiTEX11
DMDMi156637425

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002969551 – 940Testis-expressed protein 11Add BLAST940

Proteomic databases

PaxDbiQ8IYF3
PeptideAtlasiQ8IYF3
PRIDEiQ8IYF3

PTM databases

iPTMnetiQ8IYF3
PhosphoSitePlusiQ8IYF3

Expressioni

Tissue specificityi

Testis-specific. Not expressed in adult ovaries.1 Publication

Gene expression databases

BgeeiENSG00000120498
CleanExiHS_TEX11
GenevisibleiQ8IYF3 HS

Organism-specific databases

HPAiHPA002950

Interactioni

Subunit structurei

Interacts with SYCP2. Interacts with PBXIP1; may prevent interaction between PBXIP1 and ESR2 (By similarity).By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi121093, 49 interactors
IntActiQ8IYF3, 82 interactors
MINTiQ8IYF3
STRINGi9606.ENSP00000340995

Structurei

3D structure databases

ProteinModelPortaliQ8IYF3
SMRiQ8IYF3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SPO22 family.Curated

Phylogenomic databases

eggNOGiKOG4814 Eukaryota
ENOG410XQC2 LUCA
GeneTreeiENSGT00390000006492
HOGENOMiHOG000154551
HOVERGENiHBG069003
InParanoidiQ8IYF3
OMAiPEMEILW
OrthoDBiEOG091G01GL
PhylomeDBiQ8IYF3
TreeFamiTF333356

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR013940 Spo22/ZIP4/TEX11
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF08631 SPO22, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 2 hits
SUPFAMiSSF48452 SSF48452, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IYF3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MISAHCNLRL LCSSDSSASA SQVAGTTEVV ENLVTNDNSP NIPEAIDRLF
60 70 80 90 100
SDIANINRES MAEITDIQIE EMAVNLWNWA LTIGGGWLVN EEQKIRLHYV
110 120 130 140 150
ACKLLSMCEA SFASEQSIQR LIMMNMRIGK EWLDAGNFLI ADECFQAAVA
160 170 180 190 200
SLEQLYVKLI QRSSPEADLT MEKITVESDH FRVLSYQAES AVAQGDFQRA
210 220 230 240 250
SMCVLQCKDM LMRLPQMTSS LHHLCYNFGV ETQKNNKYEE SSFWLSQSYD
260 270 280 290 300
IGKMDKKSTG PEMLAKVLRL LATNYLDWDD TKYYDKALNA VNLANKEHLS
310 320 330 340 350
SPGLFLKMKI LLKGETSNEE LLEAVMEILH LDMPLDFCLN IAKLLMDHER
360 370 380 390 400
ESVGFHFLTI IHERFKSSEN IGKVLILHTD MLLQRKEELL AKEKIEEIFL
410 420 430 440 450
AHQTGRQLTA ESMNWLHNIL WRQAASSFEV QNYTDALQWY YYSLRFYSTD
460 470 480 490 500
EMDLDFTKLQ RNMACCYLNL QQLDKAKEAV AEAERHDPRN VFTQFYIFKI
510 520 530 540 550
AVIEGNSERA LQAIITLENI LTDEESEDND LVAERGSPTM LLSLAAQFAL
560 570 580 590 600
ENGQQIVAEK ALEYLAQHSE DQEQVLTAVK CLLRFLLPKI AEMPESEDKK
610 620 630 640 650
KEMDRLLTCL NRAFVKLSQP FGEEALSLES RANEAQWFRK TAWNLAVQCD
660 670 680 690 700
KDPVMMREFF ILSYKMSQFC PSDQVILIAR KTCLLMAVAV DLEQGRKAST
710 720 730 740 750
AFEQTMFLSR ALEEIQTCND IHNFLKQTGT FSNDSCEKLL LLYEFEVRAK
760 770 780 790 800
LNDPLLESFL ESVWELPHLE TKTFETIAII AMEKPAHYPL IALKALKKAL
810 820 830 840 850
LLYKKEEPID ISQYSKCMHN LVNLSVPDGA SNVELCPLEE VWGYFEDALS
860 870 880 890 900
HISRTKDYPE MEILWLMVKS WNTGVLMFSR SKYASAEKWC GLALRFLNHL
910 920 930 940
TSFKESYETQ MNMLYSQLVE ALSNNKGPVF HEHGYWSKSD
Length:940
Mass (Da):107,889
Last modified:July 24, 2007 - v3
Checksum:i20A3B0BF58B82EF9
GO
Isoform 2 (identifier: Q8IYF3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-325: Missing.

Note: No experimental confirmation available.
Show »
Length:615
Mass (Da):71,284
Checksum:i004C5FCD1B5BA3C4
GO
Isoform 3 (identifier: Q8IYF3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: MISAHCNLRLLCSSDSSASASQVAGTT → MDNDDFFSMDFK

Show »
Length:925
Mass (Da):106,689
Checksum:i94CD50F30C857FD1
GO

Sequence cautioni

The sequence AAK31973 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAI39958 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI40155 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI41496 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti65T → A in BAB71520 (PubMed:14702039).Curated1
Sequence conflicti600K → E in BAB71465 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034635130K → R. Corresponds to variant dbSNP:rs6525433Ensembl.1
Natural variantiVAR_073889171M → V in SPGFX2. 1 PublicationCorresponds to variant dbSNP:rs143246552Ensembl.1
Natural variantiVAR_034636451E → K1 PublicationCorresponds to variant dbSNP:rs4844247Ensembl.1
Natural variantiVAR_073890698A → T in SPGFX2. 1 PublicationCorresponds to variant dbSNP:rs140984555Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0272601 – 325Missing in isoform 2. 1 PublicationAdd BLAST325
Alternative sequenceiVSP_0272611 – 27MISAH…VAGTT → MDNDDFFSMDFK in isoform 3. 3 PublicationsAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057391 mRNA Translation: BAB71465.1
AK057523 mRNA Translation: BAB71520.1
AK292471 mRNA Translation: BAF85160.1
AL627390, AL139109 Genomic DNA Translation: CAI41495.1
AL139109, AL627390 Genomic DNA Translation: CAI39957.1
AL627390, AL139109, AL627071 Genomic DNA Translation: CAI41496.1 Different initiation.
AL627071, AL139109, AL627390 Genomic DNA Translation: CAI40155.1 Different initiation.
AL139109, AL627071, AL627390 Genomic DNA Translation: CAI39958.1 Different initiation.
CH471132 Genomic DNA Translation: EAX05331.1
BC036016 mRNA Translation: AAH36016.2
AF285594 mRNA Translation: AAK31973.1 Different initiation.
CCDSiCCDS35323.1 [Q8IYF3-1]
CCDS43968.1 [Q8IYF3-3]
RefSeqiNP_001003811.1, NM_001003811.1 [Q8IYF3-1]
NP_112566.2, NM_031276.2 [Q8IYF3-3]
XP_011529298.1, XM_011530996.1 [Q8IYF3-2]
UniGeneiHs.121776

Genome annotation databases

EnsembliENST00000344304; ENSP00000340995; ENSG00000120498 [Q8IYF3-1]
ENST00000374320; ENSP00000363440; ENSG00000120498 [Q8IYF3-2]
ENST00000374333; ENSP00000363453; ENSG00000120498 [Q8IYF3-3]
ENST00000395889; ENSP00000379226; ENSG00000120498 [Q8IYF3-1]
GeneIDi56159
KEGGihsa:56159
UCSCiuc004dyk.4 human [Q8IYF3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTEX11_HUMAN
AccessioniPrimary (citable) accession number: Q8IYF3
Secondary accession number(s): A8K8V6
, Q5JQQ8, Q96LZ4, Q96M47, Q9BXU6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: April 25, 2018
This is version 132 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health