Q8IYF3 (TEX11_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 88.
History...
Names·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Testis-expressed sequence 11 protein | ||
| Gene names |
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| Organism | Homo sapiens (Human) [Reference proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo![]() |
Protein attributes
| Sequence length | 940 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers By similarity. |
| Subunit structure | Interacts with SYCP2. Interacts with PBXIP1; may prevent interaction between PBXIP1 and ESR2 By similarity. |
| Subcellular location | Chromosome By similarity. Note: Forms arrays of discrete foci along synaptonemal complexes in spermatocytes and fetal oocytes By similarity. |
| Tissue specificity | Testis-specific. Not expressed in adult ovaries. Ref.6 |
| Sequence similarities | Belongs to the SPO22 family. |
| Sequence caution | The sequence AAK31973.1 differs from that shown. Reason: Erroneous initiation. The sequence CAI39958.1 differs from that shown. Reason: Erroneous initiation. The sequence CAI40155.1 differs from that shown. Reason: Erroneous initiation. The sequence CAI41496.1 differs from that shown. Reason: Erroneous initiation. |
Ontologies
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| LIN37 | Q96GY3 | 2 | EBI-742397,EBI-748884 | |
| MEF2BNB | Q96FH0 | 2 | EBI-742397,EBI-744076 | |
| STMN2 | Q93045 | 2 | EBI-742397,EBI-714194 |
Alternative products
| This entry describes 3 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q8IYF3-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q8IYF3-2) The sequence of this isoform differs from the canonical sequence as follows: 1-325: Missing. | ||||||
| Note: No experimental confirmation available. | ||||||
| Isoform 3 (identifier: Q8IYF3-3) The sequence of this isoform differs from the canonical sequence as follows: 1-27: MISAHCNLRLLCSSDSSASASQVAGTT → MDNDDFFSMDFK |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 940 | 940 | Testis-expressed sequence 11 protein | PRO_0000296955 | |||||
Natural variations | |||||||||
| Alternative sequence | 1 – 325 | 325 | Missing in isoform 2. | VSP_027260 | |||||
| Alternative sequence | 1 – 27 | 27 | MISAH…VAGTT → MDNDDFFSMDFK in isoform 3. | VSP_027261 | |||||
| Natural variant | 130 | 1 | K → R. Corresponds to variant rs6525433 [ dbSNP | Ensembl ]. | VAR_034635 | |||||
| Natural variant | 451 | 1 | E → K. Ref.4 Corresponds to variant rs4844247 [ dbSNP | Ensembl ]. | VAR_034636 | |||||
Experimental info | |||||||||
| Sequence conflict | 65 | 1 | T → A in BAB71520. Ref.1 | ||||||
| Sequence conflict | 600 | 1 | K → E in BAB71465. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3). Tissue: Testis. |
| [2] | "The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. Bentley D.R.Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT LYS-451. Tissue: Testis. |
| [5] | "An abundance of X-linked genes expressed in spermatogonia." Wang P.J., McCarrey J.R., Yang F., Page D.C. Nat. Genet. 27:422-426(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 20-940 (ISOFORM 3). Tissue: Testis. |
| [6] | "ZIP4H (TEX11) deficiency in the mouse impairs meiotic double strand break repair and the regulation of crossing over." Adelman C.A., Petrini J.H. PLoS Genet. 4:E1000042-E1000042(2008) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AK057391 mRNA. Translation: BAB71465.1. AK057523 mRNA. Translation: BAB71520.1. AK292471 mRNA. Translation: BAF85160.1. AL627390, AL139109 Genomic DNA. Translation: CAI41495.1. AL139109, AL627390 Genomic DNA. Translation: CAI39957.1. AL627390, AL139109, AL627071 Genomic DNA. Translation: CAI41496.1. Different initiation. AL627071, AL139109, AL627390 Genomic DNA. Translation: CAI40155.1. Different initiation. AL139109, AL627071, AL627390 Genomic DNA. Translation: CAI39958.1. Different initiation. CH471132 Genomic DNA. Translation: EAX05331.1. BC036016 mRNA. Translation: AAH36016.2. AF285594 mRNA. Translation: AAK31973.1. Different initiation. |
| IPI | IPI00307536. IPI00470495. IPI00646019. |
| RefSeq | NP_001003811.1. NM_001003811.1. NP_112566.2. NM_031276.2. |
| UniGene | Hs.121776. |
3D structure databases | |
| ProteinModelPortal | Q8IYF3. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q8IYF3. 22 interactions. |
| MINT | MINT-1443835. |
| STRING | 9606.ENSP00000340995. |
PTM databases | |
| PhosphoSite | Q8IYF3. |
Polymorphism databases | |
| DMDM | 156637425. |
Proteomic databases | |
| PaxDb | Q8IYF3. |
| PRIDE | Q8IYF3. |
Protocols and materials databases | |
| DNASU | 56159. |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000344304; ENSP00000340995; ENSG00000120498. ENST00000374320; ENSP00000363440; ENSG00000120498. ENST00000374333; ENSP00000363453; ENSG00000120498. ENST00000395889; ENSP00000379226; ENSG00000120498. |
| GeneID | 56159. |
| KEGG | hsa:56159. |
| UCSC | uc004dyk.3. human. uc004dym.3. human. |
Organism-specific databases | |
| CTD | 56159. |
| GeneCards | GC0XM069748. |
| H-InvDB | HIX0022351. |
| HGNC | HGNC:11733. TEX11. |
| HPA | HPA002950. |
| MIM | 300311. gene. |
| neXtProt | NX_Q8IYF3. |
| PharmGKB | PA36450. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | NOG314839. |
| HOGENOM | HOG000154551. |
| HOVERGEN | HBG069003. |
| InParanoid | Q8IYF3. |
| OMA | FRKIAWN. |
| PhylomeDB | Q8IYF3. |
Gene expression databases | |
| Bgee | Q8IYF3. |
| CleanEx | HS_TEX11. |
| Genevestigator | Q8IYF3. |
Family and domain databases | |
| Gene3D | 1.25.40.10. 1 hit. |
| InterPro | IPR013940. Meiosis_specific_SPO22. IPR011990. TPR-like_helical. [Graphical view] |
| Pfam | PF08631. SPO22. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| GenomeRNAi | 56159. |
| NextBio | 61780. |
| SOURCE | Search... |
Entry information
| Entry name | TEX11_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q8IYF3 Secondary accession number(s): A8K8V6 Q9BXU6 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome X Human chromosome X: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with
