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Q8IYF3 (TEX11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Testis-expressed sequence 11 protein
Gene names
Name:TEX11
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length940 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers By similarity.

Subunit structure

Interacts with SYCP2. Interacts with PBXIP1; may prevent interaction between PBXIP1 and ESR2 By similarity.

Subcellular location

Chromosome By similarity. Note: Forms arrays of discrete foci along synaptonemal complexes in spermatocytes and fetal oocytes By similarity.

Tissue specificity

Testis-specific. Not expressed in adult ovaries. Ref.6

Sequence similarities

Belongs to the SPO22 family.

Sequence caution

The sequence AAK31973.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAI39958.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAI40155.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAI41496.1 differs from that shown. Reason: Erroneous initiation.

Binary interactions

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8IYF3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8IYF3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-325: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q8IYF3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: MISAHCNLRLLCSSDSSASASQVAGTT → MDNDDFFSMDFK

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 940940Testis-expressed sequence 11 protein
PRO_0000296955

Natural variations

Alternative sequence1 – 325325Missing in isoform 2.
VSP_027260
Alternative sequence1 – 2727MISAH…VAGTT → MDNDDFFSMDFK in isoform 3.
VSP_027261
Natural variant1301K → R.
Corresponds to variant rs6525433 [ dbSNP | Ensembl ].
VAR_034635
Natural variant4511E → K. Ref.4
Corresponds to variant rs4844247 [ dbSNP | Ensembl ].
VAR_034636

Experimental info

Sequence conflict651T → A in BAB71520. Ref.1
Sequence conflict6001K → E in BAB71465. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 24, 2007. Version 3.
Checksum: 20A3B0BF58B82EF9

FASTA940107,889
        10         20         30         40         50         60 
MISAHCNLRL LCSSDSSASA SQVAGTTEVV ENLVTNDNSP NIPEAIDRLF SDIANINRES 

        70         80         90        100        110        120 
MAEITDIQIE EMAVNLWNWA LTIGGGWLVN EEQKIRLHYV ACKLLSMCEA SFASEQSIQR 

       130        140        150        160        170        180 
LIMMNMRIGK EWLDAGNFLI ADECFQAAVA SLEQLYVKLI QRSSPEADLT MEKITVESDH 

       190        200        210        220        230        240 
FRVLSYQAES AVAQGDFQRA SMCVLQCKDM LMRLPQMTSS LHHLCYNFGV ETQKNNKYEE 

       250        260        270        280        290        300 
SSFWLSQSYD IGKMDKKSTG PEMLAKVLRL LATNYLDWDD TKYYDKALNA VNLANKEHLS 

       310        320        330        340        350        360 
SPGLFLKMKI LLKGETSNEE LLEAVMEILH LDMPLDFCLN IAKLLMDHER ESVGFHFLTI 

       370        380        390        400        410        420 
IHERFKSSEN IGKVLILHTD MLLQRKEELL AKEKIEEIFL AHQTGRQLTA ESMNWLHNIL 

       430        440        450        460        470        480 
WRQAASSFEV QNYTDALQWY YYSLRFYSTD EMDLDFTKLQ RNMACCYLNL QQLDKAKEAV 

       490        500        510        520        530        540 
AEAERHDPRN VFTQFYIFKI AVIEGNSERA LQAIITLENI LTDEESEDND LVAERGSPTM 

       550        560        570        580        590        600 
LLSLAAQFAL ENGQQIVAEK ALEYLAQHSE DQEQVLTAVK CLLRFLLPKI AEMPESEDKK 

       610        620        630        640        650        660 
KEMDRLLTCL NRAFVKLSQP FGEEALSLES RANEAQWFRK TAWNLAVQCD KDPVMMREFF 

       670        680        690        700        710        720 
ILSYKMSQFC PSDQVILIAR KTCLLMAVAV DLEQGRKAST AFEQTMFLSR ALEEIQTCND 

       730        740        750        760        770        780 
IHNFLKQTGT FSNDSCEKLL LLYEFEVRAK LNDPLLESFL ESVWELPHLE TKTFETIAII 

       790        800        810        820        830        840 
AMEKPAHYPL IALKALKKAL LLYKKEEPID ISQYSKCMHN LVNLSVPDGA SNVELCPLEE 

       850        860        870        880        890        900 
VWGYFEDALS HISRTKDYPE MEILWLMVKS WNTGVLMFSR SKYASAEKWC GLALRFLNHL 

       910        920        930        940 
TSFKESYETQ MNMLYSQLVE ALSNNKGPVF HEHGYWSKSD 

« Hide

Isoform 2 [UniParc].

Checksum: 004C5FCD1B5BA3C4
Show »

FASTA61571,284
Isoform 3 [UniParc].

Checksum: 94CD50F30C857FD1
Show »

FASTA925106,689

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
Tissue: Testis.
[2]"The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. expand/collapse author list , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT LYS-451.
Tissue: Testis.
[5]"An abundance of X-linked genes expressed in spermatogonia."
Wang P.J., McCarrey J.R., Yang F., Page D.C.
Nat. Genet. 27:422-426(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 20-940 (ISOFORM 3).
Tissue: Testis.
[6]"ZIP4H (TEX11) deficiency in the mouse impairs meiotic double strand break repair and the regulation of crossing over."
Adelman C.A., Petrini J.H.
PLoS Genet. 4:E1000042-E1000042(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK057391 mRNA. Translation: BAB71465.1.
AK057523 mRNA. Translation: BAB71520.1.
AK292471 mRNA. Translation: BAF85160.1.
AL627390, AL139109 Genomic DNA. Translation: CAI41495.1.
AL139109, AL627390 Genomic DNA. Translation: CAI39957.1.
AL627390, AL139109, AL627071 Genomic DNA. Translation: CAI41496.1. Different initiation.
AL627071, AL139109, AL627390 Genomic DNA. Translation: CAI40155.1. Different initiation.
AL139109, AL627071, AL627390 Genomic DNA. Translation: CAI39958.1. Different initiation.
CH471132 Genomic DNA. Translation: EAX05331.1.
BC036016 mRNA. Translation: AAH36016.2.
AF285594 mRNA. Translation: AAK31973.1. Different initiation.
CCDSCCDS35323.1. [Q8IYF3-1]
CCDS43968.1. [Q8IYF3-3]
RefSeqNP_001003811.1. NM_001003811.1. [Q8IYF3-1]
NP_112566.2. NM_031276.2. [Q8IYF3-3]
UniGeneHs.121776.

3D structure databases

ProteinModelPortalQ8IYF3.
SMRQ8IYF3. Positions 455-517.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121093. 24 interactions.
IntActQ8IYF3. 22 interactions.
MINTMINT-1443835.
STRING9606.ENSP00000340995.

PTM databases

PhosphoSiteQ8IYF3.

Polymorphism databases

DMDM156637425.

Proteomic databases

PaxDbQ8IYF3.
PRIDEQ8IYF3.

Protocols and materials databases

DNASU56159.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000344304; ENSP00000340995; ENSG00000120498. [Q8IYF3-1]
ENST00000374320; ENSP00000363440; ENSG00000120498. [Q8IYF3-2]
ENST00000374333; ENSP00000363453; ENSG00000120498. [Q8IYF3-3]
ENST00000395889; ENSP00000379226; ENSG00000120498. [Q8IYF3-1]
GeneID56159.
KEGGhsa:56159.
UCSCuc004dyk.3. human. [Q8IYF3-1]
uc004dym.3. human. [Q8IYF3-3]

Organism-specific databases

CTD56159.
GeneCardsGC0XM069748.
H-InvDBHIX0022351.
HGNCHGNC:11733. TEX11.
HPAHPA002950.
MIM300311. gene.
neXtProtNX_Q8IYF3.
PharmGKBPA36450.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG314839.
HOGENOMHOG000154551.
HOVERGENHBG069003.
InParanoidQ8IYF3.
OMAFRKIAWN.
OrthoDBEOG79PJNG.
PhylomeDBQ8IYF3.
TreeFamTF333356.

Gene expression databases

BgeeQ8IYF3.
CleanExHS_TEX11.
GenevestigatorQ8IYF3.

Family and domain databases

Gene3D1.25.40.10. 1 hit.
InterProIPR013940. Meiosis_specific_SPO22.
IPR011990. TPR-like_helical.
[Graphical view]
PfamPF08631. SPO22. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi56159.
NextBio61780.
PROQ8IYF3.
SOURCESearch...

Entry information

Entry nameTEX11_HUMAN
AccessionPrimary (citable) accession number: Q8IYF3
Secondary accession number(s): A8K8V6 expand/collapse secondary AC list , Q5JQQ8, Q96LZ4, Q96M47, Q9BXU6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 24, 2007
Last modified: July 9, 2014
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM