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Protein

RNA polymerase II transcription factor SIII subunit A2

Gene

TCEB3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A2 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).1 Publication

GO - Molecular functioni

GO - Biological processi

  • regulation of DNA-templated transcription, elongation Source: ProtInc
  • transcription elongation from RNA polymerase II promoter Source: GO_Central
  • transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II transcription factor SIII subunit A2
Alternative name(s):
Elongin-A2
Short name:
EloA2
Transcription elongation factor B polypeptide 3B
Gene namesi
Name:TCEB3B
Synonyms:TCEB3L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:30771. TCEB3B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134932220.

Polymorphism and mutation databases

BioMutaiTCEB3B.
DMDMi145559470.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 753753RNA polymerase II transcription factor SIII subunit A2PRO_0000086963Add
BLAST

Proteomic databases

PaxDbiQ8IYF1.
PRIDEiQ8IYF1.

PTM databases

iPTMnetiQ8IYF1.
PhosphoSiteiQ8IYF1.

Expressioni

Tissue specificityi

Specifically expressed in testis.1 Publication

Gene expression databases

BgeeiQ8IYF1.
CleanExiHS_TCEB3B.
ExpressionAtlasiQ8IYF1. baseline and differential.
GenevisibleiQ8IYF1. HS.

Organism-specific databases

HPAiHPA041009.
HPA043501.
HPA048971.
HPA049178.
HPA050086.

Interactioni

Subunit structurei

Heterotrimer of an A (A1, A2 or A3), B and C subunit.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ZCCHC10Q8TBK63EBI-741705,EBI-597063

Protein-protein interaction databases

BioGridi119388. 17 interactions.
IntActiQ8IYF1. 14 interactions.
MINTiMINT-1446639.
STRINGi9606.ENSP00000331302.

Structurei

3D structure databases

ProteinModelPortaliQ8IYF1.
SMRiQ8IYF1. Positions 552-625.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 8076TFIIS N-terminalPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni500 – 659160Activation domainBy similarityAdd
BLAST
Regioni528 – 53710Interacting with Elongin BC complexBy similarity

Domaini

The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].

Sequence similaritiesi

Contains 1 TFIIS N-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2821. Eukaryota.
ENOG4110PG3. LUCA.
GeneTreeiENSGT00390000002428.
HOGENOMiHOG000059565.
HOVERGENiHBG051467.
InParanoidiQ8IYF1.
KOiK15076.
OMAiLSEAWMQ.
OrthoDBiEOG7P2XSR.
PhylomeDBiQ8IYF1.
TreeFamiTF317259.

Family and domain databases

Gene3Di1.20.930.10. 1 hit.
InterProiIPR010684. RNA_pol_II_trans_fac_SIII_A.
IPR003617. TFIIS/CRSP70_N_sub.
IPR017923. TFIIS_N.
[Graphical view]
PfamiPF06881. Elongin_A. 1 hit.
PF08711. Med26. 1 hit.
[Graphical view]
SMARTiSM00509. TFS2N. 1 hit.
[Graphical view]
SUPFAMiSSF47676. SSF47676. 1 hit.
PROSITEiPS51319. TFIIS_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IYF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGSTTLHA VEKLQVRLAT KTEPKKLEKY LQKLSALPMT ADILAETGIR
60 70 80 90 100
KTVKRLRKHQ HVGDFARDLA ARWKKLVLVD RNTRPGPQDP EESASRQRFG
110 120 130 140 150
EALQDQEKAW GFPENATAPR SPSHSPEHRR TARRTPPGQQ RPHPRSHSRE
160 170 180 190 200
PRAERKCPRI APADSGRYRA SPTRTAPLRM PEGPEPAAPG KQPGRGHTHA
210 220 230 240 250
AQGGPLLCPG CQGQPQGKAV VSHSKGHKSS RQEKRPLCAQ GDWHSPTLIR
260 270 280 290 300
EKSCGACLRE ETPRMPSWAS ARDRQPSDFK TDKEGGQAGS GQRVPALEEA
310 320 330 340 350
PDSHQKRPQH SHSNKKRPSL DGRDPGNGTH GLSPEEKEQL SNDRETQEGK
360 370 380 390 400
PPTAHLDRTS VSSLSEVEEV DMAEEFEQPT LSCEKYLTYD QLRKQKKKTG
410 420 430 440 450
KSATTALGDK QRKANESKGT RESWDSAKKL PPVQESQSER LQAAGADSAG
460 470 480 490 500
PKTVPSHVFS ELWDLSEAWM QANYDPLSDS DSMTSQAKPE ALSSPKFREE
510 520 530 540 550
AAFPGRRVNA KMPVYSGSRP ACQLQVPTLR QQCAQVLRNN PDALSDVGEV
560 570 580 590 600
PYWVLEPVLE GWRPDQLYRR KKDNHALVRE TDELRRNHCF QDFKEEKPQE
610 620 630 640 650
NKTWREQYLR LPDAPEQRLR VMTTNIRSAR GNNPNGREAK MICFKSVAKT
660 670 680 690 700
PYDTSRRQEK SAGDADPENG EIKPASKPAG SSHTPSSQSS SGGGRDSSSS
710 720 730 740 750
ILRWLPEKRA NPCLSSSNEH AAPAAKTRKQ AAKKVAPLMA KAIRDYKRRF

SRR
Length:753
Mass (Da):83,921
Last modified:April 17, 2007 - v2
Checksum:iA4CFDF5A0D3AD529
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti55 – 551R → L in BAA90665 (PubMed:10692460).Curated
Sequence conflicti236 – 2361P → L in BAA90665 (PubMed:10692460).Curated
Sequence conflicti456 – 4561S → N in AAH36022 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti179 – 1791R → P.1 Publication
Corresponds to variant rs2571028 [ dbSNP | Ensembl ].
VAR_050965
Natural varianti254 – 2541C → F.1 Publication
Corresponds to variant rs2010834 [ dbSNP | Ensembl ].
VAR_050966
Natural varianti403 – 4031A → S.1 Publication
Corresponds to variant rs892586 [ dbSNP | Ensembl ].
VAR_050967
Natural varianti446 – 4461A → T.1 Publication
Corresponds to variant rs3744863 [ dbSNP | Ensembl ].
VAR_061646
Natural varianti498 – 4981R → Q in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035914

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030834 mRNA. Translation: BAA90665.1.
BC036022 mRNA. Translation: AAH36022.1.
CCDSiCCDS11932.1.
RefSeqiNP_057511.2. NM_016427.2.
UniGeneiHs.375035.

Genome annotation databases

EnsembliENST00000332567; ENSP00000331302; ENSG00000206181.
GeneIDi51224.
KEGGihsa:51224.
UCSCiuc002lcr.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030834 mRNA. Translation: BAA90665.1.
BC036022 mRNA. Translation: AAH36022.1.
CCDSiCCDS11932.1.
RefSeqiNP_057511.2. NM_016427.2.
UniGeneiHs.375035.

3D structure databases

ProteinModelPortaliQ8IYF1.
SMRiQ8IYF1. Positions 552-625.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119388. 17 interactions.
IntActiQ8IYF1. 14 interactions.
MINTiMINT-1446639.
STRINGi9606.ENSP00000331302.

PTM databases

iPTMnetiQ8IYF1.
PhosphoSiteiQ8IYF1.

Polymorphism and mutation databases

BioMutaiTCEB3B.
DMDMi145559470.

Proteomic databases

PaxDbiQ8IYF1.
PRIDEiQ8IYF1.

Protocols and materials databases

DNASUi51224.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332567; ENSP00000331302; ENSG00000206181.
GeneIDi51224.
KEGGihsa:51224.
UCSCiuc002lcr.2. human.

Organism-specific databases

CTDi51224.
GeneCardsiTCEB3B.
H-InvDBHIX0027351.
HGNCiHGNC:30771. TCEB3B.
HPAiHPA041009.
HPA043501.
HPA048971.
HPA049178.
HPA050086.
MIMi609522. gene.
neXtProtiNX_Q8IYF1.
PharmGKBiPA134932220.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2821. Eukaryota.
ENOG4110PG3. LUCA.
GeneTreeiENSGT00390000002428.
HOGENOMiHOG000059565.
HOVERGENiHBG051467.
InParanoidiQ8IYF1.
KOiK15076.
OMAiLSEAWMQ.
OrthoDBiEOG7P2XSR.
PhylomeDBiQ8IYF1.
TreeFamiTF317259.

Miscellaneous databases

GenomeRNAii51224.
NextBioi54306.
PROiQ8IYF1.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IYF1.
CleanExiHS_TCEB3B.
ExpressionAtlasiQ8IYF1. baseline and differential.
GenevisibleiQ8IYF1. HS.

Family and domain databases

Gene3Di1.20.930.10. 1 hit.
InterProiIPR010684. RNA_pol_II_trans_fac_SIII_A.
IPR003617. TFIIS/CRSP70_N_sub.
IPR017923. TFIIS_N.
[Graphical view]
PfamiPF06881. Elongin_A. 1 hit.
PF08711. Med26. 1 hit.
[Graphical view]
SMARTiSM00509. TFS2N. 1 hit.
[Graphical view]
SUPFAMiSSF47676. SSF47676. 1 hit.
PROSITEiPS51319. TFIIS_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of Elongin A2, a new member of the Elongin family of transcription elongation factors, specifically expressed in the testis."
    Aso T., Yamazaki K., Amimoto K., Kuroiwa A., Higashi H., Matsuda Y., Kitajima S., Hatakeyama M.
    J. Biol. Chem. 275:6546-6552(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT, TISSUE SPECIFICITY, VARIANTS PRO-179; PHE-254; SER-403 AND THR-446.
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-498.

Entry informationi

Entry nameiELOA2_HUMAN
AccessioniPrimary (citable) accession number: Q8IYF1
Secondary accession number(s): Q9P2V9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: April 17, 2007
Last modified: March 16, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.