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Protein

Coiled-coil domain-containing protein 146

Gene

CCDC146

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 146
Gene namesi
Name:CCDC146
Synonyms:KIAA1505
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000135205.14.
HGNCiHGNC:29296. CCDC146.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi57639.
OpenTargetsiENSG00000135205.
PharmGKBiPA162381475.

Polymorphism and mutation databases

BioMutaiCCDC146.
DMDMi167006541.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003172521 – 955Coiled-coil domain-containing protein 146Add BLAST955

Proteomic databases

EPDiQ8IYE0.
PaxDbiQ8IYE0.
PeptideAtlasiQ8IYE0.
PRIDEiQ8IYE0.

PTM databases

iPTMnetiQ8IYE0.
PhosphoSitePlusiQ8IYE0.

Expressioni

Gene expression databases

BgeeiENSG00000135205.
CleanExiHS_CCDC146.
ExpressionAtlasiQ8IYE0. baseline and differential.
GenevisibleiQ8IYE0. HS.

Organism-specific databases

HPAiHPA020082.
HPA020105.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi121678. 37 interactors.
IntActiQ8IYE0. 65 interactors.
STRINGi9606.ENSP00000285871.

Structurei

3D structure databases

ProteinModelPortaliQ8IYE0.
SMRiQ8IYE0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili114 – 141Sequence analysisAdd BLAST28
Coiled coili169 – 321Sequence analysisAdd BLAST153
Coiled coili400 – 461Sequence analysisAdd BLAST62
Coiled coili534 – 640Sequence analysisAdd BLAST107
Coiled coili667 – 832Sequence analysisAdd BLAST166

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi9 – 15Poly-Glu7
Compositional biasi98 – 103Poly-Gln6
Compositional biasi501 – 504Poly-Lys4

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IF2S. Eukaryota.
ENOG410XSB7. LUCA.
GeneTreeiENSGT00530000063534.
HOGENOMiHOG000006542.
HOVERGENiHBG097466.
InParanoidiQ8IYE0.
OMAiNAYIPEA.
OrthoDBiEOG091G04GF.
PhylomeDBiQ8IYE0.
TreeFamiTF328680.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IYE0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEDSSTDTEK EEEEEKDEKD QEPIYAIVPT INIQDERFVD LSETPAFIFL
60 70 80 90 100
HELHAMGKLP GTRMAALKAK YTLLHDAVMS TQESEVQLLQ NAKRFTEQIQ
110 120 130 140 150
QQQFHLQQAD NFPEAFSTEV SKMREQLLKY QNEYNAVKER EFHNQYRLNS
160 170 180 190 200
LKEEKIIIVK EFEKITKPGE MEKKMKILRE STEELRKEIM QKKLEIKNLR
210 220 230 240 250
EDLASKQKQL LKEQKELEEL LGHQVVLKDE VAHHQTIPVQ IGKEIEKITR
260 270 280 290 300
KKVEMEKKKI VLEQEVKTLN DSLKKVENKV SAIVDEKENV IKEVEGKRAL
310 320 330 340 350
LEIKEREHNQ LVKLLELARE NEATSLTERG ILDLNLRNSL IDKQNYHDEL
360 370 380 390 400
SRKQREKERD FRNLRKMELL LKVSWDALRQ TQALHQRLLL EMEAIPKDDS
410 420 430 440 450
TLSERRRELH KEVEVAKRNL AQQKIISEME SKLVEQQLAE ENKLLKEQEN
460 470 480 490 500
MKELVVNLLR MTQIKIDEKE QKSKDFLKAQ QKYTNIVKEM KAKDLEIRIH
510 520 530 540 550
KKKKCEIYRR LREFAKLYDT IRNERNKFVN LLHKAHQKVN EIKERHKMSL
560 570 580 590 600
NELEILRNSA VSQERKLQNS MLKHANNVTI RESMQNDVRK IVSKLQEMKE
610 620 630 640 650
KKEAQLNNID RLANTITMIE EEMVQLRKRY EKAVQHRNES GVQLIEREEE
660 670 680 690 700
ICIFYEKINI QEKMKLNGEI EIHLLEEKIQ FLKMKIAEKQ RQICVTQKLL
710 720 730 740 750
PAKRSLDADL AVLQIQFSQC TDRIKDLEKQ FVKPDGENRA RFLPGKDLTE
760 770 780 790 800
KEMIQKLDKL ELQLAKKEEK LLEKDFIYEQ VSRLTDRLCS KTQGCKQDTL
810 820 830 840 850
LLAKKMNGYQ RRIKNATEKM MALVAELSMK QALTIELQKE VREKEDFIFT
860 870 880 890 900
CNSRIEKGLP LNKEIEKEWL KVLRDEEMHA LAIAEKSQEF LEADNRQLPN
910 920 930 940 950
GVYTTAEQRP NAYIPEADAT LPLPKPYGAL APFKPSEPGA NMRHIRKPVI

KPVEI
Length:955
Mass (Da):112,806
Last modified:February 5, 2008 - v2
Checksum:iB434DD95EF1019FF
GO
Isoform 2 (identifier: Q8IYE0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-254: Missing.
     392-423: Missing.

Note: No experimental confirmation available.
Show »
Length:669
Mass (Da):79,031
Checksum:iC242C0AD54AB19E9
GO

Sequence cautioni

Q8IYE0: The sequence BAA96029 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti655Y → H in BAF85180 (PubMed:14702039).Curated1
Sequence conflicti829M → I in BAF85180 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061583263E → Q1 PublicationCorresponds to variant dbSNP:rs17853516Ensembl.1
Natural variantiVAR_050742345N → S1 PublicationCorresponds to variant dbSNP:rs1109968Ensembl.1
Natural variantiVAR_061584466I → T. Corresponds to variant dbSNP:rs58545343Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0309261 – 254Missing in isoform 2. 1 PublicationAdd BLAST254
Alternative sequenceiVSP_030927392 – 423Missing in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040938 mRNA. Translation: BAA96029.1. Different initiation.
AK292491 mRNA. Translation: BAF85180.1.
BC036053 mRNA. Translation: AAH36053.1.
CCDSiCCDS34671.1. [Q8IYE0-1]
RefSeqiNP_065930.2. NM_020879.2. [Q8IYE0-1]
UniGeneiHs.113940.

Genome annotation databases

EnsembliENST00000285871; ENSP00000285871; ENSG00000135205. [Q8IYE0-1]
GeneIDi57639.
KEGGihsa:57639.
UCSCiuc003uga.3. human. [Q8IYE0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCC146_HUMAN
AccessioniPrimary (citable) accession number: Q8IYE0
Secondary accession number(s): A8K8X6, Q9P223
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: September 27, 2017
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

A report observed N-glycosylation at Asn-815 (PubMed:19139490). However, as the protein is not predicted to localize in an extracellular compartment of the cell, additional evidences are required to confirm this result.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations