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Protein

Coiled-coil domain-containing protein 146

Gene

CCDC146

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 146
Gene namesi
Name:CCDC146
Synonyms:KIAA1505
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:29296. CCDC146.

Subcellular locationi

GO - Cellular componenti

  • centriole Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162381475.

Polymorphism and mutation databases

BioMutaiCCDC146.
DMDMi167006541.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 955955Coiled-coil domain-containing protein 146PRO_0000317252Add
BLAST

Proteomic databases

EPDiQ8IYE0.
PaxDbiQ8IYE0.
PeptideAtlasiQ8IYE0.
PRIDEiQ8IYE0.

PTM databases

iPTMnetiQ8IYE0.
PhosphoSiteiQ8IYE0.

Expressioni

Gene expression databases

BgeeiENSG00000135205.
CleanExiHS_CCDC146.
ExpressionAtlasiQ8IYE0. baseline and differential.
GenevisibleiQ8IYE0. HS.

Organism-specific databases

HPAiHPA020082.
HPA020105.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC136Q96JN2-23EBI-10247802,EBI-10171416
CCNDBP1O952733EBI-10247802,EBI-748961
CEP170P1Q96L143EBI-10247802,EBI-743488
CEP44Q9C0F13EBI-10247802,EBI-744115
DTNBP1Q96EV83EBI-10247802,EBI-465804
GMNNO754963EBI-10247802,EBI-371669
GOLGA2Q083793EBI-10247802,EBI-618309
KRT18P057833EBI-10247802,EBI-297888
KRT19P087273EBI-10247802,EBI-742756
KRT38O760154EBI-10247802,EBI-1047263
KRT40Q6A1623EBI-10247802,EBI-10171697
MAGEA11P43364-23EBI-10247802,EBI-10178634
MAGEA6P433603EBI-10247802,EBI-1045155
MED4Q9NPJ63EBI-10247802,EBI-394607
MTUS2Q5JR593EBI-10247802,EBI-742948
NECAB2H3BTW23EBI-10247802,EBI-10172876
NINLQ9Y2I63EBI-10247802,EBI-719716
NUP62P371983EBI-10247802,EBI-347978
PNMA1Q8ND903EBI-10247802,EBI-302345
PSMC6P623333EBI-10247802,EBI-357669
RINT1Q6NUQ13EBI-10247802,EBI-726876
RNF40O751503EBI-10247802,EBI-744408
RPGRIP1Q96KN73EBI-10247802,EBI-1050213
SPERTQ8NA613EBI-10247802,EBI-741724
TFIP11Q9UBB93EBI-10247802,EBI-1105213
TNRA1L3063EBI-10247802,EBI-10182881
TPM3Q5VU623EBI-10247802,EBI-10184033
TRAF1Q130773EBI-10247802,EBI-359224
TRIM23P364063EBI-10247802,EBI-740098
TRIM54Q9BYV23EBI-10247802,EBI-2130429
TSC22D4Q9Y3Q83EBI-10247802,EBI-739485
USHBP1Q8N6Y03EBI-10247802,EBI-739895
VPS52Q8N1B43EBI-10247802,EBI-2799833

Protein-protein interaction databases

BioGridi121678. 36 interactions.
IntActiQ8IYE0. 33 interactions.
STRINGi9606.ENSP00000285871.

Structurei

3D structure databases

ProteinModelPortaliQ8IYE0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili114 – 14128Sequence analysisAdd
BLAST
Coiled coili169 – 321153Sequence analysisAdd
BLAST
Coiled coili400 – 46162Sequence analysisAdd
BLAST
Coiled coili534 – 640107Sequence analysisAdd
BLAST
Coiled coili667 – 832166Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi9 – 157Poly-Glu
Compositional biasi98 – 1036Poly-Gln
Compositional biasi501 – 5044Poly-Lys

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IF2S. Eukaryota.
ENOG410XSB7. LUCA.
GeneTreeiENSGT00530000063534.
HOGENOMiHOG000006542.
HOVERGENiHBG097466.
InParanoidiQ8IYE0.
OMAiKDFIYEQ.
OrthoDBiEOG091G04GF.
PhylomeDBiQ8IYE0.
TreeFamiTF328680.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IYE0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEDSSTDTEK EEEEEKDEKD QEPIYAIVPT INIQDERFVD LSETPAFIFL
60 70 80 90 100
HELHAMGKLP GTRMAALKAK YTLLHDAVMS TQESEVQLLQ NAKRFTEQIQ
110 120 130 140 150
QQQFHLQQAD NFPEAFSTEV SKMREQLLKY QNEYNAVKER EFHNQYRLNS
160 170 180 190 200
LKEEKIIIVK EFEKITKPGE MEKKMKILRE STEELRKEIM QKKLEIKNLR
210 220 230 240 250
EDLASKQKQL LKEQKELEEL LGHQVVLKDE VAHHQTIPVQ IGKEIEKITR
260 270 280 290 300
KKVEMEKKKI VLEQEVKTLN DSLKKVENKV SAIVDEKENV IKEVEGKRAL
310 320 330 340 350
LEIKEREHNQ LVKLLELARE NEATSLTERG ILDLNLRNSL IDKQNYHDEL
360 370 380 390 400
SRKQREKERD FRNLRKMELL LKVSWDALRQ TQALHQRLLL EMEAIPKDDS
410 420 430 440 450
TLSERRRELH KEVEVAKRNL AQQKIISEME SKLVEQQLAE ENKLLKEQEN
460 470 480 490 500
MKELVVNLLR MTQIKIDEKE QKSKDFLKAQ QKYTNIVKEM KAKDLEIRIH
510 520 530 540 550
KKKKCEIYRR LREFAKLYDT IRNERNKFVN LLHKAHQKVN EIKERHKMSL
560 570 580 590 600
NELEILRNSA VSQERKLQNS MLKHANNVTI RESMQNDVRK IVSKLQEMKE
610 620 630 640 650
KKEAQLNNID RLANTITMIE EEMVQLRKRY EKAVQHRNES GVQLIEREEE
660 670 680 690 700
ICIFYEKINI QEKMKLNGEI EIHLLEEKIQ FLKMKIAEKQ RQICVTQKLL
710 720 730 740 750
PAKRSLDADL AVLQIQFSQC TDRIKDLEKQ FVKPDGENRA RFLPGKDLTE
760 770 780 790 800
KEMIQKLDKL ELQLAKKEEK LLEKDFIYEQ VSRLTDRLCS KTQGCKQDTL
810 820 830 840 850
LLAKKMNGYQ RRIKNATEKM MALVAELSMK QALTIELQKE VREKEDFIFT
860 870 880 890 900
CNSRIEKGLP LNKEIEKEWL KVLRDEEMHA LAIAEKSQEF LEADNRQLPN
910 920 930 940 950
GVYTTAEQRP NAYIPEADAT LPLPKPYGAL APFKPSEPGA NMRHIRKPVI

KPVEI
Length:955
Mass (Da):112,806
Last modified:February 5, 2008 - v2
Checksum:iB434DD95EF1019FF
GO
Isoform 2 (identifier: Q8IYE0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-254: Missing.
     392-423: Missing.

Note: No experimental confirmation available.
Show »
Length:669
Mass (Da):79,031
Checksum:iC242C0AD54AB19E9
GO

Sequence cautioni

The sequence BAA96029 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti655 – 6551Y → H in BAF85180 (PubMed:14702039).Curated
Sequence conflicti829 – 8291M → I in BAF85180 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti263 – 2631E → Q.1 Publication
Corresponds to variant rs17853516 [ dbSNP | Ensembl ].
VAR_061583
Natural varianti345 – 3451N → S.1 Publication
Corresponds to variant rs1109968 [ dbSNP | Ensembl ].
VAR_050742
Natural varianti466 – 4661I → T.
Corresponds to variant rs58545343 [ dbSNP | Ensembl ].
VAR_061584

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 254254Missing in isoform 2. 1 PublicationVSP_030926Add
BLAST
Alternative sequencei392 – 42332Missing in isoform 2. 1 PublicationVSP_030927Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040938 mRNA. Translation: BAA96029.1. Different initiation.
AK292491 mRNA. Translation: BAF85180.1.
BC036053 mRNA. Translation: AAH36053.1.
CCDSiCCDS34671.1. [Q8IYE0-1]
RefSeqiNP_065930.2. NM_020879.2. [Q8IYE0-1]
UniGeneiHs.113940.

Genome annotation databases

EnsembliENST00000285871; ENSP00000285871; ENSG00000135205. [Q8IYE0-1]
GeneIDi57639.
KEGGihsa:57639.
UCSCiuc003uga.3. human. [Q8IYE0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040938 mRNA. Translation: BAA96029.1. Different initiation.
AK292491 mRNA. Translation: BAF85180.1.
BC036053 mRNA. Translation: AAH36053.1.
CCDSiCCDS34671.1. [Q8IYE0-1]
RefSeqiNP_065930.2. NM_020879.2. [Q8IYE0-1]
UniGeneiHs.113940.

3D structure databases

ProteinModelPortaliQ8IYE0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121678. 36 interactions.
IntActiQ8IYE0. 33 interactions.
STRINGi9606.ENSP00000285871.

PTM databases

iPTMnetiQ8IYE0.
PhosphoSiteiQ8IYE0.

Polymorphism and mutation databases

BioMutaiCCDC146.
DMDMi167006541.

Proteomic databases

EPDiQ8IYE0.
PaxDbiQ8IYE0.
PeptideAtlasiQ8IYE0.
PRIDEiQ8IYE0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000285871; ENSP00000285871; ENSG00000135205. [Q8IYE0-1]
GeneIDi57639.
KEGGihsa:57639.
UCSCiuc003uga.3. human. [Q8IYE0-1]

Organism-specific databases

CTDi57639.
GeneCardsiCCDC146.
H-InvDBHIX0006794.
HGNCiHGNC:29296. CCDC146.
HPAiHPA020082.
HPA020105.
neXtProtiNX_Q8IYE0.
PharmGKBiPA162381475.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF2S. Eukaryota.
ENOG410XSB7. LUCA.
GeneTreeiENSGT00530000063534.
HOGENOMiHOG000006542.
HOVERGENiHBG097466.
InParanoidiQ8IYE0.
OMAiKDFIYEQ.
OrthoDBiEOG091G04GF.
PhylomeDBiQ8IYE0.
TreeFamiTF328680.

Miscellaneous databases

ChiTaRSiCCDC146. human.
GenomeRNAii57639.
PROiQ8IYE0.

Gene expression databases

BgeeiENSG00000135205.
CleanExiHS_CCDC146.
ExpressionAtlasiQ8IYE0. baseline and differential.
GenevisibleiQ8IYE0. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCC146_HUMAN
AccessioniPrimary (citable) accession number: Q8IYE0
Secondary accession number(s): A8K8X6, Q9P223
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: September 7, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

A report observed N-glycosylation at Asn-815 (PubMed:19139490). However, as the protein is not predicted to localize in an extracellular compartment of the cell, additional evidences are required to confirm this result.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.