Reviewed, UniProtKB/Swiss-Prot Q8IYD9 (CR054_HUMAN)

Names and origin

Protein names

Recommended name:
    Uncharacterized protein C18orf54

Gene names

Name:

C18orf54

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	372 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location

Secreted Potential.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IYD9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8IYD9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     197-197: G → GRLKNPKLMN...PGQSTKPFSG

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 31	31	Potential
	Chain	32 – 372	341	Uncharacterized protein C18orf54		PRO_0000019561
Natural variations
	Alternative sequence	197	1	G → GRLKNPKLMNRTNNCISESS LSFPKKSSFKDSSEHSLEKN YPRWLTSQKSDLNVSGITSI PDFKYPVWLHNQDLLPDANS QRVYQIFKDDQCSPRHSHQA QGTSRLINKLDCFEYAFEPS NFSNSLSDDKELVNEYKCDF EHSQCQCENPLLPGQSTKPF SG in isoform 2.		VSP_015085
	Natural variant	147	1	R → P: dbSNP rs1657907.		VAR_050903
	Natural variant	196	1	C → F: dbSNP rs16958096.		VAR_050904
Experimental info
	Sequence conflict	102	1	K → E in CAE45934. Ref.1
	Sequence conflict	114	1	T → I in CAE45934. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: F4BCD1BEA28FF61E	FASTA	372	41,811
	10 20 30 40 50 60 MAKSKTKHRL CSQESSVSAL LASCTLSGSN SSNSDGSFHY KDKLYRSASQ ALQAYIDDFD 70 80 90 100 110 120 LGQIYPGAST GKINIDEDFT NMSQFCNYIY KPNNAFENLD HKKHSNFISC RRHTVNDIDS 130 140 150 160 170 180 MSLTTDDLLR LPADGSFSYT YVGPSHRTSK KNKKCRGRLG SLDIEKNPHF QGPYTSMGKD 190 200 210 220 230 240 NFVTPVIRSN INGKQCGDKI ELLILKAKRN LEQCTEELPK SMKKDDSPCS LDKLEADRSW 250 260 270 280 290 300 ENIPVTFKSP VPVNSDDSPQ QTSRAKSAKG VLEDFLNNDN QSCTLSGGKH HGPVEALKQM 310 320 330 340 350 360 LFNLQAVQER FNQNKTTDPK EEIKQVSEDD FSKLQLKESM IPITRSLQKA LHHLSRLRDL 370 VDDTNGERSP KM
	Isoform 2. Checksum: FE15C3FFA41DFC41	FASTA	533	60,320
	10 20 30 40 50 60 MAKSKTKHRL CSQESSVSAL LASCTLSGSN SSNSDGSFHY KDKLYRSASQ ALQAYIDDFD 70 80 90 100 110 120 LGQIYPGAST GKINIDEDFT NMSQFCNYIY KPNNAFENLD HKKHSNFISC RRHTVNDIDS 130 140 150 160 170 180 MSLTTDDLLR LPADGSFSYT YVGPSHRTSK KNKKCRGRLG SLDIEKNPHF QGPYTSMGKD 190 200 210 220 230 240 NFVTPVIRSN INGKQCGRLK NPKLMNRTNN CISESSLSFP KKSSFKDSSE HSLEKNYPRW 250 260 270 280 290 300 LTSQKSDLNV SGITSIPDFK YPVWLHNQDL LPDANSQRVY QIFKDDQCSP RHSHQAQGTS 310 320 330 340 350 360 RLINKLDCFE YAFEPSNFSN SLSDDKELVN EYKCDFEHSQ CQCENPLLPG QSTKPFSGDK 370 380 390 400 410 420 IELLILKAKR NLEQCTEELP KSMKKDDSPC SLDKLEADRS WENIPVTFKS PVPVNSDDSP 430 440 450 460 470 480 QQTSRAKSAK GVLEDFLNND NQSCTLSGGK HHGPVEALKQ MLFNLQAVQE RFNQNKTTDP 490 500 510 520 530 KEEIKQVSED DFSKLQLKES MIPITRSLQK ALHHLSRLRD LVDDTNGERS PKM

References

[1]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Uterine endothelium.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Testis.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 88-372 (ISOFORM 2). Tissue: Uterus.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX640877 mRNA. Translation: CAE45934.1. BC036054 mRNA. Translation: AAH36054.1. AK126503 mRNA. Translation: BAC86570.1. Different initiation.
IPI	IPI00217756. IPI00445152.
RefSeq	NP_775800.3.
UniGene	Hs.208701
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8IYD9. 1 interaction.
Proteomic databases
PRIDE	Q8IYD9.
Genome annotation databases
Ensembl	ENST00000300091; ENSP00000300091; ENSG00000166845; Homo sapiens. [Genome view]
GeneID	162681.
KEGG	hsa:162681.
UCSC	uc002lfn.2. human. uc002lfo.2. human.
Organism-specific databases
CTD	162681.
GeneCards	GC18P050140.
HGNC	HGNC:13796. C18orf54.
PharmGKB	PA134942612.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q8IYD9.
OMA	MKKDDSP
OrthoDB	EOG99W51M
Enzyme and pathway databases
BioCyc	CATTLE:ENSBTAG00000008169-MON.
Gene expression databases
ArrayExpress	Q8IYD9.
Bgee	Q8IYD9.
CleanEx	HS_C18orf54.
Genevestigator	Q8IYD9.
GermOnline	ENSG00000166845. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	88212.

Entry information

Entry name

CR054_HUMAN

Accession

Primary (citable) accession number: Q8IYD9
Secondary accession number(s): Q6MZU3, Q6ZTL6

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2005
Last sequence update:	March 1, 2003
Last modified:	November 24, 2009
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.