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Protein

Lung adenoma susceptibility protein 2

Gene

LAS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Might play a role in cell proliferation.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Lung adenoma susceptibility protein 2
Gene namesi
Name:LAS2
Synonyms:C18orf54
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000166845.13
HGNCiHGNC:13796 C18orf54
MIMi613258 gene
neXtProtiNX_Q8IYD9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi162681
OpenTargetsiENSG00000166845
PharmGKBiPA134942612

Polymorphism and mutation databases

BioMutaiLAS2
DMDMi73620600

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000001956132 – 372Lung adenoma susceptibility protein 2Add BLAST341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei161PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8IYD9
PeptideAtlasiQ8IYD9
PRIDEiQ8IYD9
ProteomicsDBi71160
71161 [Q8IYD9-2]

PTM databases

iPTMnetiQ8IYD9
PhosphoSitePlusiQ8IYD9

Expressioni

Gene expression databases

BgeeiENSG00000166845
CleanExiHS_C18orf54
ExpressionAtlasiQ8IYD9 baseline and differential
GenevisibleiQ8IYD9 HS

Organism-specific databases

HPAiHPA040704

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MAGEA11P433643EBI-749878,EBI-739552

Protein-protein interaction databases

BioGridi127828, 4 interactors
IntActiQ8IYD9, 5 interactors
MINTiQ8IYD9
STRINGi9606.ENSP00000300091

Structurei

3D structure databases

ProteinModelPortaliQ8IYD9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IGEU Eukaryota
ENOG4111V88 LUCA
GeneTreeiENSGT00390000008823
HOGENOMiHOG000111961
HOVERGENiHBG081341
InParanoidiQ8IYD9
OMAiRSWENIP
OrthoDBiEOG091G0P9S
PhylomeDBiQ8IYD9
TreeFamiTF337548

Family and domain databases

InterProiView protein in InterPro
IPR031587 LAS2
PfamiView protein in Pfam
PF15792 LAS2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IYD9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKSKTKHRL CSQESSVSAL LASCTLSGSN SSNSDGSFHY KDKLYRSASQ
60 70 80 90 100
ALQAYIDDFD LGQIYPGAST GKINIDEDFT NMSQFCNYIY KPNNAFENLD
110 120 130 140 150
HKKHSNFISC RRHTVNDIDS MSLTTDDLLR LPADGSFSYT YVGPSHRTSK
160 170 180 190 200
KNKKCRGRLG SLDIEKNPHF QGPYTSMGKD NFVTPVIRSN INGKQCGDKI
210 220 230 240 250
ELLILKAKRN LEQCTEELPK SMKKDDSPCS LDKLEADRSW ENIPVTFKSP
260 270 280 290 300
VPVNSDDSPQ QTSRAKSAKG VLEDFLNNDN QSCTLSGGKH HGPVEALKQM
310 320 330 340 350
LFNLQAVQER FNQNKTTDPK EEIKQVSEDD FSKLQLKESM IPITRSLQKA
360 370
LHHLSRLRDL VDDTNGERSP KM
Length:372
Mass (Da):41,811
Last modified:March 1, 2003 - v1
Checksum:iF4BCD1BEA28FF61E
GO
Isoform 2 (identifier: Q8IYD9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     197-197: G → GRLKNPKLMN...PGQSTKPFSG

Show »
Length:533
Mass (Da):60,320
Checksum:iFE15C3FFA41DFC41
GO

Sequence cautioni

The sequence BAC86570 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti102K → E in CAE45934 (PubMed:17974005).Curated1
Sequence conflicti114T → I in CAE45934 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050903147R → P. Corresponds to variant dbSNP:rs1657907Ensembl.1
Natural variantiVAR_050904196C → F. Corresponds to variant dbSNP:rs16958096Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_015085197G → GRLKNPKLMNRTNNCISESS LSFPKKSSFKDSSEHSLEKN YPRWLTSQKSDLNVSGITSI PDFKYPVWLHNQDLLPDANS QRVYQIFKDDQCSPRHSHQA QGTSRLINKLDCFEYAFEPS NFSNSLSDDKELVNEYKCDF EHSQCQCENPLLPGQSTKPF SG in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB353076 mRNA Translation: BAM34476.1
AB353077 mRNA Translation: BAM34477.1
AB267906 mRNA Translation: BAM35939.1
BX640877 mRNA Translation: CAE45934.1
CH471096 Genomic DNA Translation: EAW63006.1
BC036054 mRNA Translation: AAH36054.1
AK126503 mRNA Translation: BAC86570.1 Different initiation.
CCDSiCCDS11956.1 [Q8IYD9-1]
CCDS74223.1 [Q8IYD9-2]
RefSeqiNP_001275909.1, NM_001288980.1 [Q8IYD9-2]
NP_001275910.1, NM_001288981.1 [Q8IYD9-2]
NP_775800.3, NM_173529.5 [Q8IYD9-1]
XP_005258258.1, XM_005258201.1 [Q8IYD9-2]
XP_016881056.1, XM_017025567.1 [Q8IYD9-2]
UniGeneiHs.208701

Genome annotation databases

EnsembliENST00000300091; ENSP00000300091; ENSG00000166845 [Q8IYD9-1]
ENST00000382911; ENSP00000372368; ENSG00000166845 [Q8IYD9-2]
ENST00000620105; ENSP00000477654; ENSG00000166845 [Q8IYD9-2]
GeneIDi162681
KEGGihsa:162681
UCSCiuc002lfo.6 human [Q8IYD9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLAS2_HUMAN
AccessioniPrimary (citable) accession number: Q8IYD9
Secondary accession number(s): I7HFJ6, Q6MZU3, Q6ZTL6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: March 1, 2003
Last modified: June 20, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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