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Protein

Lung adenoma susceptibility protein 2

Gene

LAS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Might play a role in cell proliferation.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Lung adenoma susceptibility protein 2
Gene namesi
Name:LAS2
Synonyms:C18orf54
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:13796. C18orf54.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134942612.

Polymorphism and mutation databases

BioMutaiLAS2.
DMDMi73620600.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence analysisAdd
BLAST
Chaini32 – 372341Lung adenoma susceptibility protein 2PRO_0000019561Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei161 – 1611PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8IYD9.
PRIDEiQ8IYD9.

PTM databases

iPTMnetiQ8IYD9.
PhosphoSiteiQ8IYD9.

Expressioni

Gene expression databases

BgeeiQ8IYD9.
CleanExiHS_C18orf54.
ExpressionAtlasiQ8IYD9. baseline and differential.
GenevisibleiQ8IYD9. HS.

Organism-specific databases

HPAiHPA040704.
HPA041098.

Interactioni

Protein-protein interaction databases

BioGridi127828. 3 interactions.
IntActiQ8IYD9. 3 interactions.
MINTiMINT-1485365.
STRINGi9606.ENSP00000300091.

Structurei

3D structure databases

ProteinModelPortaliQ8IYD9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IGEU. Eukaryota.
ENOG4111V88. LUCA.
GeneTreeiENSGT00390000008823.
HOGENOMiHOG000111961.
HOVERGENiHBG081341.
InParanoidiQ8IYD9.
OMAiRSWENIP.
PhylomeDBiQ8IYD9.
TreeFamiTF337548.

Family and domain databases

InterProiIPR031587. LAS2.
[Graphical view]
PfamiPF15792. LAS2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IYD9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKSKTKHRL CSQESSVSAL LASCTLSGSN SSNSDGSFHY KDKLYRSASQ
60 70 80 90 100
ALQAYIDDFD LGQIYPGAST GKINIDEDFT NMSQFCNYIY KPNNAFENLD
110 120 130 140 150
HKKHSNFISC RRHTVNDIDS MSLTTDDLLR LPADGSFSYT YVGPSHRTSK
160 170 180 190 200
KNKKCRGRLG SLDIEKNPHF QGPYTSMGKD NFVTPVIRSN INGKQCGDKI
210 220 230 240 250
ELLILKAKRN LEQCTEELPK SMKKDDSPCS LDKLEADRSW ENIPVTFKSP
260 270 280 290 300
VPVNSDDSPQ QTSRAKSAKG VLEDFLNNDN QSCTLSGGKH HGPVEALKQM
310 320 330 340 350
LFNLQAVQER FNQNKTTDPK EEIKQVSEDD FSKLQLKESM IPITRSLQKA
360 370
LHHLSRLRDL VDDTNGERSP KM
Length:372
Mass (Da):41,811
Last modified:March 1, 2003 - v1
Checksum:iF4BCD1BEA28FF61E
GO
Isoform 2 (identifier: Q8IYD9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     197-197: G → GRLKNPKLMN...PGQSTKPFSG

Show »
Length:533
Mass (Da):60,320
Checksum:iFE15C3FFA41DFC41
GO

Sequence cautioni

The sequence BAC86570.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti102 – 1021K → E in CAE45934 (PubMed:17974005).Curated
Sequence conflicti114 – 1141T → I in CAE45934 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti147 – 1471R → P.
Corresponds to variant rs1657907 [ dbSNP | Ensembl ].
VAR_050903
Natural varianti196 – 1961C → F.
Corresponds to variant rs16958096 [ dbSNP | Ensembl ].
VAR_050904

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei197 – 1971G → GRLKNPKLMNRTNNCISESS LSFPKKSSFKDSSEHSLEKN YPRWLTSQKSDLNVSGITSI PDFKYPVWLHNQDLLPDANS QRVYQIFKDDQCSPRHSHQA QGTSRLINKLDCFEYAFEPS NFSNSLSDDKELVNEYKCDF EHSQCQCENPLLPGQSTKPF SG in isoform 2. 2 PublicationsVSP_015085

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB353076 mRNA. Translation: BAM34476.1.
AB353077 mRNA. Translation: BAM34477.1.
AB267906 mRNA. Translation: BAM35939.1.
BX640877 mRNA. Translation: CAE45934.1.
CH471096 Genomic DNA. Translation: EAW63006.1.
BC036054 mRNA. Translation: AAH36054.1.
AK126503 mRNA. Translation: BAC86570.1. Different initiation.
CCDSiCCDS11956.1. [Q8IYD9-1]
CCDS74223.1. [Q8IYD9-2]
RefSeqiNP_001275909.1. NM_001288980.1. [Q8IYD9-2]
NP_001275910.1. NM_001288981.1. [Q8IYD9-2]
NP_775800.3. NM_173529.5. [Q8IYD9-1]
XP_005258258.1. XM_005258201.1. [Q8IYD9-2]
UniGeneiHs.208701.

Genome annotation databases

EnsembliENST00000300091; ENSP00000300091; ENSG00000166845. [Q8IYD9-1]
ENST00000382911; ENSP00000372368; ENSG00000166845. [Q8IYD9-2]
ENST00000620105; ENSP00000477654; ENSG00000166845. [Q8IYD9-2]
GeneIDi162681.
KEGGihsa:162681.
UCSCiuc002lfo.6. human. [Q8IYD9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB353076 mRNA. Translation: BAM34476.1.
AB353077 mRNA. Translation: BAM34477.1.
AB267906 mRNA. Translation: BAM35939.1.
BX640877 mRNA. Translation: CAE45934.1.
CH471096 Genomic DNA. Translation: EAW63006.1.
BC036054 mRNA. Translation: AAH36054.1.
AK126503 mRNA. Translation: BAC86570.1. Different initiation.
CCDSiCCDS11956.1. [Q8IYD9-1]
CCDS74223.1. [Q8IYD9-2]
RefSeqiNP_001275909.1. NM_001288980.1. [Q8IYD9-2]
NP_001275910.1. NM_001288981.1. [Q8IYD9-2]
NP_775800.3. NM_173529.5. [Q8IYD9-1]
XP_005258258.1. XM_005258201.1. [Q8IYD9-2]
UniGeneiHs.208701.

3D structure databases

ProteinModelPortaliQ8IYD9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127828. 3 interactions.
IntActiQ8IYD9. 3 interactions.
MINTiMINT-1485365.
STRINGi9606.ENSP00000300091.

PTM databases

iPTMnetiQ8IYD9.
PhosphoSiteiQ8IYD9.

Polymorphism and mutation databases

BioMutaiLAS2.
DMDMi73620600.

Proteomic databases

PaxDbiQ8IYD9.
PRIDEiQ8IYD9.

Protocols and materials databases

DNASUi162681.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300091; ENSP00000300091; ENSG00000166845. [Q8IYD9-1]
ENST00000382911; ENSP00000372368; ENSG00000166845. [Q8IYD9-2]
ENST00000620105; ENSP00000477654; ENSG00000166845. [Q8IYD9-2]
GeneIDi162681.
KEGGihsa:162681.
UCSCiuc002lfo.6. human. [Q8IYD9-1]

Organism-specific databases

CTDi162681.
GeneCardsiC18orf54.
H-InvDBHIX0027365.
HGNCiHGNC:13796. C18orf54.
HPAiHPA040704.
HPA041098.
MIMi613258. gene.
neXtProtiNX_Q8IYD9.
PharmGKBiPA134942612.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGEU. Eukaryota.
ENOG4111V88. LUCA.
GeneTreeiENSGT00390000008823.
HOGENOMiHOG000111961.
HOVERGENiHBG081341.
InParanoidiQ8IYD9.
OMAiRSWENIP.
PhylomeDBiQ8IYD9.
TreeFamiTF337548.

Miscellaneous databases

GenomeRNAii162681.
PROiQ8IYD9.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IYD9.
CleanExiHS_C18orf54.
ExpressionAtlasiQ8IYD9. baseline and differential.
GenevisibleiQ8IYD9. HS.

Family and domain databases

InterProiIPR031587. LAS2.
[Graphical view]
PfamiPF15792. LAS2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Overexpression of B9838 in bladder cancers."
    Katagiri T., Harada Y., Nakamura Y.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Urinary bladder.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Uterine endothelium.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 88-372 (ISOFORM 2).
    Tissue: Uterus.
  6. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-161, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Erythroleukemia.

Entry informationi

Entry nameiLAS2_HUMAN
AccessioniPrimary (citable) accession number: Q8IYD9
Secondary accession number(s): I7HFJ6, Q6MZU3, Q6ZTL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: March 1, 2003
Last modified: July 6, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.