Q8IYD8 (FANCM_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fanconi anemia group M protein
Short name=Protein FACM
EC=3.6.4.13

Alternative name(s):
ATP-dependent RNA helicase FANCM
Fanconi anemia-associated polypeptide of 250 kDa
Short name=FAAP250
Protein Hef ortholog

Gene names

Name:	FANCM
Synonyms:	KIAA1596

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2048 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair. Binds to ssDNA but not to dsDNA. Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions. Ref.1 Ref.5 Ref.7 Ref.8
Catalytic activity	ATP + H2O = ADP + phosphate.
Subunit structure	Belongs to the multisubunit FA complex composed of APITD1, FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9, FANCM, FAAP24 and STRA13/CENPX. The complex is not found in FA patients. Interacts with APITD1/CENPS, FAAP24 and EME1. Ref.1 Ref.6 Ref.7 Ref.8
Subcellular location	Nucleus Ref.1 Ref.7 Ref.8.
Post-translational modification	Phosphorylated; hyperphosphorylated in response to genotoxic stress. Ref.1
Involvement in disease	Fanconi anemia complementation group M (FANCM) [MIM:614087]: A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.1
Sequence similarities	Belongs to the DEAD box helicase family. DEAH subfamily. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain.
Sequence caution	The sequence BAB13422.1 differs from that shown. Reason: Intron retention.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Fanconi anemia
Ligand	ATP-binding DNA-binding Nucleotide-binding
Molecular function	Helicase Hydrolase
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA repair Traceable author statement. Source: Reactome nucleic acid phosphodiester bond hydrolysis Inferred from electronic annotation. Source: GOC replication fork processing Inferred from mutant phenotype PubMed 20347428. Source: UniProtKB resolution of meiotic recombination intermediates Inferred from mutant phenotype PubMed 20347428. Source: UniProtKB
Cellular_component	FANCM-MHF complex Inferred from direct assay PubMed 20347428. Source: UniProtKB Fanconi anaemia nuclear complex Inferred from direct assay PubMed 20347428PubMed 20347429. Source: UniProtKB
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATP-dependent helicase activity Inferred from electronic annotation. Source: InterPro DNA binding Inferred from electronic annotation. Source: UniProtKB-KW chromatin binding Inferred from direct assay PubMed 20347429. Source: UniProtKB nuclease activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IYD8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8IYD8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     669-669: M → K
     670-2048: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 2048

2048

Fanconi anemia group M protein

PRO_0000055176

Regions

Domain

98 – 266

169

Helicase ATP-binding

Domain

452 – 627

176

Helicase C-terminal

Nucleotide binding

111 – 118

8

ATP Probable

Region

1727 – 2048

322

Interaction with FAAP24 and EME1

Motif

214 – 217

4

DEAH box

Natural variations

Alternative sequence

669

1

M → K in isoform 2.

VSP_015989

Alternative sequence

670 – 2048

1379

Missing in isoform 2.

VSP_015990

Natural variant

175

1

S → F.
Corresponds to variant rs10138997 [ dbSNP | Ensembl ].

VAR_023697

Natural variant

208

1

I → M.
Corresponds to variant rs45547534 [ dbSNP | Ensembl ].

VAR_061827

Natural variant

878

1

V → L. Ref.4
Corresponds to variant rs1367580 [ dbSNP | Ensembl ].

VAR_023698

Natural variant

1812

1

P → A. Ref.4
Corresponds to variant rs3736772 [ dbSNP | Ensembl ].

VAR_023699

Experimental info

Mutagenesis

116

1

G → A: Reduces ATPase activity. Ref.5

Mutagenesis

117

1

K → R: Abolishes ATPase activity. Ref.1

Sequence conflict

68

1

L → F in BAC04159. Ref.2

Sequence conflict

1460

1

I → V in BAB13422. Ref.4

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

2048

Helix Strand Turn

Details...

Helix

682 – 691

10

Beta strand

698 – 700

3

Beta strand

702 – 704

3

Turn

711 – 713

3

Beta strand

727 – 730

4

Helix

737 – 739

3

Beta strand

747 – 749

3

Helix

753 – 767

15

Helix

776 – 782

7

Helix

787 – 789

3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 25, 2005. Version 2. Checksum: BDE0D6640B73C255	FASTA	2,048	232,191
	10 20 30 40 50 60 MSGRQRTLFQ TWGSSISRSS GTPGCSSGTE RPQSPGSSKA PLPAAAEAQL ESDDDVLLVA 70 80 90 100 110 120 AYEAERQLCL ENGGFCTSAG ALWIYPTNCP VRDYQLHISR AALFCNTLVC LPTGLGKTFI 130 140 150 160 170 180 AAVVMYNFYR WFPSGKVVFM APTKPLVTQQ IEACYQVMGI PQSHMAEMTG STQASTRKEI 190 200 210 220 230 240 WCSKRVLFLT PQVMVNDLSR GACPAAEIKC LVIDEAHKAL GNYAYCQVVR ELVKYTNHFR 250 260 270 280 290 300 ILALSATPGS DIKAVQQVIT NLLIGQIELR SEDSPDILTY SHERKVEKLI VPLGEELAAI 310 320 330 340 350 360 QKTYIQILES FARSLIQRNV LMRRDIPNLT KYQIILARDQ FRKNPSPNIV GIQQGIIEGE 370 380 390 400 410 420 FAICISLYHG YELLQQMGMR SLYFFLCGIM DGTKGMTRSK NELGRNEDFM KLYNHLECMF 430 440 450 460 470 480 ARTRSTSANG ISAIQQGDKN KKFVYSHPKL KKLEEVVIEH FKSWNAENTT EKKRDETRVM 490 500 510 520 530 540 IFSSFRDSVQ EIAEMLSQHQ PIIRVMTFVG HASGKSTKGF TQKEQLEVVK QFRDGGYNTL 550 560 570 580 590 600 VSTCVGEEGL DIGEVDLIIC FDSQKSPIRL VQRMGRTGRK RQGRIVIILS EGREERIYNQ 610 620 630 640 650 660 SQSNKRSIYK AISSNRQVLH FYQRSPRMVP DGINPKLHKM FITHGVYEPE KPSRNLQRKS 670 680 690 700 710 720 SIFSYRDGMR QSSLKKDWFL SEEEFKLWNR LYRLRDSDEI KEITLPQVQF SSLQNEENKP 730 740 750 760 770 780 AQESTTGIHQ LSLSEWRLWQ DHPLPTHQVD HSDRCRHFIG LMQMIEGMRH EEGECSYELE 790 800 810 820 830 840 VESYLQMEDV TSTFIAPRNE SNNLASDTFI THKKSSFIKN INQGSSSSVI ESDEECAEIV 850 860 870 880 890 900 KQTHIKPTKI VSLKKKVSKE IKKDQLKKEN NHGIIDSVDN DRNSTVENIF QEDLPNDKRT 910 920 930 940 950 960 SDTDEIAATC TINENVIKEP CVLLTECQFT NKSTSSLAGN VLDSGYNSFN DEKSVSSNLF 970 980 990 1000 1010 1020 LPFEEELYIV RTDDQFYNCH SLTKEVLANV ERFLSYSPPP LSGLSDLEYE IAKGTALENL 1030 1040 1050 1060 1070 1080 LFLPCAEHLR SDKCTCLLSH SAVNSQQNLE LNSLKCINYP SEKSCLYDIP NDNISDEPSL 1090 1100 1110 1120 1130 1140 CDCDVHKHNQ NENLVPNNRV QIHRSPAQNL VGENNHDVDN SDLPVLSTDQ DESLLLFEDV 1150 1160 1170 1180 1190 1200 NTEFDDVSLS PLNSKSESLP VSDKTAISET PLVSQFLISD ELLLDNNSEL QDQITRDANS 1210 1220 1230 1240 1250 1260 FKSRDQRGVQ EEKVKNHEDI FDCSRDLFSV TFDLGFCSPD SDDEILEHTS DSNRPLDDLY 1270 1280 1290 1300 1310 1320 GRYLEIKEIS DANYVSNQAL IPRDHSKNFT SGTVIIPSNE DMQNPNYVHL PLSAAKNEEL 1330 1340 1350 1360 1370 1380 LSPGYSQFSL PVQKKVMSTP LSKSNTLNSF SKIRKEILKT PDSSKEKVNL QRFKEALNST 1390 1400 1410 1420 1430 1440 FDYSEFSLEK SKSSGPMYLH KSCHSVEDGQ LLTSNESEDD EIFRRKVKRA KGNVLNSPED 1450 1460 1470 1480 1490 1500 QKNSEVDSPL HAVKKRRFPI NRSELSSSDE SENFPKPCSQ LEDFKVCNGN ARRGIKVPKR 1510 1520 1530 1540 1550 1560 QSHLKHVARK FLDDEAELSE EDAEYVSSDE NDESENEQDS SLLDFLNDET QLSQAINDSE 1570 1580 1590 1600 1610 1620 MRAIYMKSLR SPMMNNKYKM IHKTHKNINI FSQIPEQDET YLEDSFCVDE EESCKGQSSE 1630 1640 1650 1660 1670 1680 EEVCVDFNLI TDDCFANSKK YKTRRAVMLK EMMEQNCAHS KKKLSRIILP DDSSEEENNV 1690 1700 1710 1720 1730 1740 NDKRESNIAV NPSTVKKNKQ QDHCLNSVPS GSSAQSKVRS TPRVNPLAKQ SKQTSLNLKD 1750 1760 1770 1780 1790 1800 TISEVSDFKP QNHNEVQSTT PPFTTVDSQK DCRKFPVPQK DGSALEDSST SGASCSKSRP 1810 1820 1830 1840 1850 1860 HLAGTHTSLR LPQEGKGTCI LVGGHEITSG LEVISSLRAI HGLQVEVCPL NGCDYIVSNR 1870 1880 1890 1900 1910 1920 MVVERRSQSE MLNSVNKNKF IEQIQHLQSM FERICVIVEK DREKTGDTSR MFRRTKSYDS 1930 1940 1950 1960 1970 1980 LLTTLIGAGI RILFSSCQEE TADLLKELSL VEQRKNVGIH VPTVVNSNKS EALQFYLSIP 1990 2000 2010 2020 2030 2040 NISYITALNM CHQFSSVKRM ANSSLQEISM YAQVTHQKAE EIYRYIHYVF DIQMLPNDLN QDRLKSDI
	Isoform 2 [UniParc]. Checksum: A10DBC94FFA28C0B	FASTA	669	75,579
	10 20 30 40 50 60 MSGRQRTLFQ TWGSSISRSS GTPGCSSGTE RPQSPGSSKA PLPAAAEAQL ESDDDVLLVA 70 80 90 100 110 120 AYEAERQLCL ENGGFCTSAG ALWIYPTNCP VRDYQLHISR AALFCNTLVC LPTGLGKTFI 130 140 150 160 170 180 AAVVMYNFYR WFPSGKVVFM APTKPLVTQQ IEACYQVMGI PQSHMAEMTG STQASTRKEI 190 200 210 220 230 240 WCSKRVLFLT PQVMVNDLSR GACPAAEIKC LVIDEAHKAL GNYAYCQVVR ELVKYTNHFR 250 260 270 280 290 300 ILALSATPGS DIKAVQQVIT NLLIGQIELR SEDSPDILTY SHERKVEKLI VPLGEELAAI 310 320 330 340 350 360 QKTYIQILES FARSLIQRNV LMRRDIPNLT KYQIILARDQ FRKNPSPNIV GIQQGIIEGE 370 380 390 400 410 420 FAICISLYHG YELLQQMGMR SLYFFLCGIM DGTKGMTRSK NELGRNEDFM KLYNHLECMF 430 440 450 460 470 480 ARTRSTSANG ISAIQQGDKN KKFVYSHPKL KKLEEVVIEH FKSWNAENTT EKKRDETRVM 490 500 510 520 530 540 IFSSFRDSVQ EIAEMLSQHQ PIIRVMTFVG HASGKSTKGF TQKEQLEVVK QFRDGGYNTL 550 560 570 580 590 600 VSTCVGEEGL DIGEVDLIIC FDSQKSPIRL VQRMGRTGRK RQGRIVIILS EGREERIYNQ 610 620 630 640 650 660 SQSNKRSIYK AISSNRQVLH FYQRSPRMVP DGINPKLHKM FITHGVYEPE KPSRNLQRKS SIFSYRDGK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M." Meetei A.R., Medhurst A.L., Ling C., Xue Y., Singh T.R., Bier P., Steltenpool J., Stone S., Dokal I., Mathew C.G., Hoatlin M., Joenje H., de Winter J.P., Wang W. Nat. Genet. 37:958-963(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN A COMPLEX WITH FANCA; FANCB; FANCC; FANCE; FANCF; FANCG AND FANCL, SUBCELLULAR LOCATION, INVOLVEMENT IN FANCM, PHOSPHORYLATION, FUNCTION, MUTAGENESIS OF LYS-117.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Testis.
[4]	"Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O. DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 794-2048 (ISOFORM 1), VARIANTS LEU-878 AND ALA-1812. Tissue: Brain.
[5]	"The vertebrate Hef ortholog is a component of the Fanconi anemia tumor-suppressor pathway." Mosedale G., Niedzwiedz W., Alpi A., Perrina F., Pereira-Leal J.B., Johnson M., Langevin F., Pace P., Patel K.J. Nat. Struct. Mol. Biol. 12:763-771(2005) [PubMed] [Europe PMC] [Abstract] Cited for: DNA-BINDING, MUTAGENESIS OF GLY-116, IDENTIFICATION AS PART OF THE FA COMPLEX, FUNCTION.
[6]	"Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM." Ciccia A., Ling C., Coulthard R., Yan Z., Xue Y., Meetei A.R., Laghmani el H., Joenje H., McDonald N., de Winter J.P., Wang W., West S.C. Mol. Cell 25:331-343(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH EME1 AND FAAP24.
[7]	"A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability." Yan Z., Delannoy M., Ling C., Daee D., Osman F., Muniandy P.A., Shen X., Oostra A.B., Du H., Steltenpool J., Lin T., Schuster B., Decaillet C., Stasiak A., Stasiak A.Z., Stone S., Hoatlin M.E., Schindler D. , Woodcock C.L., Joenje H., Sen R., de Winter J.P., Li L., Seidman M.M., Whitby M.C., Myung K., Constantinousend A., Wang W. Mol. Cell 37:865-878(2010) Cited for: IDENTIFICATION IN THE FA CORE COMPLEX, INTERACTION WITH APITD1, SUBCELLULAR LOCATION, FUNCTION.
[8]	"MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM." Singh T.R., Saro D., Ali A.M., Zheng X.-F., Du C., Killen M.W., Sachpatzidis A., Wahengbam K., Pierce A.J., Xiong Y., Sung P., Meetei A.R. Mol. Cell 37:879-886(2010) Cited for: IDENTIFICATION IN THE FA CORE COMPLEX, INTERACTION WITH APITD1, SUBCELLULAR LOCATION, FUNCTION.
+	Additional computationally mapped references.

Web resources

Fanconi Anemia Mutation Database

GeneReviews

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

DQ140356 mRNA. Translation: AAZ53290.1.
AK093422 mRNA. Translation: BAC04159.1.
BC036056 mRNA. Translation: AAH36056.1.
AB046816 mRNA. Translation: BAB13422.1. Sequence problems.

IPI

IPI00176581.
IPI00217755.

RefSeq

NP_065988.1. NM_020937.2.

UniGene

Hs.509229.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4DAY	X-ray	3.30	C	1218-1251	[»]
4DRB	X-ray	2.63	C/F/I	661-800	[»]

ProteinModelPortal

Q8IYD8.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q8IYD8. 2 interactions.

STRING

9606.ENSP00000267430.

PTM databases

PhosphoSite

Q8IYD8.

Polymorphism databases

DMDM

78099254.

Proteomic databases

PaxDb

Q8IYD8.

PRIDE

Q8IYD8.

Protocols and materials databases

DNASU

57697.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000267430; ENSP00000267430; ENSG00000187790.
ENST00000556036; ENSP00000450596; ENSG00000187790.

GeneID

57697.

KEGG

hsa:57697.

UCSC

uc001wwc.2. human.
uc001wwd.4. human.

Organism-specific databases

CTD

57697.

GeneCards

GC14P045605.

HGNC

HGNC:23168. FANCM.

MIM

609644. gene.
614087. phenotype.

neXtProt

NX_Q8IYD8.

Orphanet

84. Fanconi anemia.

PharmGKB

PA134943156.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG1948.

HOGENOM

HOG000112498.

HOVERGEN

HBG081520.

InParanoid

Q8IYD8.

KO

K10896.

OMA

QMGMRSL.

OrthoDB

EOG4C5CHK.

Enzyme and pathway databases

Reactome

REACT_216. DNA Repair.

Gene expression databases

ArrayExpress

Q8IYD8.

Bgee

Q8IYD8.

CleanEx

HS_FANCM.

Genevestigator

Q8IYD8.

GermOnline

ENSG00000187790. Homo sapiens.

Family and domain databases

Gene3D

3.40.50.10130. 1 hit.

InterPro

IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR020819. DNA_repair_nuc_XPF/helicase.
IPR006166. ERCC4_domain.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR011335. Restrct_endonuc-II-like.
IPR010994. RuvA_2-like.
[Graphical view]

Pfam

PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]

SMART

SM00487. DEXDc. 1 hit.
SM00891. ERCC4. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]

SUPFAM

SSF52980. Restrict_endonuc_II-like_core. 1 hit.
SSF47781. RuvA_2_like. 1 hit.

PROSITE

PS00690. DEAH_ATP_HELICASE. False negative.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

GenomeRNAi

57697.

NextBio

64551.

SOURCE

Search...

Entry information

Entry name

FANCM_HUMAN

Accession

Primary (citable) accession number: Q8IYD8
Secondary accession number(s): Q3YFH9, Q8N9X6, Q9HCH6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 25, 2005
Last sequence update:	October 25, 2005
Last modified:	May 1, 2013
This is version 99 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.