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Protein

Fanconi anemia group M protein

Gene

FANCM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair. Binds to ssDNA but not to dsDNA. Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions.4 Publications

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi111 – 118ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • chromatin binding Source: UniProtKB
  • DNA binding Source: UniProtKB-KW
  • helicase activity Source: UniProtKB-KW
  • nuclease activity Source: InterPro

GO - Biological processi

  • interstrand cross-link repair Source: Reactome
  • replication fork processing Source: UniProtKB
  • resolution of meiotic recombination intermediates Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-6783310. Fanconi Anemia Pathway.
SIGNORiQ8IYD8.

Names & Taxonomyi

Protein namesi
Recommended name:
Fanconi anemia group M protein (EC:3.6.4.13)
Short name:
Protein FACM
Alternative name(s):
ATP-dependent RNA helicase FANCM
Fanconi anemia-associated polypeptide of 250 kDa
Short name:
FAAP250
Protein Hef ortholog
Gene namesi
Name:FANCM
Synonyms:KIAA1596
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:23168. FANCM.

Subcellular locationi

GO - Cellular componenti

  • FANCM-MHF complex Source: UniProtKB
  • Fanconi anaemia nuclear complex Source: UniProtKB
  • nucleoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi116G → A: Reduces ATPase activity. 1 Publication1
Mutagenesisi117K → R: Abolishes ATPase activity. 1 Publication1

Organism-specific databases

DisGeNETi57697.
MalaCardsiFANCM.
OpenTargetsiENSG00000187790.
Orphaneti84. Fanconi anemia.
PharmGKBiPA134943156.

Polymorphism and mutation databases

BioMutaiFANCM.
DMDMi78099254.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000551761 – 2048Fanconi anemia group M proteinAdd BLAST2048

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34PhosphoserineCombined sources1
Modified residuei1673PhosphoserineCombined sources1
Modified residuei1674PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated; hyperphosphorylated in response to genotoxic stress.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IYD8.
MaxQBiQ8IYD8.
PaxDbiQ8IYD8.
PeptideAtlasiQ8IYD8.
PRIDEiQ8IYD8.

PTM databases

iPTMnetiQ8IYD8.
PhosphoSitePlusiQ8IYD8.

Expressioni

Gene expression databases

BgeeiENSG00000187790.
CleanExiHS_FANCM.
ExpressionAtlasiQ8IYD8. baseline and differential.
GenevisibleiQ8IYD8. HS.

Organism-specific databases

HPAiHPA055144.

Interactioni

Subunit structurei

Belongs to the multisubunit FA complex composed of APITD1, FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9, FANCM, FAAP24 and STRA13/CENPX. The complex is not found in FA patients. Interacts with APITD1/CENPS, FAAP24 and EME1.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TRIM27P143733EBI-3957237,EBI-719493

Protein-protein interaction databases

BioGridi121722. 41 interactors.
DIPiDIP-43972N.
IntActiQ8IYD8. 16 interactors.
MINTiMINT-4789123.
STRINGi9606.ENSP00000267430.

Structurei

Secondary structure

12048
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi682 – 691Combined sources10
Beta strandi698 – 700Combined sources3
Beta strandi702 – 704Combined sources3
Turni711 – 713Combined sources3
Beta strandi728 – 730Combined sources3
Helixi737 – 739Combined sources3
Beta strandi747 – 749Combined sources3
Helixi753 – 768Combined sources16
Helixi776 – 781Combined sources6
Helixi782 – 784Combined sources3
Helixi787 – 789Combined sources3
Beta strandi1819 – 1823Combined sources5
Helixi1826 – 1829Combined sources4
Helixi1831 – 1838Combined sources8
Beta strandi1844 – 1848Combined sources5
Beta strandi1854 – 1856Combined sources3
Beta strandi1858 – 1867Combined sources10
Helixi1868 – 1872Combined sources5
Helixi1877 – 1888Combined sources12
Beta strandi1892 – 1899Combined sources8
Helixi1916 – 1927Combined sources12
Beta strandi1931 – 1937Combined sources7
Helixi1938 – 1954Combined sources17
Helixi1970 – 1977Combined sources8
Helixi1984 – 1993Combined sources10
Helixi1997 – 2001Combined sources5
Helixi2005 – 2012Combined sources8
Helixi2016 – 2027Combined sources12
Helixi2032 – 2034Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BXOX-ray2.15A1798-2048[»]
4DAYX-ray3.30C1218-1251[»]
4DRBX-ray2.63C/F/I661-800[»]
4E45X-ray2.00E/J/O667-800[»]
4M6WX-ray2.90A1813-2031[»]
ProteinModelPortaliQ8IYD8.
SMRiQ8IYD8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini98 – 266Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST169
Domaini452 – 627Helicase C-terminalPROSITE-ProRule annotationAdd BLAST176

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1727 – 2048Interaction with FAAP24 and EME11 PublicationAdd BLAST322

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi214 – 217DEAH boxPROSITE-ProRule annotation4

Sequence similaritiesi

Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0354. Eukaryota.
KOG0442. Eukaryota.
COG1111. LUCA.
COG1948. LUCA.
GeneTreeiENSGT00510000046789.
HOGENOMiHOG000112498.
HOVERGENiHBG081520.
InParanoidiQ8IYD8.
KOiK10896.
OMAiSLYFFLC.
OrthoDBiEOG091G042T.
PhylomeDBiQ8IYD8.
TreeFamiTF324610.

Family and domain databases

Gene3Di3.40.50.10130. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR020819. DNA_repair_nuc_XPF/helicase.
IPR006166. ERCC4_domain.
IPR031879. FANCM-MHF-bd.
IPR006935. Helicase/UvrB_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR011335. Restrct_endonuc-II-like.
IPR010994. RuvA_2-like.
[Graphical view]
PfamiPF02732. ERCC4. 1 hit.
PF16783. FANCM-MHF_bd. 1 hit.
PF00271. Helicase_C. 1 hit.
PF04851. ResIII. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00891. ERCC4. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF47781. SSF47781. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF52980. SSF52980. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IYD8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGRQRTLFQ TWGSSISRSS GTPGCSSGTE RPQSPGSSKA PLPAAAEAQL
60 70 80 90 100
ESDDDVLLVA AYEAERQLCL ENGGFCTSAG ALWIYPTNCP VRDYQLHISR
110 120 130 140 150
AALFCNTLVC LPTGLGKTFI AAVVMYNFYR WFPSGKVVFM APTKPLVTQQ
160 170 180 190 200
IEACYQVMGI PQSHMAEMTG STQASTRKEI WCSKRVLFLT PQVMVNDLSR
210 220 230 240 250
GACPAAEIKC LVIDEAHKAL GNYAYCQVVR ELVKYTNHFR ILALSATPGS
260 270 280 290 300
DIKAVQQVIT NLLIGQIELR SEDSPDILTY SHERKVEKLI VPLGEELAAI
310 320 330 340 350
QKTYIQILES FARSLIQRNV LMRRDIPNLT KYQIILARDQ FRKNPSPNIV
360 370 380 390 400
GIQQGIIEGE FAICISLYHG YELLQQMGMR SLYFFLCGIM DGTKGMTRSK
410 420 430 440 450
NELGRNEDFM KLYNHLECMF ARTRSTSANG ISAIQQGDKN KKFVYSHPKL
460 470 480 490 500
KKLEEVVIEH FKSWNAENTT EKKRDETRVM IFSSFRDSVQ EIAEMLSQHQ
510 520 530 540 550
PIIRVMTFVG HASGKSTKGF TQKEQLEVVK QFRDGGYNTL VSTCVGEEGL
560 570 580 590 600
DIGEVDLIIC FDSQKSPIRL VQRMGRTGRK RQGRIVIILS EGREERIYNQ
610 620 630 640 650
SQSNKRSIYK AISSNRQVLH FYQRSPRMVP DGINPKLHKM FITHGVYEPE
660 670 680 690 700
KPSRNLQRKS SIFSYRDGMR QSSLKKDWFL SEEEFKLWNR LYRLRDSDEI
710 720 730 740 750
KEITLPQVQF SSLQNEENKP AQESTTGIHQ LSLSEWRLWQ DHPLPTHQVD
760 770 780 790 800
HSDRCRHFIG LMQMIEGMRH EEGECSYELE VESYLQMEDV TSTFIAPRNE
810 820 830 840 850
SNNLASDTFI THKKSSFIKN INQGSSSSVI ESDEECAEIV KQTHIKPTKI
860 870 880 890 900
VSLKKKVSKE IKKDQLKKEN NHGIIDSVDN DRNSTVENIF QEDLPNDKRT
910 920 930 940 950
SDTDEIAATC TINENVIKEP CVLLTECQFT NKSTSSLAGN VLDSGYNSFN
960 970 980 990 1000
DEKSVSSNLF LPFEEELYIV RTDDQFYNCH SLTKEVLANV ERFLSYSPPP
1010 1020 1030 1040 1050
LSGLSDLEYE IAKGTALENL LFLPCAEHLR SDKCTCLLSH SAVNSQQNLE
1060 1070 1080 1090 1100
LNSLKCINYP SEKSCLYDIP NDNISDEPSL CDCDVHKHNQ NENLVPNNRV
1110 1120 1130 1140 1150
QIHRSPAQNL VGENNHDVDN SDLPVLSTDQ DESLLLFEDV NTEFDDVSLS
1160 1170 1180 1190 1200
PLNSKSESLP VSDKTAISET PLVSQFLISD ELLLDNNSEL QDQITRDANS
1210 1220 1230 1240 1250
FKSRDQRGVQ EEKVKNHEDI FDCSRDLFSV TFDLGFCSPD SDDEILEHTS
1260 1270 1280 1290 1300
DSNRPLDDLY GRYLEIKEIS DANYVSNQAL IPRDHSKNFT SGTVIIPSNE
1310 1320 1330 1340 1350
DMQNPNYVHL PLSAAKNEEL LSPGYSQFSL PVQKKVMSTP LSKSNTLNSF
1360 1370 1380 1390 1400
SKIRKEILKT PDSSKEKVNL QRFKEALNST FDYSEFSLEK SKSSGPMYLH
1410 1420 1430 1440 1450
KSCHSVEDGQ LLTSNESEDD EIFRRKVKRA KGNVLNSPED QKNSEVDSPL
1460 1470 1480 1490 1500
HAVKKRRFPI NRSELSSSDE SENFPKPCSQ LEDFKVCNGN ARRGIKVPKR
1510 1520 1530 1540 1550
QSHLKHVARK FLDDEAELSE EDAEYVSSDE NDESENEQDS SLLDFLNDET
1560 1570 1580 1590 1600
QLSQAINDSE MRAIYMKSLR SPMMNNKYKM IHKTHKNINI FSQIPEQDET
1610 1620 1630 1640 1650
YLEDSFCVDE EESCKGQSSE EEVCVDFNLI TDDCFANSKK YKTRRAVMLK
1660 1670 1680 1690 1700
EMMEQNCAHS KKKLSRIILP DDSSEEENNV NDKRESNIAV NPSTVKKNKQ
1710 1720 1730 1740 1750
QDHCLNSVPS GSSAQSKVRS TPRVNPLAKQ SKQTSLNLKD TISEVSDFKP
1760 1770 1780 1790 1800
QNHNEVQSTT PPFTTVDSQK DCRKFPVPQK DGSALEDSST SGASCSKSRP
1810 1820 1830 1840 1850
HLAGTHTSLR LPQEGKGTCI LVGGHEITSG LEVISSLRAI HGLQVEVCPL
1860 1870 1880 1890 1900
NGCDYIVSNR MVVERRSQSE MLNSVNKNKF IEQIQHLQSM FERICVIVEK
1910 1920 1930 1940 1950
DREKTGDTSR MFRRTKSYDS LLTTLIGAGI RILFSSCQEE TADLLKELSL
1960 1970 1980 1990 2000
VEQRKNVGIH VPTVVNSNKS EALQFYLSIP NISYITALNM CHQFSSVKRM
2010 2020 2030 2040
ANSSLQEISM YAQVTHQKAE EIYRYIHYVF DIQMLPNDLN QDRLKSDI
Length:2,048
Mass (Da):232,191
Last modified:October 25, 2005 - v2
Checksum:iBDE0D6640B73C255
GO
Isoform 2 (identifier: Q8IYD8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     669-669: M → K
     670-2048: Missing.

Show »
Length:669
Mass (Da):75,579
Checksum:iA10DBC94FFA28C0B
GO
Isoform 3 (identifier: Q8IYD8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     228-253: Missing.

Note: No experimental confirmation available.
Show »
Length:2,022
Mass (Da):229,281
Checksum:iF31611E4697FA196
GO

Sequence cautioni

The sequence BAB13422 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti68L → F in BAC04159 (PubMed:14702039).Curated1
Sequence conflicti1460I → V in BAB13422 (PubMed:10997877).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_023697175S → F.Corresponds to variant rs10138997dbSNPEnsembl.1
Natural variantiVAR_061827208I → M.Corresponds to variant rs45547534dbSNPEnsembl.1
Natural variantiVAR_023698878V → L.1 PublicationCorresponds to variant rs1367580dbSNPEnsembl.1
Natural variantiVAR_0236991812P → A.1 PublicationCorresponds to variant rs3736772dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054504228 – 253Missing in isoform 3. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_015989669M → K in isoform 2. 2 Publications1
Alternative sequenceiVSP_015990670 – 2048Missing in isoform 2. 2 PublicationsAdd BLAST1379

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ140356 mRNA. Translation: AAZ53290.1.
AK093422 mRNA. Translation: BAC04159.1.
AL121809 Genomic DNA. No translation available.
BC036056 mRNA. Translation: AAH36056.1.
BC140776 mRNA. Translation: AAI40777.1.
BC144511 mRNA. Translation: AAI44512.1.
AB046816 mRNA. Translation: BAB13422.1. Sequence problems.
CCDSiCCDS32070.1. [Q8IYD8-1]
CCDS76677.1. [Q8IYD8-3]
CCDS81802.1. [Q8IYD8-2]
RefSeqiNP_001295062.1. NM_001308133.1. [Q8IYD8-3]
NP_001295063.1. NM_001308134.1. [Q8IYD8-2]
NP_065988.1. NM_020937.3. [Q8IYD8-1]
UniGeneiHs.509229.

Genome annotation databases

EnsembliENST00000267430; ENSP00000267430; ENSG00000187790. [Q8IYD8-1]
ENST00000542564; ENSP00000442493; ENSG00000187790. [Q8IYD8-3]
ENST00000556036; ENSP00000450596; ENSG00000187790. [Q8IYD8-2]
GeneIDi57697.
KEGGihsa:57697.
UCSCiuc001wwc.3. human. [Q8IYD8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Fanconi Anemia Mutation Database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ140356 mRNA. Translation: AAZ53290.1.
AK093422 mRNA. Translation: BAC04159.1.
AL121809 Genomic DNA. No translation available.
BC036056 mRNA. Translation: AAH36056.1.
BC140776 mRNA. Translation: AAI40777.1.
BC144511 mRNA. Translation: AAI44512.1.
AB046816 mRNA. Translation: BAB13422.1. Sequence problems.
CCDSiCCDS32070.1. [Q8IYD8-1]
CCDS76677.1. [Q8IYD8-3]
CCDS81802.1. [Q8IYD8-2]
RefSeqiNP_001295062.1. NM_001308133.1. [Q8IYD8-3]
NP_001295063.1. NM_001308134.1. [Q8IYD8-2]
NP_065988.1. NM_020937.3. [Q8IYD8-1]
UniGeneiHs.509229.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BXOX-ray2.15A1798-2048[»]
4DAYX-ray3.30C1218-1251[»]
4DRBX-ray2.63C/F/I661-800[»]
4E45X-ray2.00E/J/O667-800[»]
4M6WX-ray2.90A1813-2031[»]
ProteinModelPortaliQ8IYD8.
SMRiQ8IYD8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121722. 41 interactors.
DIPiDIP-43972N.
IntActiQ8IYD8. 16 interactors.
MINTiMINT-4789123.
STRINGi9606.ENSP00000267430.

PTM databases

iPTMnetiQ8IYD8.
PhosphoSitePlusiQ8IYD8.

Polymorphism and mutation databases

BioMutaiFANCM.
DMDMi78099254.

Proteomic databases

EPDiQ8IYD8.
MaxQBiQ8IYD8.
PaxDbiQ8IYD8.
PeptideAtlasiQ8IYD8.
PRIDEiQ8IYD8.

Protocols and materials databases

DNASUi57697.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267430; ENSP00000267430; ENSG00000187790. [Q8IYD8-1]
ENST00000542564; ENSP00000442493; ENSG00000187790. [Q8IYD8-3]
ENST00000556036; ENSP00000450596; ENSG00000187790. [Q8IYD8-2]
GeneIDi57697.
KEGGihsa:57697.
UCSCiuc001wwc.3. human. [Q8IYD8-1]

Organism-specific databases

CTDi57697.
DisGeNETi57697.
GeneCardsiFANCM.
GeneReviewsiFANCM.
HGNCiHGNC:23168. FANCM.
HPAiHPA055144.
MalaCardsiFANCM.
MIMi609644. gene.
neXtProtiNX_Q8IYD8.
OpenTargetsiENSG00000187790.
Orphaneti84. Fanconi anemia.
PharmGKBiPA134943156.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0354. Eukaryota.
KOG0442. Eukaryota.
COG1111. LUCA.
COG1948. LUCA.
GeneTreeiENSGT00510000046789.
HOGENOMiHOG000112498.
HOVERGENiHBG081520.
InParanoidiQ8IYD8.
KOiK10896.
OMAiSLYFFLC.
OrthoDBiEOG091G042T.
PhylomeDBiQ8IYD8.
TreeFamiTF324610.

Enzyme and pathway databases

ReactomeiR-HSA-6783310. Fanconi Anemia Pathway.
SIGNORiQ8IYD8.

Miscellaneous databases

GenomeRNAii57697.
PROiQ8IYD8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000187790.
CleanExiHS_FANCM.
ExpressionAtlasiQ8IYD8. baseline and differential.
GenevisibleiQ8IYD8. HS.

Family and domain databases

Gene3Di3.40.50.10130. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR020819. DNA_repair_nuc_XPF/helicase.
IPR006166. ERCC4_domain.
IPR031879. FANCM-MHF-bd.
IPR006935. Helicase/UvrB_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR011335. Restrct_endonuc-II-like.
IPR010994. RuvA_2-like.
[Graphical view]
PfamiPF02732. ERCC4. 1 hit.
PF16783. FANCM-MHF_bd. 1 hit.
PF00271. Helicase_C. 1 hit.
PF04851. ResIII. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00891. ERCC4. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF47781. SSF47781. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF52980. SSF52980. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFANCM_HUMAN
AccessioniPrimary (citable) accession number: Q8IYD8
Secondary accession number(s): B2RTQ9
, Q3YFH9, Q8N9X6, Q9HCH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2005
Last modified: November 30, 2016
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.