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Protein

Zinc finger protein 595

Gene

ZNF595

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri145 – 167C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri173 – 194C2H2-type 2PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri200 – 222C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 334C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri340 – 362C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri368 – 390C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri396 – 418C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri424 – 446C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri452 – 474C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri480 – 502C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri508 – 530C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri536 – 558C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri564 – 586C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri592 – 614C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri620 – 642C2H2-type 18PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 595
Gene namesi
Name:ZNF595
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000272602.5
HGNCiHGNC:27196 ZNF595
neXtProtiNX_Q8IYB9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000272602

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476861 – 648Zinc finger protein 595Add BLAST648

Proteomic databases

EPDiQ8IYB9
PeptideAtlasiQ8IYB9
PRIDEiQ8IYB9
ProteomicsDBi71154

PTM databases

iPTMnetiQ8IYB9
PhosphoSitePlusiQ8IYB9

Expressioni

Gene expression databases

CleanExiHS_ZNF595

Interactioni

Protein-protein interaction databases

IntActiQ8IYB9, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ8IYB9
SMRiQ8IYB9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 75KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri145 – 167C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri173 – 194C2H2-type 2PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri200 – 222C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 334C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri340 – 362C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri368 – 390C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri396 – 418C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri424 – 446C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri452 – 474C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri480 – 502C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri508 – 530C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri536 – 558C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri564 – 586C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri592 – 614C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri620 – 642C2H2-type 18PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00910000144042
HOVERGENiHBG018163
InParanoidiQ8IYB9
KOiK09228
OMAiYQCLSTT
PhylomeDBiQ8IYB9

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 18 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 17 hits
PS50157 ZINC_FINGER_C2H2_2, 18 hits

Sequencei

Sequence statusi: Complete.

Q8IYB9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELVTFRDVA IEFSPEEWKC LDPAQQNLYR DVMLENYRNL VSLGFVISNP
60 70 80 90 100
DLVTCLEQIK EPCNLKIHET AAKPPAICSP FSQDLSPVQG IEDSFHKLIL
110 120 130 140 150
KRYEKCGHEN LQLRKGCKRV NECKVQKGVN NGVYQCLSTT QSKIFQCNTC
160 170 180 190 200
VKVFSKFSNS NKHKIRHTGE KPFKCTECGR SFYMSHLTQH TGIHAGEKPY
210 220 230 240 250
KCEKCGKAFN RSTSLSKHKR IHTGEKPYTC EECGKAFRRS TVLNEHKKIH
260 270 280 290 300
TGEKPYKCEE CGKAFTRSTT LNEHKKIHTG EKPYKCKECG KAFRWSTSLN
310 320 330 340 350
EHKNIHTGEK PYKCKECGKA FRQSRSLNEH KNIHTGEKPY TCEKCGKAFN
360 370 380 390 400
QSSSLIIHRS IHSEQKLYKC EECGKAFTWS SSLNKHKRIH TGEKPYTCEE
410 420 430 440 450
CGKAFYRSSH LAKHKRIHTG EKPYTCEECG KAFNQSSTLI LHKRIHSGQK
460 470 480 490 500
PYKCEECGKA FTRSTTLNEH KKIHTGEKPY KCEECGKAFI WSASLNEHKN
510 520 530 540 550
IHTGEKPYKC KECGKAFNQS SGLIIHRSIH SEQKLYKCEE CGKAFTRSTA
560 570 580 590 600
LNEHKKIHSG EKPYKCKECG KAYNLSSTLT KHKRIHTGEK PFTCEECGKA
610 620 630 640
FNWSSSLTKH KIIHTGEKSY KCEECGKAFN RPSTLTVHKR IHTGKEHS
Length:648
Mass (Da):74,302
Last modified:March 28, 2018 - v2
Checksum:iEBCB193E1D4660E1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti299L → M in AAH36110 (PubMed:15489334).1
Sequence conflicti299L → M in AAH43151 (PubMed:15489334).1
Sequence conflicti397T → A in AAH36110 (PubMed:15489334).1
Sequence conflicti397T → A in AAH43151 (PubMed:15489334).1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061958628A → G. Corresponds to variant dbSNP:rs2006764Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX537887 mRNA Translation: CAD97883.1
AC253576 Genomic DNA No translation available.
BC036110 mRNA Translation: AAH36110.1
BC043151 mRNA Translation: AAH43151.1
CCDSiCCDS75075.1
RefSeqiNP_001272981.1, NM_001286052.1
NP_001272982.1, NM_001286053.1
NP_001272983.1, NM_001286054.1
NP_872330.1, NM_182524.3
UniGeneiHs.709469

Genome annotation databases

EnsembliENST00000610261; ENSP00000477392; ENSG00000272602
GeneIDi152687
KEGGihsa:152687
UCSCiuc032szy.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN595_HUMAN
AccessioniPrimary (citable) accession number: Q8IYB9
Secondary accession number(s): Q7Z3I0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 28, 2018
Last modified: June 20, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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