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Protein

Zinc finger protein 595

Gene

ZNF595

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri145 – 16723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri173 – 19422C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri200 – 22223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri228 – 25023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri256 – 27823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri284 – 30623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri312 – 33423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri340 – 36223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri368 – 39023C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri396 – 41823C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri424 – 44623C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri452 – 47423C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri480 – 50223C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri508 – 53023C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri536 – 55823C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri564 – 58623C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri592 – 61423C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri620 – 64223C2H2-type 18PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 595
Gene namesi
Name:ZNF595
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:27196. ZNF595.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 648648Zinc finger protein 595PRO_0000047686Add
BLAST

Proteomic databases

EPDiQ8IYB9.
MaxQBiQ8IYB9.
PeptideAtlasiQ8IYB9.
PRIDEiQ8IYB9.

PTM databases

iPTMnetiQ8IYB9.
PhosphoSiteiQ8IYB9.

Expressioni

Gene expression databases

CleanExiHS_ZNF595.

Structurei

3D structure databases

ProteinModelPortaliQ8IYB9.
SMRiQ8IYB9. Positions 4-45, 130-642.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 7572KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 18 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri145 – 16723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri173 – 19422C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri200 – 22223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri228 – 25023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri256 – 27823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri284 – 30623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri312 – 33423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri340 – 36223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri368 – 39023C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri396 – 41823C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri424 – 44623C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri452 – 47423C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri480 – 50223C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri508 – 53023C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri536 – 55823C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri564 – 58623C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri592 – 61423C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri620 – 64223C2H2-type 18PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOVERGENiHBG018163.
InParanoidiQ8IYB9.
PhylomeDBiQ8IYB9.

Family and domain databases

Gene3Di3.30.160.60. 18 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 7 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 18 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 17 hits.
PS50157. ZINC_FINGER_C2H2_2. 18 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IYB9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELVTFRDVA IEFSPEEWKC LDPAQQNLYR DVMLENYRNL VSLGFVISNP
60 70 80 90 100
DLVTCLEQIK EPCNLKIHET AAKPPAICSP FSQDLSPVQG IEDSFHKLIL
110 120 130 140 150
KRYEKCGHEN LQLRKGCKRV NECKVQKGVN NGVYQCLSTT QSKIFQCNTC
160 170 180 190 200
VKVFSKFSNS NKHKIRHTGE KPFKCTECGR SFYMSHLTQH TGIHAGEKPY
210 220 230 240 250
KCEKCGKAFN RSTSLSKHKR IHTGEKPYTC EECGKAFRRS TVLNEHKKIH
260 270 280 290 300
TGEKPYKCEE CGKAFTRSTT LNEHKKIHTG EKPYKCKECG KAFRWSTSMN
310 320 330 340 350
EHKNIHTGEK PYKCKECGKA FRQSRSLNEH KNIHTGEKPY TCEKCGKAFN
360 370 380 390 400
QSSSLIIHRS IHSEQKLYKC EECGKAFTWS SSLNKHKRIH TGEKPYACEE
410 420 430 440 450
CGKAFYRSSH LAKHKRIHTG EKPYTCEECG KAFNQSSTLI LHKRIHSGQK
460 470 480 490 500
PYKCEECGKA FTRSTTLNEH KKIHTGEKPY KCEECGKAFI WSASLNEHKN
510 520 530 540 550
IHTGEKPYKC KECGKAFNQS SGLIIHRSIH SEQKLYKCEE CGKAFTRSTA
560 570 580 590 600
LNEHKKIHSG EKPYKCKECG KAYNLSSTLT KHKRIHTGEK PFTCEECGKA
610 620 630 640
FNWSSSLTKH KIIHTGEKSY KCEECGKAFN RPSTLTVHKR IHTGKEHS
Length:648
Mass (Da):74,290
Last modified:March 1, 2003 - v1
Checksum:i2E7A3F834A698407
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti628 – 6281A → G.
Corresponds to variant rs2006764 [ dbSNP | Ensembl ].
VAR_061958

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC036110 mRNA. Translation: AAH36110.1.
BC043151 mRNA. Translation: AAH43151.1.
CCDSiCCDS75075.1.
UniGeneiHs.709469.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC036110 mRNA. Translation: AAH36110.1.
BC043151 mRNA. Translation: AAH43151.1.
CCDSiCCDS75075.1.
UniGeneiHs.709469.

3D structure databases

ProteinModelPortaliQ8IYB9.
SMRiQ8IYB9. Positions 4-45, 130-642.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ8IYB9.
PhosphoSiteiQ8IYB9.

Proteomic databases

EPDiQ8IYB9.
MaxQBiQ8IYB9.
PeptideAtlasiQ8IYB9.
PRIDEiQ8IYB9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiZNF595.
HGNCiHGNC:27196. ZNF595.
neXtProtiNX_Q8IYB9.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG018163.
InParanoidiQ8IYB9.
PhylomeDBiQ8IYB9.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

PROiQ8IYB9.

Gene expression databases

CleanExiHS_ZNF595.

Family and domain databases

Gene3Di3.30.160.60. 18 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 7 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 18 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 17 hits.
PS50157. ZINC_FINGER_C2H2_2. 18 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiZN595_HUMAN
AccessioniPrimary (citable) accession number: Q8IYB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2003
Last modified: July 6, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.