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Protein

Stromal membrane-associated protein 1

Gene

SMAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GTPase activating protein that acts on ARF6. Plays a role in clathrin-dependent endocytosis. May play a role in erythropoiesis (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri33 – 5624C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Stromal membrane-associated protein 1
Gene namesi
Name:SMAP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:19651. SMAP1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134893764.

Polymorphism and mutation databases

BioMutaiSMAP1.
DMDMi97190718.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 467467Stromal membrane-associated protein 1PRO_0000235838Add
BLAST

Proteomic databases

EPDiQ8IYB5.
MaxQBiQ8IYB5.
PaxDbiQ8IYB5.
PeptideAtlasiQ8IYB5.
PRIDEiQ8IYB5.

PTM databases

iPTMnetiQ8IYB5.
PhosphoSiteiQ8IYB5.

Expressioni

Tissue specificityi

Detected in bone marrow, adrenal gland, trachea, lymph node, spinal cord, peripheral blood leukocytes, thyroid and stomach.1 Publication

Gene expression databases

BgeeiENSG00000112305.
CleanExiHS_SMAP1.
ExpressionAtlasiQ8IYB5. baseline and differential.
GenevisibleiQ8IYB5. HS.

Organism-specific databases

HPAiHPA030574.

Interactioni

Subunit structurei

Interacts with ARF6. Interacts with clathrin heavy chains via the clathrin box-like motif (By similarity).By similarity

Protein-protein interaction databases

BioGridi121956. 9 interactions.
IntActiQ8IYB5. 3 interactions.
STRINGi9606.ENSP00000359484.

Structurei

Secondary structure

1
467
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni10 – 156Combined sources
Helixi17 – 2610Combined sources
Helixi28 – 303Combined sources
Beta strandi34 – 363Combined sources
Beta strandi43 – 453Combined sources
Turni46 – 494Combined sources
Helixi54 – 6310Combined sources
Turni65 – 673Combined sources
Beta strandi73 – 764Combined sources
Helixi80 – 889Combined sources
Helixi90 – 978Combined sources
Helixi98 – 1003Combined sources
Helixi112 – 12312Combined sources
Helixi132 – 1343Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CRRNMR-A9-136[»]
ProteinModelPortaliQ8IYB5.
SMRiQ8IYB5. Positions 9-141.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8IYB5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 136119Arf-GAPPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi218 – 2225Interaction with clathrin heavy chainsBy similarity

Sequence similaritiesi

Contains 1 Arf-GAP domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri33 – 5624C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG0703. Eukaryota.
COG5347. LUCA.
GeneTreeiENSGT00820000127006.
HOVERGENiHBG055260.
InParanoidiQ8IYB5.
KOiK12486.
OMAiGMPNGFT.
OrthoDBiEOG091G0E7F.
PhylomeDBiQ8IYB5.
TreeFamiTF313876.

Family and domain databases

InterProiIPR001164. ArfGAP.
[Graphical view]
PfamiPF01412. ArfGap. 1 hit.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00105. ArfGap. 1 hit.
[Graphical view]
PROSITEiPS50115. ARFGAP. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IYB5-1) [UniParc]FASTAAdd to basket
Also known as: SMAP1A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATRSCREKA QKLNEQHQLI LSKLLREEDN KYCADCEAKG PRWASWNIGV
60 70 80 90 100
FICIRCAGIH RNLGVHISRV KSVNLDQWTA EQIQCMQDMG NTKARLLYEA
110 120 130 140 150
NLPENFRRPQ TDQAVEFFIR DKYEKKKYYD KNAIAITNIS SSDAPLQPLV
160 170 180 190 200
SSPSLQAAVD KNKLEKEKEK KKEEKKREKE PEKPAKPLTA EKLQKKDQQL
210 220 230 240 250
EPKKSTSPKK AAEPTVDLLG LDGPAVAPVT NGNTTVPPLN DDLDIFGPMI
260 270 280 290 300
SNPLPATVMP PAQGTPSAPA AATLSTVTSG DLDLFTEQTT KSEEVAKKQL
310 320 330 340 350
SKDSILSLYG TGTIQQQSTP GVFMGPTNIP FTSQAPAAFQ GFPSMGVPVP
360 370 380 390 400
AAPGLIGNVM GQSPSMMVGM PMPNGFMGNA QTGVMPLPQN VVGPQGGMVG
410 420 430 440 450
QMGAPQSKFG LPQAQQPQWS LSQMNQQMAG MSISSATPTA GFGQPSSTTA
460
GWSGSSSGQT LSTQLWK
Length:467
Mass (Da):50,386
Last modified:May 16, 2006 - v2
Checksum:i75935CB6F9F99DA9
GO
Isoform 2 (identifier: Q8IYB5-2) [UniParc]FASTAAdd to basket
Also known as: SMAP1B

The sequence of this isoform differs from the canonical sequence as follows:
     139-165: Missing.

Show »
Length:440
Mass (Da):47,609
Checksum:iB7D7AE5387DB9E25
GO
Isoform 3 (identifier: Q8IYB5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     139-165: Missing.
     424-467: MNQQMAGMSI...GQTLSTQLWK → IMQKGDAVLQ...ESADGWHEYQ

Show »
Length:436
Mass (Da):47,862
Checksum:iB4C4E780E6BEDCED
GO

Sequence cautioni

The sequence AAH08672 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti394 – 3941P → H in AAH36123 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti212 – 2121A → V.1 Publication
Corresponds to variant rs2273566 [ dbSNP | Ensembl ].
VAR_048326

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei139 – 16527Missing in isoform 2 and isoform 3. 4 PublicationsVSP_018502Add
BLAST
Alternative sequencei424 – 46744MNQQM…TQLWK → IMQKGDAVLQHSISAIYWPM TRWLKCPLVDESADGWHEYQ in isoform 3. 1 PublicationVSP_018503Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY055003 mRNA. Translation: AAL14714.1.
AY055004 mRNA. Translation: AAL14715.1.
AY055015
, AY055005, AY055006, AY055007, AY055008, AY055009, AY055010, AY055011, AY055012, AY055013, AY055014 Genomic DNA. Translation: AAL14716.1.
AY055015
, AY055005, AY055006, AY055007, AY055008, AY055010, AY055011, AY055012, AY055013, AY055014 Genomic DNA. Translation: AAL14717.1.
AK023221 mRNA. Translation: BAB14473.1.
AF442495 mRNA. Translation: AAP97320.1.
AK222711 mRNA. Translation: BAD96431.1.
AL354943, AL591049, AL121961 Genomic DNA. Translation: CAI12310.1.
AL354943, AL121961, AL591049 Genomic DNA. Translation: CAI12311.1.
AL354943, AL121961, AL591049 Genomic DNA. Translation: CAI12312.1.
AL591049, AL121961, AL354943 Genomic DNA. Translation: CAI14240.1.
AL591049, AL121961, AL354943 Genomic DNA. Translation: CAI14241.1.
AL591049, AL121961, AL354943 Genomic DNA. Translation: CAI14242.1.
AL121961, AL591049, AL354943 Genomic DNA. Translation: CAI42146.1.
AL121961, AL354943, AL591049 Genomic DNA. Translation: CAI42147.1.
AL121961, AL354943, AL591049 Genomic DNA. Translation: CAI42148.1.
BC008672 mRNA. Translation: AAH08672.1. Sequence problems.
BC028074 mRNA. Translation: AAH28074.1.
BC036123 mRNA. Translation: AAH36123.1.
AL833906 mRNA. Translation: CAD38762.1.
CCDSiCCDS43478.1. [Q8IYB5-1]
CCDS4973.1. [Q8IYB5-2]
CCDS64459.1. [Q8IYB5-3]
RefSeqiNP_001037770.1. NM_001044305.2. [Q8IYB5-1]
NP_001268368.1. NM_001281439.1. [Q8IYB5-3]
NP_001268369.1. NM_001281440.1.
NP_068759.2. NM_021940.4. [Q8IYB5-2]
UniGeneiHs.485717.

Genome annotation databases

EnsembliENST00000316999; ENSP00000313382; ENSG00000112305. [Q8IYB5-2]
ENST00000370452; ENSP00000359481; ENSG00000112305. [Q8IYB5-3]
ENST00000370455; ENSP00000359484; ENSG00000112305. [Q8IYB5-1]
GeneIDi60682.
KEGGihsa:60682.
UCSCiuc003pfr.5. human. [Q8IYB5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY055003 mRNA. Translation: AAL14714.1.
AY055004 mRNA. Translation: AAL14715.1.
AY055015
, AY055005, AY055006, AY055007, AY055008, AY055009, AY055010, AY055011, AY055012, AY055013, AY055014 Genomic DNA. Translation: AAL14716.1.
AY055015
, AY055005, AY055006, AY055007, AY055008, AY055010, AY055011, AY055012, AY055013, AY055014 Genomic DNA. Translation: AAL14717.1.
AK023221 mRNA. Translation: BAB14473.1.
AF442495 mRNA. Translation: AAP97320.1.
AK222711 mRNA. Translation: BAD96431.1.
AL354943, AL591049, AL121961 Genomic DNA. Translation: CAI12310.1.
AL354943, AL121961, AL591049 Genomic DNA. Translation: CAI12311.1.
AL354943, AL121961, AL591049 Genomic DNA. Translation: CAI12312.1.
AL591049, AL121961, AL354943 Genomic DNA. Translation: CAI14240.1.
AL591049, AL121961, AL354943 Genomic DNA. Translation: CAI14241.1.
AL591049, AL121961, AL354943 Genomic DNA. Translation: CAI14242.1.
AL121961, AL591049, AL354943 Genomic DNA. Translation: CAI42146.1.
AL121961, AL354943, AL591049 Genomic DNA. Translation: CAI42147.1.
AL121961, AL354943, AL591049 Genomic DNA. Translation: CAI42148.1.
BC008672 mRNA. Translation: AAH08672.1. Sequence problems.
BC028074 mRNA. Translation: AAH28074.1.
BC036123 mRNA. Translation: AAH36123.1.
AL833906 mRNA. Translation: CAD38762.1.
CCDSiCCDS43478.1. [Q8IYB5-1]
CCDS4973.1. [Q8IYB5-2]
CCDS64459.1. [Q8IYB5-3]
RefSeqiNP_001037770.1. NM_001044305.2. [Q8IYB5-1]
NP_001268368.1. NM_001281439.1. [Q8IYB5-3]
NP_001268369.1. NM_001281440.1.
NP_068759.2. NM_021940.4. [Q8IYB5-2]
UniGeneiHs.485717.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CRRNMR-A9-136[»]
ProteinModelPortaliQ8IYB5.
SMRiQ8IYB5. Positions 9-141.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121956. 9 interactions.
IntActiQ8IYB5. 3 interactions.
STRINGi9606.ENSP00000359484.

PTM databases

iPTMnetiQ8IYB5.
PhosphoSiteiQ8IYB5.

Polymorphism and mutation databases

BioMutaiSMAP1.
DMDMi97190718.

Proteomic databases

EPDiQ8IYB5.
MaxQBiQ8IYB5.
PaxDbiQ8IYB5.
PeptideAtlasiQ8IYB5.
PRIDEiQ8IYB5.

Protocols and materials databases

DNASUi60682.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316999; ENSP00000313382; ENSG00000112305. [Q8IYB5-2]
ENST00000370452; ENSP00000359481; ENSG00000112305. [Q8IYB5-3]
ENST00000370455; ENSP00000359484; ENSG00000112305. [Q8IYB5-1]
GeneIDi60682.
KEGGihsa:60682.
UCSCiuc003pfr.5. human. [Q8IYB5-1]

Organism-specific databases

CTDi60682.
GeneCardsiSMAP1.
HGNCiHGNC:19651. SMAP1.
HPAiHPA030574.
MIMi611372. gene.
neXtProtiNX_Q8IYB5.
PharmGKBiPA134893764.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0703. Eukaryota.
COG5347. LUCA.
GeneTreeiENSGT00820000127006.
HOVERGENiHBG055260.
InParanoidiQ8IYB5.
KOiK12486.
OMAiGMPNGFT.
OrthoDBiEOG091G0E7F.
PhylomeDBiQ8IYB5.
TreeFamiTF313876.

Miscellaneous databases

ChiTaRSiSMAP1. human.
EvolutionaryTraceiQ8IYB5.
GeneWikiiSMAP1.
GenomeRNAii60682.
PROiQ8IYB5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000112305.
CleanExiHS_SMAP1.
ExpressionAtlasiQ8IYB5. baseline and differential.
GenevisibleiQ8IYB5. HS.

Family and domain databases

InterProiIPR001164. ArfGAP.
[Graphical view]
PfamiPF01412. ArfGap. 1 hit.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00105. ArfGap. 1 hit.
[Graphical view]
PROSITEiPS50115. ARFGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSMAP1_HUMAN
AccessioniPrimary (citable) accession number: Q8IYB5
Secondary accession number(s): Q53H70
, Q5SYQ2, Q6PK24, Q8NDH4, Q96L38, Q96L39, Q9H8X4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: September 7, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.