Q8IYB4 (PEX5R_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
PEX5-related protein

Alternative name(s):
PEX2-related protein
PEX5-like protein
Peroxin-5-related protein
Peroxisome biogenesis factor 5-like
Tetratricopeptide repeat-containing Rab8b-interacting protein
Short name=Pex5Rp
Short name=TRIP8b

Gene names

Name:	PEX5L
Synonyms:	PEX5R, PXR2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	626 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence By similarity.
Subunit structure	Interacts with RAB8B. Forms an obligate 4:4 complex with HCN2 By similarity. May interact with the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type); the relevance of such interaction is however unclear. Ref.6
Subcellular location	Cytoplasm By similarity. Membrane; Peripheral membrane protein By similarity. Note: Some fraction is membrane associated via its interaction with RAB8B By similarity. Ref.6
Tissue specificity	Mainly expressed in brain. Also expressed in pancreas, testis and pituitary. Ref.6
Sequence similarities	Belongs to the peroxisomal targeting signal receptor family. Contains 6 TPR repeats.
Sequence caution	The sequence CAC01120.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat TPR repeat
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	maintenance of protein location Inferred from electronic annotation. Source: Compara protein import into peroxisome matrix, docking Inferred from Biological aspect of Ancestor. Source: RefGenome regulation of cAMP-mediated signaling Inferred from sequence or structural similarity. Source: UniProtKB regulation of membrane potential Inferred from electronic annotation. Source: Compara
Cellular_component	cytosol Inferred from Biological aspect of Ancestor. Source: RefGenome dendrite Inferred from electronic annotation. Source: Compara peroxisomal membrane Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	peroxisome matrix targeting signal-1 binding Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IYB4-1)

Also known as: PXR2b;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8IYB4-2)

Also known as: PXR2a;

The sequence of this isoform differs from the canonical sequence as follows:
     8-31: KSKEQGYGKLSSDEDLEIIVDQKQ → VVGVTLKKKWHCLQKSDLTLAL

Isoform 3 (identifier: Q8IYB4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     32-66: Missing.

Isoform 4 (identifier: Q8IYB4-4)

The sequence of this isoform differs from the canonical sequence as follows:
     7-65: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: Q8IYB4-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 626	626	PEX5-related protein		PRO_0000106317
Regions
	Repeat	326 – 359	34	TPR 1
	Repeat	360 – 393	34	TPR 2
	Repeat	395 – 427	33	TPR 3
	Repeat	474 – 507	34	TPR 4
	Repeat	509 – 541	33	TPR 5
	Repeat	543 – 575	33	TPR 6
Amino acid modifications
	Modified residue	261	1	Phosphoserine By similarity
	Modified residue	447	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1 – 43	43	Missing in isoform 5.		VSP_045136
	Alternative sequence	7 – 65	59	Missing in isoform 4.		VSP_044743
	Alternative sequence	8 – 31	24	KSKEQ…VDQKQ → VVGVTLKKKWHCLQKSDLTL AL in isoform 2.		VSP_010435
	Alternative sequence	32 – 66	35	Missing in isoform 3.		VSP_010436
	Natural variant	226	1	A → T in a colorectal cancer sample; somatic mutation. Ref.7		VAR_035865
Experimental info
	Sequence conflict	216	1	S → Y in AAH36183. Ref.5
	Sequence conflict	318	1	H → P in BAH11791. Ref.2
	Sequence conflict	474	1	P → T in AAH36183. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (PXR2b) [UniParc]. Last modified May 24, 2004. Version 2. Checksum: 07109ABE1B2314C1	FASTA	626	69,697
	10 20 30 40 50 60 MYQGHMQKSK EQGYGKLSSD EDLEIIVDQK QGKGSRAADK AVAMVMKEIP REESAEEKPL 70 80 90 100 110 120 LTMTSQLVNE QQESRPLLSP SIDDFLCETK SEAIARPVTS NTAVLTTGLD LLDLSEPVSQ 130 140 150 160 170 180 TQTKAKKSEP SSKTSSLKKK ADGSDLISTD AEQRGQPLRV PETSSLDLDI QTQLEKWDDV 190 200 210 220 230 240 KFHGDRNTKG HPMAERKSSS SRTGSKELLW SSEHRSQPEL SGGKSALNSE SASELELVAP 250 260 270 280 290 300 TQARLTKEHR WGSALLSRNH SLEEEFERAK AAVESDTEFW DKMQAEWEEM ARRNWISENQ 310 320 330 340 350 360 EAQNQVTISA SEKGYYFHTE NPFKDWPGAF EEGLKRLKEG DLPVTILFME AAILQDPGDA 370 380 390 400 410 420 EAWQFLGITQ AENENEQAAI VALQRCLELQ PNNLKALMAL AVSYTNTGHQ QDACDALKNW 430 440 450 460 470 480 IKQNPKYKYL VKSKKGSPGL TRRMSKSPVD SSVLEGVKEL YLEAAHQNGD MIDPDLQTGL 490 500 510 520 530 540 GVLFHLSGEF NRAIDAFNAA LTVRPEDYSL WNRLGATLAN GDRSEEAVEA YTRALEIQPG 550 560 570 580 590 600 FIRSRYNLGI SCINLGAYRE AVSNFLTALS LQRKSRNQQQ VPHPAISGNI WAALRIALSL 610 620 MDQPELFQAA NLGDLDVLLR AFNLDP
	Isoform 2 (PXR2a) [UniParc]. Checksum: 1DDBBDDC6F190235	FASTA	624	69,440
	10 20 30 40 50 60 MYQGHMQVVG VTLKKKWHCL QKSDLTLALG KGSRAADKAV AMVMKEIPRE ESAEEKPLLT 70 80 90 100 110 120 MTSQLVNEQQ ESRPLLSPSI DDFLCETKSE AIARPVTSNT AVLTTGLDLL DLSEPVSQTQ 130 140 150 160 170 180 TKAKKSEPSS KTSSLKKKAD GSDLISTDAE QRGQPLRVPE TSSLDLDIQT QLEKWDDVKF 190 200 210 220 230 240 HGDRNTKGHP MAERKSSSSR TGSKELLWSS EHRSQPELSG GKSALNSESA SELELVAPTQ 250 260 270 280 290 300 ARLTKEHRWG SALLSRNHSL EEEFERAKAA VESDTEFWDK MQAEWEEMAR RNWISENQEA 310 320 330 340 350 360 QNQVTISASE KGYYFHTENP FKDWPGAFEE GLKRLKEGDL PVTILFMEAA ILQDPGDAEA 370 380 390 400 410 420 WQFLGITQAE NENEQAAIVA LQRCLELQPN NLKALMALAV SYTNTGHQQD ACDALKNWIK 430 440 450 460 470 480 QNPKYKYLVK SKKGSPGLTR RMSKSPVDSS VLEGVKELYL EAAHQNGDMI DPDLQTGLGV 490 500 510 520 530 540 LFHLSGEFNR AIDAFNAALT VRPEDYSLWN RLGATLANGD RSEEAVEAYT RALEIQPGFI 550 560 570 580 590 600 RSRYNLGISC INLGAYREAV SNFLTALSLQ RKSRNQQQVP HPAISGNIWA ALRIALSLMD 610 620 QPELFQAANL GDLDVLLRAF NLDP
	Isoform 3 [UniParc]. Checksum: 62176C47BB9C5C21	FASTA	591	65,925
	10 20 30 40 50 60 MYQGHMQKSK EQGYGKLSSD EDLEIIVDQK QLVNEQQESR PLLSPSIDDF LCETKSEAIA 70 80 90 100 110 120 RPVTSNTAVL TTGLDLLDLS EPVSQTQTKA KKSEPSSKTS SLKKKADGSD LISTDAEQRG 130 140 150 160 170 180 QPLRVPETSS LDLDIQTQLE KWDDVKFHGD RNTKGHPMAE RKSSSSRTGS KELLWSSEHR 190 200 210 220 230 240 SQPELSGGKS ALNSESASEL ELVAPTQARL TKEHRWGSAL LSRNHSLEEE FERAKAAVES 250 260 270 280 290 300 DTEFWDKMQA EWEEMARRNW ISENQEAQNQ VTISASEKGY YFHTENPFKD WPGAFEEGLK 310 320 330 340 350 360 RLKEGDLPVT ILFMEAAILQ DPGDAEAWQF LGITQAENEN EQAAIVALQR CLELQPNNLK 370 380 390 400 410 420 ALMALAVSYT NTGHQQDACD ALKNWIKQNP KYKYLVKSKK GSPGLTRRMS KSPVDSSVLE 430 440 450 460 470 480 GVKELYLEAA HQNGDMIDPD LQTGLGVLFH LSGEFNRAID AFNAALTVRP EDYSLWNRLG 490 500 510 520 530 540 ATLANGDRSE EAVEAYTRAL EIQPGFIRSR YNLGISCINL GAYREAVSNF LTALSLQRKS 550 560 570 580 590 RNQQQVPHPA ISGNIWAALR IALSLMDQPE LFQAANLGDL DVLLRAFNLD P
	Isoform 4 [UniParc]. Checksum: DB22E2E2FE2BC3F9	FASTA	567	63,205
	10 20 30 40 50 60 MYQGHMQLVN EQQESRPLLS PSIDDFLCET KSEAIARPVT SNTAVLTTGL DLLDLSEPVS 70 80 90 100 110 120 QTQTKAKKSE PSSKTSSLKK KADGSDLIST DAEQRGQPLR VPETSSLDLD IQTQLEKWDD 130 140 150 160 170 180 VKFHGDRNTK GHPMAERKSS SSRTGSKELL WSSEHRSQPE LSGGKSALNS ESASELELVA 190 200 210 220 230 240 PTQARLTKEH RWGSALLSRN HSLEEEFERA KAAVESDTEF WDKMQAEWEE MARRNWISEN 250 260 270 280 290 300 QEAQNQVTIS ASEKGYYFHT ENPFKDWPGA FEEGLKRLKE GDLPVTILFM EAAILQDPGD 310 320 330 340 350 360 AEAWQFLGIT QAENENEQAA IVALQRCLEL QPNNLKALMA LAVSYTNTGH QQDACDALKN 370 380 390 400 410 420 WIKQNPKYKY LVKSKKGSPG LTRRMSKSPV DSSVLEGVKE LYLEAAHQNG DMIDPDLQTG 430 440 450 460 470 480 LGVLFHLSGE FNRAIDAFNA ALTVRPEDYS LWNRLGATLA NGDRSEEAVE AYTRALEIQP 490 500 510 520 530 540 GFIRSRYNLG ISCINLGAYR EAVSNFLTAL SLQRKSRNQQ QVPHPAISGN IWAALRIALS 550 560 LMDQPELFQA ANLGDLDVLL RAFNLDP
	Isoform 5 [UniParc]. Checksum: BA1CD881FACB3C60	FASTA	583	64,989
	10 20 30 40 50 60 MVMKEIPREE SAEEKPLLTM TSQLVNEQQE SRPLLSPSID DFLCETKSEA IARPVTSNTA 70 80 90 100 110 120 VLTTGLDLLD LSEPVSQTQT KAKKSEPSSK TSSLKKKADG SDLISTDAEQ RGQPLRVPET 130 140 150 160 170 180 SSLDLDIQTQ LEKWDDVKFH GDRNTKGHPM AERKSSSSRT GSKELLWSSE HRSQPELSGG 190 200 210 220 230 240 KSALNSESAS ELELVAPTQA RLTKEHRWGS ALLSRNHSLE EEFERAKAAV ESDTEFWDKM 250 260 270 280 290 300 QAEWEEMARR NWISENQEAQ NQVTISASEK GYYFHTENPF KDWPGAFEEG LKRLKEGDLP 310 320 330 340 350 360 VTILFMEAAI LQDPGDAEAW QFLGITQAEN ENEQAAIVAL QRCLELQPNN LKALMALAVS 370 380 390 400 410 420 YTNTGHQQDA CDALKNWIKQ NPKYKYLVKS KKGSPGLTRR MSKSPVDSSV LEGVKELYLE 430 440 450 460 470 480 AAHQNGDMID PDLQTGLGVL FHLSGEFNRA IDAFNAALTV RPEDYSLWNR LGATLANGDR 490 500 510 520 530 540 SEEAVEAYTR ALEIQPGFIR SRYNLGISCI NLGAYREAVS NFLTALSLQR KSRNQQQVPH 550 560 570 580 PAISGNIWAA LRIALSLMDQ PELFQAANLG DLDVLLRAFN LDP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel peroxisomal targeting signal 1 receptor-like gene, PXR2, preferentially expressed in brain." Sano H., Snider J., Ohta M. Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5). Tissue: Amygdala and Kidney.
[3]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Brain.
[6]	"Identification of PEX5p-related novel peroxisome-targeting signal 1 (PTS1)-binding proteins in mammals." Amery L., Sano H., Mannaerts G.P., Snider J., Van Looy J., Fransen M., Van Veldhoven P.P. Biochem. J. 357:635-646(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 264-626, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, POSSIBLE INTERACTION WITH PTS1 PROTEINS. Tissue: Liver.
[7]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-226.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB032592 mRNA. Translation: BAA92878.1. AB032593 mRNA. Translation: BAA92879.1. AK294501 mRNA. Translation: BAH11791.1. AK303716 mRNA. Translation: BAH14028.1. AC007687 Genomic DNA. No translation available. AC090024 Genomic DNA. No translation available. AC092939 Genomic DNA. No translation available. CH471052 Genomic DNA. Translation: EAW78382.1. BC036183 mRNA. Translation: AAH36183.2. AJ245503 mRNA. Translation: CAC01120.1. Different initiation.
IPI	IPI00009809. IPI00163742. IPI00477011. IPI00983212.
RefSeq	NP_001243679.1. NM_001256750.1. NP_001243680.1. NM_001256751.1. NP_001243681.1. NM_001256752.1. NP_001243682.1. NM_001256753.1. NP_001243683.1. NM_001256754.1. NP_001243684.1. NM_001256755.1. NP_001243685.1. NM_001256756.1. NP_057643.1. NM_016559.2.
UniGene	Hs.235331.
3D structure databases
ProteinModelPortal	Q8IYB4.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-58547N.
STRING	9606.ENSP00000419975.
PTM databases
PhosphoSite	Q8IYB4.
Polymorphism databases
DMDM	47606040.
Proteomic databases
PaxDb	Q8IYB4.
PRIDE	Q8IYB4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000263962; ENSP00000263962; ENSG00000114757. ENST00000467460; ENSP00000419975; ENSG00000114757. ENST00000472994; ENSP00000418054; ENSG00000114757. ENST00000476138; ENSP00000420555; ENSG00000114757. ENST00000485199; ENSP00000418440; ENSG00000114757.
GeneID	51555.
KEGG	hsa:51555.
UCSC	uc003fki.1. human. uc003fkj.1. human. uc010hxd.1. human.
Organism-specific databases
CTD	51555.
GeneCards	GC03M179512.
HGNC	HGNC:30024. PEX5L.
HPA	HPA040216.
MIM	611058. gene.
neXtProt	NX_Q8IYB4.
PharmGKB	PA134892044.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0457.
HOGENOM	HOG000158146.
HOVERGEN	HBG053575.
InParanoid	Q8IYB4.
OMA	NSKGHPM.
OrthoDB	EOG4ZW59S.
PhylomeDB	Q8IYB4.
Gene expression databases
ArrayExpress	Q8IYB4.
Bgee	Q8IYB4.
CleanEx	HS_PEX5L.
Genevestigator	Q8IYB4.
GermOnline	ENSG00000114757. Homo sapiens.
Family and domain databases
Gene3D	1.25.40.10. 2 hits.
InterPro	IPR024112. PEX5-rel. IPR024111. PTS1R_family. IPR001440. TPR-1. IPR013026. TPR-contain_dom. IPR011990. TPR-like_helical. IPR019734. TPR_repeat. [Graphical view]
PANTHER	PTHR10130. PTHR10130. 1 hit. PTHR10130:SF1. PTHR10130:SF1. 1 hit.
Pfam	PF00515. TPR_1. 2 hits. [Graphical view]
SMART	SM00028. TPR. 5 hits. [Graphical view]
PROSITE	PS50005. TPR. 5 hits. PS50293. TPR_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	51555.
NextBio	55344.
SOURCE	Search...

Entry information

Entry name

PEX5R_HUMAN

Accession

Primary (citable) accession number: Q8IYB4
Secondary accession number(s): B7Z2A5 , B7Z8P2, E7EUZ0, Q9NQD1, Q9P2U3, Q9P2U4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 24, 2004
Last sequence update:	May 24, 2004
Last modified:	May 1, 2013
This is version 97 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.