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Q8IYB4

- PEX5R_HUMAN

UniProt

Q8IYB4 - PEX5R_HUMAN

Protein

PEX5-related protein

Gene

PEX5L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (24 May 2004)
      Previous versions | rss
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    Functioni

    Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence.By similarity

    GO - Molecular functioni

    1. peroxisome matrix targeting signal-1 binding Source: RefGenome
    2. peroxisome targeting sequence binding Source: UniProtKB
    3. small GTPase binding Source: UniProtKB

    GO - Biological processi

    1. maintenance of protein location Source: Ensembl
    2. protein import into peroxisome matrix Source: RefGenome
    3. protein import into peroxisome matrix, docking Source: RefGenome
    4. regulation of cAMP-mediated signaling Source: UniProtKB
    5. regulation of membrane potential Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    PEX5-related protein
    Alternative name(s):
    PEX2-related protein
    PEX5-like protein
    Peroxin-5-related protein
    Peroxisome biogenesis factor 5-like
    Tetratricopeptide repeat-containing Rab8b-interacting protein
    Short name:
    Pex5Rp
    Short name:
    TRIP8b
    Gene namesi
    Name:PEX5L
    Synonyms:PEX5R, PXR2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:30024. PEX5L.

    Subcellular locationi

    Cytoplasm By similarity. Membrane By similarity; Peripheral membrane protein By similarity
    Note: Some fraction is membrane associated via its interaction with RAB8B.By similarity

    GO - Cellular componenti

    1. cytosol Source: RefGenome
    2. dendrite Source: Ensembl
    3. peroxisomal membrane Source: RefGenome
    4. receptor complex Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134892044.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 626626PEX5-related proteinPRO_0000106317Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei261 – 2611PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ8IYB4.
    PRIDEiQ8IYB4.

    PTM databases

    PhosphoSiteiQ8IYB4.

    Expressioni

    Tissue specificityi

    Mainly expressed in brain. Also expressed in pancreas, testis and pituitary.1 Publication

    Gene expression databases

    ArrayExpressiQ8IYB4.
    BgeeiQ8IYB4.
    CleanExiHS_PEX5L.
    GenevestigatoriQ8IYB4.

    Organism-specific databases

    HPAiHPA040216.

    Interactioni

    Subunit structurei

    Interacts with RAB8B. Forms an obligate 4:4 complex with HCN2 By similarity. May interact with the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type); the relevance of such interaction is however unclear.By similarity

    Protein-protein interaction databases

    BioGridi119607. 1 interaction.
    DIPiDIP-58547N.
    STRINGi9606.ENSP00000419975.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IYB4.
    SMRiQ8IYB4. Positions 314-625.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati326 – 35934TPR 1Add
    BLAST
    Repeati360 – 39334TPR 2Add
    BLAST
    Repeati395 – 42733TPR 3Add
    BLAST
    Repeati474 – 50734TPR 4Add
    BLAST
    Repeati509 – 54133TPR 5Add
    BLAST
    Repeati543 – 57533TPR 6Add
    BLAST

    Sequence similaritiesi

    Contains 6 TPR repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, TPR repeat

    Phylogenomic databases

    eggNOGiCOG0457.
    HOGENOMiHOG000158146.
    HOVERGENiHBG053575.
    InParanoidiQ8IYB4.
    OMAiQPLRGPE.
    OrthoDBiEOG793B77.
    PhylomeDBiQ8IYB4.
    TreeFamiTF315044.

    Family and domain databases

    Gene3Di1.25.40.10. 2 hits.
    InterProiIPR024112. PEX5-rel.
    IPR024111. PTS1R_family.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR019734. TPR_repeat.
    [Graphical view]
    PANTHERiPTHR10130. PTHR10130. 1 hit.
    PTHR10130:SF1. PTHR10130:SF1. 1 hit.
    PfamiPF00515. TPR_1. 2 hits.
    [Graphical view]
    SMARTiSM00028. TPR. 5 hits.
    [Graphical view]
    PROSITEiPS50005. TPR. 5 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view]

    Sequences (8)i

    Sequence statusi: Complete.

    This entry describes 8 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8IYB4-1) [UniParc]FASTAAdd to Basket

    Also known as: PXR2b

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MYQGHMQKSK EQGYGKLSSD EDLEIIVDQK QGKGSRAADK AVAMVMKEIP    50
    REESAEEKPL LTMTSQLVNE QQESRPLLSP SIDDFLCETK SEAIARPVTS 100
    NTAVLTTGLD LLDLSEPVSQ TQTKAKKSEP SSKTSSLKKK ADGSDLISTD 150
    AEQRGQPLRV PETSSLDLDI QTQLEKWDDV KFHGDRNTKG HPMAERKSSS 200
    SRTGSKELLW SSEHRSQPEL SGGKSALNSE SASELELVAP TQARLTKEHR 250
    WGSALLSRNH SLEEEFERAK AAVESDTEFW DKMQAEWEEM ARRNWISENQ 300
    EAQNQVTISA SEKGYYFHTE NPFKDWPGAF EEGLKRLKEG DLPVTILFME 350
    AAILQDPGDA EAWQFLGITQ AENENEQAAI VALQRCLELQ PNNLKALMAL 400
    AVSYTNTGHQ QDACDALKNW IKQNPKYKYL VKSKKGSPGL TRRMSKSPVD 450
    SSVLEGVKEL YLEAAHQNGD MIDPDLQTGL GVLFHLSGEF NRAIDAFNAA 500
    LTVRPEDYSL WNRLGATLAN GDRSEEAVEA YTRALEIQPG FIRSRYNLGI 550
    SCINLGAYRE AVSNFLTALS LQRKSRNQQQ VPHPAISGNI WAALRIALSL 600
    MDQPELFQAA NLGDLDVLLR AFNLDP 626
    Length:626
    Mass (Da):69,697
    Last modified:May 24, 2004 - v2
    Checksum:i07109ABE1B2314C1
    GO
    Isoform 2 (identifier: Q8IYB4-2) [UniParc]FASTAAdd to Basket

    Also known as: PXR2a

    The sequence of this isoform differs from the canonical sequence as follows:
         8-31: KSKEQGYGKLSSDEDLEIIVDQKQ → VVGVTLKKKWHCLQKSDLTLAL

    Show »
    Length:624
    Mass (Da):69,440
    Checksum:i1DDBBDDC6F190235
    GO
    Isoform 3 (identifier: Q8IYB4-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         32-66: Missing.

    Show »
    Length:591
    Mass (Da):65,925
    Checksum:i62176C47BB9C5C21
    GO
    Isoform 4 (identifier: Q8IYB4-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         7-65: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:567
    Mass (Da):63,205
    Checksum:iDB22E2E2FE2BC3F9
    GO
    Isoform 5 (identifier: Q8IYB4-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-43: Missing.

    Show »
    Length:583
    Mass (Da):64,989
    Checksum:iBA1CD881FACB3C60
    GO
    Isoform 6 (identifier: Q8IYB4-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         7-30: Missing.

    Show »
    Length:602
    Mass (Da):66,977
    Checksum:i167497DDAC5F36B4
    GO
    Isoform 7 (identifier: Q8IYB4-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-43: Missing.
         104-168: Missing.

    Show »
    Length:518
    Mass (Da):58,079
    Checksum:iD27BA80B03F9F914
    GO
    Isoform 8 (identifier: Q8IYB4-8) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-192: Missing.

    Show »
    Length:434
    Mass (Da):48,529
    Checksum:i510C8912004FB8F9
    GO

    Sequence cautioni

    The sequence CAC01120.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti88 – 881E → K in BAH12041. (PubMed:14702039)Curated
    Sequence conflicti216 – 2161S → Y in AAH36183. (PubMed:15489334)Curated
    Sequence conflicti292 – 2921R → Q in BAH13081. (PubMed:14702039)Curated
    Sequence conflicti318 – 3181H → P in BAH11791. (PubMed:14702039)Curated
    Sequence conflicti409 – 4091H → Y in BAH12054. (PubMed:14702039)Curated
    Sequence conflicti474 – 4741P → T in AAH36183. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti226 – 2261A → T in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035865

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 192192Missing in isoform 8. 1 PublicationVSP_046976Add
    BLAST
    Alternative sequencei1 – 4343Missing in isoform 5 and isoform 7. 1 PublicationVSP_045136Add
    BLAST
    Alternative sequencei7 – 6559Missing in isoform 4. 1 PublicationVSP_044743Add
    BLAST
    Alternative sequencei7 – 3024Missing in isoform 6. 1 PublicationVSP_046977Add
    BLAST
    Alternative sequencei8 – 3124KSKEQ…VDQKQ → VVGVTLKKKWHCLQKSDLTL AL in isoform 2. 1 PublicationVSP_010435Add
    BLAST
    Alternative sequencei32 – 6635Missing in isoform 3. 1 PublicationVSP_010436Add
    BLAST
    Alternative sequencei104 – 16865Missing in isoform 7. 1 PublicationVSP_046978Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB032592 mRNA. Translation: BAA92878.1.
    AB032593 mRNA. Translation: BAA92879.1.
    AK294501 mRNA. Translation: BAH11791.1.
    AK295349 mRNA. Translation: BAH12041.1.
    AK295386 mRNA. Translation: BAH12054.1.
    AK299633 mRNA. Translation: BAH13081.1.
    AK303716 mRNA. Translation: BAH14028.1.
    AC007687 Genomic DNA. No translation available.
    AC090024 Genomic DNA. No translation available.
    AC092939 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW78382.1.
    BC036183 mRNA. Translation: AAH36183.2.
    AJ245503 mRNA. Translation: CAC01120.1. Different initiation.
    CCDSiCCDS3236.1. [Q8IYB4-1]
    CCDS58861.1. [Q8IYB4-8]
    CCDS58862.1. [Q8IYB4-7]
    CCDS58863.1. [Q8IYB4-5]
    CCDS58864.1. [Q8IYB4-4]
    CCDS58865.1. [Q8IYB4-6]
    CCDS58866.1. [Q8IYB4-2]
    CCDS58867.1. [Q8IYB4-3]
    RefSeqiNP_001243679.1. NM_001256750.1. [Q8IYB4-2]
    NP_001243680.1. NM_001256751.1. [Q8IYB4-6]
    NP_001243681.1. NM_001256752.1. [Q8IYB4-3]
    NP_001243682.1. NM_001256753.1. [Q8IYB4-4]
    NP_001243683.1. NM_001256754.1. [Q8IYB4-5]
    NP_001243684.1. NM_001256755.1. [Q8IYB4-7]
    NP_001243685.1. NM_001256756.1. [Q8IYB4-8]
    NP_057643.1. NM_016559.2. [Q8IYB4-1]
    XP_006713719.1. XM_006713656.1. [Q8IYB4-5]
    UniGeneiHs.235331.

    Genome annotation databases

    EnsembliENST00000263962; ENSP00000263962; ENSG00000114757. [Q8IYB4-2]
    ENST00000392649; ENSP00000376420; ENSG00000114757. [Q8IYB4-7]
    ENST00000464614; ENSP00000417270; ENSG00000114757. [Q8IYB4-7]
    ENST00000465751; ENSP00000419348; ENSG00000114757. [Q8IYB4-6]
    ENST00000467460; ENSP00000419975; ENSG00000114757. [Q8IYB4-1]
    ENST00000468741; ENSP00000418665; ENSG00000114757. [Q8IYB4-8]
    ENST00000472994; ENSP00000418054; ENSG00000114757. [Q8IYB4-4]
    ENST00000476138; ENSP00000420555; ENSG00000114757. [Q8IYB4-5]
    ENST00000485199; ENSP00000418440; ENSG00000114757. [Q8IYB4-3]
    GeneIDi51555.
    KEGGihsa:51555.
    UCSCiuc003fki.2. human. [Q8IYB4-1]
    uc003fkj.2. human. [Q8IYB4-3]
    uc010hxd.2. human. [Q8IYB4-2]

    Polymorphism databases

    DMDMi47606040.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB032592 mRNA. Translation: BAA92878.1 .
    AB032593 mRNA. Translation: BAA92879.1 .
    AK294501 mRNA. Translation: BAH11791.1 .
    AK295349 mRNA. Translation: BAH12041.1 .
    AK295386 mRNA. Translation: BAH12054.1 .
    AK299633 mRNA. Translation: BAH13081.1 .
    AK303716 mRNA. Translation: BAH14028.1 .
    AC007687 Genomic DNA. No translation available.
    AC090024 Genomic DNA. No translation available.
    AC092939 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW78382.1 .
    BC036183 mRNA. Translation: AAH36183.2 .
    AJ245503 mRNA. Translation: CAC01120.1 . Different initiation.
    CCDSi CCDS3236.1. [Q8IYB4-1 ]
    CCDS58861.1. [Q8IYB4-8 ]
    CCDS58862.1. [Q8IYB4-7 ]
    CCDS58863.1. [Q8IYB4-5 ]
    CCDS58864.1. [Q8IYB4-4 ]
    CCDS58865.1. [Q8IYB4-6 ]
    CCDS58866.1. [Q8IYB4-2 ]
    CCDS58867.1. [Q8IYB4-3 ]
    RefSeqi NP_001243679.1. NM_001256750.1. [Q8IYB4-2 ]
    NP_001243680.1. NM_001256751.1. [Q8IYB4-6 ]
    NP_001243681.1. NM_001256752.1. [Q8IYB4-3 ]
    NP_001243682.1. NM_001256753.1. [Q8IYB4-4 ]
    NP_001243683.1. NM_001256754.1. [Q8IYB4-5 ]
    NP_001243684.1. NM_001256755.1. [Q8IYB4-7 ]
    NP_001243685.1. NM_001256756.1. [Q8IYB4-8 ]
    NP_057643.1. NM_016559.2. [Q8IYB4-1 ]
    XP_006713719.1. XM_006713656.1. [Q8IYB4-5 ]
    UniGenei Hs.235331.

    3D structure databases

    ProteinModelPortali Q8IYB4.
    SMRi Q8IYB4. Positions 314-625.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119607. 1 interaction.
    DIPi DIP-58547N.
    STRINGi 9606.ENSP00000419975.

    PTM databases

    PhosphoSitei Q8IYB4.

    Polymorphism databases

    DMDMi 47606040.

    Proteomic databases

    PaxDbi Q8IYB4.
    PRIDEi Q8IYB4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000263962 ; ENSP00000263962 ; ENSG00000114757 . [Q8IYB4-2 ]
    ENST00000392649 ; ENSP00000376420 ; ENSG00000114757 . [Q8IYB4-7 ]
    ENST00000464614 ; ENSP00000417270 ; ENSG00000114757 . [Q8IYB4-7 ]
    ENST00000465751 ; ENSP00000419348 ; ENSG00000114757 . [Q8IYB4-6 ]
    ENST00000467460 ; ENSP00000419975 ; ENSG00000114757 . [Q8IYB4-1 ]
    ENST00000468741 ; ENSP00000418665 ; ENSG00000114757 . [Q8IYB4-8 ]
    ENST00000472994 ; ENSP00000418054 ; ENSG00000114757 . [Q8IYB4-4 ]
    ENST00000476138 ; ENSP00000420555 ; ENSG00000114757 . [Q8IYB4-5 ]
    ENST00000485199 ; ENSP00000418440 ; ENSG00000114757 . [Q8IYB4-3 ]
    GeneIDi 51555.
    KEGGi hsa:51555.
    UCSCi uc003fki.2. human. [Q8IYB4-1 ]
    uc003fkj.2. human. [Q8IYB4-3 ]
    uc010hxd.2. human. [Q8IYB4-2 ]

    Organism-specific databases

    CTDi 51555.
    GeneCardsi GC03M179512.
    HGNCi HGNC:30024. PEX5L.
    HPAi HPA040216.
    MIMi 611058. gene.
    neXtProti NX_Q8IYB4.
    PharmGKBi PA134892044.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0457.
    HOGENOMi HOG000158146.
    HOVERGENi HBG053575.
    InParanoidi Q8IYB4.
    OMAi QPLRGPE.
    OrthoDBi EOG793B77.
    PhylomeDBi Q8IYB4.
    TreeFami TF315044.

    Miscellaneous databases

    GenomeRNAii 51555.
    NextBioi 55344.
    PROi Q8IYB4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8IYB4.
    Bgeei Q8IYB4.
    CleanExi HS_PEX5L.
    Genevestigatori Q8IYB4.

    Family and domain databases

    Gene3Di 1.25.40.10. 2 hits.
    InterProi IPR024112. PEX5-rel.
    IPR024111. PTS1R_family.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR019734. TPR_repeat.
    [Graphical view ]
    PANTHERi PTHR10130. PTHR10130. 1 hit.
    PTHR10130:SF1. PTHR10130:SF1. 1 hit.
    Pfami PF00515. TPR_1. 2 hits.
    [Graphical view ]
    SMARTi SM00028. TPR. 5 hits.
    [Graphical view ]
    PROSITEi PS50005. TPR. 5 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel peroxisomal targeting signal 1 receptor-like gene, PXR2, preferentially expressed in brain."
      Sano H., Snider J., Ohta M.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4; 5; 6; 7 AND 8).
      Tissue: Amygdala, Brain, Corpus callosum and Kidney.
    3. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Brain.
    6. "Identification of PEX5p-related novel peroxisome-targeting signal 1 (PTS1)-binding proteins in mammals."
      Amery L., Sano H., Mannaerts G.P., Snider J., Van Looy J., Fransen M., Van Veldhoven P.P.
      Biochem. J. 357:635-646(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 264-626, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, POSSIBLE INTERACTION WITH PTS1 PROTEINS.
      Tissue: Liver.
    7. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-226.

    Entry informationi

    Entry nameiPEX5R_HUMAN
    AccessioniPrimary (citable) accession number: Q8IYB4
    Secondary accession number(s): B7Z2A5
    , B7Z305, B7Z318, B7Z5Z5, B7Z8P2, E7EUV8, E7EUZ0, E9PEC1, E9PH97, Q9NQD1, Q9P2U3, Q9P2U4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: May 24, 2004
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3