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Protein

Protein MB21D2

Gene

MB21D2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • protein complex binding Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MB21D2
Alternative name(s):
Mab-21 domain-containing protein 2
Gene namesi
Name:MB21D2
Synonyms:C3orf59
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000180611.6.
HGNCiHGNC:30438. MB21D2.

Pathology & Biotechi

Organism-specific databases

DisGeNETi151963.
OpenTargetsiENSG00000180611.
PharmGKBiPA143485335.

Polymorphism and mutation databases

BioMutaiMB21D2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002393031 – 491Protein MB21D2Add BLAST491

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei435PhosphothreonineBy similarity1
Modified residuei436PhosphoserineBy similarity1
Modified residuei439PhosphoserineBy similarity1
Modified residuei442PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IYB1.
MaxQBiQ8IYB1.
PaxDbiQ8IYB1.
PeptideAtlasiQ8IYB1.
PRIDEiQ8IYB1.

PTM databases

iPTMnetiQ8IYB1.
PhosphoSitePlusiQ8IYB1.

Expressioni

Gene expression databases

BgeeiENSG00000180611.
CleanExiHS_C3orf59.
GenevisibleiQ8IYB1. HS.

Organism-specific databases

HPAiHPA044026.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SLC12A4Q9UP954EBI-11323212,EBI-7244836

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • protein complex binding Source: MGI

Protein-protein interaction databases

BioGridi127413. 28 interactors.
IntActiQ8IYB1. 19 interactors.
STRINGi9606.ENSP00000376246.

Structurei

3D structure databases

ProteinModelPortaliQ8IYB1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mab-21 family.Curated

Phylogenomic databases

eggNOGiKOG3963. Eukaryota.
ENOG410XNRJ. LUCA.
GeneTreeiENSGT00530000063769.
HOVERGENiHBG081021.
InParanoidiQ8IYB1.
OMAiEGTINKW.
OrthoDBiEOG091G06D0.
PhylomeDBiQ8IYB1.
TreeFamiTF329089.

Family and domain databases

InterProiView protein in InterPro
IPR024810. Mab-21_dom.
PfamiView protein in Pfam
PF03281. Mab-21. 1 hit.
SMARTiView protein in SMART
SM01265. Mab-21. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8IYB1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMAAPTANK AASLGCNNKP AFPELDFRSG ARVEELNKLI QEFTKHDQRE
60 70 80 90 100
YDDQRALEIH TAKDFIFSML GMVQKLDQKL PVANEYLLLS GGVREGVVDL
110 120 130 140 150
DLDELNVYAR GTDYDMDFTL LVPALKLHDR NQPVTLDMRH SALCHSWLSL
160 170 180 190 200
RLFDEGTISK WKDCCTIVDH INGATNYFFS PTKVADWFYD SISIVLSEIQ
210 220 230 240 250
KKPQRGMPKV EKVEKNGTII SIILGVGSSR MLYDIVPVVS FKGWPAVAQS
260 270 280 290 300
WLMENHFWDG KITEEEVISG FYLVPACSYK GKKDNEWRLS FARSEVQLKK
310 320 330 340 350
CISSSLMQAY QACKAIIIKL LSRPKAISPY HLRSMMLWAC DRLPANYLAQ
360 370 380 390 400
EDYAAHFLLG LIDDLQHCLV NKMCPNYFIP QCNMLEHLSE ETVMLHARKL
410 420 430 440 450
SSVRSDPAEH LRTAIEHVKA ANRLTLELQR RGSTTSIPSP QSDGGDPNQP
460 470 480 490
DDRLAKKLQQ LVTENPGKSI SVFINPDDVT RPHFRIDDKF F
Length:491
Mass (Da):55,800
Last modified:November 28, 2006 - v3
Checksum:i7AF79038FE3D4534
GO

Sequence cautioni

Q8IYB1: The sequence AAH13123 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
Q8IYB1: The sequence AAH45582 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC090025 Genomic DNA. No translation available.
AC117416 Genomic DNA. No translation available.
BC013123 mRNA. Translation: AAH13123.1. Different initiation.
BC036194 mRNA. Translation: AAH36194.3.
BC045582 mRNA. Translation: AAH45582.1. Different initiation.
CCDSiCCDS3302.2.
RefSeqiNP_848591.2. NM_178496.3.
UniGeneiHs.151443.

Genome annotation databases

EnsembliENST00000392452; ENSP00000376246; ENSG00000180611.
GeneIDi151963.
KEGGihsa:151963.
UCSCiuc011bsp.3. human.

Similar proteinsi

Entry informationi

Entry nameiM21D2_HUMAN
AccessioniPrimary (citable) accession number: Q8IYB1
Secondary accession number(s): Q86VD8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: November 28, 2006
Last modified: October 25, 2017
This is version 112 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families