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Protein

Protein MB21D2

Gene

MB21D2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • protein complex binding Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MB21D2
Alternative name(s):
Mab-21 domain-containing protein 2
Gene namesi
Name:MB21D2
Synonyms:C3orf59
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:30438. MB21D2.

Subcellular locationi

GO - Cellular componenti

  • cell-cell adherens junction Source: BHF-UCL
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi151963.
OpenTargetsiENSG00000180611.
PharmGKBiPA143485335.

Polymorphism and mutation databases

BioMutaiMB21D2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002393031 – 491Protein MB21D2Add BLAST491

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei435PhosphothreonineBy similarity1
Modified residuei436PhosphoserineBy similarity1
Modified residuei439PhosphoserineBy similarity1
Modified residuei442PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IYB1.
MaxQBiQ8IYB1.
PaxDbiQ8IYB1.
PeptideAtlasiQ8IYB1.
PRIDEiQ8IYB1.

PTM databases

iPTMnetiQ8IYB1.
PhosphoSitePlusiQ8IYB1.

Expressioni

Gene expression databases

BgeeiENSG00000180611.
CleanExiHS_C3orf59.
GenevisibleiQ8IYB1. HS.

Organism-specific databases

HPAiHPA044026.

Interactioni

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • protein complex binding Source: MGI

Protein-protein interaction databases

BioGridi127413. 14 interactors.
IntActiQ8IYB1. 17 interactors.
STRINGi9606.ENSP00000376246.

Structurei

3D structure databases

ProteinModelPortaliQ8IYB1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mab-21 family.Curated

Phylogenomic databases

eggNOGiKOG3963. Eukaryota.
ENOG410XNRJ. LUCA.
GeneTreeiENSGT00530000063769.
HOVERGENiHBG081021.
InParanoidiQ8IYB1.
OMAiSYLAQED.
OrthoDBiEOG091G06D0.
PhylomeDBiQ8IYB1.
TreeFamiTF329089.

Family and domain databases

InterProiIPR024810. Mab-21_dom.
[Graphical view]
PfamiPF03281. Mab-21. 1 hit.
[Graphical view]
SMARTiSM01265. Mab-21. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IYB1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMAAPTANK AASLGCNNKP AFPELDFRSG ARVEELNKLI QEFTKHDQRE
60 70 80 90 100
YDDQRALEIH TAKDFIFSML GMVQKLDQKL PVANEYLLLS GGVREGVVDL
110 120 130 140 150
DLDELNVYAR GTDYDMDFTL LVPALKLHDR NQPVTLDMRH SALCHSWLSL
160 170 180 190 200
RLFDEGTISK WKDCCTIVDH INGATNYFFS PTKVADWFYD SISIVLSEIQ
210 220 230 240 250
KKPQRGMPKV EKVEKNGTII SIILGVGSSR MLYDIVPVVS FKGWPAVAQS
260 270 280 290 300
WLMENHFWDG KITEEEVISG FYLVPACSYK GKKDNEWRLS FARSEVQLKK
310 320 330 340 350
CISSSLMQAY QACKAIIIKL LSRPKAISPY HLRSMMLWAC DRLPANYLAQ
360 370 380 390 400
EDYAAHFLLG LIDDLQHCLV NKMCPNYFIP QCNMLEHLSE ETVMLHARKL
410 420 430 440 450
SSVRSDPAEH LRTAIEHVKA ANRLTLELQR RGSTTSIPSP QSDGGDPNQP
460 470 480 490
DDRLAKKLQQ LVTENPGKSI SVFINPDDVT RPHFRIDDKF F
Length:491
Mass (Da):55,800
Last modified:November 28, 2006 - v3
Checksum:i7AF79038FE3D4534
GO

Sequence cautioni

The sequence AAH13123 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH45582 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC090025 Genomic DNA. No translation available.
AC117416 Genomic DNA. No translation available.
BC013123 mRNA. Translation: AAH13123.1. Different initiation.
BC036194 mRNA. Translation: AAH36194.3.
BC045582 mRNA. Translation: AAH45582.1. Different initiation.
CCDSiCCDS3302.2.
RefSeqiNP_848591.2. NM_178496.3.
UniGeneiHs.151443.

Genome annotation databases

EnsembliENST00000392452; ENSP00000376246; ENSG00000180611.
GeneIDi151963.
KEGGihsa:151963.
UCSCiuc011bsp.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC090025 Genomic DNA. No translation available.
AC117416 Genomic DNA. No translation available.
BC013123 mRNA. Translation: AAH13123.1. Different initiation.
BC036194 mRNA. Translation: AAH36194.3.
BC045582 mRNA. Translation: AAH45582.1. Different initiation.
CCDSiCCDS3302.2.
RefSeqiNP_848591.2. NM_178496.3.
UniGeneiHs.151443.

3D structure databases

ProteinModelPortaliQ8IYB1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127413. 14 interactors.
IntActiQ8IYB1. 17 interactors.
STRINGi9606.ENSP00000376246.

PTM databases

iPTMnetiQ8IYB1.
PhosphoSitePlusiQ8IYB1.

Polymorphism and mutation databases

BioMutaiMB21D2.

Proteomic databases

EPDiQ8IYB1.
MaxQBiQ8IYB1.
PaxDbiQ8IYB1.
PeptideAtlasiQ8IYB1.
PRIDEiQ8IYB1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000392452; ENSP00000376246; ENSG00000180611.
GeneIDi151963.
KEGGihsa:151963.
UCSCiuc011bsp.3. human.

Organism-specific databases

CTDi151963.
DisGeNETi151963.
GeneCardsiMB21D2.
HGNCiHGNC:30438. MB21D2.
HPAiHPA044026.
neXtProtiNX_Q8IYB1.
OpenTargetsiENSG00000180611.
PharmGKBiPA143485335.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3963. Eukaryota.
ENOG410XNRJ. LUCA.
GeneTreeiENSGT00530000063769.
HOVERGENiHBG081021.
InParanoidiQ8IYB1.
OMAiSYLAQED.
OrthoDBiEOG091G06D0.
PhylomeDBiQ8IYB1.
TreeFamiTF329089.

Miscellaneous databases

ChiTaRSiMB21D2. human.
GenomeRNAii151963.
PROiQ8IYB1.

Gene expression databases

BgeeiENSG00000180611.
CleanExiHS_C3orf59.
GenevisibleiQ8IYB1. HS.

Family and domain databases

InterProiIPR024810. Mab-21_dom.
[Graphical view]
PfamiPF03281. Mab-21. 1 hit.
[Graphical view]
SMARTiSM01265. Mab-21. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiM21D2_HUMAN
AccessioniPrimary (citable) accession number: Q8IYB1
Secondary accession number(s): Q86VD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: November 28, 2006
Last modified: November 30, 2016
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.