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Protein

Interactor of HORMAD1 protein 1

Gene

CCDC36

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.By similarity

GO - Biological processi

Keywordsi

Biological processDifferentiation, DNA recombination, Meiosis, Oogenesis, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Interactor of HORMAD1 protein 11 Publication
Alternative name(s):
Cancer/testis antigen 74
Short name:
CT74
Coiled-coil domain-containing protein 36Imported
Gene namesi
Name:CCDC36Imported
Synonyms:IHO11 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000173421.16.
HGNCiHGNC:27945. CCDC36.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000173421.
PharmGKBiPA142672191.

Polymorphism and mutation databases

BioMutaiCCDC36.
DMDMi313104087.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003028751 – 594Interactor of HORMAD1 protein 1Add BLAST594

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei588PhosphoserineBy similarity1
Modified residuei589PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IYA8.
PaxDbiQ8IYA8.
PeptideAtlasiQ8IYA8.
PRIDEiQ8IYA8.

PTM databases

iPTMnetiQ8IYA8.
PhosphoSitePlusiQ8IYA8.

Expressioni

Gene expression databases

BgeeiENSG00000173421.
CleanExiHS_CCDC36.
GenevisibleiQ8IYA8. HS.

Organism-specific databases

HPAiHPA045690.
HPA069534.

Interactioni

Subunit structurei

Interacts with HORMAD1 (PubMed:27723721). Interacts with REC114 (By similarity). Part of the MCD recombinosome complex, at least composed of IHO1/CCDC36, REC114 and MEI4 (By similarity).By similarity1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi130947. 35 interactors.
IntActiQ8IYA8. 86 interactors.
STRINGi9606.ENSP00000296449.

Structurei

3D structure databases

ProteinModelPortaliQ8IYA8.
SMRiQ8IYA8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili109 – 135Sequence analysisAdd BLAST27
Coiled coili165 – 189Sequence analysisAdd BLAST25
Coiled coili219 – 245Sequence analysisAdd BLAST27

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IH7Y. Eukaryota.
ENOG410YHF5. LUCA.
GeneTreeiENSGT00390000012418.
HOGENOMiHOG000111410.
HOVERGENiHBG107615.
InParanoidiQ8IYA8.
OMAiKDKCDSE.
OrthoDBiEOG091G09OZ.
PhylomeDBiQ8IYA8.
TreeFamiTF337135.

Family and domain databases

InterProiView protein in InterPro
IPR031529. IHO1.
PANTHERiPTHR35662:SF2. PTHR35662:SF2. 1 hit.
PfamiView protein in Pfam
PF15771. IHO1. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IYA8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNFNVWNIKE MLSIPSGSGN KKSSNWNNNQ NDYSSLSDSQ FLFGSQFCPE
60 70 80 90 100
NSETLSAPLD FGAHLRHSKQ SQQNYLEGEP SIFTKYQTKP QLFGGDIKDG
110 120 130 140 150
GLFPPPLSVG KSKGLLEQFE EKKKRAKDKC DSETLYNFVS NVRESILRLQ
160 170 180 190 200
TSVEKSEDHL SSRSQSILDS LETVAKTLQE TIQAQNDLVF EAVQDKGNME
210 220 230 240 250
QAILEMKKRF EARQGEFIEM KSNLKHLEVL VAQQSQEFQQ LCEQLGQLNV
260 270 280 290 300
PSVLAELKRL ISVPPVKDSA SQTSPPLAQS LNLTRQEKYT SEKPVLWQAQ
310 320 330 340 350
ALPAAWNPGM GSLQPGEFDV WGEGAKNDDL QEEAALPAFG SHERNRHVKD
360 370 380 390 400
KVVQTNCKNW AVTKTGAKNH GSSVPGHKIP SDRDLVSQGA SQLTSLEINF
410 420 430 440 450
STSIKNACQK YQAQSMFLCD PREHLVIKQK DGTVEMRGKD KKQQPRKAHR
460 470 480 490 500
AHRGRLIASK QKQIPIQTCK FNSKYQSPQP AISVPQSPFL GQQEPRAQPL
510 520 530 540 550
HLQCPRSPRK PVCPILGGTV MPNKTVRAVQ GRLLQLSRCS SQDNWLLSSS
560 570 580 590
SQGDHQMSWF SDLNLGCSET PLCKEAGKNL LYDLGFDSSD DDGF
Length:594
Mass (Da):66,343
Last modified:November 30, 2010 - v2
Checksum:i36E6C739E55DF4B1
GO
Isoform 2 (identifier: Q8IYA8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: MNFNVWNIKEMLSIPSGSG → MARVDAKAKEAPRASEGCQHAVTSQR
     91-117: Missing.

Note: No experimental confirmation available.
Show »
Length:574
Mass (Da):64,264
Checksum:i9127B48535B0C518
GO
Isoform 3 (identifier: Q8IYA8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     133-203: ETLYNFVSNV...QDKGNMEQAI → CRRLWKSLRT...HRVSDERMGI
     204-594: Missing.

Note: No experimental confirmation available.
Show »
Length:203
Mass (Da):23,196
Checksum:i39D09FB06217D536
GO

Sequence cautioni

The sequence AAH36202 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035002440D → E. Corresponds to variant dbSNP:rs13068038Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0279871 – 19MNFNV…PSGSG → MARVDAKAKEAPRASEGCQH AVTSQR in isoform 2. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_02798891 – 117Missing in isoform 2. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_027989133 – 203ETLYN…MEQAI → CRRLWKSLRTISVQEANLFW ILWRLWPRHVSASCLRYQQR ALVNDEHELSDPSLVSSGEV PHRVSDERMGI in isoform 3. 1 PublicationAdd BLAST71
Alternative sequenceiVSP_027990204 – 594Missing in isoform 3. 1 PublicationAdd BLAST391

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121247 Genomic DNA. No translation available.
AC135506 Genomic DNA. No translation available.
BC015057 mRNA. No translation available.
BC036202 mRNA. Translation: AAH36202.1. Different initiation.
AK058049 mRNA. Translation: BAB71640.1.
CCDSiCCDS33755.2. [Q8IYA8-1]
RefSeqiNP_001128669.1. NM_001135197.1. [Q8IYA8-1]
NP_835467.2. NM_178173.3. [Q8IYA8-1]
XP_006713187.1. XM_006713124.3. [Q8IYA8-1]
XP_011531974.1. XM_011533672.2. [Q8IYA8-1]
XP_011531975.1. XM_011533673.2. [Q8IYA8-1]
UniGeneiHs.631931.

Genome annotation databases

EnsembliENST00000296449; ENSP00000296449; ENSG00000173421. [Q8IYA8-1]
ENST00000366429; ENSP00000403700; ENSG00000173421. [Q8IYA8-3]
ENST00000438782; ENSP00000391788; ENSG00000173421. [Q8IYA8-1]
ENST00000452691; ENSP00000407837; ENSG00000173421. [Q8IYA8-1]
GeneIDi339834.
KEGGihsa:339834.
UCSCiuc003cwk.3. human. [Q8IYA8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiIHO1_HUMAN
AccessioniPrimary (citable) accession number: Q8IYA8
Secondary accession number(s): C9JJL0, Q05DG9, Q96LP7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 30, 2010
Last modified: September 27, 2017
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations