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Protein

Coiled-coil domain-containing protein 36

Gene

CCDC36

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • positive regulation of defense response to virus by host Source: ParkinsonsUK-UCL
  • xenophagy Source: ParkinsonsUK-UCL
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 36
Alternative name(s):
Cancer/testis antigen 74
Short name:
CT74
Gene namesi
Name:CCDC36
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:27945. CCDC36.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672191.

Polymorphism and mutation databases

BioMutaiCCDC36.
DMDMi313104087.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 594594Coiled-coil domain-containing protein 36PRO_0000302875Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei588 – 5881PhosphoserineBy similarity
Modified residuei589 – 5891PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8IYA8.
PRIDEiQ8IYA8.

PTM databases

iPTMnetiQ8IYA8.
PhosphoSiteiQ8IYA8.

Expressioni

Gene expression databases

BgeeiQ8IYA8.
CleanExiHS_CCDC36.
GenevisibleiQ8IYA8. HS.

Organism-specific databases

HPAiHPA045690.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Q9H6143EBI-8638439,EBI-10249899
ABI2Q9NYB94EBI-8638439,EBI-743598
AQP1P299723EBI-8638439,EBI-745213
C1orf109Q9NX043EBI-8638439,EBI-8643161
CARD9Q9H2573EBI-8638439,EBI-751319
CDC23Q9UJX23EBI-8638439,EBI-396137
COX5BP106064EBI-8638439,EBI-1053725
DYNLL1P631673EBI-8638439,EBI-349105
DYNLL2Q96FJ23EBI-8638439,EBI-742371
FAM124AQ86V423EBI-8638439,EBI-744506
FANCLQ9NW383EBI-8638439,EBI-2339898
FKBP6O753443EBI-8638439,EBI-744771
GYS1P138073EBI-8638439,EBI-740553
HEXIM2Q96MH23EBI-8638439,EBI-5460660
IQUBQ8NA543EBI-8638439,EBI-10220600
KANK2Q63ZY33EBI-8638439,EBI-2556193
KLC3Q6P5973EBI-8638439,EBI-1643885
LMO2P257913EBI-8638439,EBI-739696
LONRF1Q17RB83EBI-8638439,EBI-2341787
MRFAP1L1Q96HT83EBI-8638439,EBI-748896
NEK6Q9HC983EBI-8638439,EBI-740364
NGBQ9NPG23EBI-8638439,EBI-10311409
POLR1CO151603EBI-8638439,EBI-1055079
PRKAB2O437413EBI-8638439,EBI-1053424
RUNX1T1Q06455-43EBI-8638439,EBI-10224192
SDCBPO005603EBI-8638439,EBI-727004
STK25O005063EBI-8638439,EBI-618295
TRIM42A1L4B63EBI-8638439,EBI-10172216
TTC19Q6DKK23EBI-8638439,EBI-948354
USP2O756043EBI-8638439,EBI-743272
USP20Q9Y2K63EBI-8638439,EBI-2511991

Protein-protein interaction databases

BioGridi130947. 35 interactions.
IntActiQ8IYA8. 32 interactions.
STRINGi9606.ENSP00000296449.

Structurei

3D structure databases

ProteinModelPortaliQ8IYA8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili109 – 13527Sequence analysisAdd
BLAST
Coiled coili165 – 18925Sequence analysisAdd
BLAST
Coiled coili219 – 24527Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IH7Y. Eukaryota.
ENOG410YHF5. LUCA.
GeneTreeiENSGT00390000012418.
HOGENOMiHOG000111410.
HOVERGENiHBG107615.
InParanoidiQ8IYA8.
OMAiKDKCDSE.
OrthoDBiEOG78M01X.
PhylomeDBiQ8IYA8.
TreeFamiTF337135.

Family and domain databases

InterProiIPR031529. DUF4700.
[Graphical view]
PfamiPF15771. DUF4700. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IYA8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNFNVWNIKE MLSIPSGSGN KKSSNWNNNQ NDYSSLSDSQ FLFGSQFCPE
60 70 80 90 100
NSETLSAPLD FGAHLRHSKQ SQQNYLEGEP SIFTKYQTKP QLFGGDIKDG
110 120 130 140 150
GLFPPPLSVG KSKGLLEQFE EKKKRAKDKC DSETLYNFVS NVRESILRLQ
160 170 180 190 200
TSVEKSEDHL SSRSQSILDS LETVAKTLQE TIQAQNDLVF EAVQDKGNME
210 220 230 240 250
QAILEMKKRF EARQGEFIEM KSNLKHLEVL VAQQSQEFQQ LCEQLGQLNV
260 270 280 290 300
PSVLAELKRL ISVPPVKDSA SQTSPPLAQS LNLTRQEKYT SEKPVLWQAQ
310 320 330 340 350
ALPAAWNPGM GSLQPGEFDV WGEGAKNDDL QEEAALPAFG SHERNRHVKD
360 370 380 390 400
KVVQTNCKNW AVTKTGAKNH GSSVPGHKIP SDRDLVSQGA SQLTSLEINF
410 420 430 440 450
STSIKNACQK YQAQSMFLCD PREHLVIKQK DGTVEMRGKD KKQQPRKAHR
460 470 480 490 500
AHRGRLIASK QKQIPIQTCK FNSKYQSPQP AISVPQSPFL GQQEPRAQPL
510 520 530 540 550
HLQCPRSPRK PVCPILGGTV MPNKTVRAVQ GRLLQLSRCS SQDNWLLSSS
560 570 580 590
SQGDHQMSWF SDLNLGCSET PLCKEAGKNL LYDLGFDSSD DDGF
Length:594
Mass (Da):66,343
Last modified:November 30, 2010 - v2
Checksum:i36E6C739E55DF4B1
GO
Isoform 2 (identifier: Q8IYA8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: MNFNVWNIKEMLSIPSGSG → MARVDAKAKEAPRASEGCQHAVTSQR
     91-117: Missing.

Note: No experimental confirmation available.
Show »
Length:574
Mass (Da):64,264
Checksum:i9127B48535B0C518
GO
Isoform 3 (identifier: Q8IYA8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     133-203: ETLYNFVSNV...QDKGNMEQAI → CRRLWKSLRT...HRVSDERMGI
     204-594: Missing.

Note: No experimental confirmation available.
Show »
Length:203
Mass (Da):23,196
Checksum:i39D09FB06217D536
GO

Sequence cautioni

The sequence AAH36202.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti440 – 4401D → E.
Corresponds to variant rs13068038 [ dbSNP | Ensembl ].
VAR_035002

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1919MNFNV…PSGSG → MARVDAKAKEAPRASEGCQH AVTSQR in isoform 2. 1 PublicationVSP_027987Add
BLAST
Alternative sequencei91 – 11727Missing in isoform 2. 1 PublicationVSP_027988Add
BLAST
Alternative sequencei133 – 20371ETLYN…MEQAI → CRRLWKSLRTISVQEANLFW ILWRLWPRHVSASCLRYQQR ALVNDEHELSDPSLVSSGEV PHRVSDERMGI in isoform 3. 1 PublicationVSP_027989Add
BLAST
Alternative sequencei204 – 594391Missing in isoform 3. 1 PublicationVSP_027990Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121247 Genomic DNA. No translation available.
AC135506 Genomic DNA. No translation available.
BC015057 mRNA. No translation available.
BC036202 mRNA. Translation: AAH36202.1. Different initiation.
AK058049 mRNA. Translation: BAB71640.1.
CCDSiCCDS33755.2. [Q8IYA8-1]
RefSeqiNP_001128669.1. NM_001135197.1. [Q8IYA8-1]
NP_835467.2. NM_178173.3. [Q8IYA8-1]
XP_006713187.1. XM_006713124.2. [Q8IYA8-1]
XP_011531974.1. XM_011533672.1. [Q8IYA8-1]
XP_011531975.1. XM_011533673.1. [Q8IYA8-1]
UniGeneiHs.631931.

Genome annotation databases

EnsembliENST00000296449; ENSP00000296449; ENSG00000173421. [Q8IYA8-1]
ENST00000366429; ENSP00000403700; ENSG00000173421. [Q8IYA8-3]
ENST00000438782; ENSP00000391788; ENSG00000173421. [Q8IYA8-1]
ENST00000452691; ENSP00000407837; ENSG00000173421. [Q8IYA8-1]
GeneIDi339834.
KEGGihsa:339834.
UCSCiuc003cwk.3. human. [Q8IYA8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121247 Genomic DNA. No translation available.
AC135506 Genomic DNA. No translation available.
BC015057 mRNA. No translation available.
BC036202 mRNA. Translation: AAH36202.1. Different initiation.
AK058049 mRNA. Translation: BAB71640.1.
CCDSiCCDS33755.2. [Q8IYA8-1]
RefSeqiNP_001128669.1. NM_001135197.1. [Q8IYA8-1]
NP_835467.2. NM_178173.3. [Q8IYA8-1]
XP_006713187.1. XM_006713124.2. [Q8IYA8-1]
XP_011531974.1. XM_011533672.1. [Q8IYA8-1]
XP_011531975.1. XM_011533673.1. [Q8IYA8-1]
UniGeneiHs.631931.

3D structure databases

ProteinModelPortaliQ8IYA8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130947. 35 interactions.
IntActiQ8IYA8. 32 interactions.
STRINGi9606.ENSP00000296449.

PTM databases

iPTMnetiQ8IYA8.
PhosphoSiteiQ8IYA8.

Polymorphism and mutation databases

BioMutaiCCDC36.
DMDMi313104087.

Proteomic databases

PaxDbiQ8IYA8.
PRIDEiQ8IYA8.

Protocols and materials databases

DNASUi339834.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296449; ENSP00000296449; ENSG00000173421. [Q8IYA8-1]
ENST00000366429; ENSP00000403700; ENSG00000173421. [Q8IYA8-3]
ENST00000438782; ENSP00000391788; ENSG00000173421. [Q8IYA8-1]
ENST00000452691; ENSP00000407837; ENSG00000173421. [Q8IYA8-1]
GeneIDi339834.
KEGGihsa:339834.
UCSCiuc003cwk.3. human. [Q8IYA8-1]

Organism-specific databases

CTDi339834.
GeneCardsiCCDC36.
H-InvDBHIX0017873.
HGNCiHGNC:27945. CCDC36.
HPAiHPA045690.
neXtProtiNX_Q8IYA8.
PharmGKBiPA142672191.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH7Y. Eukaryota.
ENOG410YHF5. LUCA.
GeneTreeiENSGT00390000012418.
HOGENOMiHOG000111410.
HOVERGENiHBG107615.
InParanoidiQ8IYA8.
OMAiKDKCDSE.
OrthoDBiEOG78M01X.
PhylomeDBiQ8IYA8.
TreeFamiTF337135.

Miscellaneous databases

ChiTaRSiCCDC36. human.
GenomeRNAii339834.
PROiQ8IYA8.

Gene expression databases

BgeeiQ8IYA8.
CleanExiHS_CCDC36.
GenevisibleiQ8IYA8. HS.

Family and domain databases

InterProiIPR031529. DUF4700.
[Graphical view]
PfamiPF15771. DUF4700. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Testis.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-408 (ISOFORM 2).
    Tissue: Testis.

Entry informationi

Entry nameiCCD36_HUMAN
AccessioniPrimary (citable) accession number: Q8IYA8
Secondary accession number(s): C9JJL0, Q05DG9, Q96LP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 30, 2010
Last modified: June 8, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.