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Protein

Homeobox protein Mohawk

Gene

MKX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May act as a morphogenetic regulator of cell adhesion.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi71 – 132Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST62

GO - Molecular functioni

GO - Biological processi

  • muscle organ development Source: HGNC
  • regulation of transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Mohawk
Gene namesi
Name:MKX
Synonyms:C10orf48, IRXL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23729. MKX.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi283078.
OpenTargetsiENSG00000150051.
PharmGKBiPA134964449.

Polymorphism and mutation databases

BioMutaiMKX.
DMDMi296437371.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002688561 – 352Homeobox protein MohawkAdd BLAST352

Proteomic databases

PaxDbiQ8IYA7.
PeptideAtlasiQ8IYA7.
PRIDEiQ8IYA7.

PTM databases

iPTMnetiQ8IYA7.
PhosphoSitePlusiQ8IYA7.

Expressioni

Gene expression databases

BgeeiENSG00000150051.
CleanExiHS_MKX.
ExpressionAtlasiQ8IYA7. baseline and differential.
GenevisibleiQ8IYA7. HS.

Organism-specific databases

HPAiHPA006927.

Interactioni

Protein-protein interaction databases

BioGridi129453. 9 interactors.
IntActiQ8IYA7. 1 interactor.
STRINGi9606.ENSP00000364946.

Structurei

3D structure databases

ProteinModelPortaliQ8IYA7.
SMRiQ8IYA7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TALE/IRO homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0773. Eukaryota.
ENOG410XPMQ. LUCA.
GeneTreeiENSGT00750000117365.
HOGENOMiHOG000290195.
HOVERGENiHBG057105.
InParanoidiQ8IYA7.
OMAiCDSAANR.
OrthoDBiEOG091G09ZM.
PhylomeDBiQ8IYA7.
TreeFamiTF319371.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IYA7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTIVFNKLS GAVLFEDGGA SERERGGRPY SGVLDSPHAR PEVGIPDGPP
60 70 80 90 100
LKDNLGLRHR RTGARQNGGK VRHKRQALQD MARPLKQWLY KHRDNPYPTK
110 120 130 140 150
TEKILLALGS QMTLVQVSNW FANARRRLKN TVRQPDLSWA LRIKLYNKYV
160 170 180 190 200
QGNAERLSVS SDDSCSEDGE NPPRTHMNEG GYNTPVHHPV IKSENSVIKA
210 220 230 240 250
GVRPESRASE DYVAPPKYKS SLLNRYLNDS LRHVMATNTT MMGKTRQRNH
260 270 280 290 300
SGSFSSNEFE EELVSPSSSE TEGNFVYRTD TLENGSNKGE SAANRKGPSK
310 320 330 340 350
DDTYWKEINA AMALTNLAQG KDKLQGTTSC IIQKSSHIAE VKTVKVPLVQ

QF
Length:352
Mass (Da):39,331
Last modified:May 18, 2010 - v2
Checksum:i6450BDEF5BCCEDE9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11G → S in AAH36207 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03387540R → H.Corresponds to variant rs34439626dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125339 mRNA. Translation: BAG54187.1.
AC024606 Genomic DNA. No translation available.
CH471072 Genomic DNA. Translation: EAW86052.1.
CH471072 Genomic DNA. Translation: EAW86053.1.
BC036207 mRNA. Translation: AAH36207.1.
CCDSiCCDS7156.1.
RefSeqiNP_001229631.1. NM_001242702.1.
NP_775847.2. NM_173576.2.
XP_016871594.1. XM_017016105.1.
XP_016871595.1. XM_017016106.1.
UniGeneiHs.128193.

Genome annotation databases

EnsembliENST00000375790; ENSP00000364946; ENSG00000150051.
ENST00000419761; ENSP00000400896; ENSG00000150051.
GeneIDi283078.
KEGGihsa:283078.
UCSCiuc001itx.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125339 mRNA. Translation: BAG54187.1.
AC024606 Genomic DNA. No translation available.
CH471072 Genomic DNA. Translation: EAW86052.1.
CH471072 Genomic DNA. Translation: EAW86053.1.
BC036207 mRNA. Translation: AAH36207.1.
CCDSiCCDS7156.1.
RefSeqiNP_001229631.1. NM_001242702.1.
NP_775847.2. NM_173576.2.
XP_016871594.1. XM_017016105.1.
XP_016871595.1. XM_017016106.1.
UniGeneiHs.128193.

3D structure databases

ProteinModelPortaliQ8IYA7.
SMRiQ8IYA7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129453. 9 interactors.
IntActiQ8IYA7. 1 interactor.
STRINGi9606.ENSP00000364946.

PTM databases

iPTMnetiQ8IYA7.
PhosphoSitePlusiQ8IYA7.

Polymorphism and mutation databases

BioMutaiMKX.
DMDMi296437371.

Proteomic databases

PaxDbiQ8IYA7.
PeptideAtlasiQ8IYA7.
PRIDEiQ8IYA7.

Protocols and materials databases

DNASUi283078.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375790; ENSP00000364946; ENSG00000150051.
ENST00000419761; ENSP00000400896; ENSG00000150051.
GeneIDi283078.
KEGGihsa:283078.
UCSCiuc001itx.5. human.

Organism-specific databases

CTDi283078.
DisGeNETi283078.
GeneCardsiMKX.
HGNCiHGNC:23729. MKX.
HPAiHPA006927.
neXtProtiNX_Q8IYA7.
OpenTargetsiENSG00000150051.
PharmGKBiPA134964449.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0773. Eukaryota.
ENOG410XPMQ. LUCA.
GeneTreeiENSGT00750000117365.
HOGENOMiHOG000290195.
HOVERGENiHBG057105.
InParanoidiQ8IYA7.
OMAiCDSAANR.
OrthoDBiEOG091G09ZM.
PhylomeDBiQ8IYA7.
TreeFamiTF319371.

Miscellaneous databases

ChiTaRSiMKX. human.
GeneWikiiMKX.
GenomeRNAii283078.
PROiQ8IYA7.

Gene expression databases

BgeeiENSG00000150051.
CleanExiHS_MKX.
ExpressionAtlasiQ8IYA7. baseline and differential.
GenevisibleiQ8IYA7. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMKX_HUMAN
AccessioniPrimary (citable) accession number: Q8IYA7
Secondary accession number(s): B3KWM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.