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Q8IY95 (TM192_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane protein 192
Gene names
Name:TMEM192
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length271 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Homodimer Probable. Ref.8

Subcellular location

Lysosome membrane; Multi-pass membrane protein. Late endosome Ref.6 Ref.8.

Tissue specificity

Strongly expressed in kidney, liver, lung and pancreas. Ref.8

Post-translational modification

Not N-glycosylated.

Sequence similarities

Belongs to the TMEM192 family.

Sequence caution

The sequence CAD97974.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8IY95-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8IY95-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MAAGGRMED → MNKAT
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 271271Transmembrane protein 192
PRO_0000311267

Regions

Topological domain1 – 4646Cytoplasmic Potential
Transmembrane47 – 6721Helical; Potential
Topological domain68 – 9326Lumenal Potential
Transmembrane94 – 11421Helical; Potential
Topological domain115 – 13824Cytoplasmic Potential
Transmembrane139 – 15921Helical; Potential
Topological domain160 – 17112Lumenal Potential
Transmembrane172 – 19221Helical; Potential
Topological domain193 – 27179Cytoplasmic Potential

Amino acid modifications

Modified residue151Phosphothreonine Ref.5
Modified residue171Phosphoserine Ref.5
Modified residue2131Phosphotyrosine Ref.7

Natural variations

Alternative sequence1 – 99MAAGGRMED → MNKAT in isoform 2.
VSP_029502

Experimental info

Sequence conflict941T → A in CAD97974. Ref.2
Sequence conflict1631E → K in CAD97974. Ref.2
Sequence conflict1901Y → C in BAC04628. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: F156D08011315D04

FASTA27130,922
        10         20         30         40         50         60 
MAAGGRMEDG SLDITQSIED DPLLDAQLLP HHSLQAHFRP RFHPLPTVII VNLLWFIHLV 

        70         80         90        100        110        120 
FVVLAFLTGV LCSYPNPNED KCPGNYTNPL KVQTVIILGK VILWILHLLL ECYIQYHHSK 

       130        140        150        160        170        180 
IRNRGYNLIY RSTRHLKRLA LMIQSSGNTV LLLILCMQHS FPEPGRLYLD LILAILALEL 

       190        200        210        220        230        240 
ICSLICLLIY TVKIRRFNKA KPEPDILEEE KIYAYPSNIT SETGFRTISS LEEIVEKQGD 

       250        260        270 
TIEYLKRHNA LLSKRLLALT SSDLGCQPSR T 

« Hide

Isoform 2 [UniParc].

Checksum: DD5C15EB968845A5
Show »

FASTA26730,549

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Endometrial tumor.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Skin.
[5]"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.
Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-15 AND SER-17, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic kidney.
[6]"Integral and associated lysosomal membrane proteins."
Schroeder B., Wrocklage C., Pan C., Jaeger R., Koesters B., Schaefer H., Elsaesser H.-P., Mann M., Hasilik A.
Traffic 8:1676-1686(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
Tissue: Placenta.
[7]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-213, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[8]"Molecular characterisation of 'transmembrane protein 192' (TMEM192), a novel protein of the lysosomal membrane."
Schroder B., Wrocklage C., Hasilik A., Saftig P.
Biol. Chem. 391:695-704(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, SUBUNIT, TISSUE SPECIFICITY.
[9]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK095801 mRNA. Translation: BAC04628.1.
BX538029 mRNA. Translation: CAD97974.1. Different initiation.
CH471056 Genomic DNA. Translation: EAX04826.1.
BC036301 mRNA. Translation: AAH36301.1.
RefSeqNP_001093859.1. NM_001100389.1.
UniGeneHs.704511.

3D structure databases

ProteinModelPortalQ8IY95.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid128407. 3 interactions.
IntActQ8IY95. 2 interactions.
STRING9606.ENSP00000305069.

Protein family/group databases

TCDB9.B.134.1.1. the lysosomal autophagy and apoptosis-related protein, tmem192 (tmem192) family.

PTM databases

PhosphoSiteQ8IY95.

Polymorphism databases

DMDM74728307.

Proteomic databases

PaxDbQ8IY95.
PeptideAtlasQ8IY95.
PRIDEQ8IY95.

Protocols and materials databases

DNASU201931.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000306480; ENSP00000305069; ENSG00000170088. [Q8IY95-1]
ENST00000506087; ENSP00000425335; ENSG00000170088. [Q8IY95-2]
GeneID201931.
KEGGhsa:201931.
UCSCuc003iqz.4. human. [Q8IY95-1]

Organism-specific databases

CTD201931.
GeneCardsGC04M165997.
H-InvDBHIX0004615.
HGNCHGNC:26775. TMEM192.
HPAHPA014717.
HPA024110.
neXtProtNX_Q8IY95.
PharmGKBPA162406273.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG87586.
HOGENOMHOG000082527.
HOVERGENHBG055288.
InParanoidQ8IY95.
OMAERYIQYH.
OrthoDBEOG7Q5HG9.
PhylomeDBQ8IY95.
TreeFamTF323773.

Gene expression databases

ArrayExpressQ8IY95.
BgeeQ8IY95.
CleanExHS_TMEM192.
GenevestigatorQ8IY95.

Family and domain databases

ProtoNetSearch...

Other

ChiTaRSTMEM192. human.
GenomeRNAi201931.
NextBio90214.
PROQ8IY95.

Entry information

Entry nameTM192_HUMAN
AccessionPrimary (citable) accession number: Q8IY95
Secondary accession number(s): Q7Z3A1, Q8N928
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM