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Protein

Transmembrane protein 192

Gene

TMEM192

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein homodimerization activity Source: UniProtKB
Complete GO annotation...

Protein family/group databases

TCDBi9.B.134.1.1. the lysosomal autophagy and apoptosis-related protein, tmem192 (tmem192) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 192
Gene namesi
Name:TMEM192
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:26775. TMEM192.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4646CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei47 – 6721HelicalSequence AnalysisAdd
BLAST
Topological domaini68 – 9326LumenalSequence AnalysisAdd
BLAST
Transmembranei94 – 11421HelicalSequence AnalysisAdd
BLAST
Topological domaini115 – 13824CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei139 – 15921HelicalSequence AnalysisAdd
BLAST
Topological domaini160 – 17112LumenalSequence AnalysisAdd
BLAST
Transmembranei172 – 19221HelicalSequence AnalysisAdd
BLAST
Topological domaini193 – 27179CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
  3. late endosome Source: UniProtKB
  4. lysosomal membrane Source: UniProtKB
  5. lysosome Source: UniProtKB
  6. perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162406273.

Polymorphism and mutation databases

BioMutaiTMEM192.
DMDMi74728307.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271Transmembrane protein 192PRO_0000311267Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei15 – 151Phosphothreonine1 Publication
Modified residuei17 – 171Phosphoserine1 Publication
Modified residuei213 – 2131Phosphotyrosine1 Publication
Modified residuei269 – 2691Phosphoserine1 Publication

Post-translational modificationi

Not N-glycosylated.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8IY95.
PaxDbiQ8IY95.
PeptideAtlasiQ8IY95.
PRIDEiQ8IY95.

PTM databases

PhosphoSiteiQ8IY95.

Expressioni

Tissue specificityi

Strongly expressed in kidney, liver, lung and pancreas.1 Publication

Gene expression databases

BgeeiQ8IY95.
CleanExiHS_TMEM192.
ExpressionAtlasiQ8IY95. baseline and differential.
GenevestigatoriQ8IY95.

Organism-specific databases

HPAiHPA014717.
HPA024110.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi128407. 13 interactions.
IntActiQ8IY95. 2 interactions.
STRINGi9606.ENSP00000305069.

Structurei

3D structure databases

ProteinModelPortaliQ8IY95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM192 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG87586.
GeneTreeiENSGT00390000013749.
HOGENOMiHOG000082527.
HOVERGENiHBG055288.
InParanoidiQ8IY95.
OMAiERYIQYH.
OrthoDBiEOG7Q5HG9.
PhylomeDBiQ8IY95.
TreeFamiTF323773.

Family and domain databases

InterProiIPR029399. TMEM192.
[Graphical view]
PfamiPF14802. TMEM192. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IY95-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAGGRMEDG SLDITQSIED DPLLDAQLLP HHSLQAHFRP RFHPLPTVII
60 70 80 90 100
VNLLWFIHLV FVVLAFLTGV LCSYPNPNED KCPGNYTNPL KVQTVIILGK
110 120 130 140 150
VILWILHLLL ECYIQYHHSK IRNRGYNLIY RSTRHLKRLA LMIQSSGNTV
160 170 180 190 200
LLLILCMQHS FPEPGRLYLD LILAILALEL ICSLICLLIY TVKIRRFNKA
210 220 230 240 250
KPEPDILEEE KIYAYPSNIT SETGFRTISS LEEIVEKQGD TIEYLKRHNA
260 270
LLSKRLLALT SSDLGCQPSR T
Length:271
Mass (Da):30,922
Last modified:March 1, 2003 - v1
Checksum:iF156D08011315D04
GO
Isoform 2 (identifier: Q8IY95-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MAAGGRMED → MNKAT

Note: No experimental confirmation available.

Show »
Length:267
Mass (Da):30,549
Checksum:iDD5C15EB968845A5
GO

Sequence cautioni

The sequence CAD97974.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti94 – 941T → A in CAD97974 (PubMed:17974005).Curated
Sequence conflicti163 – 1631E → K in CAD97974 (PubMed:17974005).Curated
Sequence conflicti190 – 1901Y → C in BAC04628 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 99MAAGGRMED → MNKAT in isoform 2. 1 PublicationVSP_029502

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095801 mRNA. Translation: BAC04628.1.
BX538029 mRNA. Translation: CAD97974.1. Different initiation.
CH471056 Genomic DNA. Translation: EAX04826.1.
BC036301 mRNA. Translation: AAH36301.1.
CCDSiCCDS43279.1. [Q8IY95-1]
RefSeqiNP_001093859.1. NM_001100389.1. [Q8IY95-1]
UniGeneiHs.704511.

Genome annotation databases

EnsembliENST00000306480; ENSP00000305069; ENSG00000170088. [Q8IY95-1]
ENST00000506087; ENSP00000425335; ENSG00000170088. [Q8IY95-2]
GeneIDi201931.
KEGGihsa:201931.
UCSCiuc003iqz.4. human. [Q8IY95-1]

Polymorphism and mutation databases

BioMutaiTMEM192.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095801 mRNA. Translation: BAC04628.1.
BX538029 mRNA. Translation: CAD97974.1. Different initiation.
CH471056 Genomic DNA. Translation: EAX04826.1.
BC036301 mRNA. Translation: AAH36301.1.
CCDSiCCDS43279.1. [Q8IY95-1]
RefSeqiNP_001093859.1. NM_001100389.1. [Q8IY95-1]
UniGeneiHs.704511.

3D structure databases

ProteinModelPortaliQ8IY95.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128407. 13 interactions.
IntActiQ8IY95. 2 interactions.
STRINGi9606.ENSP00000305069.

Protein family/group databases

TCDBi9.B.134.1.1. the lysosomal autophagy and apoptosis-related protein, tmem192 (tmem192) family.

PTM databases

PhosphoSiteiQ8IY95.

Polymorphism and mutation databases

BioMutaiTMEM192.
DMDMi74728307.

Proteomic databases

MaxQBiQ8IY95.
PaxDbiQ8IY95.
PeptideAtlasiQ8IY95.
PRIDEiQ8IY95.

Protocols and materials databases

DNASUi201931.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306480; ENSP00000305069; ENSG00000170088. [Q8IY95-1]
ENST00000506087; ENSP00000425335; ENSG00000170088. [Q8IY95-2]
GeneIDi201931.
KEGGihsa:201931.
UCSCiuc003iqz.4. human. [Q8IY95-1]

Organism-specific databases

CTDi201931.
GeneCardsiGC04M165997.
H-InvDBHIX0004615.
HGNCiHGNC:26775. TMEM192.
HPAiHPA014717.
HPA024110.
neXtProtiNX_Q8IY95.
PharmGKBiPA162406273.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG87586.
GeneTreeiENSGT00390000013749.
HOGENOMiHOG000082527.
HOVERGENiHBG055288.
InParanoidiQ8IY95.
OMAiERYIQYH.
OrthoDBiEOG7Q5HG9.
PhylomeDBiQ8IY95.
TreeFamiTF323773.

Miscellaneous databases

ChiTaRSiTMEM192. human.
GenomeRNAii201931.
NextBioi90214.
PROiQ8IY95.

Gene expression databases

BgeeiQ8IY95.
CleanExiHS_TMEM192.
ExpressionAtlasiQ8IY95. baseline and differential.
GenevestigatoriQ8IY95.

Family and domain databases

InterProiIPR029399. TMEM192.
[Graphical view]
PfamiPF14802. TMEM192. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Endometrial tumor.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skin.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-15 AND SER-17, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Placenta.
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-213, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. "Molecular characterisation of 'transmembrane protein 192' (TMEM192), a novel protein of the lysosomal membrane."
    Schroder B., Wrocklage C., Hasilik A., Saftig P.
    Biol. Chem. 391:695-704(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, SUBUNIT, TISSUE SPECIFICITY.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-269, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiTM192_HUMAN
AccessioniPrimary (citable) accession number: Q8IY95
Secondary accession number(s): Q7Z3A1, Q8N928
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 1, 2003
Last modified: April 29, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.