Q8IY95 (TM192_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transmembrane protein 192

Gene names

Name:

TMEM192

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Homodimer Probable. Ref.8
Subcellular location	Lysosome membrane; Multi-pass membrane protein. Late endosome Ref.6 Ref.8.
Tissue specificity	Strongly expressed in kidney, liver, lung and pancreas. Ref.8
Post-translational modification	Not N-glycosylated.
Sequence similarities	Belongs to the TMEM192 family.
Sequence caution	The sequence CAD97974.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Endosome Lysosome Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW late endosome Inferred from electronic annotation. Source: UniProtKB-SubCell lysosomal membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IY95-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8IY95-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MAAGGRMED → MNKAT

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 271	271	Transmembrane protein 192		PRO_0000311267
Regions
	Topological domain	1 – 46	46	Cytoplasmic Potential
	Transmembrane	47 – 67	21	Helical; Potential
	Topological domain	68 – 93	26	Lumenal Potential
	Transmembrane	94 – 114	21	Helical; Potential
	Topological domain	115 – 138	24	Cytoplasmic Potential
	Transmembrane	139 – 159	21	Helical; Potential
	Topological domain	160 – 171	12	Lumenal Potential
	Transmembrane	172 – 192	21	Helical; Potential
	Topological domain	193 – 271	79	Cytoplasmic Potential
Amino acid modifications
	Modified residue	15	1	Phosphothreonine Ref.5
	Modified residue	17	1	Phosphoserine Ref.5
	Modified residue	213	1	Phosphotyrosine Ref.7
Natural variations
	Alternative sequence	1 – 9	9	MAAGGRMED → MNKAT in isoform 2.		VSP_029502
Experimental info
	Sequence conflict	94	1	T → A in CAD97974. Ref.2
	Sequence conflict	163	1	E → K in CAD97974. Ref.2
	Sequence conflict	190	1	Y → C in BAC04628. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: F156D08011315D04	FASTA	271	30,922
	10 20 30 40 50 60 MAAGGRMEDG SLDITQSIED DPLLDAQLLP HHSLQAHFRP RFHPLPTVII VNLLWFIHLV 70 80 90 100 110 120 FVVLAFLTGV LCSYPNPNED KCPGNYTNPL KVQTVIILGK VILWILHLLL ECYIQYHHSK 130 140 150 160 170 180 IRNRGYNLIY RSTRHLKRLA LMIQSSGNTV LLLILCMQHS FPEPGRLYLD LILAILALEL 190 200 210 220 230 240 ICSLICLLIY TVKIRRFNKA KPEPDILEEE KIYAYPSNIT SETGFRTISS LEEIVEKQGD 250 260 270 TIEYLKRHNA LLSKRLLALT SSDLGCQPSR T
	Isoform 2 [UniParc]. Checksum: DD5C15EB968845A5	FASTA	267	30,549
	10 20 30 40 50 60 MNKATGSLDI TQSIEDDPLL DAQLLPHHSL QAHFRPRFHP LPTVIIVNLL WFIHLVFVVL 70 80 90 100 110 120 AFLTGVLCSY PNPNEDKCPG NYTNPLKVQT VIILGKVILW ILHLLLECYI QYHHSKIRNR 130 140 150 160 170 180 GYNLIYRSTR HLKRLALMIQ SSGNTVLLLI LCMQHSFPEP GRLYLDLILA ILALELICSL 190 200 210 220 230 240 ICLLIYTVKI RRFNKAKPEP DILEEEKIYA YPSNITSETG FRTISSLEEI VEKQGDTIEY 250 260 LKRHNALLSK RLLALTSSDL GCQPSRT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Endometrial tumor.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Skin.
[5]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-15 AND SER-17, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[6]	"Integral and associated lysosomal membrane proteins." Schroeder B., Wrocklage C., Pan C., Jaeger R., Koesters B., Schaefer H., Elsaesser H.-P., Mann M., Hasilik A. Traffic 8:1676-1686(2007) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. Tissue: Placenta.
[7]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-213, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[8]	"Molecular characterisation of 'transmembrane protein 192' (TMEM192), a novel protein of the lysosomal membrane." Schroder B., Wrocklage C., Hasilik A., Saftig P. Biol. Chem. 391:695-704(2010) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, SUBUNIT, TISSUE SPECIFICITY.
[9]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK095801 mRNA. Translation: BAC04628.1. BX538029 mRNA. Translation: CAD97974.1. Different initiation. CH471056 Genomic DNA. Translation: EAX04826.1. BC036301 mRNA. Translation: AAH36301.1.
IPI	IPI00855873. IPI00873121.
RefSeq	NP_001093859.1. NM_001100389.1.
UniGene	Hs.704511.
3D structure databases
ProteinModelPortal	Q8IY95.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8IY95. 2 interactions.
STRING	9606.ENSP00000305069.
PTM databases
PhosphoSite	Q8IY95.
Polymorphism databases
DMDM	74728307.
Proteomic databases
PaxDb	Q8IY95.
PeptideAtlas	Q8IY95.
PRIDE	Q8IY95.
Protocols and materials databases
DNASU	201931.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000306480; ENSP00000305069; ENSG00000170088. ENST00000506087; ENSP00000425335; ENSG00000170088.
GeneID	201931.
KEGG	hsa:201931.
UCSC	uc003iqz.4. human.
Organism-specific databases
CTD	201931.
GeneCards	GC04M165997.
H-InvDB	HIX0004615.
HGNC	HGNC:26775. TMEM192.
HPA	HPA014717. HPA024110.
neXtProt	NX_Q8IY95.
PharmGKB	PA162406273.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG87586.
HOGENOM	HOG000082527.
HOVERGEN	HBG055288.
InParanoid	Q8IY95.
OMA	ERYIQYH.
OrthoDB	EOG4Q84ZJ.
PhylomeDB	Q8IY95.
Gene expression databases
ArrayExpress	Q8IY95.
Bgee	Q8IY95.
CleanEx	HS_TMEM192.
Genevestigator	Q8IY95.
Family and domain databases
ProtoNet	Search...
Other
ChiTaRS	TMEM192. human.
GenomeRNAi	201931.
NextBio	90214.

Entry information

Entry name

TM192_HUMAN

Accession

Primary (citable) accession number: Q8IY95
Secondary accession number(s): Q7Z3A1, Q8N928

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	March 1, 2003
Last modified:	April 3, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.