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Q8IY95

- TM192_HUMAN

UniProt

Q8IY95 - TM192_HUMAN

Protein

Transmembrane protein 192

Gene

TMEM192

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein homodimerization activity Source: UniProt

    Protein family/group databases

    TCDBi9.B.134.1.1. the lysosomal autophagy and apoptosis-related protein, tmem192 (tmem192) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protein 192
    Gene namesi
    Name:TMEM192
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:26775. TMEM192.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of membrane Source: UniProtKB-KW
    3. late endosome Source: UniProt
    4. lysosomal membrane Source: UniProt
    5. lysosome Source: UniProt
    6. perinuclear region of cytoplasm Source: UniProt

    Keywords - Cellular componenti

    Endosome, Lysosome, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162406273.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 271271Transmembrane protein 192PRO_0000311267Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei15 – 151Phosphothreonine1 Publication
    Modified residuei17 – 171Phosphoserine1 Publication
    Modified residuei213 – 2131Phosphotyrosine1 Publication

    Post-translational modificationi

    Not N-glycosylated.

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8IY95.
    PaxDbiQ8IY95.
    PeptideAtlasiQ8IY95.
    PRIDEiQ8IY95.

    PTM databases

    PhosphoSiteiQ8IY95.

    Expressioni

    Tissue specificityi

    Strongly expressed in kidney, liver, lung and pancreas.1 Publication

    Gene expression databases

    ArrayExpressiQ8IY95.
    BgeeiQ8IY95.
    CleanExiHS_TMEM192.
    GenevestigatoriQ8IY95.

    Organism-specific databases

    HPAiHPA014717.
    HPA024110.

    Interactioni

    Subunit structurei

    Homodimer.1 Publication

    Protein-protein interaction databases

    BioGridi128407. 3 interactions.
    IntActiQ8IY95. 2 interactions.
    STRINGi9606.ENSP00000305069.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IY95.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4646CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini68 – 9326LumenalSequence AnalysisAdd
    BLAST
    Topological domaini115 – 13824CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini160 – 17112LumenalSequence AnalysisAdd
    BLAST
    Topological domaini193 – 27179CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei47 – 6721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei94 – 11421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei139 – 15921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei172 – 19221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TMEM192 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG87586.
    HOGENOMiHOG000082527.
    HOVERGENiHBG055288.
    InParanoidiQ8IY95.
    OMAiERYIQYH.
    OrthoDBiEOG7Q5HG9.
    PhylomeDBiQ8IY95.
    TreeFamiTF323773.

    Family and domain databases

    InterProiIPR029399. TMEM192.
    [Graphical view]
    PfamiPF14802. TMEM192. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8IY95-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAGGRMEDG SLDITQSIED DPLLDAQLLP HHSLQAHFRP RFHPLPTVII    50
    VNLLWFIHLV FVVLAFLTGV LCSYPNPNED KCPGNYTNPL KVQTVIILGK 100
    VILWILHLLL ECYIQYHHSK IRNRGYNLIY RSTRHLKRLA LMIQSSGNTV 150
    LLLILCMQHS FPEPGRLYLD LILAILALEL ICSLICLLIY TVKIRRFNKA 200
    KPEPDILEEE KIYAYPSNIT SETGFRTISS LEEIVEKQGD TIEYLKRHNA 250
    LLSKRLLALT SSDLGCQPSR T 271
    Length:271
    Mass (Da):30,922
    Last modified:March 1, 2003 - v1
    Checksum:iF156D08011315D04
    GO
    Isoform 2 (identifier: Q8IY95-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-9: MAAGGRMED → MNKAT

    Note: No experimental confirmation available.

    Show »
    Length:267
    Mass (Da):30,549
    Checksum:iDD5C15EB968845A5
    GO

    Sequence cautioni

    The sequence CAD97974.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti94 – 941T → A in CAD97974. (PubMed:17974005)Curated
    Sequence conflicti163 – 1631E → K in CAD97974. (PubMed:17974005)Curated
    Sequence conflicti190 – 1901Y → C in BAC04628. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 99MAAGGRMED → MNKAT in isoform 2. 1 PublicationVSP_029502

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK095801 mRNA. Translation: BAC04628.1.
    BX538029 mRNA. Translation: CAD97974.1. Different initiation.
    CH471056 Genomic DNA. Translation: EAX04826.1.
    BC036301 mRNA. Translation: AAH36301.1.
    CCDSiCCDS43279.1. [Q8IY95-1]
    RefSeqiNP_001093859.1. NM_001100389.1. [Q8IY95-1]
    UniGeneiHs.704511.

    Genome annotation databases

    EnsembliENST00000306480; ENSP00000305069; ENSG00000170088. [Q8IY95-1]
    ENST00000506087; ENSP00000425335; ENSG00000170088. [Q8IY95-2]
    GeneIDi201931.
    KEGGihsa:201931.
    UCSCiuc003iqz.4. human. [Q8IY95-1]

    Polymorphism databases

    DMDMi74728307.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK095801 mRNA. Translation: BAC04628.1 .
    BX538029 mRNA. Translation: CAD97974.1 . Different initiation.
    CH471056 Genomic DNA. Translation: EAX04826.1 .
    BC036301 mRNA. Translation: AAH36301.1 .
    CCDSi CCDS43279.1. [Q8IY95-1 ]
    RefSeqi NP_001093859.1. NM_001100389.1. [Q8IY95-1 ]
    UniGenei Hs.704511.

    3D structure databases

    ProteinModelPortali Q8IY95.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128407. 3 interactions.
    IntActi Q8IY95. 2 interactions.
    STRINGi 9606.ENSP00000305069.

    Protein family/group databases

    TCDBi 9.B.134.1.1. the lysosomal autophagy and apoptosis-related protein, tmem192 (tmem192) family.

    PTM databases

    PhosphoSitei Q8IY95.

    Polymorphism databases

    DMDMi 74728307.

    Proteomic databases

    MaxQBi Q8IY95.
    PaxDbi Q8IY95.
    PeptideAtlasi Q8IY95.
    PRIDEi Q8IY95.

    Protocols and materials databases

    DNASUi 201931.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000306480 ; ENSP00000305069 ; ENSG00000170088 . [Q8IY95-1 ]
    ENST00000506087 ; ENSP00000425335 ; ENSG00000170088 . [Q8IY95-2 ]
    GeneIDi 201931.
    KEGGi hsa:201931.
    UCSCi uc003iqz.4. human. [Q8IY95-1 ]

    Organism-specific databases

    CTDi 201931.
    GeneCardsi GC04M165997.
    H-InvDB HIX0004615.
    HGNCi HGNC:26775. TMEM192.
    HPAi HPA014717.
    HPA024110.
    neXtProti NX_Q8IY95.
    PharmGKBi PA162406273.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG87586.
    HOGENOMi HOG000082527.
    HOVERGENi HBG055288.
    InParanoidi Q8IY95.
    OMAi ERYIQYH.
    OrthoDBi EOG7Q5HG9.
    PhylomeDBi Q8IY95.
    TreeFami TF323773.

    Miscellaneous databases

    ChiTaRSi TMEM192. human.
    GenomeRNAii 201931.
    NextBioi 90214.
    PROi Q8IY95.

    Gene expression databases

    ArrayExpressi Q8IY95.
    Bgeei Q8IY95.
    CleanExi HS_TMEM192.
    Genevestigatori Q8IY95.

    Family and domain databases

    InterProi IPR029399. TMEM192.
    [Graphical view ]
    Pfami PF14802. TMEM192. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Endometrial tumor.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Skin.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-15 AND SER-17, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Tissue: Placenta.
    7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-213, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    8. "Molecular characterisation of 'transmembrane protein 192' (TMEM192), a novel protein of the lysosomal membrane."
      Schroder B., Wrocklage C., Hasilik A., Saftig P.
      Biol. Chem. 391:695-704(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, SUBUNIT, TISSUE SPECIFICITY.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTM192_HUMAN
    AccessioniPrimary (citable) accession number: Q8IY95
    Secondary accession number(s): Q7Z3A1, Q8N928
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3