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Protein

Transmembrane protein 192

Gene

TMEM192

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

Protein family/group databases

TCDBi9.B.134.1.1 the lysosomal autophagy and apoptosis-related protein, tmem192 (tmem192) family

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 192
Gene namesi
Name:TMEM192
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000170088.13
HGNCiHGNC:26775 TMEM192
neXtProtiNX_Q8IY95

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 46CytoplasmicSequence analysisAdd BLAST46
Transmembranei47 – 67HelicalSequence analysisAdd BLAST21
Topological domaini68 – 93LumenalSequence analysisAdd BLAST26
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
Topological domaini115 – 138CytoplasmicSequence analysisAdd BLAST24
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Topological domaini160 – 171LumenalSequence analysisAdd BLAST12
Transmembranei172 – 192HelicalSequence analysisAdd BLAST21
Topological domaini193 – 271CytoplasmicSequence analysisAdd BLAST79

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000170088
PharmGKBiPA162406273

Polymorphism and mutation databases

BioMutaiTMEM192
DMDMi74728307

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003112671 – 271Transmembrane protein 192Add BLAST271

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei15PhosphothreonineCombined sources1
Modified residuei17PhosphoserineCombined sources1
Modified residuei213PhosphotyrosineCombined sources1
Modified residuei229PhosphoserineCombined sources1
Modified residuei230PhosphoserineCombined sources1
Modified residuei269PhosphoserineCombined sources1

Post-translational modificationi

Not N-glycosylated.

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IY95
MaxQBiQ8IY95
PaxDbiQ8IY95
PeptideAtlasiQ8IY95
PRIDEiQ8IY95

PTM databases

iPTMnetiQ8IY95
PhosphoSitePlusiQ8IY95
SwissPalmiQ8IY95

Expressioni

Tissue specificityi

Strongly expressed in kidney, liver, lung and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000170088
CleanExiHS_TMEM192
ExpressionAtlasiQ8IY95 baseline and differential
GenevisibleiQ8IY95 HS

Organism-specific databases

HPAiHPA014717
HPA024110

Interactioni

Subunit structurei

Homodimer.1 Publication

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi128407, 47 interactors
IntActiQ8IY95, 2 interactors
STRINGi9606.ENSP00000305069

Structurei

3D structure databases

ProteinModelPortaliQ8IY95
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM192 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGAC Eukaryota
ENOG4111V8N LUCA
GeneTreeiENSGT00390000013749
HOGENOMiHOG000082527
HOVERGENiHBG055288
InParanoidiQ8IY95
OMAiYIQYHHS
OrthoDBiEOG091G0HP9
PhylomeDBiQ8IY95
TreeFamiTF323773

Family and domain databases

InterProiView protein in InterPro
IPR029399 TMEM192
PANTHERiPTHR31592 PTHR31592, 1 hit
PfamiView protein in Pfam
PF14802 TMEM192, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IY95-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAGGRMEDG SLDITQSIED DPLLDAQLLP HHSLQAHFRP RFHPLPTVII
60 70 80 90 100
VNLLWFIHLV FVVLAFLTGV LCSYPNPNED KCPGNYTNPL KVQTVIILGK
110 120 130 140 150
VILWILHLLL ECYIQYHHSK IRNRGYNLIY RSTRHLKRLA LMIQSSGNTV
160 170 180 190 200
LLLILCMQHS FPEPGRLYLD LILAILALEL ICSLICLLIY TVKIRRFNKA
210 220 230 240 250
KPEPDILEEE KIYAYPSNIT SETGFRTISS LEEIVEKQGD TIEYLKRHNA
260 270
LLSKRLLALT SSDLGCQPSR T
Length:271
Mass (Da):30,922
Last modified:March 1, 2003 - v1
Checksum:iF156D08011315D04
GO
Isoform 2 (identifier: Q8IY95-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MAAGGRMED → MNKAT

Note: No experimental confirmation available.
Show »
Length:267
Mass (Da):30,549
Checksum:iDD5C15EB968845A5
GO

Sequence cautioni

The sequence CAD97974 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti94T → A in CAD97974 (PubMed:17974005).Curated1
Sequence conflicti163E → K in CAD97974 (PubMed:17974005).Curated1
Sequence conflicti190Y → C in BAC04628 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0295021 – 9MAAGGRMED → MNKAT in isoform 2. 1 Publication9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095801 mRNA Translation: BAC04628.1
BX538029 mRNA Translation: CAD97974.1 Different initiation.
CH471056 Genomic DNA Translation: EAX04826.1
BC036301 mRNA Translation: AAH36301.1
CCDSiCCDS43279.1 [Q8IY95-1]
RefSeqiNP_001093859.1, NM_001100389.1 [Q8IY95-1]
UniGeneiHs.704511

Genome annotation databases

EnsembliENST00000306480; ENSP00000305069; ENSG00000170088 [Q8IY95-1]
ENST00000506087; ENSP00000425335; ENSG00000170088 [Q8IY95-2]
GeneIDi201931
KEGGihsa:201931
UCSCiuc003iqz.5 human [Q8IY95-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTM192_HUMAN
AccessioniPrimary (citable) accession number: Q8IY95
Secondary accession number(s): Q7Z3A1, Q8N928
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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