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Q8IY92

- SLX4_HUMAN

UniProt

Q8IY92 - SLX4_HUMAN

Protein

Structure-specific endonuclease subunit SLX4

Gene

SLX4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 3 (02 Sep 2008)
      Previous versions | rss
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    Functioni

    Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks.4 Publications

    GO - Molecular functioni

    1. 5'-flap endonuclease activity Source: InterPro
    2. enzyme activator activity Source: UniProtKB
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. DNA catabolic process, endonucleolytic Source: GOC
    2. DNA double-strand break processing involved in repair via single-strand annealing Source: UniProtKB
    3. DNA repair Source: UniProtKB
    4. DNA replication Source: InterPro
    5. double-strand break repair via homologous recombination Source: UniProtKB
    6. nucleotide-excision repair Source: UniProtKB
    7. positive regulation of catalytic activity Source: GOC
    8. response to intra-S DNA damage checkpoint signaling Source: MGI

    Keywords - Biological processi

    DNA damage, DNA recombination, DNA repair

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Structure-specific endonuclease subunit SLX4
    Alternative name(s):
    BTB/POZ domain-containing protein 12
    Gene namesi
    Name:SLX4
    Synonyms:BTBD12, KIAA1784, KIAA1987
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:23845. SLX4.

    Subcellular locationi

    Nucleus 2 Publications
    Note: Localizes to sites of DNA dammage.

    GO - Cellular componenti

    1. cell junction Source: HPA
    2. cytoplasm Source: HPA
    3. nucleus Source: HPA
    4. Slx1-Slx4 complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Fanconi anemia complementation group P (FANCP) [MIM:613951]: A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. Some individuals affected by Fanconi anemia of complementation group P have skeletal anomalies.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Keywords - Diseasei

    Fanconi anemia

    Organism-specific databases

    MIMi613951. phenotype.
    Orphaneti84. Fanconi anemia.
    PharmGKBiPA134983583.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 18341834Structure-specific endonuclease subunit SLX4PRO_0000186219Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei287 – 2871Phosphoserine1 Publication
    Modified residuei1044 – 10441Phosphoserine1 Publication
    Modified residuei1469 – 14691Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8IY92.
    PaxDbiQ8IY92.
    PRIDEiQ8IY92.

    PTM databases

    PhosphoSiteiQ8IY92.

    Expressioni

    Gene expression databases

    BgeeiQ8IY92.
    CleanExiHS_BTBD12.
    GenevestigatoriQ8IY92.

    Organism-specific databases

    HPAiHPA049421.

    Interactioni

    Subunit structurei

    Forms a heterodimer with SLX1A/GIYD1. Interacts with ERCC4; catalytic subunit of the ERCC4-ERCC1 endonuclease. Interacts with MUS81; catalytic subunit of the MUS81-EME1 endonuclease. Interacts with MSH2; component of the MSH2-MSH3 mismatch repair complex. Interacts with TERF2-TERF2IP. Interacts with PLK1 and SLX4IP.4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    EME1Q96AY24EBI-2370740,EBI-2370825
    ERCC1P079926EBI-2370740,EBI-750962
    ERCC4Q9288910EBI-2370740,EBI-2370770
    MSH2P432465EBI-2370740,EBI-355888
    MUS81Q96NY98EBI-2370740,EBI-2370806
    PLK1P533506EBI-2370740,EBI-476768
    SLX1BQ9BQ8310EBI-2370740,EBI-2370858
    SLX4IPQ5VYV74EBI-2370740,EBI-2370881
    TERF2Q155545EBI-2370740,EBI-706637
    TERF2IPQ9NYB04EBI-2370740,EBI-750109

    Protein-protein interaction databases

    BioGridi124097. 34 interactions.
    IntActiQ8IY92. 157 interactions.

    Structurei

    Secondary structure

    1
    1834
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi1016 – 10194

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4M7CX-ray2.05C/D1014-1025[»]
    ProteinModelPortaliQ8IY92.
    SMRiQ8IY92. Positions 676-790.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini691 – 76474BTBPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 669669Interaction with SLX4IP, ERCC4 and MSH2Add
    BLAST
    Regioni684 – 18341151Interaction with PLK1 and TERF2-TERF2IPAdd
    BLAST
    Regioni1328 – 1648321Interaction with MUS81Add
    BLAST
    Regioni1632 – 1834203Interaction with SLX1Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili801 – 87070Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi520 – 5234Poly-Pro
    Compositional biasi796 – 85661Glu-richAdd
    BLAST
    Compositional biasi1710 – 172112Poly-SerAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SLX4 family.Curated
    Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG44550.
    HOGENOMiHOG000095273.
    InParanoidiQ8IY92.
    KOiK10484.
    OMAiHKFVLYA.
    OrthoDBiEOG7ZKSDH.
    PhylomeDBiQ8IY92.
    TreeFamiTF106446.

    Family and domain databases

    Gene3Di3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR018574. Structure-sp_endonuc_su_Slx4.
    [Graphical view]
    PfamiPF00651. BTB. 1 hit.
    PF09494. Slx4. 1 hit.
    [Graphical view]
    SMARTiSM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.
    PROSITEiPS50097. BTB. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8IY92-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKLSVNEAQL GFYLGSLSHL SACPGIDPRS SEDQPESLKT GQMMDESDED     50
    FKELCASFFQ RVKKHGIKEV SGERKTQKAA SNGTQIRSKL KRTKQTATKT 100
    KTLQGPAEKK PPSGSQAPRT KKQRVTKWQA SEPAHSVNGE GGVLASAPDP 150
    PVLRETAQNT QTGNQQEPSP NLSREKTREN VPNSDSQPPP SCLTTAVPSP 200
    SKPRTAQLVL QRMQQFKRAD PERLRHASEE CSLEAAREEN VPKDPQEEMM 250
    AGNVYGLGPP APESDAAVAL TLQQEFARVG ASAHDDSLEE KGLFFCQICQ 300
    KNLSAMNVTR REQHVNRCLD EAEKTLRPSV PQIPECPICG KPFLTLKSRT 350
    SHLKQCAVKM EVGPQLLLQA VRLQTAQPEG SSSPPMFSFS DHSRGLKRRG 400
    PTSKKEPRKR RKVDEAPSED LLVAMALSRS EMEPGAAVPA LRLESAFSER 450
    IRPEAENKSR KKKPPVSPPL LLVQDSETTG RQIEDRVALL LSEEVELSST 500
    PPLPASRILK EGWERAGQCP PPPERKQSFL WEGSALTGAW AMEDFYTARL 550
    VPPLVPQRPA QGLMQEPVPP LVPPEHSELS ERRSPALHGT PTAGCGSRGP 600
    SPSASQREHQ ALQDLVDLAR EGLSASPWPG SGGLAGSEGT AGLDVVPGGL 650
    PLTGFVVPSQ DKHPDRGGRT LLSLGLLVAD FGAMVNNPHL SDVQFQTDSG 700
    EVLYAHKFVL YARCPLLIQY VNNEGFSAVE DGVLTQRVLL GDVSTEAART 750
    FLHYLYTADT GLPPGLSSEL SSLAHRFGVS ELVHLCEQVP IATDSEGKPW 800
    EEKEAENCES RAENFQELLR SMWADEEEEA ETLLKSKDHE EDQENVNEAE 850
    MEEIYEFAAT QRKLLQEERA AGAGEDADWL EGGSPVSGQL LAGVQVQKQW 900
    DKVEEMEPLE PGRDEAATTW EKMGQCALPP PQGQHSGARG AEAPEQEAPE 950
    EALGHSSCSS PSRDCQAERK EGSLPHSDDA GDYEQLFSST QGEISEPSQI 1000
    TSEPEEQSGA VRERGLEVSH RLAPWQASPP HPCRFLLGPP QGGSPRGSHH 1050
    TSGSSLSTPR SRGGTSQVGS PTLLSPAVPS KQKRDRSILT LSKEPGHQKG 1100
    KERRSVLECR NKGVLMFPEK SPSIDLTQSN PDHSSSRSQK SSSKLNEEDE 1150
    VILLLDSDEE LELEQTKMKS ISSDPLEEKK ALEISPRSCE LFSIIDVDAD 1200
    QEPSQSPPRS EAVLQQEDEG ALPENRGSLG RRGAPWLFCD RESSPSEAST 1250
    TDTSWLVPAT PLASRSRDCS SQTQISSLRS GLAVQAVTQH TPRASVGNRE 1300
    GNEVAQKFSV IRPQTPPPQT PSSCLTPVSP GTSDGRRQGH RSPSRPHPGG 1350
    HPHSSPLAPH PISGDRAHFS RRFLKHSPPG PSFLNQTPAG EVVEVGDSDD 1400
    EQEVASHQAN RSPPLDSDPP IPIDDCCWHM EPLSPIPIDH WNLERTGPLS 1450
    TSSPSRRMNE AADSRDCRSP GLLDTTPIRG SCTTQRKLQE KSSGAGSLGN 1500
    SRPSFLNSAL WDVWDGEEQR PPETPPPAQM PSAGGAQKPE GLETPKGANR 1550
    KKNLPPKVPI TPMPQYSIME TPVLKKELDR FGVRPLPKRQ MVLKLKEIFQ 1600
    YTHQTLDSDS EDESQSSQPL LQAPHCQTLA SQTYKPSRAG VHAQQEATTG 1650
    PGAHRPKGPA KTKGPRHQRK HHESITPPSR SPTKEAPPGL NDDAQIPASQ 1700
    ESVATSVDGS DSSLSSQSSS SCEFGAAFES AGEEEGEGEV SASQAAVQAA 1750
    DTDEALRCYI RSKPALYQKV LLYQPFELRE LQAELRQNGL RVSSRRLLDF 1800
    LDTHCITFTT AATRREKLQG RRRQPRGKKK VERN 1834
    Length:1,834
    Mass (Da):200,012
    Last modified:September 2, 2008 - v3
    Checksum:i9131E88628DB15D5
    GO
    Isoform 2 (identifier: Q8IY92-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-312: Missing.
         313-316: QHVN → MFSF

    Show »
    Length:1,522
    Mass (Da):165,903
    Checksum:iA3C234F1E746C5FA
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti38 – 381L → F.1 Publication
    Corresponds to variant rs141167501 [ dbSNP | Ensembl ].
    VAR_068982
    Natural varianti141 – 1411G → W.1 Publication
    Corresponds to variant rs137976282 [ dbSNP | Ensembl ].
    VAR_068983
    Natural varianti197 – 1971V → A.1 Publication
    Corresponds to variant rs147826749 [ dbSNP | Ensembl ].
    VAR_068984
    Natural varianti204 – 2041R → C.1 Publication
    Corresponds to variant rs79842542 [ dbSNP | Ensembl ].
    VAR_068985
    Natural varianti237 – 2371R → Q.1 Publication
    Corresponds to variant rs138615800 [ dbSNP | Ensembl ].
    VAR_068986
    Natural varianti284 – 2841H → R.1 Publication
    VAR_068987
    Natural varianti378 – 3781P → T Polymorphism that does not modify the functional properties of the protein. 1 Publication
    VAR_068988
    Natural varianti385 – 3851P → T.1 Publication
    Corresponds to variant rs115694169 [ dbSNP | Ensembl ].
    VAR_068989
    Natural varianti386 – 3861M → V.1 Publication
    Corresponds to variant rs113490934 [ dbSNP | Ensembl ].
    VAR_068990
    Natural varianti424 – 4241A → V.1 Publication
    VAR_068991
    Natural varianti457 – 4571N → K.1 Publication
    Corresponds to variant rs74319927 [ dbSNP | Ensembl ].
    VAR_068992
    Natural varianti458 – 4581K → E.1 Publication
    Corresponds to variant rs149126845 [ dbSNP | Ensembl ].
    VAR_068993
    Natural varianti505 – 5051A → T.1 Publication
    VAR_068994
    Natural varianti506 – 5061S → N.1 Publication
    VAR_068995
    Natural varianti568 – 5681V → M.1 Publication
    VAR_068996
    Natural varianti579 – 5791L → P.1 Publication
    VAR_068997
    Natural varianti671 – 6711L → S.2 Publications
    Corresponds to variant rs77985244 [ dbSNP | Ensembl ].
    VAR_068998
    Natural varianti787 – 7871E → K Polymorphism that does not modify the functional properties of the protein. 1 Publication
    Corresponds to variant rs140600202 [ dbSNP | Ensembl ].
    VAR_068999
    Natural varianti870 – 8701A → V.1 Publication
    Corresponds to variant rs149584080 [ dbSNP | Ensembl ].
    VAR_069000
    Natural varianti894 – 8941V → G.1 Publication
    Corresponds to variant rs145137472 [ dbSNP | Ensembl ].
    VAR_069001
    Natural varianti929 – 9291P → L.1 Publication
    Corresponds to variant rs117707719 [ dbSNP | Ensembl ].
    VAR_069002
    Natural varianti942 – 9421E → Q.1 Publication
    Corresponds to variant rs114014006 [ dbSNP | Ensembl ].
    VAR_069003
    Natural varianti952 – 9521A → M Requires 2 nucleotide substitutions. 2 Publications
    VAR_069004
    Natural varianti975 – 9751P → L.1 Publication
    Corresponds to variant rs114472821 [ dbSNP | Ensembl ].
    VAR_069005
    Natural varianti1007 – 10071Q → K.1 Publication
    Corresponds to variant rs138798067 [ dbSNP | Ensembl ].
    VAR_069006
    Natural varianti1060 – 10601R → W.1 Publication
    VAR_069007
    Natural varianti1122 – 11221P → L.2 Publications
    Corresponds to variant rs714181 [ dbSNP | Ensembl ].
    VAR_019326
    Natural varianti1123 – 11231S → Y.1 Publication
    Corresponds to variant rs144647122 [ dbSNP | Ensembl ].
    VAR_069008
    Natural varianti1221 – 12211A → V.2 Publications
    Corresponds to variant rs3827530 [ dbSNP | Ensembl ].
    VAR_019729
    Natural varianti1271 – 12711S → F.1 Publication
    Corresponds to variant rs3810813 [ dbSNP | Ensembl ].
    VAR_019327
    Natural varianti1286 – 12861A → V.1 Publication
    Corresponds to variant rs149011965 [ dbSNP | Ensembl ].
    VAR_069009
    Natural varianti1287 – 12871V → G.1 Publication
    VAR_069010
    Natural varianti1342 – 13421S → G.1 Publication
    Corresponds to variant rs140051968 [ dbSNP | Ensembl ].
    VAR_069011
    Natural varianti1367 – 13671A → T.
    Corresponds to variant rs17136464 [ dbSNP | Ensembl ].
    VAR_046337
    Natural varianti1421 – 14211I → F.1 Publication
    Corresponds to variant rs141567438 [ dbSNP | Ensembl ].
    VAR_069012
    Natural varianti1476 – 14761T → S.1 Publication
    VAR_069013
    Natural varianti1550 – 15501R → W Polymorphism that does not modify the functional properties of the protein. 1 Publication
    Corresponds to variant rs77021998 [ dbSNP | Ensembl ].
    VAR_069014
    Natural varianti1677 – 16771P → S.
    Corresponds to variant rs7196345 [ dbSNP | Ensembl ].
    VAR_046338
    Natural varianti1694 – 16941A → V.1 Publication
    VAR_069015
    Natural varianti1814 – 18141R → C.1 Publication
    VAR_069016
    Natural varianti1834 – 18341N → S Polymorphism that does not modify the functional properties of the protein. 1 Publication
    Corresponds to variant rs111738042 [ dbSNP | Ensembl ].
    VAR_069017

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 312312Missing in isoform 2. 1 PublicationVSP_035295Add
    BLAST
    Alternative sequencei313 – 3164QHVN → MFSF in isoform 2. 1 PublicationVSP_035296

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC006111 Genomic DNA. No translation available.
    AB075867 mRNA. Translation: BAB85573.1.
    AB058687 mRNA. Translation: BAB47413.1.
    AL442083 mRNA. Translation: CAH10659.1.
    CCDSiCCDS10506.2. [Q8IY92-1]
    RefSeqiNP_115820.2. NM_032444.2. [Q8IY92-1]
    UniGeneiHs.143681.

    Genome annotation databases

    EnsembliENST00000294008; ENSP00000294008; ENSG00000188827. [Q8IY92-1]
    GeneIDi84464.
    KEGGihsa:84464.
    UCSCiuc002cvp.2. human. [Q8IY92-1]

    Polymorphism databases

    DMDMi205371796.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) (SLX4)

    Leiden Open Variation Database (LOVD)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC006111 Genomic DNA. No translation available.
    AB075867 mRNA. Translation: BAB85573.1 .
    AB058687 mRNA. Translation: BAB47413.1 .
    AL442083 mRNA. Translation: CAH10659.1 .
    CCDSi CCDS10506.2. [Q8IY92-1 ]
    RefSeqi NP_115820.2. NM_032444.2. [Q8IY92-1 ]
    UniGenei Hs.143681.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4M7C X-ray 2.05 C/D 1014-1025 [» ]
    ProteinModelPortali Q8IY92.
    SMRi Q8IY92. Positions 676-790.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124097. 34 interactions.
    IntActi Q8IY92. 157 interactions.

    PTM databases

    PhosphoSitei Q8IY92.

    Polymorphism databases

    DMDMi 205371796.

    Proteomic databases

    MaxQBi Q8IY92.
    PaxDbi Q8IY92.
    PRIDEi Q8IY92.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000294008 ; ENSP00000294008 ; ENSG00000188827 . [Q8IY92-1 ]
    GeneIDi 84464.
    KEGGi hsa:84464.
    UCSCi uc002cvp.2. human. [Q8IY92-1 ]

    Organism-specific databases

    CTDi 84464.
    GeneCardsi GC16M003632.
    GeneReviewsi SLX4.
    H-InvDB HIX0202244.
    HGNCi HGNC:23845. SLX4.
    HPAi HPA049421.
    MIMi 613278. gene.
    613951. phenotype.
    neXtProti NX_Q8IY92.
    Orphaneti 84. Fanconi anemia.
    PharmGKBi PA134983583.
    HUGEi Search...
    Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44550.
    HOGENOMi HOG000095273.
    InParanoidi Q8IY92.
    KOi K10484.
    OMAi HKFVLYA.
    OrthoDBi EOG7ZKSDH.
    PhylomeDBi Q8IY92.
    TreeFami TF106446.

    Miscellaneous databases

    ChiTaRSi SLX4. human.
    GeneWikii SLX4.
    GenomeRNAii 84464.
    NextBioi 74266.
    PROi Q8IY92.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8IY92.
    CleanExi HS_BTBD12.
    Genevestigatori Q8IY92.

    Family and domain databases

    Gene3Di 3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR018574. Structure-sp_endonuc_su_Slx4.
    [Graphical view ]
    Pfami PF00651. BTB. 1 hit.
    PF09494. Slx4. 1 hit.
    [Graphical view ]
    SMARTi SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    PROSITEi PS50097. BTB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins."
      Nagase T., Kikuno R., Ohara O.
      DNA Res. 8:319-327(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-669 (ISOFORM 2).
      Tissue: Brain.
    3. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
      DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 668-1834 (ISOFORMS 1/2), VARIANTS SER-671; MET-952; LEU-1122 AND VAL-1221.
      Tissue: Brain.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1612-1834 (ISOFORMS 1/2).
      Tissue: Brain.
    5. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1469, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-287 AND SER-1469, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair."
      Svendsen J.M., Smogorzewska A., Sowa M.E., O'Connell B.C., Gygi S.P., Elledge S.J., Harper J.W.
      Cell 138:63-77(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH SLX4IP; ERCC4; SLX1A; MSH2; MUS81; PLK1; TERF2 AND TERF2IP, SUBCELLULAR LOCATION.
    8. "Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases."
      Fekairi S., Scaglione S., Chahwan C., Taylor E.R., Tissier A., Coulon S., Dong M.-Q., Ruse C., Yates J.R. III, Russell P., Fuchs R.P., McGowan C.H., Gaillard P.-H.L.
      Cell 138:78-89(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH ERCC4; SLX1A AND MUS81, SUBCELLULAR LOCATION.
    9. Cited for: FUNCTION, INTERACTION WITH ERCC4; SLX1A AND MUS81-EME1.
    10. "Drosophila MUS312 and the vertebrate ortholog BTBD12 interact with DNA structure-specific endonucleases in DNA repair and recombination."
      Andersen S.L., Bergstralh D.T., Kohl K.P., LaRocque J.R., Moore C.B., Sekelsky J.
      Mol. Cell 35:128-135(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH ERCC4.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1044, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. Cited for: INVOLVEMENT IN FANCP.
    15. Cited for: INVOLVEMENT IN FANCP.
    16. Cited for: VARIANTS PHE-38; TRP-141; ALA-197; CYS-204; GLN-237; ARG-284; THR-378; THR-385; VAL-386; VAL-424; LYS-457; GLU-458; THR-505; ASN-506; MET-568; PRO-579; SER-671; LYS-787; VAL-870; GLY-894; LEU-929; GLN-942; MET-952; LEU-975; LYS-1007; TRP-1060; LEU-1122; TYR-1123; VAL-1221; PHE-1271; VAL-1286; GLY-1287; GLY-1342; PHE-1421; SER-1476; TRP-1550; VAL-1694; CYS-1814 AND SER-1834, CHARACTERIZATION OF VARIANTS THR-378; LYS-787; TRP-1550 AND CYS-1814, NO ASSOCIATION WITH BREAST CANCER.

    Entry informationi

    Entry nameiSLX4_HUMAN
    AccessioniPrimary (citable) accession number: Q8IY92
    Secondary accession number(s): Q69YT8, Q8TF15, Q96JP1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 107 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3