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Q8IY84

- NIM1_HUMAN

UniProt

Q8IY84 - NIM1_HUMAN

Protein

Serine/threonine-protein kinase NIM1

Gene

NIM1K

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.1 Publication

    Cofactori

    Magnesium.1 Publication

    Enzyme regulationi

    Activated by phosphorylation at Thr-229, probably by autophosphorylation.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei103 – 1031ATPBy similarityPROSITE-ProRule annotation
    Active sitei196 – 1961Proton acceptorBy similarityPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi80 – 889ATPBy similarityPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB
    2. magnesium ion binding Source: UniProtKB
    3. protein serine/threonine kinase activity Source: UniProtKB

    GO - Biological processi

    1. protein phosphorylation Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiQ8IY84.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase NIM1 (EC:2.7.11.1)
    Alternative name(s):
    NIM1 serine/threonine-protein kinase
    Gene namesi
    Name:NIM1K
    Synonyms:NIM1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:28646. NIM1K.

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi229 – 2291T → A: Loss of autophosphorylation and kinase activity. 1 Publication
    Mutagenesisi229 – 2291T → E: Constitutively active. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 436436Serine/threonine-protein kinase NIM1PRO_0000247666Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei229 – 2291Phosphothreonine; by autocatalysis1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ8IY84.
    PRIDEiQ8IY84.

    PTM databases

    PhosphoSiteiQ8IY84.

    Expressioni

    Gene expression databases

    BgeeiQ8IY84.
    GenevestigatoriQ8IY84.

    Organism-specific databases

    HPAiHPA007695.

    Interactioni

    Protein-protein interaction databases

    BioGridi127945. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IY84.
    SMRiQ8IY84. Positions 24-390.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini74 – 325252Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233016.
    HOVERGENiHBG082029.
    InParanoidiQ8IY84.
    KOiK16310.
    OMAiHMHENQI.
    PhylomeDBiQ8IY84.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8IY84-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTAVYMNGGG LVNPHYARWD RRDSVESGCQ TESSKEGEEG QPRQLTPFEK    50
    LTQDMSQDEK VVREITLGKR IGFYRIRGEI GSGNFSQVKL GIHSLTKEKV 100
    AIKILDKTKL DQKTQRLLSR EISSMEKLHH PNIIRLYEVV ETLSKLHLVM 150
    EYAGGGELFG KISTEGKLSE PESKLIFSQI VSAVKHMHEN QIIHRDLKAE 200
    NVFYTSNTCV KVGDFGFSTV SKKGEMLNTF CGSPPYAAPE LFRDEHYIGI 250
    YVDIWALGVL LYFMVTGTMP FRAETVAKLK KSILEGTYSV PPHVSEPCHR 300
    LIRGVLQQIP TERYGIDCIM NDEWMQGVPY PTPLEPFQLD PKHLSETSTL 350
    KEEENEVKST LEHLGITEEH IRNNQGRDAR SSITGVYRII LHRVQRKKAL 400
    ESVPVMMLPD PKERDLKKGS RVYRGIRHTS KFCSIL 436
    Length:436
    Mass (Da):49,606
    Last modified:March 1, 2003 - v1
    Checksum:iC183F11F54E3B87C
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti21 – 211R → W.1 Publication
    VAR_040945
    Natural varianti64 – 641E → Q.1 Publication
    VAR_040946
    Natural varianti260 – 2601L → I.1 Publication
    VAR_040947
    Natural varianti320 – 3201M → I.1 Publication
    VAR_040948
    Natural varianti333 – 3331P → S in a lung neuroendocrine carcinoma sample; somatic mutation. 1 Publication
    VAR_040949
    Natural varianti411 – 4111P → T in a lung large cell carcinoma sample; somatic mutation. 1 Publication
    VAR_040950

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK122985 mRNA. Translation: BAG53833.1.
    AC106800 Genomic DNA. No translation available.
    AC114947 Genomic DNA. No translation available.
    CH471119 Genomic DNA. Translation: EAW56053.1.
    BC036422 mRNA. Translation: AAH36422.1.
    CCDSiCCDS3943.1.
    RefSeqiNP_699192.1. NM_153361.3.
    XP_006714513.1. XM_006714450.1.
    UniGeneiHs.25845.

    Genome annotation databases

    EnsembliENST00000326035; ENSP00000313572; ENSG00000177453.
    ENST00000512796; ENSP00000420849; ENSG00000177453.
    GeneIDi167359.
    KEGGihsa:167359.
    UCSCiuc003jno.4. human.

    Polymorphism databases

    DMDMi74759697.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK122985 mRNA. Translation: BAG53833.1 .
    AC106800 Genomic DNA. No translation available.
    AC114947 Genomic DNA. No translation available.
    CH471119 Genomic DNA. Translation: EAW56053.1 .
    BC036422 mRNA. Translation: AAH36422.1 .
    CCDSi CCDS3943.1.
    RefSeqi NP_699192.1. NM_153361.3.
    XP_006714513.1. XM_006714450.1.
    UniGenei Hs.25845.

    3D structure databases

    ProteinModelPortali Q8IY84.
    SMRi Q8IY84. Positions 24-390.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127945. 1 interaction.

    Chemistry

    BindingDBi Q8IY84.
    ChEMBLi CHEMBL3542.
    GuidetoPHARMACOLOGYi 2291.

    PTM databases

    PhosphoSitei Q8IY84.

    Polymorphism databases

    DMDMi 74759697.

    Proteomic databases

    PaxDbi Q8IY84.
    PRIDEi Q8IY84.

    Protocols and materials databases

    DNASUi 167359.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000326035 ; ENSP00000313572 ; ENSG00000177453 .
    ENST00000512796 ; ENSP00000420849 ; ENSG00000177453 .
    GeneIDi 167359.
    KEGGi hsa:167359.
    UCSCi uc003jno.4. human.

    Organism-specific databases

    CTDi 167359.
    GeneCardsi GC05P043193.
    HGNCi HGNC:28646. NIM1K.
    HPAi HPA007695.
    neXtProti NX_Q8IY84.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233016.
    HOVERGENi HBG082029.
    InParanoidi Q8IY84.
    KOi K16310.
    OMAi HMHENQI.
    PhylomeDBi Q8IY84.

    Enzyme and pathway databases

    SignaLinki Q8IY84.

    Miscellaneous databases

    GenomeRNAii 167359.
    NextBioi 88667.
    PROi Q8IY84.

    Gene expression databases

    Bgeei Q8IY84.
    Genevestigatori Q8IY84.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate."
      Jaleel M., McBride A., Lizcano J.M., Deak M., Toth R., Morrice N.A., Alessi D.R.
      FEBS Lett. 579:1417-1423(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, ENZYME REGULATION, PHOSPHORYLATION AT THR-229, MUTAGENESIS OF THR-229.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Amygdala.
    3. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: BrainImported.
    6. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] TRP-21; GLN-64; ILE-260; ILE-320; SER-333 AND THR-411.

    Entry informationi

    Entry nameiNIM1_HUMAN
    AccessioniPrimary (citable) accession number: Q8IY84
    Secondary accession number(s): B3KVM1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3