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Protein

Serine/threonine-protein kinase NIM1

Gene

NIM1K

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.1 Publication

Cofactori

Mg2+1 Publication

Enzyme regulationi

Activated by phosphorylation at Thr-229, probably by autophosphorylation.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei103ATPPROSITE-ProRule annotationBy similarity1
Active sitei196Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi80 – 88ATPPROSITE-ProRule annotationBy similarity9

GO - Molecular functioni

  • ATP binding Source: UniProtKB
  • magnesium ion binding Source: UniProtKB
  • protein serine/threonine kinase activity Source: UniProtKB

GO - Biological processi

  • intracellular signal transduction Source: GO_Central
  • protein phosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS16857-MONOMER.
SignaLinkiQ8IY84.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase NIM1 (EC:2.7.11.1)
Alternative name(s):
NIM1 serine/threonine-protein kinase
Gene namesi
Name:NIM1K
Synonyms:NIM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:28646. NIM1K.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi229T → A: Loss of autophosphorylation and kinase activity. 1 Publication1
Mutagenesisi229T → E: Constitutively active. 1 Publication1

Organism-specific databases

DisGeNETi167359.
OpenTargetsiENSG00000177453.

Chemistry databases

ChEMBLiCHEMBL3542.
GuidetoPHARMACOLOGYi2291.

Polymorphism and mutation databases

BioMutaiNIM1.
DMDMi74759697.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002476661 – 436Serine/threonine-protein kinase NIM1Add BLAST436

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei229Phosphothreonine; by autocatalysis1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8IY84.
PeptideAtlasiQ8IY84.
PRIDEiQ8IY84.

PTM databases

iPTMnetiQ8IY84.
PhosphoSitePlusiQ8IY84.

Expressioni

Gene expression databases

BgeeiENSG00000177453.
GenevisibleiQ8IY84. HS.

Organism-specific databases

HPAiHPA007695.

Interactioni

Protein-protein interaction databases

BioGridi127945. 1 interactor.
STRINGi9606.ENSP00000313572.

Chemistry databases

BindingDBiQ8IY84.

Structurei

3D structure databases

ProteinModelPortaliQ8IY84.
SMRiQ8IY84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini74 – 325Protein kinasePROSITE-ProRule annotationAdd BLAST252

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0583. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00790000122947.
HOGENOMiHOG000233016.
HOVERGENiHBG082029.
InParanoidiQ8IY84.
KOiK16310.
OMAiYARWDRR.
OrthoDBiEOG091G07AG.
PhylomeDBiQ8IY84.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IY84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAVYMNGGG LVNPHYARWD RRDSVESGCQ TESSKEGEEG QPRQLTPFEK
60 70 80 90 100
LTQDMSQDEK VVREITLGKR IGFYRIRGEI GSGNFSQVKL GIHSLTKEKV
110 120 130 140 150
AIKILDKTKL DQKTQRLLSR EISSMEKLHH PNIIRLYEVV ETLSKLHLVM
160 170 180 190 200
EYAGGGELFG KISTEGKLSE PESKLIFSQI VSAVKHMHEN QIIHRDLKAE
210 220 230 240 250
NVFYTSNTCV KVGDFGFSTV SKKGEMLNTF CGSPPYAAPE LFRDEHYIGI
260 270 280 290 300
YVDIWALGVL LYFMVTGTMP FRAETVAKLK KSILEGTYSV PPHVSEPCHR
310 320 330 340 350
LIRGVLQQIP TERYGIDCIM NDEWMQGVPY PTPLEPFQLD PKHLSETSTL
360 370 380 390 400
KEEENEVKST LEHLGITEEH IRNNQGRDAR SSITGVYRII LHRVQRKKAL
410 420 430
ESVPVMMLPD PKERDLKKGS RVYRGIRHTS KFCSIL
Length:436
Mass (Da):49,606
Last modified:March 1, 2003 - v1
Checksum:iC183F11F54E3B87C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04094521R → W.1 PublicationCorresponds to variant rs55664335dbSNPEnsembl.1
Natural variantiVAR_04094664E → Q.1 PublicationCorresponds to variant rs55663207dbSNPEnsembl.1
Natural variantiVAR_040947260L → I.1 PublicationCorresponds to variant rs35659008dbSNPEnsembl.1
Natural variantiVAR_040948320M → I.1 PublicationCorresponds to variant rs55770078dbSNPEnsembl.1
Natural variantiVAR_040949333P → S in a lung neuroendocrine carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_040950411P → T in a lung large cell carcinoma sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122985 mRNA. Translation: BAG53833.1.
AC106800 Genomic DNA. No translation available.
AC114947 Genomic DNA. No translation available.
CH471119 Genomic DNA. Translation: EAW56053.1.
BC036422 mRNA. Translation: AAH36422.1.
CCDSiCCDS3943.1.
RefSeqiNP_699192.1. NM_153361.3.
XP_006714513.1. XM_006714450.1.
UniGeneiHs.25845.

Genome annotation databases

EnsembliENST00000326035; ENSP00000313572; ENSG00000177453.
ENST00000512796; ENSP00000420849; ENSG00000177453.
GeneIDi167359.
KEGGihsa:167359.
UCSCiuc003jno.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122985 mRNA. Translation: BAG53833.1.
AC106800 Genomic DNA. No translation available.
AC114947 Genomic DNA. No translation available.
CH471119 Genomic DNA. Translation: EAW56053.1.
BC036422 mRNA. Translation: AAH36422.1.
CCDSiCCDS3943.1.
RefSeqiNP_699192.1. NM_153361.3.
XP_006714513.1. XM_006714450.1.
UniGeneiHs.25845.

3D structure databases

ProteinModelPortaliQ8IY84.
SMRiQ8IY84.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127945. 1 interactor.
STRINGi9606.ENSP00000313572.

Chemistry databases

BindingDBiQ8IY84.
ChEMBLiCHEMBL3542.
GuidetoPHARMACOLOGYi2291.

PTM databases

iPTMnetiQ8IY84.
PhosphoSitePlusiQ8IY84.

Polymorphism and mutation databases

BioMutaiNIM1.
DMDMi74759697.

Proteomic databases

PaxDbiQ8IY84.
PeptideAtlasiQ8IY84.
PRIDEiQ8IY84.

Protocols and materials databases

DNASUi167359.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326035; ENSP00000313572; ENSG00000177453.
ENST00000512796; ENSP00000420849; ENSG00000177453.
GeneIDi167359.
KEGGihsa:167359.
UCSCiuc003jno.5. human.

Organism-specific databases

CTDi167359.
DisGeNETi167359.
GeneCardsiNIM1K.
HGNCiHGNC:28646. NIM1K.
HPAiHPA007695.
neXtProtiNX_Q8IY84.
OpenTargetsiENSG00000177453.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0583. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00790000122947.
HOGENOMiHOG000233016.
HOVERGENiHBG082029.
InParanoidiQ8IY84.
KOiK16310.
OMAiYARWDRR.
OrthoDBiEOG091G07AG.
PhylomeDBiQ8IY84.

Enzyme and pathway databases

BioCyciZFISH:HS16857-MONOMER.
SignaLinkiQ8IY84.

Miscellaneous databases

GenomeRNAii167359.
PROiQ8IY84.

Gene expression databases

BgeeiENSG00000177453.
GenevisibleiQ8IY84. HS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNIM1_HUMAN
AccessioniPrimary (citable) accession number: Q8IY84
Secondary accession number(s): B3KVM1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.