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Protein

pre-rRNA processing protein FTSJ3

Gene

FTSJ3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.UniRule annotation1 Publication

Catalytic activityi

S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methylnucleoside.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei56S-adenosyl-L-methionine; via amide nitrogenUniRule annotation1
Binding sitei58S-adenosyl-L-methionine; via amide nitrogenUniRule annotation1
Binding sitei76S-adenosyl-L-methionineUniRule annotation1
Binding sitei92S-adenosyl-L-methionineUniRule annotation1
Binding sitei117S-adenosyl-L-methionineUniRule annotation1
Active sitei157Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
pre-rRNA processing protein FTSJ3UniRule annotation (EC:2.1.1.-UniRule annotation)
Alternative name(s):
2'-O-ribose RNA methyltransferase SPB1 homologUniRule annotation
Protein ftsJ homolog 3UniRule annotation
Putative rRNA methyltransferase 3UniRule annotation
Gene namesi
Name:FTSJ3UniRule annotation
ORF Names:SB92
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:17136. FTSJ3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi117246.
OpenTargetsiENSG00000108592.
PharmGKBiPA28419.

Polymorphism and mutation databases

BioMutaiFTSJ3.
DMDMi296452883.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001555771 – 847pre-rRNA processing protein FTSJ3Add BLAST847

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei333PhosphoserineCombined sources1
Modified residuei335PhosphoserineCombined sources1
Modified residuei336PhosphoserineCombined sources1
Modified residuei347PhosphoserineCombined sources1
Modified residuei356PhosphoserineCombined sources1
Modified residuei392CitrullineBy similarity1
Modified residuei549PhosphoserineCombined sources1
Modified residuei573PhosphothreonineCombined sources1
Modified residuei584PhosphoserineCombined sources1
Modified residuei644PhosphoserineCombined sources1
Modified residuei676PhosphoserineCombined sources1
Modified residuei688PhosphoserineCombined sources1
Modified residuei783CitrullineBy similarity1

Post-translational modificationi

Citrullinated by PADI4.By similarity

Keywords - PTMi

Citrullination, Phosphoprotein

Proteomic databases

EPDiQ8IY81.
MaxQBiQ8IY81.
PaxDbiQ8IY81.
PeptideAtlasiQ8IY81.
PRIDEiQ8IY81.

2D gel databases

SWISS-2DPAGEQ8IY81.

PTM databases

iPTMnetiQ8IY81.
PhosphoSitePlusiQ8IY81.
SwissPalmiQ8IY81.

Expressioni

Gene expression databases

BgeeiENSG00000108592.
CleanExiHS_FTSJ3.
ExpressionAtlasiQ8IY81. baseline and differential.
GenevisibleiQ8IY81. HS.

Organism-specific databases

HPAiHPA055544.
HPA062628.

Interactioni

Subunit structurei

Interacts with NIP7.UniRule annotation1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
EIF2AK2P195252EBI-744088,EBI-640775
OAS3Q9Y6K52EBI-744088,EBI-6115729

Protein-protein interaction databases

BioGridi125581. 122 interactors.
IntActiQ8IY81. 20 interactors.
MINTiMINT-1468947.
STRINGi9606.ENSP00000396673.

Structurei

3D structure databases

ProteinModelPortaliQ8IY81.
SMRiQ8IY81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili355 – 407UniRule annotationAdd BLAST53
Coiled coili739 – 777UniRule annotationAdd BLAST39

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.UniRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1098. Eukaryota.
COG0293. LUCA.
GeneTreeiENSGT00550000075004.
HOVERGENiHBG075246.
InParanoidiQ8IY81.
KOiK14857.
OMAiMIDRIYK.
OrthoDBiEOG091G03NZ.
PhylomeDBiQ8IY81.
TreeFamiTF106102.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01547. RNA_methyltr_E. 1 hit.
MF_03163. RNA_methyltr_E_SPB1. 1 hit.
InterProiIPR015507. rRNA-MeTfrase_E.
IPR012920. rRNA_MeTfrase_Spb1_C.
IPR024576. rRNA_MeTfrase_Spb1_DUF3381.
IPR002877. rRNA_MeTrfase_FtsJ_dom.
IPR029063. SAM-dependent_MTases.
IPR028589. Spb1.
[Graphical view]
PANTHERiPTHR10920. PTHR10920. 3 hits.
PTHR10920:SF13. PTHR10920:SF13. 3 hits.
PfamiPF11861. DUF3381. 1 hit.
PF01728. FtsJ. 1 hit.
PF07780. Spb1_C. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8IY81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKKGKVGKS RRDKFYHLAK ETGYRSRSAF KLIQLNRRFQ FLQKARALLD
60 70 80 90 100
LCAAPGGWLQ VAAKFMPVSS LIVGVDLVPI KPLPNVVTLQ QDITTERCRQ
110 120 130 140 150
ALRKELKTWK VDVVLNDGAP NVGASWVHDA YSQAHLTLMA LRLACDFLAR
160 170 180 190 200
GGSFITKVFR SRDYQPLLWI FQQLFRRVQA TKPQASRHES AEIFVVCQGF
210 220 230 240 250
LAPDKVDSKF FDPKFAFKEV EVQAKTVTEL VTKKKPKAEG YAEGDLTLYH
260 270 280 290 300
RTSVTDFLRA ANPVDFLSKA SEIMVDDEEL AQHPATTEDI RVCCQDIRVL
310 320 330 340 350
GRKELRSLLN WRTKLRRYVA KKLKEQAKAL DISLSSGEED EGDEEDSTAG
360 370 380 390 400
TTKQPSKEEE EEEEEEQLNQ TLAEMKAQEV AELKRKKKKL LREQRKQRER
410 420 430 440 450
VELKMDLPGV SIADEGETGM FSLSTIRGHQ LLEEVTQGDM SAADTFLSDL
460 470 480 490 500
PRDDIYVSDV EDDGDDTSLD SDLDPEELAG VRGHQGLRDQ KRMRLTEVQD
510 520 530 540 550
DKEEEEEENP LLVPLEEKAV LQEEQANLWF SKGSFAGIED DADEALEISQ
560 570 580 590 600
AQLLFENRRK GRQQQQKQQL PQTPPSCLKT EIMSPLYQDE APKGTEASSG
610 620 630 640 650
TEAATGLEGE EKDGISDSDS STSSEEEESW EPLRGKKRSR GPKSDDDGFE
660 670 680 690 700
IVPIEDPAKH RILDPEGLAL GAVIASSKKA KRDLIDNSFN RYTFNEDEGE
710 720 730 740 750
LPEWFVQEEK QHRIRQLPVG KKEVEHYRKR WREINARPIK KVAEAKARKK
760 770 780 790 800
RRMLKRLEQT RKKAEAVVNT VDISEREKVA QLRSLYKKAG LGKEKRHVTY
810 820 830 840
VVAKKGVGRK VRRPAGVRGH FKVVDSRMKK DQRAQQRKEQ KKKHKRK
Length:847
Mass (Da):96,558
Last modified:May 18, 2010 - v2
Checksum:i06B2F4D28A48026F
GO

Sequence cautioni

The sequence BAA90924 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti278E → I in AAL56015 (Ref. 1) Curated1
Sequence conflicti278E → I in BAA90924 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02328491Q → E.3 PublicationsCorresponds to variant rs2584625dbSNPEnsembl.1
Natural variantiVAR_023285424S → C.4 PublicationsCorresponds to variant rs2727288dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF327355 mRNA. Translation: AAL56015.1.
AK000069 mRNA. Translation: BAA90924.1. Different initiation.
AK315010 mRNA. Translation: BAG37502.1.
AC015651 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94273.1.
CH471109 Genomic DNA. Translation: EAW94274.1.
CH471109 Genomic DNA. Translation: EAW94275.1.
BC000131 mRNA. Translation: AAH00131.2.
BC036710 mRNA. Translation: AAH36710.1.
AL834482 mRNA. Translation: CAD39141.1.
CCDSiCCDS11644.1.
RefSeqiNP_060117.3. NM_017647.3.
UniGeneiHs.463785.

Genome annotation databases

EnsembliENST00000427159; ENSP00000396673; ENSG00000108592.
GeneIDi117246.
KEGGihsa:117246.
UCSCiuc002jca.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF327355 mRNA. Translation: AAL56015.1.
AK000069 mRNA. Translation: BAA90924.1. Different initiation.
AK315010 mRNA. Translation: BAG37502.1.
AC015651 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94273.1.
CH471109 Genomic DNA. Translation: EAW94274.1.
CH471109 Genomic DNA. Translation: EAW94275.1.
BC000131 mRNA. Translation: AAH00131.2.
BC036710 mRNA. Translation: AAH36710.1.
AL834482 mRNA. Translation: CAD39141.1.
CCDSiCCDS11644.1.
RefSeqiNP_060117.3. NM_017647.3.
UniGeneiHs.463785.

3D structure databases

ProteinModelPortaliQ8IY81.
SMRiQ8IY81.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125581. 122 interactors.
IntActiQ8IY81. 20 interactors.
MINTiMINT-1468947.
STRINGi9606.ENSP00000396673.

PTM databases

iPTMnetiQ8IY81.
PhosphoSitePlusiQ8IY81.
SwissPalmiQ8IY81.

Polymorphism and mutation databases

BioMutaiFTSJ3.
DMDMi296452883.

2D gel databases

SWISS-2DPAGEQ8IY81.

Proteomic databases

EPDiQ8IY81.
MaxQBiQ8IY81.
PaxDbiQ8IY81.
PeptideAtlasiQ8IY81.
PRIDEiQ8IY81.

Protocols and materials databases

DNASUi117246.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000427159; ENSP00000396673; ENSG00000108592.
GeneIDi117246.
KEGGihsa:117246.
UCSCiuc002jca.3. human.

Organism-specific databases

CTDi117246.
DisGeNETi117246.
GeneCardsiFTSJ3.
HGNCiHGNC:17136. FTSJ3.
HPAiHPA055544.
HPA062628.
neXtProtiNX_Q8IY81.
OpenTargetsiENSG00000108592.
PharmGKBiPA28419.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1098. Eukaryota.
COG0293. LUCA.
GeneTreeiENSGT00550000075004.
HOVERGENiHBG075246.
InParanoidiQ8IY81.
KOiK14857.
OMAiMIDRIYK.
OrthoDBiEOG091G03NZ.
PhylomeDBiQ8IY81.
TreeFamiTF106102.

Miscellaneous databases

ChiTaRSiFTSJ3. human.
GeneWikiiFTSJ3.
GenomeRNAii117246.
PROiQ8IY81.

Gene expression databases

BgeeiENSG00000108592.
CleanExiHS_FTSJ3.
ExpressionAtlasiQ8IY81. baseline and differential.
GenevisibleiQ8IY81. HS.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01547. RNA_methyltr_E. 1 hit.
MF_03163. RNA_methyltr_E_SPB1. 1 hit.
InterProiIPR015507. rRNA-MeTfrase_E.
IPR012920. rRNA_MeTfrase_Spb1_C.
IPR024576. rRNA_MeTfrase_Spb1_DUF3381.
IPR002877. rRNA_MeTrfase_FtsJ_dom.
IPR029063. SAM-dependent_MTases.
IPR028589. Spb1.
[Graphical view]
PANTHERiPTHR10920. PTHR10920. 3 hits.
PTHR10920:SF13. PTHR10920:SF13. 3 hits.
PfamiPF11861. DUF3381. 1 hit.
PF01728. FtsJ. 1 hit.
PF07780. Spb1_C. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSPB1_HUMAN
AccessioniPrimary (citable) accession number: Q8IY81
Secondary accession number(s): B2RCA5
, D3DU22, Q8N3A3, Q8WXX1, Q9BWM4, Q9NXT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.