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Protein

pre-rRNA processing protein FTSJ3

Gene

FTSJ3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.UniRule annotation1 Publication

Catalytic activityi

S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methylnucleoside.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei56S-adenosyl-L-methionine; via amide nitrogenUniRule annotation1
Binding sitei58S-adenosyl-L-methionine; via amide nitrogenUniRule annotation1
Binding sitei76S-adenosyl-L-methionineUniRule annotation1
Binding sitei92S-adenosyl-L-methionineUniRule annotation1
Binding sitei117S-adenosyl-L-methionineUniRule annotation1
Active sitei157Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processRibosome biogenesis, rRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

ReactomeiR-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
pre-rRNA processing protein FTSJ3UniRule annotation (EC:2.1.1.-UniRule annotation)
Alternative name(s):
2'-O-ribose RNA methyltransferase SPB1 homologUniRule annotation
Protein ftsJ homolog 3UniRule annotation
Putative rRNA methyltransferase 3UniRule annotation
Gene namesi
Name:FTSJ3UniRule annotation
ORF Names:SB92
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000108592.16
HGNCiHGNC:17136 FTSJ3
neXtProtiNX_Q8IY81

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi117246
OpenTargetsiENSG00000108592
PharmGKBiPA28419

Polymorphism and mutation databases

BioMutaiFTSJ3
DMDMi296452883

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001555771 – 847pre-rRNA processing protein FTSJ3Add BLAST847

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei333PhosphoserineCombined sources1
Modified residuei335PhosphoserineCombined sources1
Modified residuei336PhosphoserineCombined sources1
Modified residuei347PhosphoserineCombined sources1
Modified residuei356PhosphoserineCombined sources1
Cross-linki357Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei392CitrullineBy similarity1
Modified residuei549PhosphoserineCombined sources1
Modified residuei573PhosphothreonineCombined sources1
Cross-linki579Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei584PhosphoserineCombined sources1
Cross-linki643Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei644PhosphoserineCombined sources1
Cross-linki659Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei676PhosphoserineCombined sources1
Cross-linki678Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei688PhosphoserineCombined sources1
Cross-linki710Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei783CitrullineBy similarity1

Post-translational modificationi

Citrullinated by PADI4.By similarity

Keywords - PTMi

Citrullination, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8IY81
MaxQBiQ8IY81
PaxDbiQ8IY81
PeptideAtlasiQ8IY81
PRIDEiQ8IY81

2D gel databases

SWISS-2DPAGEQ8IY81

PTM databases

iPTMnetiQ8IY81
PhosphoSitePlusiQ8IY81
SwissPalmiQ8IY81

Expressioni

Gene expression databases

BgeeiENSG00000108592
CleanExiHS_FTSJ3
ExpressionAtlasiQ8IY81 baseline and differential
GenevisibleiQ8IY81 HS

Organism-specific databases

HPAiHPA055544
HPA062628

Interactioni

Subunit structurei

Interacts with NIP7.UniRule annotation1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi125581, 145 interactors
IntActiQ8IY81, 34 interactors
MINTiQ8IY81
STRINGi9606.ENSP00000396673

Structurei

3D structure databases

ProteinModelPortaliQ8IY81
SMRiQ8IY81
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili355 – 407UniRule annotationAdd BLAST53
Coiled coili739 – 777UniRule annotationAdd BLAST39

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.UniRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1098 Eukaryota
COG0293 LUCA
GeneTreeiENSGT00550000075004
HOVERGENiHBG075246
InParanoidiQ8IY81
KOiK14857
OMAiWFVQEEK
OrthoDBiEOG091G03NZ
PhylomeDBiQ8IY81
TreeFamiTF106102

Family and domain databases

HAMAPiMF_01547 RNA_methyltr_E, 1 hit
MF_03163 RNA_methyltr_E_SPB1, 1 hit
InterProiView protein in InterPro
IPR015507 rRNA-MeTfrase_E
IPR012920 rRNA_MeTfrase_Spb1_C
IPR024576 rRNA_MeTfrase_Spb1_DUF3381
IPR002877 rRNA_MeTrfase_FtsJ_dom
IPR029063 SAM-dependent_MTases
IPR028589 Spb1
PfamiView protein in Pfam
PF11861 DUF3381, 1 hit
PF01728 FtsJ, 1 hit
PF07780 Spb1_C, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit

Sequencei

Sequence statusi: Complete.

Q8IY81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKKGKVGKS RRDKFYHLAK ETGYRSRSAF KLIQLNRRFQ FLQKARALLD
60 70 80 90 100
LCAAPGGWLQ VAAKFMPVSS LIVGVDLVPI KPLPNVVTLQ QDITTERCRQ
110 120 130 140 150
ALRKELKTWK VDVVLNDGAP NVGASWVHDA YSQAHLTLMA LRLACDFLAR
160 170 180 190 200
GGSFITKVFR SRDYQPLLWI FQQLFRRVQA TKPQASRHES AEIFVVCQGF
210 220 230 240 250
LAPDKVDSKF FDPKFAFKEV EVQAKTVTEL VTKKKPKAEG YAEGDLTLYH
260 270 280 290 300
RTSVTDFLRA ANPVDFLSKA SEIMVDDEEL AQHPATTEDI RVCCQDIRVL
310 320 330 340 350
GRKELRSLLN WRTKLRRYVA KKLKEQAKAL DISLSSGEED EGDEEDSTAG
360 370 380 390 400
TTKQPSKEEE EEEEEEQLNQ TLAEMKAQEV AELKRKKKKL LREQRKQRER
410 420 430 440 450
VELKMDLPGV SIADEGETGM FSLSTIRGHQ LLEEVTQGDM SAADTFLSDL
460 470 480 490 500
PRDDIYVSDV EDDGDDTSLD SDLDPEELAG VRGHQGLRDQ KRMRLTEVQD
510 520 530 540 550
DKEEEEEENP LLVPLEEKAV LQEEQANLWF SKGSFAGIED DADEALEISQ
560 570 580 590 600
AQLLFENRRK GRQQQQKQQL PQTPPSCLKT EIMSPLYQDE APKGTEASSG
610 620 630 640 650
TEAATGLEGE EKDGISDSDS STSSEEEESW EPLRGKKRSR GPKSDDDGFE
660 670 680 690 700
IVPIEDPAKH RILDPEGLAL GAVIASSKKA KRDLIDNSFN RYTFNEDEGE
710 720 730 740 750
LPEWFVQEEK QHRIRQLPVG KKEVEHYRKR WREINARPIK KVAEAKARKK
760 770 780 790 800
RRMLKRLEQT RKKAEAVVNT VDISEREKVA QLRSLYKKAG LGKEKRHVTY
810 820 830 840
VVAKKGVGRK VRRPAGVRGH FKVVDSRMKK DQRAQQRKEQ KKKHKRK
Length:847
Mass (Da):96,558
Last modified:May 18, 2010 - v2
Checksum:i06B2F4D28A48026F
GO

Sequence cautioni

The sequence BAA90924 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti278E → I in AAL56015 (Ref. 1) Curated1
Sequence conflicti278E → I in BAA90924 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02328491Q → E3 PublicationsCorresponds to variant dbSNP:rs2584625Ensembl.1
Natural variantiVAR_023285424S → C4 PublicationsCorresponds to variant dbSNP:rs2727288Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF327355 mRNA Translation: AAL56015.1
AK000069 mRNA Translation: BAA90924.1 Different initiation.
AK315010 mRNA Translation: BAG37502.1
AC015651 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94273.1
CH471109 Genomic DNA Translation: EAW94274.1
CH471109 Genomic DNA Translation: EAW94275.1
BC000131 mRNA Translation: AAH00131.2
BC036710 mRNA Translation: AAH36710.1
AL834482 mRNA Translation: CAD39141.1
CCDSiCCDS11644.1
RefSeqiNP_060117.3, NM_017647.3
UniGeneiHs.463785

Genome annotation databases

EnsembliENST00000427159; ENSP00000396673; ENSG00000108592
GeneIDi117246
KEGGihsa:117246
UCSCiuc002jca.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSPB1_HUMAN
AccessioniPrimary (citable) accession number: Q8IY81
Secondary accession number(s): B2RCA5
, D3DU22, Q8N3A3, Q8WXX1, Q9BWM4, Q9NXT6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: May 18, 2010
Last modified: May 23, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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