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Protein

Ribonucleoprotein PTB-binding 1

Gene

RAVER1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA (By similarity).By similarity

GO - Molecular functioni

  • nucleic acid binding Source: GO_Central
  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoprotein PTB-binding 1
Alternative name(s):
Protein raver-1
Gene namesi
Name:RAVER1
Synonyms:KIAA1978
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:30296. RAVER1.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity

  • Note: Nuclear, in perinucleolar structures. Shuttles between nucleus and cytoplasm. Cytoplasm, at focal contacts and cell-cell contacts. Associated with myotubes during muscle differentiation (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000161847.
PharmGKBiPA144596390.

Polymorphism and mutation databases

BioMutaiRAVER1.
DMDMi74759693.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000814872 – 606Ribonucleoprotein PTB-binding 1Add BLAST605

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei6PhosphoserineCombined sources1
Modified residuei14PhosphoserineCombined sources1
Modified residuei463PhosphothreonineCombined sources1
Modified residuei474PhosphoserineCombined sources1
Modified residuei562PhosphoserineBy similarity1
Isoform 2 (identifier: Q8IY67-2)
Modified residuei488PhosphothreonineCombined sources1
Modified residuei567PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8IY67.
MaxQBiQ8IY67.
PaxDbiQ8IY67.
PeptideAtlasiQ8IY67.
PRIDEiQ8IY67.

PTM databases

iPTMnetiQ8IY67.
PhosphoSitePlusiQ8IY67.

Expressioni

Gene expression databases

CleanExiHS_RAVER1.
ExpressionAtlasiQ8IY67. baseline and differential.
GenevisibleiQ8IY67. HS.

Organism-specific databases

HPAiHPA043575.
HPA049457.

Interactioni

Subunit structurei

Interacts with PTBP1, RAVER2, VCL and ACTN1. Part of a complex containing RAVER1, VCL and ACTN1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi125936. 57 interactors.
DIPiDIP-46973N.
IntActiQ8IY67. 6 interactors.
MINTiMINT-2812331.
STRINGi9606.ENSP00000293677.

Structurei

Secondary structure

1606
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi41 – 56Combined sources16
Beta strandi60 – 64Combined sources5
Helixi72 – 78Combined sources7
Turni79 – 81Combined sources3
Beta strandi84 – 90Combined sources7
Turni91 – 94Combined sources4
Beta strandi95 – 102Combined sources8
Helixi103 – 113Combined sources11
Beta strandi124 – 127Combined sources4
Beta strandi133 – 138Combined sources6
Helixi145 – 152Combined sources8
Helixi153 – 155Combined sources3
Beta strandi158 – 165Combined sources8
Turni167 – 169Combined sources3
Beta strandi172 – 182Combined sources11
Helixi183 – 193Combined sources11
Beta strandi204 – 207Combined sources4
Helixi210 – 212Combined sources3
Turni215 – 218Combined sources4
Beta strandi221 – 226Combined sources6
Helixi235 – 241Combined sources7
Beta strandi244 – 246Combined sources3
Beta strandi249 – 255Combined sources7
Beta strandi261 – 268Combined sources8
Helixi272 – 282Combined sources11
Beta strandi293 – 296Combined sources4
Beta strandi299 – 301Combined sources3
Helixi303 – 313Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3H2UX-ray2.75B/D39-321[»]
3H2VX-ray2.90E/F/G/H59-130[»]
3SMZX-ray1.99A39-320[»]
3VF0X-ray2.54B39-321[»]
ProteinModelPortaliQ8IY67.
SMRiQ8IY67.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8IY67.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini59 – 130RRM 1PROSITE-ProRule annotationAdd BLAST72
Domaini132 – 210RRM 2PROSITE-ProRule annotationAdd BLAST79
Domaini221 – 299RRM 3PROSITE-ProRule annotationAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni307 – 395Interaction with PTBP1By similarityAdd BLAST89

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi45 – 60Nuclear localization signalSequence analysisAdd BLAST16

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi406 – 468Pro-richAdd BLAST63

Sequence similaritiesi

Contains 3 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IJBP. Eukaryota.
ENOG410ZP6I. LUCA.
GeneTreeiENSGT00390000006046.
HOGENOMiHOG000253941.
HOVERGENiHBG059515.
InParanoidiQ8IY67.
PhylomeDBiQ8IY67.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IY67-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAADVSVTHR PPLSPKSGAE VEAGDAAERR APEEELPPLD PEEIRKRLEH
60 70 80 90 100
TERQFRNRRK ILIRGLPGDV TNQEVHDLLS DYELKYCFVD KYKGTAFVTL
110 120 130 140 150
LNGEQAEAAI NAFHQSRLRE RELSVQLQPT DALLCVANLP PSLTQQQFEE
160 170 180 190 200
LVRPFGSLER CFLVYSERTG QSKGYGFAEY MKKDSAARAK SDLLGKPLGP
210 220 230 240 250
RTLYVHWTDA GQLTPALLHS RCLCVDRLPP GFNDVDALCR ALSAVHSPTF
260 270 280 290 300
CQLACGQDGQ LKGFAVLEYE TAEMAEEAQQ QADGLSLGGS HLRVSFCAPG
310 320 330 340 350
PPGRSMLAAL IAAQATALNR GKGLLPEPNI LQLLNNLGPS ASLQLLLNPL
360 370 380 390 400
LHGSAGGKQG LLGAPPAMPL LNGPALSTAL LQLALQTQGQ KKPGILGDSP
410 420 430 440 450
LGALQPGAQP ANPLLGELPA GGGLPPELPP RRGKPPPLLP SVLGPAGGDR
460 470 480 490 500
EALGLGPPAA QLTPPPAPVG LRGSGLRGPL SHFYSGSPTS YFTSGLQAGL
510 520 530 540 550
KQSHLSKAIG SSPLGSGEGL LGLSPGPNGH SHLLKVRAGG GDMQGWEAPA
560 570 580 590 600
PQRPLTRPAL PSVSRPHWAA RNAALPTCCP RPSPAQKAAM WASTPRASAA

TTRTPT
Length:606
Mass (Da):63,877
Last modified:March 1, 2003 - v1
Checksum:i09FA9935A6281B42
GO
Isoform 2 (identifier: Q8IY67-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     477-477: R → RGLQKDSGPL...GERSSGGSGG
     536-606: VRAGGGDMQG...ASAATTRTPT → TPLGGQKRSF...DSYLKRKRIF

Show »
Length:739
Mass (Da):77,860
Checksum:i62EAC25B58B730C8
GO
Isoform 3 (identifier: Q8IY67-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-75: EV → PS
     76-606: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:75
Mass (Da):8,419
Checksum:i5FDDB0267473DDDC
GO

Sequence cautioni

The sequence AAH37565 differs from that shown. Probable cloning artifact.Curated
The sequence BAB85564 differs from that shown. Intron retention.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04096874 – 75EV → PS in isoform 3. 1 Publication2
Alternative sequenceiVSP_04096976 – 606Missing in isoform 3. 1 PublicationAdd BLAST531
Alternative sequenceiVSP_017035477R → RGLQKDSGPLPTPPGVSLLG EPPKDYRIPLNPYLNLHSLL PASNLAGKEARGWGGAGRSR RPAEGPLTNPPAPGGGSSSS KAFQLKSRLLSPLSSARLPP EPGLSDSYSFDYPSDMGPRR LFSHPREPALGPHGPSRHKM SPPPSGFGERSSGGSGG in isoform 2. 1 Publication1
Alternative sequenceiVSP_017036536 – 606VRAGG…TRTPT → TPLGGQKRSFAHLLPSPEPS PEGSYVGQHSQGLGGHYADS YLKRKRIF in isoform 2. 1 PublicationAdd BLAST71

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB075858 mRNA. Translation: BAB85564.1. Sequence problems.
AC011511 Genomic DNA. No translation available.
BC037428 mRNA. No translation available.
BC037565 mRNA. Translation: AAH37565.1. Sequence problems.
RefSeqiNP_597709.2. NM_133452.2.
UniGeneiHs.744952.

Genome annotation databases

EnsembliENST00000615032; ENSP00000479520; ENSG00000161847. [Q8IY67-1]
GeneIDi125950.
KEGGihsa:125950.
UCSCiuc060tgw.1. human. [Q8IY67-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB075858 mRNA. Translation: BAB85564.1. Sequence problems.
AC011511 Genomic DNA. No translation available.
BC037428 mRNA. No translation available.
BC037565 mRNA. Translation: AAH37565.1. Sequence problems.
RefSeqiNP_597709.2. NM_133452.2.
UniGeneiHs.744952.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3H2UX-ray2.75B/D39-321[»]
3H2VX-ray2.90E/F/G/H59-130[»]
3SMZX-ray1.99A39-320[»]
3VF0X-ray2.54B39-321[»]
ProteinModelPortaliQ8IY67.
SMRiQ8IY67.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125936. 57 interactors.
DIPiDIP-46973N.
IntActiQ8IY67. 6 interactors.
MINTiMINT-2812331.
STRINGi9606.ENSP00000293677.

PTM databases

iPTMnetiQ8IY67.
PhosphoSitePlusiQ8IY67.

Polymorphism and mutation databases

BioMutaiRAVER1.
DMDMi74759693.

Proteomic databases

EPDiQ8IY67.
MaxQBiQ8IY67.
PaxDbiQ8IY67.
PeptideAtlasiQ8IY67.
PRIDEiQ8IY67.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000615032; ENSP00000479520; ENSG00000161847. [Q8IY67-1]
GeneIDi125950.
KEGGihsa:125950.
UCSCiuc060tgw.1. human. [Q8IY67-1]

Organism-specific databases

CTDi125950.
GeneCardsiRAVER1.
H-InvDBHIX0202703.
HGNCiHGNC:30296. RAVER1.
HPAiHPA043575.
HPA049457.
MIMi609950. gene.
neXtProtiNX_Q8IY67.
OpenTargetsiENSG00000161847.
PharmGKBiPA144596390.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJBP. Eukaryota.
ENOG410ZP6I. LUCA.
GeneTreeiENSGT00390000006046.
HOGENOMiHOG000253941.
HOVERGENiHBG059515.
InParanoidiQ8IY67.
PhylomeDBiQ8IY67.

Miscellaneous databases

ChiTaRSiRAVER1. human.
EvolutionaryTraceiQ8IY67.
GeneWikiiRAVER1.
GenomeRNAii125950.
PROiQ8IY67.
SOURCEiSearch...

Gene expression databases

CleanExiHS_RAVER1.
ExpressionAtlasiQ8IY67. baseline and differential.
GenevisibleiQ8IY67. HS.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAVR1_HUMAN
AccessioniPrimary (citable) accession number: Q8IY67
Secondary accession number(s): A6NMU4, Q8IY60, Q8TF24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.