ID   AMOL1_HUMAN             Reviewed;         956 AA.
AC   Q8IY63; Q63HK7; Q8NDN0; Q8WXD1; Q96CM5;
DT   27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   07-JUL-2009, entry version 45.
DE   RecName: Full=Angiomotin-like protein 1;
GN   Name=AMOTL1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Skeletal muscle, and Testis;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Blocker H.,
RA   Heubner D., Hoerlein A., Michel G., Wedler H., Kohrer K.,
RA   Ottenwalder B., Poustka A., Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Muscle, and Skin;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-557 (ISOFORM 1).
RC   TISSUE=Brain;
RX   MEDLINE=22294023; PubMed=12406577; DOI=10.1016/S0378-1119(02)00928-9;
RA   Bratt A., Wilson W.J., Troyanovsky B., Aase K., Kessler R.,
RA   Van Meir E.G., Holmgren L.;
RT   "Angiomotin belongs to a novel protein family with conserved coiled-
RT   coil and PDZ binding domains.";
RL   Gene 298:69-77(2002).
RN   [4]
RP   ERRATUM.
RA   Bratt A., Wilson W.J., Troyanovsky B., Aase K., Kessler R.,
RA   Van Meir E.G., Holmgren L.;
RL   Gene 310:231-231(2003).
RN   [5]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-51; SER-52 AND SER-61,
RP   AND MASS SPECTROMETRY.
RC   TISSUE=Epithelium;
RX   PubMed=17924679; DOI=10.1021/pr070152u;
RA   Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
RT   "Improved titanium dioxide enrichment of phosphopeptides from HeLa
RT   cells and high confident phosphopeptide identification by cross-
RT   validation of MS/MS and MS/MS/MS spectra.";
RL   J. Proteome Res. 6:4150-4162(2007).
RN   [6]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-803 AND SER-805, AND
RP   MASS SPECTROMETRY.
RX   PubMed=18220336; DOI=10.1021/pr0705441;
RA   Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,
RA   Yates J.R. III;
RT   "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for
RT   efficient phosphoproteomic analysis.";
RL   J. Proteome Res. 7:1346-1351(2008).
RN   [7]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-295, AND MASS
RP   SPECTROMETRY.
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
CC   -!- INTERACTION:
CC       Q86UL8:MAGI2; NbExp=1; IntAct=EBI-1057112, EBI-311035;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8IY63-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8IY63-2; Sequence=VSP_015710;
CC         Note=No experimental confirmation available;
CC   -!- SIMILARITY: Belongs to the angiomotin family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AL833833; CAD38693.1; -; mRNA.
DR   EMBL; BX648729; CAH56180.1; -; mRNA.
DR   EMBL; BC014126; AAH14126.1; -; mRNA.
DR   EMBL; BC037539; AAH37539.1; -; mRNA.
DR   EMBL; AF453742; AAL49764.1; -; mRNA.
DR   IPI; IPI00217664; -.
DR   IPI; IPI00651638; -.
DR   RefSeq; NP_570899.1; -.
DR   UniGene; Hs.503594; -.
DR   HSSP; P25054; 1DEB.
DR   IntAct; Q8IY63; 1.
DR   PhosphoSite; Q8IY63; -.
DR   Ensembl; ENSG00000166025; Homo sapiens.
DR   GeneID; 154810; -.
DR   KEGG; hsa:154810; -.
DR   UCSC; uc001pfb.1; human.
DR   UCSC; uc001pfc.1; human.
DR   GeneCards; GC11P094141; -.
DR   H-InvDB; HIX0010033; -.
DR   HGNC; HGNC:17811; AMOTL1.
DR   HPA; HPA001196; -.
DR   PharmGKB; PA24774; -.
DR   HOGENOM; Q8IY63; -.
DR   HOVERGEN; Q8IY63; -.
DR   NextBio; 87322; -.
DR   ArrayExpress; Q8IY63; -.
DR   Bgee; Q8IY63; -.
DR   CleanEx; HS_AMOTL1; -.
DR   GermOnline; ENSG00000166025; Homo sapiens.
DR   GO; GO:0005737; C:cytoplasm; IDA:HPA.
DR   GO; GO:0005923; C:tight junction; IDA:MGI.
DR   GO; GO:0042802; F:identical protein binding; IDA:MGI.
DR   InterPro; IPR009114; Angiomotin.
DR   PANTHER; PTHR14826; Angiomotin; 1.
DR   PRINTS; PR01807; ANGIOMOTIN.
PE   1: Evidence at protein level;
KW   Alternative splicing; Coiled coil; Complete proteome; Phosphoprotein;
KW   Polymorphism.
FT   CHAIN         1    956       Angiomotin-like protein 1.
FT                                /FTId=PRO_0000190670.
FT   COILED      259    279       Potential.
FT   COILED      438    639       Potential.
FT   COILED      665    694       Potential.
FT   COILED      729    762       Potential.
FT   MOTIF       953    956       PDZ-binding.
FT   MOD_RES      51     51       Phosphothreonine.
FT   MOD_RES      52     52       Phosphoserine.
FT   MOD_RES      61     61       Phosphoserine.
FT   MOD_RES     295    295       Phosphoserine.
FT   MOD_RES     803    803       Phosphothreonine.
FT   MOD_RES     805    805       Phosphoserine.
FT   VAR_SEQ      17     66       Missing (in isoform 2).
FT                                /FTId=VSP_015710.
FT   VARIANT     847    847       P -> L (in dbSNP:rs11020968).
FT                                /FTId=VAR_033498.
FT   CONFLICT    459    460       LQ -> HE (in Ref. 2; AAH14126).
FT   CONFLICT    649    649       K -> E (in Ref. 1; CAH56180).
SQ   SEQUENCE   956 AA;  106574 MW;  6F47AE3A13816E95 CRC64;
     MWRAKLRRGT CEPAVKGSPS ACYSPSSPVQ VLEDSTYFSP DFQLYSGRHE TSALTVEATS
     SIREKVVEDP LCNFHSPNFL RISEVEMRGS EDAAAGTVLQ RLIQEQLRYG TPTENMNLLA
     IQHQATGSAG PAHPTNNFSS TENLTQEDPQ MVYQSARQEP QGQEHQVDNT VMEKQVRSTQ
     PQQNNEELPT YEEAKAQSQF FRGQQQQQQQ QGAVGHGYYM AGGTSQKSRT EGRPTVNRAN
     SGQAHKDEAL KELKQGHVRS LSERIMQLSL ERNGAKQHLP GSGNGKGFKV GGGPSPAQPA
     GKVLDPRGPP PEYPFKTKQM MSPVSKTQEH GLFYGDQHPG MLHEMVKPYP APQPVRTDVA
     VLRYQPPPEY GVTSRPCQLP FPSTMQQHSP MSSQTSSASG PLHSVSLPLP LPMALGAPQP
     PPAASPSQQL GPDAFAIVER AQQMVEILTE ENRVLHQELQ GYYDNADKLH KFEKELQRIS
     EAYESLVKST TKRESLDKAM RNKLEGEIRR LHDFNRDLRD RLETANRQLS SREYEGHEDK
     AAEGHYASQN KEFLKEKEKL EMELAAVRTA SEDHRRHIEI LDQALSNAQA RVIKLEEELR
     EKQAYVEKVE KLQQALTQLQ SACEKREQME RRLRTWLERE LDALRTQQKH GNGQPANMPE
     YNAPALLELV REKEERILAL EADMTKWEQK YLEESTIRHF AMNAAATAAA ERDTTIINHS
     RNGSYGESSL EAHIWQEEEE VVQANRRCQD MEYTIKNLHA KIIEKDAMIK VLQQRSRKDA
     GKTDSSSLRP ARSVPSIAAA TGTHSRQTSL TSSQLAEEKK EEKTWKGSIG LLLGKEHHEH
     ASAPLLPPPP TSALSSIAST TAASSAHAKT GSKDSSTQTD KSAELFWPSM ASLPSRGRLS
     TTPAHSPVLK HPAAKGTAEK LENSPGHGKS PDHRGRVSSL LHKPEFPDGE MMEVLI
//