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Q8IY63

- AMOL1_HUMAN

UniProt

Q8IY63 - AMOL1_HUMAN

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Protein
Angiomotin-like protein 1
Gene
AMOTL1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus.1 Publication

GO - Molecular functioni

  1. identical protein binding Source: MGI
  2. protein binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. Wnt signaling pathway Source: UniProtKB-KW
  2. establishment of cell polarity involved in ameboidal cell migration Source: Ensembl
  3. hippo signaling Source: Reactome
  4. positive regulation of blood vessel endothelial cell migration Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_118607. Signaling by Hippo.

Names & Taxonomyi

Protein namesi
Recommended name:
Angiomotin-like protein 1
Gene namesi
Name:AMOTL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:17811. AMOTL1.

Subcellular locationi

Cell junctiontight junction By similarity

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. cell junction Source: HPA
  3. cytoplasm Source: HPA
  4. cytoplasmic vesicle Source: Ensembl
  5. cytosol Source: Reactome
  6. lamellipodium Source: Ensembl
  7. tight junction Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Tight junction

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24774.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 956956Angiomotin-like protein 1
PRO_0000190670Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei241 – 2411Phosphoserine1 Publication
Modified residuei295 – 2951Phosphoserine1 Publication
Modified residuei720 – 7201Phosphoserine1 Publication
Modified residuei906 – 9061Phosphoserine1 Publication

Post-translational modificationi

Polyubiquitinated by NEDD4, leading to proteasomal degradation.

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ8IY63.
PaxDbiQ8IY63.
PRIDEiQ8IY63.

PTM databases

PhosphoSiteiQ8IY63.

Expressioni

Gene expression databases

ArrayExpressiQ8IY63.
BgeeiQ8IY63.
CleanExiHS_AMOTL1.
GenevestigatoriQ8IY63.

Organism-specific databases

HPAiHPA001196.

Interactioni

Protein-protein interaction databases

BioGridi127559. 13 interactions.
IntActiQ8IY63. 8 interactions.
MINTiMINT-2809859.
STRINGi9606.ENSP00000387739.

Structurei

3D structure databases

ProteinModelPortaliQ8IY63.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili259 – 27921 Reviewed prediction
Add
BLAST
Coiled coili438 – 639202 Reviewed prediction
Add
BLAST
Coiled coili665 – 69430 Reviewed prediction
Add
BLAST
Coiled coili729 – 76234 Reviewed prediction
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi953 – 9564PDZ-binding

Sequence similaritiesi

Belongs to the angiomotin family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG131728.
HOGENOMiHOG000233789.
HOVERGENiHBG066485.
InParanoidiQ8IY63.
KOiK06104.
OMAiQEHGLFY.
OrthoDBiEOG7M6D6Q.
PhylomeDBiQ8IY63.
TreeFamiTF333368.

Family and domain databases

InterProiIPR009114. Angiomotin.
IPR024646. Angiomotin_C.
[Graphical view]
PANTHERiPTHR14826. PTHR14826. 1 hit.
PfamiPF12240. Angiomotin_C. 1 hit.
[Graphical view]
PRINTSiPR01807. ANGIOMOTIN.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IY63-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MWRAKLRRGT CEPAVKGSPS ACYSPSSPVQ VLEDSTYFSP DFQLYSGRHE    50
TSALTVEATS SIREKVVEDP LCNFHSPNFL RISEVEMRGS EDAAAGTVLQ 100
RLIQEQLRYG TPTENMNLLA IQHQATGSAG PAHPTNNFSS TENLTQEDPQ 150
MVYQSARQEP QGQEHQVDNT VMEKQVRSTQ PQQNNEELPT YEEAKAQSQF 200
FRGQQQQQQQ QGAVGHGYYM AGGTSQKSRT EGRPTVNRAN SGQAHKDEAL 250
KELKQGHVRS LSERIMQLSL ERNGAKQHLP GSGNGKGFKV GGGPSPAQPA 300
GKVLDPRGPP PEYPFKTKQM MSPVSKTQEH GLFYGDQHPG MLHEMVKPYP 350
APQPVRTDVA VLRYQPPPEY GVTSRPCQLP FPSTMQQHSP MSSQTSSASG 400
PLHSVSLPLP LPMALGAPQP PPAASPSQQL GPDAFAIVER AQQMVEILTE 450
ENRVLHQELQ GYYDNADKLH KFEKELQRIS EAYESLVKST TKRESLDKAM 500
RNKLEGEIRR LHDFNRDLRD RLETANRQLS SREYEGHEDK AAEGHYASQN 550
KEFLKEKEKL EMELAAVRTA SEDHRRHIEI LDQALSNAQA RVIKLEEELR 600
EKQAYVEKVE KLQQALTQLQ SACEKREQME RRLRTWLERE LDALRTQQKH 650
GNGQPANMPE YNAPALLELV REKEERILAL EADMTKWEQK YLEESTIRHF 700
AMNAAATAAA ERDTTIINHS RNGSYGESSL EAHIWQEEEE VVQANRRCQD 750
MEYTIKNLHA KIIEKDAMIK VLQQRSRKDA GKTDSSSLRP ARSVPSIAAA 800
TGTHSRQTSL TSSQLAEEKK EEKTWKGSIG LLLGKEHHEH ASAPLLPPPP 850
TSALSSIAST TAASSAHAKT GSKDSSTQTD KSAELFWPSM ASLPSRGRLS 900
TTPAHSPVLK HPAAKGTAEK LENSPGHGKS PDHRGRVSSL LHKPEFPDGE 950
MMEVLI 956
Length:956
Mass (Da):106,574
Last modified:March 1, 2003 - v1
Checksum:i6F47AE3A13816E95
GO
Isoform 2 (identifier: Q8IY63-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     17-66: Missing.

Note: No experimental confirmation available.

Show »
Length:906
Mass (Da):101,179
Checksum:i8CFA1AE879538953
GO

Sequence cautioni

The sequence BAB84910.1 differs from that shown. Reason: Frameshift at positions 592 and 944.
The sequence BAB84910.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti847 – 8471P → L.
Corresponds to variant rs11020968 [ dbSNP | Ensembl ].
VAR_033498

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei17 – 6650Missing in isoform 2.
VSP_015710Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti459 – 4602LQ → HE in AAH14126. 1 Publication
Sequence conflicti649 – 6491K → E in CAH56180. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK074084 mRNA. Translation: BAB84910.1. Sequence problems.
AL833833 mRNA. Translation: CAD38693.1.
AP001152 Genomic DNA. No translation available.
AP002376 Genomic DNA. No translation available.
BX648729 mRNA. Translation: CAH56180.1.
BC014126 mRNA. Translation: AAH14126.1.
BC037539 mRNA. Translation: AAH37539.1.
AF453742 mRNA. Translation: AAL49764.1.
CCDSiCCDS44712.1. [Q8IY63-1]
RefSeqiNP_570899.1. NM_130847.2. [Q8IY63-1]
XP_005273857.1. XM_005273800.2. [Q8IY63-2]
UniGeneiHs.503594.

Genome annotation databases

EnsembliENST00000317829; ENSP00000320968; ENSG00000166025. [Q8IY63-2]
ENST00000433060; ENSP00000387739; ENSG00000166025. [Q8IY63-1]
GeneIDi154810.
KEGGihsa:154810.
UCSCiuc001pfb.3. human. [Q8IY63-1]
uc001pfc.3. human. [Q8IY63-2]

Polymorphism databases

DMDMi74728292.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK074084 mRNA. Translation: BAB84910.1 . Sequence problems.
AL833833 mRNA. Translation: CAD38693.1 .
AP001152 Genomic DNA. No translation available.
AP002376 Genomic DNA. No translation available.
BX648729 mRNA. Translation: CAH56180.1 .
BC014126 mRNA. Translation: AAH14126.1 .
BC037539 mRNA. Translation: AAH37539.1 .
AF453742 mRNA. Translation: AAL49764.1 .
CCDSi CCDS44712.1. [Q8IY63-1 ]
RefSeqi NP_570899.1. NM_130847.2. [Q8IY63-1 ]
XP_005273857.1. XM_005273800.2. [Q8IY63-2 ]
UniGenei Hs.503594.

3D structure databases

ProteinModelPortali Q8IY63.
ModBasei Search...

Protein-protein interaction databases

BioGridi 127559. 13 interactions.
IntActi Q8IY63. 8 interactions.
MINTi MINT-2809859.
STRINGi 9606.ENSP00000387739.

PTM databases

PhosphoSitei Q8IY63.

Polymorphism databases

DMDMi 74728292.

Proteomic databases

MaxQBi Q8IY63.
PaxDbi Q8IY63.
PRIDEi Q8IY63.

Protocols and materials databases

DNASUi 154810.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000317829 ; ENSP00000320968 ; ENSG00000166025 . [Q8IY63-2 ]
ENST00000433060 ; ENSP00000387739 ; ENSG00000166025 . [Q8IY63-1 ]
GeneIDi 154810.
KEGGi hsa:154810.
UCSCi uc001pfb.3. human. [Q8IY63-1 ]
uc001pfc.3. human. [Q8IY63-2 ]

Organism-specific databases

CTDi 154810.
GeneCardsi GC11P094441.
HGNCi HGNC:17811. AMOTL1.
HPAi HPA001196.
MIMi 614657. gene.
neXtProti NX_Q8IY63.
PharmGKBi PA24774.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG131728.
HOGENOMi HOG000233789.
HOVERGENi HBG066485.
InParanoidi Q8IY63.
KOi K06104.
OMAi QEHGLFY.
OrthoDBi EOG7M6D6Q.
PhylomeDBi Q8IY63.
TreeFami TF333368.

Enzyme and pathway databases

Reactomei REACT_118607. Signaling by Hippo.

Miscellaneous databases

ChiTaRSi AMOTL1. human.
GeneWikii AMOTL1.
GenomeRNAii 154810.
NextBioi 87322.
PROi Q8IY63.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8IY63.
Bgeei Q8IY63.
CleanExi HS_AMOTL1.
Genevestigatori Q8IY63.

Family and domain databases

InterProi IPR009114. Angiomotin.
IPR024646. Angiomotin_C.
[Graphical view ]
PANTHERi PTHR14826. PTHR14826. 1 hit.
Pfami PF12240. Angiomotin_C. 1 hit.
[Graphical view ]
PRINTSi PR01807. ANGIOMOTIN.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of a long cDNA clone isolated from human spleen."
    Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Spleen.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Skeletal muscle and Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Muscle and Skin.
  5. "Angiomotin belongs to a novel protein family with conserved coiled-coil and PDZ binding domains."
    Bratt A., Wilson W.J., Troyanovsky B., Aase K., Kessler R., Van Meir E.G., Holmgren L.
    Gene 298:69-77(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-557 (ISOFORM 1).
    Tissue: Brain.
  6. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-241; SER-295; SER-720 AND SER-906, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "The Nedd4-like ubiquitin E3 ligases target angiomotin/p130 to ubiquitin-dependent degradation."
    Wang C., An J., Zhang P., Xu C., Gao K., Wu D., Wang D., Yu H., Liu J.O., Yu L.
    Biochem. J. 444:279-289(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION BY NEDD4.
  11. "The Amotl2 gene inhibits Wnt/beta-catenin signaling and regulates embryonic development in zebrafish."
    Li Z., Wang Y., Zhang M., Xu P., Huang H., Wu D., Meng A.
    J. Biol. Chem. 287:13005-13015(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiAMOL1_HUMAN
AccessioniPrimary (citable) accession number: Q8IY63
Secondary accession number(s): Q63HK7
, Q8NDN0, Q8TEN8, Q8WXD1, Q96CM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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