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Protein

Angiomotin-like protein 1

Gene

AMOTL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus.1 Publication

GO - Molecular functioni

  • identical protein binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiR-HSA-2028269. Signaling by Hippo.

Names & Taxonomyi

Protein namesi
Recommended name:
Angiomotin-like protein 1
Gene namesi
Name:AMOTL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:17811. AMOTL1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Tight junction

Pathology & Biotechi

Organism-specific databases

DisGeNETi154810.
OpenTargetsiENSG00000166025.
PharmGKBiPA24774.

Polymorphism and mutation databases

BioMutaiAMOTL1.
DMDMi74728292.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001906701 – 956Angiomotin-like protein 1Add BLAST956

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei241PhosphoserineCombined sources1
Modified residuei269PhosphoserineCombined sources1
Modified residuei295PhosphoserineCombined sources1
Modified residuei720PhosphoserineCombined sources1
Modified residuei793PhosphoserineCombined sources1
Modified residuei805PhosphoserineCombined sources1
Modified residuei828PhosphoserineCombined sources1
Modified residuei900PhosphoserineCombined sources1
Modified residuei902PhosphothreonineCombined sources1
Modified residuei906PhosphoserineCombined sources1

Post-translational modificationi

Polyubiquitinated by NEDD4, leading to proteasomal degradation.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8IY63.
MaxQBiQ8IY63.
PaxDbiQ8IY63.
PeptideAtlasiQ8IY63.
PRIDEiQ8IY63.

PTM databases

iPTMnetiQ8IY63.
PhosphoSitePlusiQ8IY63.

Expressioni

Gene expression databases

BgeeiENSG00000166025.
CleanExiHS_AMOTL1.
ExpressionAtlasiQ8IY63. baseline and differential.
GenevisibleiQ8IY63. HS.

Organism-specific databases

HPAiHPA001196.

Interactioni

GO - Molecular functioni

  • identical protein binding Source: MGI

Protein-protein interaction databases

BioGridi127559. 31 interactors.
DIPiDIP-50682N.
IntActiQ8IY63. 14 interactors.
MINTiMINT-2809859.
STRINGi9606.ENSP00000387739.

Structurei

3D structure databases

ProteinModelPortaliQ8IY63.
SMRiQ8IY63.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili259 – 279Sequence analysisAdd BLAST21
Coiled coili438 – 639Sequence analysisAdd BLAST202
Coiled coili665 – 694Sequence analysisAdd BLAST30
Coiled coili729 – 762Sequence analysisAdd BLAST34

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi953 – 956PDZ-binding4

Sequence similaritiesi

Belongs to the angiomotin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJU5. Eukaryota.
ENOG410XSY2. LUCA.
GeneTreeiENSGT00530000063846.
HOGENOMiHOG000233789.
HOVERGENiHBG066485.
InParanoidiQ8IY63.
KOiK06104.
OMAiSKTQEHG.
OrthoDBiEOG091G02BL.
PhylomeDBiQ8IY63.
TreeFamiTF333368.

Family and domain databases

InterProiIPR009114. Angiomotin.
IPR024646. Angiomotin_C.
[Graphical view]
PfamiPF12240. Angiomotin_C. 1 hit.
[Graphical view]
PRINTSiPR01807. ANGIOMOTIN.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IY63-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWRAKLRRGT CEPAVKGSPS ACYSPSSPVQ VLEDSTYFSP DFQLYSGRHE
60 70 80 90 100
TSALTVEATS SIREKVVEDP LCNFHSPNFL RISEVEMRGS EDAAAGTVLQ
110 120 130 140 150
RLIQEQLRYG TPTENMNLLA IQHQATGSAG PAHPTNNFSS TENLTQEDPQ
160 170 180 190 200
MVYQSARQEP QGQEHQVDNT VMEKQVRSTQ PQQNNEELPT YEEAKAQSQF
210 220 230 240 250
FRGQQQQQQQ QGAVGHGYYM AGGTSQKSRT EGRPTVNRAN SGQAHKDEAL
260 270 280 290 300
KELKQGHVRS LSERIMQLSL ERNGAKQHLP GSGNGKGFKV GGGPSPAQPA
310 320 330 340 350
GKVLDPRGPP PEYPFKTKQM MSPVSKTQEH GLFYGDQHPG MLHEMVKPYP
360 370 380 390 400
APQPVRTDVA VLRYQPPPEY GVTSRPCQLP FPSTMQQHSP MSSQTSSASG
410 420 430 440 450
PLHSVSLPLP LPMALGAPQP PPAASPSQQL GPDAFAIVER AQQMVEILTE
460 470 480 490 500
ENRVLHQELQ GYYDNADKLH KFEKELQRIS EAYESLVKST TKRESLDKAM
510 520 530 540 550
RNKLEGEIRR LHDFNRDLRD RLETANRQLS SREYEGHEDK AAEGHYASQN
560 570 580 590 600
KEFLKEKEKL EMELAAVRTA SEDHRRHIEI LDQALSNAQA RVIKLEEELR
610 620 630 640 650
EKQAYVEKVE KLQQALTQLQ SACEKREQME RRLRTWLERE LDALRTQQKH
660 670 680 690 700
GNGQPANMPE YNAPALLELV REKEERILAL EADMTKWEQK YLEESTIRHF
710 720 730 740 750
AMNAAATAAA ERDTTIINHS RNGSYGESSL EAHIWQEEEE VVQANRRCQD
760 770 780 790 800
MEYTIKNLHA KIIEKDAMIK VLQQRSRKDA GKTDSSSLRP ARSVPSIAAA
810 820 830 840 850
TGTHSRQTSL TSSQLAEEKK EEKTWKGSIG LLLGKEHHEH ASAPLLPPPP
860 870 880 890 900
TSALSSIAST TAASSAHAKT GSKDSSTQTD KSAELFWPSM ASLPSRGRLS
910 920 930 940 950
TTPAHSPVLK HPAAKGTAEK LENSPGHGKS PDHRGRVSSL LHKPEFPDGE

MMEVLI
Length:956
Mass (Da):106,574
Last modified:March 1, 2003 - v1
Checksum:i6F47AE3A13816E95
GO
Isoform 2 (identifier: Q8IY63-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     17-66: Missing.

Note: No experimental confirmation available.
Show »
Length:906
Mass (Da):101,179
Checksum:i8CFA1AE879538953
GO

Sequence cautioni

The sequence BAB84910 differs from that shown. Reason: Frameshift at positions 592 and 944.Curated
The sequence BAB84910 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti459 – 460LQ → HE in AAH14126 (PubMed:15489334).Curated2
Sequence conflicti649K → E in CAH56180 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033498847P → L.Corresponds to variant rs11020968dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01571017 – 66Missing in isoform 2. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074084 mRNA. Translation: BAB84910.1. Sequence problems.
AL833833 mRNA. Translation: CAD38693.1.
AP001152 Genomic DNA. No translation available.
AP002376 Genomic DNA. No translation available.
BX648729 mRNA. Translation: CAH56180.1.
BC014126 mRNA. Translation: AAH14126.1.
BC037539 mRNA. Translation: AAH37539.1.
AF453742 mRNA. Translation: AAL49764.1.
CCDSiCCDS44712.1. [Q8IY63-1]
CCDS73368.1. [Q8IY63-2]
RefSeqiNP_001287936.1. NM_001301007.1. [Q8IY63-2]
NP_570899.1. NM_130847.2. [Q8IY63-1]
UniGeneiHs.503594.

Genome annotation databases

EnsembliENST00000317829; ENSP00000320968; ENSG00000166025. [Q8IY63-2]
ENST00000433060; ENSP00000387739; ENSG00000166025. [Q8IY63-1]
GeneIDi154810.
KEGGihsa:154810.
UCSCiuc001pfb.4. human. [Q8IY63-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074084 mRNA. Translation: BAB84910.1. Sequence problems.
AL833833 mRNA. Translation: CAD38693.1.
AP001152 Genomic DNA. No translation available.
AP002376 Genomic DNA. No translation available.
BX648729 mRNA. Translation: CAH56180.1.
BC014126 mRNA. Translation: AAH14126.1.
BC037539 mRNA. Translation: AAH37539.1.
AF453742 mRNA. Translation: AAL49764.1.
CCDSiCCDS44712.1. [Q8IY63-1]
CCDS73368.1. [Q8IY63-2]
RefSeqiNP_001287936.1. NM_001301007.1. [Q8IY63-2]
NP_570899.1. NM_130847.2. [Q8IY63-1]
UniGeneiHs.503594.

3D structure databases

ProteinModelPortaliQ8IY63.
SMRiQ8IY63.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127559. 31 interactors.
DIPiDIP-50682N.
IntActiQ8IY63. 14 interactors.
MINTiMINT-2809859.
STRINGi9606.ENSP00000387739.

PTM databases

iPTMnetiQ8IY63.
PhosphoSitePlusiQ8IY63.

Polymorphism and mutation databases

BioMutaiAMOTL1.
DMDMi74728292.

Proteomic databases

EPDiQ8IY63.
MaxQBiQ8IY63.
PaxDbiQ8IY63.
PeptideAtlasiQ8IY63.
PRIDEiQ8IY63.

Protocols and materials databases

DNASUi154810.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317829; ENSP00000320968; ENSG00000166025. [Q8IY63-2]
ENST00000433060; ENSP00000387739; ENSG00000166025. [Q8IY63-1]
GeneIDi154810.
KEGGihsa:154810.
UCSCiuc001pfb.4. human. [Q8IY63-1]

Organism-specific databases

CTDi154810.
DisGeNETi154810.
GeneCardsiAMOTL1.
HGNCiHGNC:17811. AMOTL1.
HPAiHPA001196.
MIMi614657. gene.
neXtProtiNX_Q8IY63.
OpenTargetsiENSG00000166025.
PharmGKBiPA24774.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJU5. Eukaryota.
ENOG410XSY2. LUCA.
GeneTreeiENSGT00530000063846.
HOGENOMiHOG000233789.
HOVERGENiHBG066485.
InParanoidiQ8IY63.
KOiK06104.
OMAiSKTQEHG.
OrthoDBiEOG091G02BL.
PhylomeDBiQ8IY63.
TreeFamiTF333368.

Enzyme and pathway databases

ReactomeiR-HSA-2028269. Signaling by Hippo.

Miscellaneous databases

ChiTaRSiAMOTL1. human.
GeneWikiiAMOTL1.
GenomeRNAii154810.
PROiQ8IY63.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166025.
CleanExiHS_AMOTL1.
ExpressionAtlasiQ8IY63. baseline and differential.
GenevisibleiQ8IY63. HS.

Family and domain databases

InterProiIPR009114. Angiomotin.
IPR024646. Angiomotin_C.
[Graphical view]
PfamiPF12240. Angiomotin_C. 1 hit.
[Graphical view]
PRINTSiPR01807. ANGIOMOTIN.
ProtoNetiSearch...

Entry informationi

Entry nameiAMOL1_HUMAN
AccessioniPrimary (citable) accession number: Q8IY63
Secondary accession number(s): Q63HK7
, Q8NDN0, Q8TEN8, Q8WXD1, Q96CM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.