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Q8IY63 (AMOL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Angiomotin-like protein 1
Gene names
Name:AMOTL1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length956 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Ref.12

Subcellular location

Cell junctiontight junction By similarity.

Post-translational modification

Polyubiquitinated by NEDD4, leading to proteasomal degradation.

Sequence similarities

Belongs to the angiomotin family.

Sequence caution

The sequence BAB84910.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence BAB84910.1 differs from that shown. Reason: Frameshift at positions 592 and 944.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8IY63-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8IY63-2)

The sequence of this isoform differs from the canonical sequence as follows:
     17-66: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 956956Angiomotin-like protein 1
PRO_0000190670

Regions

Coiled coil259 – 27921 Potential
Coiled coil438 – 639202 Potential
Coiled coil665 – 69430 Potential
Coiled coil729 – 76234 Potential
Motif953 – 9564PDZ-binding

Amino acid modifications

Modified residue2411Phosphoserine Ref.9
Modified residue2951Phosphoserine Ref.9
Modified residue7201Phosphoserine Ref.9
Modified residue9061Phosphoserine Ref.9

Natural variations

Alternative sequence17 – 6650Missing in isoform 2.
VSP_015710
Natural variant8471P → L.
Corresponds to variant rs11020968 [ dbSNP | Ensembl ].
VAR_033498

Experimental info

Sequence conflict459 – 4602LQ → HE in AAH14126. Ref.4
Sequence conflict6491K → E in CAH56180. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 6F47AE3A13816E95

FASTA956106,574
        10         20         30         40         50         60 
MWRAKLRRGT CEPAVKGSPS ACYSPSSPVQ VLEDSTYFSP DFQLYSGRHE TSALTVEATS 

        70         80         90        100        110        120 
SIREKVVEDP LCNFHSPNFL RISEVEMRGS EDAAAGTVLQ RLIQEQLRYG TPTENMNLLA 

       130        140        150        160        170        180 
IQHQATGSAG PAHPTNNFSS TENLTQEDPQ MVYQSARQEP QGQEHQVDNT VMEKQVRSTQ 

       190        200        210        220        230        240 
PQQNNEELPT YEEAKAQSQF FRGQQQQQQQ QGAVGHGYYM AGGTSQKSRT EGRPTVNRAN 

       250        260        270        280        290        300 
SGQAHKDEAL KELKQGHVRS LSERIMQLSL ERNGAKQHLP GSGNGKGFKV GGGPSPAQPA 

       310        320        330        340        350        360 
GKVLDPRGPP PEYPFKTKQM MSPVSKTQEH GLFYGDQHPG MLHEMVKPYP APQPVRTDVA 

       370        380        390        400        410        420 
VLRYQPPPEY GVTSRPCQLP FPSTMQQHSP MSSQTSSASG PLHSVSLPLP LPMALGAPQP 

       430        440        450        460        470        480 
PPAASPSQQL GPDAFAIVER AQQMVEILTE ENRVLHQELQ GYYDNADKLH KFEKELQRIS 

       490        500        510        520        530        540 
EAYESLVKST TKRESLDKAM RNKLEGEIRR LHDFNRDLRD RLETANRQLS SREYEGHEDK 

       550        560        570        580        590        600 
AAEGHYASQN KEFLKEKEKL EMELAAVRTA SEDHRRHIEI LDQALSNAQA RVIKLEEELR 

       610        620        630        640        650        660 
EKQAYVEKVE KLQQALTQLQ SACEKREQME RRLRTWLERE LDALRTQQKH GNGQPANMPE 

       670        680        690        700        710        720 
YNAPALLELV REKEERILAL EADMTKWEQK YLEESTIRHF AMNAAATAAA ERDTTIINHS 

       730        740        750        760        770        780 
RNGSYGESSL EAHIWQEEEE VVQANRRCQD MEYTIKNLHA KIIEKDAMIK VLQQRSRKDA 

       790        800        810        820        830        840 
GKTDSSSLRP ARSVPSIAAA TGTHSRQTSL TSSQLAEEKK EEKTWKGSIG LLLGKEHHEH 

       850        860        870        880        890        900 
ASAPLLPPPP TSALSSIAST TAASSAHAKT GSKDSSTQTD KSAELFWPSM ASLPSRGRLS 

       910        920        930        940        950 
TTPAHSPVLK HPAAKGTAEK LENSPGHGKS PDHRGRVSSL LHKPEFPDGE MMEVLI 

« Hide

Isoform 2 [UniParc].

Checksum: 8CFA1AE879538953
Show »

FASTA906101,179

References

« Hide 'large scale' references
[1]"The nucleotide sequence of a long cDNA clone isolated from human spleen."
Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.
Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Spleen.
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Skeletal muscle and Testis.
[3]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Muscle and Skin.
[5]"Angiomotin belongs to a novel protein family with conserved coiled-coil and PDZ binding domains."
Bratt A., Wilson W.J., Troyanovsky B., Aase K., Kessler R., Van Meir E.G., Holmgren L.
Gene 298:69-77(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-557 (ISOFORM 1).
Tissue: Brain.
[6]Erratum
Bratt A., Wilson W.J., Troyanovsky B., Aase K., Kessler R., Van Meir E.G., Holmgren L.
Gene 310:231-231(2003)
[7]"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[8]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-241; SER-295; SER-720 AND SER-906, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[10]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]"The Nedd4-like ubiquitin E3 ligases target angiomotin/p130 to ubiquitin-dependent degradation."
Wang C., An J., Zhang P., Xu C., Gao K., Wu D., Wang D., Yu H., Liu J.O., Yu L.
Biochem. J. 444:279-289(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: UBIQUITINATION BY NEDD4.
[12]"The Amotl2 gene inhibits Wnt/beta-catenin signaling and regulates embryonic development in zebrafish."
Li Z., Wang Y., Zhang M., Xu P., Huang H., Wu D., Meng A.
J. Biol. Chem. 287:13005-13015(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK074084 mRNA. Translation: BAB84910.1. Sequence problems.
AL833833 mRNA. Translation: CAD38693.1.
AP001152 Genomic DNA. No translation available.
AP002376 Genomic DNA. No translation available.
BX648729 mRNA. Translation: CAH56180.1.
BC014126 mRNA. Translation: AAH14126.1.
BC037539 mRNA. Translation: AAH37539.1.
AF453742 mRNA. Translation: AAL49764.1.
CCDSCCDS44712.1. [Q8IY63-1]
RefSeqNP_570899.1. NM_130847.2. [Q8IY63-1]
XP_005273857.1. XM_005273800.2. [Q8IY63-2]
UniGeneHs.503594.

3D structure databases

ProteinModelPortalQ8IY63.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid127559. 13 interactions.
IntActQ8IY63. 8 interactions.
MINTMINT-2809859.
STRING9606.ENSP00000387739.

PTM databases

PhosphoSiteQ8IY63.

Polymorphism databases

DMDM74728292.

Proteomic databases

MaxQBQ8IY63.
PaxDbQ8IY63.
PRIDEQ8IY63.

Protocols and materials databases

DNASU154810.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000317829; ENSP00000320968; ENSG00000166025. [Q8IY63-2]
ENST00000433060; ENSP00000387739; ENSG00000166025. [Q8IY63-1]
GeneID154810.
KEGGhsa:154810.
UCSCuc001pfb.3. human. [Q8IY63-1]
uc001pfc.3. human. [Q8IY63-2]

Organism-specific databases

CTD154810.
GeneCardsGC11P094441.
HGNCHGNC:17811. AMOTL1.
HPAHPA001196.
MIM614657. gene.
neXtProtNX_Q8IY63.
PharmGKBPA24774.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG131728.
HOGENOMHOG000233789.
HOVERGENHBG066485.
InParanoidQ8IY63.
KOK06104.
OMAQEHGLFY.
OrthoDBEOG7M6D6Q.
PhylomeDBQ8IY63.
TreeFamTF333368.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressQ8IY63.
BgeeQ8IY63.
CleanExHS_AMOTL1.
GenevestigatorQ8IY63.

Family and domain databases

InterProIPR009114. Angiomotin.
IPR024646. Angiomotin_C.
[Graphical view]
PANTHERPTHR14826. PTHR14826. 1 hit.
PfamPF12240. Angiomotin_C. 1 hit.
[Graphical view]
PRINTSPR01807. ANGIOMOTIN.
ProtoNetSearch...

Other

ChiTaRSAMOTL1. human.
GeneWikiAMOTL1.
GenomeRNAi154810.
NextBio87322.
PROQ8IY63.
SOURCESearch...

Entry information

Entry nameAMOL1_HUMAN
AccessionPrimary (citable) accession number: Q8IY63
Secondary accession number(s): Q63HK7 expand/collapse secondary AC list , Q8NDN0, Q8TEN8, Q8WXD1, Q96CM5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM