Reviewed, UniProtKB/Swiss-Prot Q8IY63 (AMOL1_HUMAN)

Names and origin

Protein names

Recommended name:
    Angiomotin-like protein 1

Gene names

Name:

AMOTL1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	956 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities

Belongs to the angiomotin family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
PTM	Phosphoprotein
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from direct assay. Source: HPA tight junction Inferred from direct assay. Source: MGI
Molecular function	identical protein binding Inferred from direct assay. Source: MGI
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
MAGI2	Q86UL8	1	EBI-1057112,EBI-311035

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IY63-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8IY63-2)

The sequence of this isoform differs from the canonical sequence as follows:
     17-66: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 956	956	Angiomotin-like protein 1		PRO_0000190670
Regions
	Coiled coil	259 – 279	21	Potential
	Coiled coil	438 – 639	202	Potential
	Coiled coil	665 – 694	30	Potential
	Coiled coil	729 – 762	34	Potential
	Motif	953 – 956	4	PDZ-binding
Amino acid modifications
	Modified residue	51	1	Phosphothreonine Ref.5
	Modified residue	52	1	Phosphoserine Ref.5
	Modified residue	61	1	Phosphoserine Ref.5
	Modified residue	295	1	Phosphoserine Ref.7
	Modified residue	803	1	Phosphothreonine Ref.6
	Modified residue	805	1	Phosphoserine Ref.6
Natural variations
	Alternative sequence	17 – 66	50	Missing in isoform 2.		VSP_015710
	Natural variant	847	1	P → L: dbSNP rs11020968.		VAR_033498
Experimental info
	Sequence conflict	459 – 460	2	LQ → HE in AAH14126. Ref.2
	Sequence conflict	649	1	K → E in CAH56180. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 6F47AE3A13816E95	FASTA	956	106,574
	10 20 30 40 50 60 MWRAKLRRGT CEPAVKGSPS ACYSPSSPVQ VLEDSTYFSP DFQLYSGRHE TSALTVEATS 70 80 90 100 110 120 SIREKVVEDP LCNFHSPNFL RISEVEMRGS EDAAAGTVLQ RLIQEQLRYG TPTENMNLLA 130 140 150 160 170 180 IQHQATGSAG PAHPTNNFSS TENLTQEDPQ MVYQSARQEP QGQEHQVDNT VMEKQVRSTQ 190 200 210 220 230 240 PQQNNEELPT YEEAKAQSQF FRGQQQQQQQ QGAVGHGYYM AGGTSQKSRT EGRPTVNRAN 250 260 270 280 290 300 SGQAHKDEAL KELKQGHVRS LSERIMQLSL ERNGAKQHLP GSGNGKGFKV GGGPSPAQPA 310 320 330 340 350 360 GKVLDPRGPP PEYPFKTKQM MSPVSKTQEH GLFYGDQHPG MLHEMVKPYP APQPVRTDVA 370 380 390 400 410 420 VLRYQPPPEY GVTSRPCQLP FPSTMQQHSP MSSQTSSASG PLHSVSLPLP LPMALGAPQP 430 440 450 460 470 480 PPAASPSQQL GPDAFAIVER AQQMVEILTE ENRVLHQELQ GYYDNADKLH KFEKELQRIS 490 500 510 520 530 540 EAYESLVKST TKRESLDKAM RNKLEGEIRR LHDFNRDLRD RLETANRQLS SREYEGHEDK 550 560 570 580 590 600 AAEGHYASQN KEFLKEKEKL EMELAAVRTA SEDHRRHIEI LDQALSNAQA RVIKLEEELR 610 620 630 640 650 660 EKQAYVEKVE KLQQALTQLQ SACEKREQME RRLRTWLERE LDALRTQQKH GNGQPANMPE 670 680 690 700 710 720 YNAPALLELV REKEERILAL EADMTKWEQK YLEESTIRHF AMNAAATAAA ERDTTIINHS 730 740 750 760 770 780 RNGSYGESSL EAHIWQEEEE VVQANRRCQD MEYTIKNLHA KIIEKDAMIK VLQQRSRKDA 790 800 810 820 830 840 GKTDSSSLRP ARSVPSIAAA TGTHSRQTSL TSSQLAEEKK EEKTWKGSIG LLLGKEHHEH 850 860 870 880 890 900 ASAPLLPPPP TSALSSIAST TAASSAHAKT GSKDSSTQTD KSAELFWPSM ASLPSRGRLS 910 920 930 940 950 TTPAHSPVLK HPAAKGTAEK LENSPGHGKS PDHRGRVSSL LHKPEFPDGE MMEVLI
	Isoform 2. Checksum: 8CFA1AE879538953	FASTA	906	101,179
	10 20 30 40 50 60 MWRAKLRRGT CEPAVKVEDP LCNFHSPNFL RISEVEMRGS EDAAAGTVLQ RLIQEQLRYG 70 80 90 100 110 120 TPTENMNLLA IQHQATGSAG PAHPTNNFSS TENLTQEDPQ MVYQSARQEP QGQEHQVDNT 130 140 150 160 170 180 VMEKQVRSTQ PQQNNEELPT YEEAKAQSQF FRGQQQQQQQ QGAVGHGYYM AGGTSQKSRT 190 200 210 220 230 240 EGRPTVNRAN SGQAHKDEAL KELKQGHVRS LSERIMQLSL ERNGAKQHLP GSGNGKGFKV 250 260 270 280 290 300 GGGPSPAQPA GKVLDPRGPP PEYPFKTKQM MSPVSKTQEH GLFYGDQHPG MLHEMVKPYP 310 320 330 340 350 360 APQPVRTDVA VLRYQPPPEY GVTSRPCQLP FPSTMQQHSP MSSQTSSASG PLHSVSLPLP 370 380 390 400 410 420 LPMALGAPQP PPAASPSQQL GPDAFAIVER AQQMVEILTE ENRVLHQELQ GYYDNADKLH 430 440 450 460 470 480 KFEKELQRIS EAYESLVKST TKRESLDKAM RNKLEGEIRR LHDFNRDLRD RLETANRQLS 490 500 510 520 530 540 SREYEGHEDK AAEGHYASQN KEFLKEKEKL EMELAAVRTA SEDHRRHIEI LDQALSNAQA 550 560 570 580 590 600 RVIKLEEELR EKQAYVEKVE KLQQALTQLQ SACEKREQME RRLRTWLERE LDALRTQQKH 610 620 630 640 650 660 GNGQPANMPE YNAPALLELV REKEERILAL EADMTKWEQK YLEESTIRHF AMNAAATAAA 670 680 690 700 710 720 ERDTTIINHS RNGSYGESSL EAHIWQEEEE VVQANRRCQD MEYTIKNLHA KIIEKDAMIK 730 740 750 760 770 780 VLQQRSRKDA GKTDSSSLRP ARSVPSIAAA TGTHSRQTSL TSSQLAEEKK EEKTWKGSIG 790 800 810 820 830 840 LLLGKEHHEH ASAPLLPPPP TSALSSIAST TAASSAHAKT GSKDSSTQTD KSAELFWPSM 850 860 870 880 890 900 ASLPSRGRLS TTPAHSPVLK HPAAKGTAEK LENSPGHGKS PDHRGRVSSL LHKPEFPDGE MMEVLI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Blocker H., Heubner D., Hoerlein A., Michel G., Wedler H., Kohrer K., Ottenwalder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Skeletal muscle and Testis.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Muscle and Skin.
[3]	"Angiomotin belongs to a novel protein family with conserved coiled-coil and PDZ binding domains." Bratt A., Wilson W.J., Troyanovsky B., Aase K., Kessler R., Van Meir E.G., Holmgren L. Gene 298:69-77(2002) [PubMed: 12406577] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-557 (ISOFORM 1). Tissue: Brain.
[4]	Erratum Bratt A., Wilson W.J., Troyanovsky B., Aase K., Kessler R., Van Meir E.G., Holmgren L. Gene 310:231-231(2003)
[5]	"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-51; SER-52 AND SER-61, MASS SPECTROMETRY. Tissue: Epithelium.
[6]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-803 AND SER-805, MASS SPECTROMETRY.
[7]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-295, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL833833 mRNA. Translation: CAD38693.1. BX648729 mRNA. Translation: CAH56180.1. BC014126 mRNA. Translation: AAH14126.1. BC037539 mRNA. Translation: AAH37539.1. AF453742 mRNA. Translation: AAL49764.1.
IPI	IPI00217664. IPI00651638.
RefSeq	NP_570899.1.
UniGene	Hs.503594
3D structure databases
HSSP	HSSP built from PDB template 1DEB based on UniProtKB P25054.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8IY63. 1 interaction.
PTM databases
PhosphoSite	Q8IY63.
Genome annotation databases
Ensembl	ENSG00000166025. Homo sapiens. [Contig view]
GeneID	154810.
KEGG	hsa:154810.
Organism-specific databases
GeneCards	GC11P094141.
H-InvDB	HIX0010033.
HGNC	HGNC:17811. AMOTL1.
HPA	HPA001196.
PharmGKB	PA24774.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q8IY63.
HOVERGEN	Q8IY63.
Gene expression databases
ArrayExpress	Q8IY63.
Bgee	Q8IY63.
CleanEx	HS_AMOTL1.
GermOnline	ENSG00000166025. Homo sapiens.
Family and domain databases
InterPro	IPR009114. Angiomotin. [Graphical view]
PANTHER	PTHR14826. Angiomotin. 1 hit.
PRINTS	PR01807. ANGIOMOTIN.
ProtoNet	Search...
Other Resources
NextBio	87322.

Entry information

Entry name

AMOL1_HUMAN

Accession

Primary (citable) accession number: Q8IY63
Secondary accession number(s): Q63HK7 , Q8NDN0, Q8WXD1, Q96CM5

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2005
Last sequence update:	March 1, 2003
Last modified:	May 5, 2009
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)