Q8IY51 (TIGD4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tigger transposable element-derived protein 4

Gene names

Name:

TIGD4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	512 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the tigger transposable element derived protein family. Contains 1 DDE domain. Contains 1 HTH CENPB-type DNA-binding domain. Contains 1 HTH psq-type DNA-binding domain.
Sequence caution	The sequence BAB71642.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 512	512	Tigger transposable element-derived protein 4		PRO_0000272616
Regions
	Domain	12 – 63	52	HTH psq-type
	Domain	75 – 146	72	HTH CENPB-type
	Domain	174 – 375	202	DDE
	DNA binding	39 – 59	21	H-T-H motif By similarity
	DNA binding	108 – 139	32	H-T-H motif By similarity
Natural variations
	Natural variant	432	1	A → T. Corresponds to variant rs34432931 [ dbSNP | Ensembl ].		VAR_057509
	Natural variant	439	1	I → V. Ref.2 Corresponds to variant rs4696354 [ dbSNP | Ensembl ].		VAR_030042
	Natural variant	489	1	Q → R. Corresponds to variant rs35581576 [ dbSNP | Ensembl ].		VAR_057510
Experimental info
	Sequence conflict	91	1	L → LSR in BAB71642. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q8IY51 [UniParc]. Last modified May 18, 2010. Version 2. Checksum: 212034AE45493CD2	FASTA	512	57,468
	10 20 30 40 50 60 MAEASVDAST LPVTVKKKKS LSIEEKIDII NAVESGKKKA EIAAEYGIKK NSLSSIMKNK 70 80 90 100 110 120 DKVLEAFESL RFDPKRKRLR TAFYTDLEEA LMRWYRIAQC LNVPVNGPML RLKANDFAQK 130 140 150 160 170 180 LGHNDFKCSN GWLDRFKSRY GLVFRAQPVE ATGVPVDPST VWYQNVLPYY LNDYHPKNVF 190 200 210 220 230 240 NIKETGLLYR MLPTNTFAFK GETCSVGKLC KDRITLVVGT NMDGSEKLPL LVIGKKRTPH 250 260 270 280 290 300 CFKGLKSLPV CYEANRMAWM TSDVFEQWMR KLDEEFQAQQ RRVVIFVESF PAHPEVKNLK 310 320 330 340 350 360 SIELAFFPSC LSSKCIAMKQ GVIKSLKIKY RHCLIKKFLS SVEGSKEFTF SLLDAVDTLH 370 380 390 400 410 420 LCWRAVTPET IVKSYEEAGF KSQKGESDIT NAEKDTGLDL VADALGAGVE FPEGLSIEEY 430 440 450 460 470 480 AALDDDLETC EAAPNGDSIC TKESKSDETG FYTSDEEDDD GSPGTELPLP SKSEAITALD 490 500 510 TLKKFLRSQD MNDGLQNSLA DLENFINSLS PK

References

[1]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-439. Tissue: Testis.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 71-512. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC106882 Genomic DNA. No translation available. BC037869 mRNA. Translation: AAH37869.1. AK058054 mRNA. Translation: BAB71642.1. Different initiation.
IPI	IPI00293368.
RefSeq	NP_663772.1. NM_145720.3.
UniGene	Hs.301243.
3D structure databases
ProteinModelPortal	Q8IY51.
SMR	Q8IY51. Positions 17-139.
ModBase	Search...
PTM databases
PhosphoSite	Q8IY51.
Polymorphism databases
DMDM	296452928.
Proteomic databases
PaxDb	Q8IY51.
PRIDE	Q8IY51.
Protocols and materials databases
DNASU	201798.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000304337; ENSP00000355162; ENSG00000169989.
GeneID	201798.
KEGG	hsa:201798.
UCSC	uc003imy.3. human.
Organism-specific databases
CTD	201798.
GeneCards	GC04M153690.
H-InvDB	HIX0004573.
HGNC	HGNC:18335. TIGD4.
HPA	HPA035649.
neXtProt	NX_Q8IY51.
PharmGKB	PA38528.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG265486.
HOGENOM	HOG000154580.
HOVERGEN	HBG086852.
InParanoid	Q8IY51.
OMA	WLDRFKS.
OrthoDB	EOG4CZBFR.
PhylomeDB	Q8IY51.
Gene expression databases
Bgee	Q8IY51.
CleanEx	HS_TIGD4.
Genevestigator	Q8IY51.
Family and domain databases
Gene3D	1.10.10.60. 2 hits.
InterPro	IPR004875. DDE_SF_endonuclease_CENPB-like. IPR009057. Homeodomain-like. IPR006600. HTH_CenpB_DNA-bd_dom. IPR007889. HTH_Psq. [Graphical view]
Pfam	PF04218. CENP-B_N. 1 hit. PF03184. DDE_1. 1 hit. PF03221. HTH_Tnp_Tc5. 1 hit. [Graphical view]
SMART	SM00674. CENPB. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 2 hits.
PROSITE	PS51253. HTH_CENPB. 1 hit. PS50960. HTH_PSQ. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	201798.
NextBio	90202.

Entry information

Entry name

TIGD4_HUMAN

Accession

Primary (citable) accession number: Q8IY51
Secondary accession number(s): Q96LP5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
Last sequence update:	May 18, 2010
Last modified:	May 29, 2013
This is version 98 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.