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Protein

Tigger transposable element-derived protein 4

Gene

TIGD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi39 – 59H-T-H motifBy similarityAdd BLAST21
DNA bindingi108 – 139H-T-H motifBy similarityAdd BLAST32

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tigger transposable element-derived protein 4
Gene namesi
Name:TIGD4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:18335. TIGD4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000169989.
PharmGKBiPA38528.

Polymorphism and mutation databases

BioMutaiTIGD4.
DMDMi296452928.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002726161 – 512Tigger transposable element-derived protein 4Add BLAST512

Proteomic databases

PaxDbiQ8IY51.
PeptideAtlasiQ8IY51.
PRIDEiQ8IY51.

PTM databases

iPTMnetiQ8IY51.
PhosphoSitePlusiQ8IY51.

Expressioni

Gene expression databases

BgeeiENSG00000169989.
CleanExiHS_TIGD4.
GenevisibleiQ8IY51. HS.

Organism-specific databases

HPAiHPA035649.

Interactioni

Protein-protein interaction databases

BioGridi128403. 2 interactors.
IntActiQ8IY51. 1 interactor.
STRINGi9606.ENSP00000355162.

Structurei

3D structure databases

ProteinModelPortaliQ8IY51.
SMRiQ8IY51.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 63HTH psq-typePROSITE-ProRule annotationAdd BLAST52
Domaini75 – 146HTH CENPB-typePROSITE-ProRule annotationAdd BLAST72
Domaini174 – 375DDE-1Sequence analysisAdd BLAST202

Sequence similaritiesi

Contains 1 DDE-1 domain.Sequence analysis
Contains 1 HTH CENPB-type DNA-binding domain.PROSITE-ProRule annotation
Contains 1 HTH psq-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3105. Eukaryota.
ENOG4110CDI. LUCA.
GeneTreeiENSGT00760000119149.
HOGENOMiHOG000154580.
HOVERGENiHBG086852.
InParanoidiQ8IY51.
OMAiSSKCIAM.
OrthoDBiEOG091G0G48.
PhylomeDBiQ8IY51.
TreeFamiTF101131.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR004875. DDE_SF_endonuclease_dom.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
IPR007889. HTH_Psq.
[Graphical view]
PfamiPF04218. CENP-B_N. 1 hit.
PF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
[Graphical view]
SMARTiSM00674. CENPB. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51253. HTH_CENPB. 1 hit.
PS50960. HTH_PSQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IY51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEASVDAST LPVTVKKKKS LSIEEKIDII NAVESGKKKA EIAAEYGIKK
60 70 80 90 100
NSLSSIMKNK DKVLEAFESL RFDPKRKRLR TAFYTDLEEA LMRWYRIAQC
110 120 130 140 150
LNVPVNGPML RLKANDFAQK LGHNDFKCSN GWLDRFKSRY GLVFRAQPVE
160 170 180 190 200
ATGVPVDPST VWYQNVLPYY LNDYHPKNVF NIKETGLLYR MLPTNTFAFK
210 220 230 240 250
GETCSVGKLC KDRITLVVGT NMDGSEKLPL LVIGKKRTPH CFKGLKSLPV
260 270 280 290 300
CYEANRMAWM TSDVFEQWMR KLDEEFQAQQ RRVVIFVESF PAHPEVKNLK
310 320 330 340 350
SIELAFFPSC LSSKCIAMKQ GVIKSLKIKY RHCLIKKFLS SVEGSKEFTF
360 370 380 390 400
SLLDAVDTLH LCWRAVTPET IVKSYEEAGF KSQKGESDIT NAEKDTGLDL
410 420 430 440 450
VADALGAGVE FPEGLSIEEY AALDDDLETC EAAPNGDSIC TKESKSDETG
460 470 480 490 500
FYTSDEEDDD GSPGTELPLP SKSEAITALD TLKKFLRSQD MNDGLQNSLA
510
DLENFINSLS PK
Length:512
Mass (Da):57,468
Last modified:May 18, 2010 - v2
Checksum:i212034AE45493CD2
GO

Sequence cautioni

The sequence BAB71642 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti91L → LSR in BAB71642 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057509432A → T.Corresponds to variant rs34432931dbSNPEnsembl.1
Natural variantiVAR_030042439I → V.1 PublicationCorresponds to variant rs4696354dbSNPEnsembl.1
Natural variantiVAR_057510489Q → R.Corresponds to variant rs35581576dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC106882 Genomic DNA. No translation available.
BC037869 mRNA. Translation: AAH37869.1.
AK058054 mRNA. Translation: BAB71642.1. Different initiation.
CCDSiCCDS34079.1.
RefSeqiNP_663772.1. NM_145720.3.
XP_005262864.1. XM_005262807.4.
UniGeneiHs.301243.

Genome annotation databases

EnsembliENST00000304337; ENSP00000355162; ENSG00000169989.
GeneIDi201798.
KEGGihsa:201798.
UCSCiuc003imy.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC106882 Genomic DNA. No translation available.
BC037869 mRNA. Translation: AAH37869.1.
AK058054 mRNA. Translation: BAB71642.1. Different initiation.
CCDSiCCDS34079.1.
RefSeqiNP_663772.1. NM_145720.3.
XP_005262864.1. XM_005262807.4.
UniGeneiHs.301243.

3D structure databases

ProteinModelPortaliQ8IY51.
SMRiQ8IY51.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128403. 2 interactors.
IntActiQ8IY51. 1 interactor.
STRINGi9606.ENSP00000355162.

PTM databases

iPTMnetiQ8IY51.
PhosphoSitePlusiQ8IY51.

Polymorphism and mutation databases

BioMutaiTIGD4.
DMDMi296452928.

Proteomic databases

PaxDbiQ8IY51.
PeptideAtlasiQ8IY51.
PRIDEiQ8IY51.

Protocols and materials databases

DNASUi201798.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304337; ENSP00000355162; ENSG00000169989.
GeneIDi201798.
KEGGihsa:201798.
UCSCiuc003imy.3. human.

Organism-specific databases

CTDi201798.
GeneCardsiTIGD4.
H-InvDBHIX0004573.
HGNCiHGNC:18335. TIGD4.
HPAiHPA035649.
neXtProtiNX_Q8IY51.
OpenTargetsiENSG00000169989.
PharmGKBiPA38528.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3105. Eukaryota.
ENOG4110CDI. LUCA.
GeneTreeiENSGT00760000119149.
HOGENOMiHOG000154580.
HOVERGENiHBG086852.
InParanoidiQ8IY51.
OMAiSSKCIAM.
OrthoDBiEOG091G0G48.
PhylomeDBiQ8IY51.
TreeFamiTF101131.

Miscellaneous databases

GenomeRNAii201798.
PROiQ8IY51.

Gene expression databases

BgeeiENSG00000169989.
CleanExiHS_TIGD4.
GenevisibleiQ8IY51. HS.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR004875. DDE_SF_endonuclease_dom.
IPR009057. Homeodomain-like.
IPR006600. HTH_CenpB_DNA-bd_dom.
IPR007889. HTH_Psq.
[Graphical view]
PfamiPF04218. CENP-B_N. 1 hit.
PF03184. DDE_1. 1 hit.
PF03221. HTH_Tnp_Tc5. 1 hit.
[Graphical view]
SMARTiSM00674. CENPB. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51253. HTH_CENPB. 1 hit.
PS50960. HTH_PSQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTIGD4_HUMAN
AccessioniPrimary (citable) accession number: Q8IY51
Secondary accession number(s): Q96LP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.