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Protein

Putative thiamine transporter SLC35F3

Gene

SLC35F3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be a thiamine transporter.1 Publication

GO - Biological processi

  • thiamine transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.7.24.8. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative thiamine transporter SLC35F3Curated
Alternative name(s):
Solute carrier family 35 member F3
Gene namesi
Name:SLC35F3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:23616. SLC35F3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei66 – 8621HelicalSequence analysisAdd
BLAST
Transmembranei98 – 11821HelicalSequence analysisAdd
BLAST
Transmembranei149 – 16921HelicalSequence analysisAdd
BLAST
Transmembranei179 – 19921HelicalSequence analysisAdd
BLAST
Transmembranei208 – 22821HelicalSequence analysisAdd
BLAST
Transmembranei232 – 25221HelicalSequence analysisAdd
BLAST
Transmembranei266 – 28621HelicalSequence analysisAdd
BLAST
Transmembranei305 – 32521HelicalSequence analysisAdd
BLAST
Transmembranei326 – 34621HelicalSequence analysisAdd
BLAST
Transmembranei352 – 37221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134938022.

Polymorphism and mutation databases

DMDMi160177558.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 421421Putative thiamine transporter SLC35F3PRO_0000307879Add
BLAST

Proteomic databases

MaxQBiQ8IY50.
PaxDbiQ8IY50.
PRIDEiQ8IY50.

PTM databases

iPTMnetiQ8IY50.
PhosphoSiteiQ8IY50.

Expressioni

Gene expression databases

BgeeiQ8IY50.
CleanExiHS_SLC35F3.
GenevisibleiQ8IY50. HS.

Organism-specific databases

HPAiHPA051327.
HPA061582.

Interactioni

Protein-protein interaction databases

MINTiMINT-4724984.
STRINGi9606.ENSP00000355577.

Structurei

3D structure databases

ProteinModelPortaliQ8IY50.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SLC35F solute transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4314. Eukaryota.
ENOG4110PN8. LUCA.
GeneTreeiENSGT00390000008727.
HOGENOMiHOG000060188.
HOVERGENiHBG108446.
InParanoidiQ8IY50.
KOiK15288.
OMAiFGIAITY.
OrthoDBiEOG7QK0BR.
PhylomeDBiQ8IY50.
TreeFamiTF313798.

Family and domain databases

InterProiIPR000620. EamA_dom.
IPR026505. Solute_c_fam_35_mem_F3/F4.
[Graphical view]
PANTHERiPTHR19346. PTHR19346. 1 hit.
PfamiPF00892. EamA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IY50-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKKHSARVAP LSACNSPVLT LTKVEGEERP RDSPGPAEAQ APAGVEAGGR
60 70 80 90 100
ASRRCWTCSR AQLKKIFWGV AVVLCVCSSW AGSTQLAKLT FRKFDAPFTL
110 120 130 140 150
TWFATNWNFL FFPLYYVGHV CKSTEKQSVK QRYRECCRFF GDNGLTLKVF
160 170 180 190 200
FTKAAPFGVL WTLTNYLYLH AIKKINTTDV SVLFCCNKAF VFLLSWIVLR
210 220 230 240 250
DRFMGVRIVA AILAIAGIVM MTYADGFHSH SVIGIALVVA SASMSALYKV
260 270 280 290 300
LFKLLLGSAK FGEAALFLSI LGVFNILFIT CIPIILYFTK VEYWSSFDDI
310 320 330 340 350
PWGNLCGFSV LLLTFNIVLN FGIAVTYPTL MSLGIVLSIP VNAVIDHYTS
360 370 380 390 400
QIVFNGVRVI AIIIIGLGFL LLLLPEEWDV WLIKLLTRLK VRKKEEPAEG
410 420
AADLSSGPQS KNRRARPSFA R
Length:421
Mass (Da):46,817
Last modified:October 23, 2007 - v2
Checksum:i7D365662E28AE251
GO
Isoform 2 (identifier: Q8IY50-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: MKKHSARVAPLSACNSPVLTLTKVEG → MGIREFPSGA...YQPWAASCKR

Note: No experimental confirmation available.
Show »
Length:490
Mass (Da):54,773
Checksum:i96412343FDC55D0A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti231 – 2311S → C.1 Publication
Corresponds to variant rs17853780 [ dbSNP | Ensembl ].
VAR_036700

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2626MKKHS…TKVEG → MGIREFPSGAPRGKSIAVGM RRSPDVSPRRLSDISPQLRQ LKYLVVDEAIKEDLKWSRSV EDLTSGPVGLTSIEERILRI TGYYGYQPWAASCKR in isoform 2. 1 PublicationVSP_028850Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095031 mRNA. Translation: BAC04479.1.
AL713868, AL122008 Genomic DNA. Translation: CAI14569.1.
AL122008, AL713868 Genomic DNA. Translation: CAI22849.1.
AL122008 Genomic DNA. Translation: CAI22850.1.
CH471098 Genomic DNA. Translation: EAW69991.1.
BC037878 mRNA. Translation: AAH37878.1.
CCDSiCCDS1600.1. [Q8IY50-2]
CCDS73050.1. [Q8IY50-1]
RefSeqiNP_001287774.1. NM_001300845.1. [Q8IY50-1]
NP_775779.1. NM_173508.3. [Q8IY50-2]
UniGeneiHs.158748.

Genome annotation databases

EnsembliENST00000366617; ENSP00000355576; ENSG00000183780. [Q8IY50-1]
ENST00000366618; ENSP00000355577; ENSG00000183780. [Q8IY50-2]
GeneIDi148641.
KEGGihsa:148641.
UCSCiuc001hvy.1. human. [Q8IY50-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK095031 mRNA. Translation: BAC04479.1.
AL713868, AL122008 Genomic DNA. Translation: CAI14569.1.
AL122008, AL713868 Genomic DNA. Translation: CAI22849.1.
AL122008 Genomic DNA. Translation: CAI22850.1.
CH471098 Genomic DNA. Translation: EAW69991.1.
BC037878 mRNA. Translation: AAH37878.1.
CCDSiCCDS1600.1. [Q8IY50-2]
CCDS73050.1. [Q8IY50-1]
RefSeqiNP_001287774.1. NM_001300845.1. [Q8IY50-1]
NP_775779.1. NM_173508.3. [Q8IY50-2]
UniGeneiHs.158748.

3D structure databases

ProteinModelPortaliQ8IY50.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4724984.
STRINGi9606.ENSP00000355577.

Protein family/group databases

TCDBi2.A.7.24.8. the drug/metabolite transporter (dmt) superfamily.

PTM databases

iPTMnetiQ8IY50.
PhosphoSiteiQ8IY50.

Polymorphism and mutation databases

DMDMi160177558.

Proteomic databases

MaxQBiQ8IY50.
PaxDbiQ8IY50.
PRIDEiQ8IY50.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366617; ENSP00000355576; ENSG00000183780. [Q8IY50-1]
ENST00000366618; ENSP00000355577; ENSG00000183780. [Q8IY50-2]
GeneIDi148641.
KEGGihsa:148641.
UCSCiuc001hvy.1. human. [Q8IY50-1]

Organism-specific databases

CTDi148641.
GeneCardsiSLC35F3.
HGNCiHGNC:23616. SLC35F3.
HPAiHPA051327.
HPA061582.
neXtProtiNX_Q8IY50.
PharmGKBiPA134938022.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4314. Eukaryota.
ENOG4110PN8. LUCA.
GeneTreeiENSGT00390000008727.
HOGENOMiHOG000060188.
HOVERGENiHBG108446.
InParanoidiQ8IY50.
KOiK15288.
OMAiFGIAITY.
OrthoDBiEOG7QK0BR.
PhylomeDBiQ8IY50.
TreeFamiTF313798.

Miscellaneous databases

ChiTaRSiSLC35F3. human.
GenomeRNAii148641.
PROiQ8IY50.

Gene expression databases

BgeeiQ8IY50.
CleanExiHS_SLC35F3.
GenevisibleiQ8IY50. HS.

Family and domain databases

InterProiIPR000620. EamA_dom.
IPR026505. Solute_c_fam_35_mem_F3/F4.
[Graphical view]
PANTHERiPTHR19346. PTHR19346. 1 hit.
PfamiPF00892. EamA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Hippocampus.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT CYS-231.
    Tissue: Brain.
  5. Cited for: FUNCTION.

Entry informationi

Entry nameiS35F3_HUMAN
AccessioniPrimary (citable) accession number: Q8IY50
Secondary accession number(s): Q5TDD6, Q8N9C9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: June 8, 2016
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Promotes thiamine uptake when expressed in E.coli. Individuals with blood hypertension and a SLC35F3 risk allele T/T homozygosity (intronic variant rs17514104) show a significant reduction in blood thiamine content.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.