Q8IY50 (S35F3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Solute carrier family 35 member F3

Gene names

Name:

SLC35F3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	421 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Putative solute transporter Potential.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the SLC35F solute transporter family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IY50-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8IY50-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: MKKHSARVAPLSACNSPVLTLTKVEG → MGIREFPSGA...YQPWAASCKR

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 421	421	Solute carrier family 35 member F3		PRO_0000307879
Regions
	Transmembrane	66 – 86	21	Helical; Potential
	Transmembrane	98 – 118	21	Helical; Potential
	Transmembrane	149 – 169	21	Helical; Potential
	Transmembrane	179 – 199	21	Helical; Potential
	Transmembrane	208 – 228	21	Helical; Potential
	Transmembrane	232 – 252	21	Helical; Potential
	Transmembrane	266 – 286	21	Helical; Potential
	Transmembrane	305 – 325	21	Helical; Potential
	Transmembrane	326 – 346	21	Helical; Potential
	Transmembrane	352 – 372	21	Helical; Potential
Natural variations
	Alternative sequence	1 – 26	26	MKKHS…TKVEG → MGIREFPSGAPRGKSIAVGM RRSPDVSPRRLSDISPQLRQ LKYLVVDEAIKEDLKWSRSV EDLTSGPVGLTSIEERILRI TGYYGYQPWAASCKR in isoform 2.		VSP_028850
	Natural variant	231	1	S → C. Ref.4 Corresponds to variant rs17853780 [ dbSNP | Ensembl ].		VAR_036700

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 23, 2007. Version 2. Checksum: 7D365662E28AE251	FASTA	421	46,817
	10 20 30 40 50 60 MKKHSARVAP LSACNSPVLT LTKVEGEERP RDSPGPAEAQ APAGVEAGGR ASRRCWTCSR 70 80 90 100 110 120 AQLKKIFWGV AVVLCVCSSW AGSTQLAKLT FRKFDAPFTL TWFATNWNFL FFPLYYVGHV 130 140 150 160 170 180 CKSTEKQSVK QRYRECCRFF GDNGLTLKVF FTKAAPFGVL WTLTNYLYLH AIKKINTTDV 190 200 210 220 230 240 SVLFCCNKAF VFLLSWIVLR DRFMGVRIVA AILAIAGIVM MTYADGFHSH SVIGIALVVA 250 260 270 280 290 300 SASMSALYKV LFKLLLGSAK FGEAALFLSI LGVFNILFIT CIPIILYFTK VEYWSSFDDI 310 320 330 340 350 360 PWGNLCGFSV LLLTFNIVLN FGIAVTYPTL MSLGIVLSIP VNAVIDHYTS QIVFNGVRVI 370 380 390 400 410 420 AIIIIGLGFL LLLLPEEWDV WLIKLLTRLK VRKKEEPAEG AADLSSGPQS KNRRARPSFA R
	Isoform 2 [UniParc]. Checksum: 96412343FDC55D0A	FASTA	490	54,773
	10 20 30 40 50 60 MGIREFPSGA PRGKSIAVGM RRSPDVSPRR LSDISPQLRQ LKYLVVDEAI KEDLKWSRSV 70 80 90 100 110 120 EDLTSGPVGL TSIEERILRI TGYYGYQPWA ASCKREERPR DSPGPAEAQA PAGVEAGGRA 130 140 150 160 170 180 SRRCWTCSRA QLKKIFWGVA VVLCVCSSWA GSTQLAKLTF RKFDAPFTLT WFATNWNFLF 190 200 210 220 230 240 FPLYYVGHVC KSTEKQSVKQ RYRECCRFFG DNGLTLKVFF TKAAPFGVLW TLTNYLYLHA 250 260 270 280 290 300 IKKINTTDVS VLFCCNKAFV FLLSWIVLRD RFMGVRIVAA ILAIAGIVMM TYADGFHSHS 310 320 330 340 350 360 VIGIALVVAS ASMSALYKVL FKLLLGSAKF GEAALFLSIL GVFNILFITC IPIILYFTKV 370 380 390 400 410 420 EYWSSFDDIP WGNLCGFSVL LLTFNIVLNF GIAVTYPTLM SLGIVLSIPV NAVIDHYTSQ 430 440 450 460 470 480 IVFNGVRVIA IIIIGLGFLL LLLPEEWDVW LIKLLTRLKV RKKEEPAEGA ADLSSGPQSK 490 NRRARPSFAR

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Hippocampus.
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT CYS-231. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK095031 mRNA. Translation: BAC04479.1. AL713868, AL122008 Genomic DNA. Translation: CAI14569.1. AL122008, AL713868 Genomic DNA. Translation: CAI22849.1. AL122008 Genomic DNA. Translation: CAI22850.1. CH471098 Genomic DNA. Translation: EAW69991.1. BC037878 mRNA. Translation: AAH37878.1.
IPI	IPI00167687. IPI00395585.
RefSeq	NP_775779.1. NM_173508.2.
UniGene	Hs.158748.
3D structure databases
ProteinModelPortal	Q8IY50.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-4724984.
STRING	9606.ENSP00000355577.
Protein family/group databases
TCDB	2.A.7.24.8. drug/metabolite transporter (DMT) superfamily.
PTM databases
PhosphoSite	Q8IY50.
Polymorphism databases
DMDM	160177558.
Proteomic databases
PaxDb	Q8IY50.
PRIDE	Q8IY50.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000366617; ENSP00000355576; ENSG00000183780. ENST00000366618; ENSP00000355577; ENSG00000183780.
GeneID	148641.
KEGG	hsa:148641.
UCSC	uc001hvy.1. human. uc001hwa.1. human.
Organism-specific databases
CTD	148641.
GeneCards	GC01P234040.
HGNC	HGNC:23616. SLC35F3.
HPA	HPA051327.
neXtProt	NX_Q8IY50.
PharmGKB	PA134938022.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG264574.
HOGENOM	HOG000060188.
HOVERGEN	HBG108446.
KO	K15288.
OMA	VGHVCKS.
Gene expression databases
Bgee	Q8IY50.
CleanEx	HS_SLC35F3.
Genevestigator	Q8IY50.
Family and domain databases
InterPro	IPR000620. DMT. IPR026505. Solute_c_fam_35_mem_F3/F4. [Graphical view]
PANTHER	PTHR19346. PTHR19346. 1 hit.
Pfam	PF00892. EamA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SLC35F3. human.
GenomeRNAi	148641.
NextBio	85960.

Entry information

Entry name

S35F3_HUMAN

Accession

Primary (citable) accession number: Q8IY50
Secondary accession number(s): Q5TDD6, Q8N9C9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	October 23, 2007
Last modified:	May 29, 2013
This is version 62 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.