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Q8IY49

- PAQRA_HUMAN

UniProt

Q8IY49 - PAQRA_HUMAN

Protein

Monocyte to macrophage differentiation factor 2

Gene

MMD2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (31 Aug 2004)
      Previous versions | rss
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    Functioni

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Monocyte to macrophage differentiation factor 2
    Alternative name(s):
    Progestin and adipoQ receptor family member 10
    Progestin and adipoQ receptor family member X
    Gene namesi
    Name:MMD2
    Synonyms:PAQR10
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:30133. MMD2.

    Subcellular locationi

    Golgi apparatus membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. Golgi membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. perinuclear region of cytoplasm Source: MGI

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134910250.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 270270Monocyte to macrophage differentiation factor 2PRO_0000218857Add
    BLAST

    Proteomic databases

    PaxDbiQ8IY49.
    PRIDEiQ8IY49.

    Expressioni

    Tissue specificityi

    Shows restricted expression with highest levels in brain and testis.1 Publication

    Gene expression databases

    BgeeiQ8IY49.
    CleanExiHS_MMD2.
    GenevestigatoriQ8IY49.

    Organism-specific databases

    HPAiHPA048714.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000384690.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IY49.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3838CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini60 – 656LumenalSequence Analysis
    Topological domaini87 – 10216CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini124 – 1329LumenalSequence Analysis
    Topological domaini154 – 18229CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini204 – 2052LumenalSequence Analysis
    Topological domaini227 – 2337CytoplasmicSequence Analysis
    Topological domaini255 – 27016LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei39 – 5921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei66 – 8621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei103 – 12321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei133 – 15321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei183 – 20321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei206 – 22621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei234 – 25421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ADIPOR family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1272.
    HOGENOMiHOG000039440.
    HOVERGENiHBG053507.
    InParanoidiQ8IY49.
    KOiK11064.
    OMAiMNHRVPS.
    OrthoDBiEOG7SJD5B.
    PhylomeDBiQ8IY49.
    TreeFamiTF313370.

    Family and domain databases

    InterProiIPR004254. HlyIII-related.
    [Graphical view]
    PANTHERiPTHR20855. PTHR20855. 1 hit.
    PfamiPF03006. HlyIII. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8IY49-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MFAPRLLDFQ KTKYARFMNH RVPAHKRYQP TEYEHAANCA THAFWIIPSI    50
    LGSSNLYFLS DDDWETISAW IYGLGLCGLF VVSTVFHTIS WKKSHLRMVE 100
    HCLHMFDRMV IYFFIAASYA PWLNLRELGP WASHMRWLVW IMASVGTIYV 150
    FFFHERTGSC VQFLRGEACP KAGTACLPAR YKLVELLCYV VMGFFPALVI 200
    LSMPNTEGIW ELVTGGVFYC LGMVFFKSDG RIPFAHAIWH LFVAFGAGTH 250
    YYAIWRYLYL PSTLQTKVSK 270
    Length:270
    Mass (Da):31,264
    Last modified:August 31, 2004 - v2
    Checksum:iA726231D6283A2DA
    GO
    Isoform 2 (identifier: Q8IY49-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         156-179: Missing.

    Show »
    Length:246
    Mass (Da):28,845
    Checksum:iF944D5B94B7E68A9
    GO
    Isoform 3 (identifier: Q8IY49-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         156-179: Missing.
         204-270: PNTEGIWELV...PSTLQTKVSK → AGKLRPGMTCLKRQ

    Note: No experimental confirmation available.

    Show »
    Length:193
    Mass (Da):22,730
    Checksum:i14147EF0A8A50C78
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti9 – 91F → L in AAR08376. (PubMed:16044242)Curated
    Sequence conflicti99 – 991V → L in AAH37881. (PubMed:15489334)Curated
    Sequence conflicti103 – 1031L → I in AAH67905. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei156 – 17924Missing in isoform 2 and isoform 3. 2 PublicationsVSP_011486Add
    BLAST
    Alternative sequencei204 – 27067PNTEG…TKVSK → AGKLRPGMTCLKRQ in isoform 3. 1 PublicationVSP_045589Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY424288 mRNA. Translation: AAR08376.1.
    AC053546 Genomic DNA. No translation available.
    AC092032 Genomic DNA. No translation available.
    CH471144 Genomic DNA. Translation: EAW87307.1.
    BC037881 mRNA. Translation: AAH37881.2.
    BC048346 mRNA. No translation available.
    BC067905 mRNA. Translation: AAH67905.1.
    CCDSiCCDS47529.1. [Q8IY49-1]
    CCDS47530.1. [Q8IY49-2]
    CCDS59047.1. [Q8IY49-3]
    RefSeqiNP_001094070.1. NM_001100600.1. [Q8IY49-1]
    NP_001257304.1. NM_001270375.1. [Q8IY49-3]
    NP_940685.3. NM_198403.3. [Q8IY49-2]
    UniGeneiHs.558694.

    Genome annotation databases

    EnsembliENST00000401401; ENSP00000384141; ENSG00000136297. [Q8IY49-2]
    ENST00000404774; ENSP00000384690; ENSG00000136297. [Q8IY49-1]
    ENST00000406755; ENSP00000385963; ENSG00000136297. [Q8IY49-3]
    GeneIDi221938.
    KEGGihsa:221938.
    UCSCiuc003snn.4. human. [Q8IY49-2]
    uc003sno.4. human. [Q8IY49-1]
    uc010ksq.3. human.

    Polymorphism databases

    DMDMi51701810.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY424288 mRNA. Translation: AAR08376.1 .
    AC053546 Genomic DNA. No translation available.
    AC092032 Genomic DNA. No translation available.
    CH471144 Genomic DNA. Translation: EAW87307.1 .
    BC037881 mRNA. Translation: AAH37881.2 .
    BC048346 mRNA. No translation available.
    BC067905 mRNA. Translation: AAH67905.1 .
    CCDSi CCDS47529.1. [Q8IY49-1 ]
    CCDS47530.1. [Q8IY49-2 ]
    CCDS59047.1. [Q8IY49-3 ]
    RefSeqi NP_001094070.1. NM_001100600.1. [Q8IY49-1 ]
    NP_001257304.1. NM_001270375.1. [Q8IY49-3 ]
    NP_940685.3. NM_198403.3. [Q8IY49-2 ]
    UniGenei Hs.558694.

    3D structure databases

    ProteinModelPortali Q8IY49.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000384690.

    Polymorphism databases

    DMDMi 51701810.

    Proteomic databases

    PaxDbi Q8IY49.
    PRIDEi Q8IY49.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000401401 ; ENSP00000384141 ; ENSG00000136297 . [Q8IY49-2 ]
    ENST00000404774 ; ENSP00000384690 ; ENSG00000136297 . [Q8IY49-1 ]
    ENST00000406755 ; ENSP00000385963 ; ENSG00000136297 . [Q8IY49-3 ]
    GeneIDi 221938.
    KEGGi hsa:221938.
    UCSCi uc003snn.4. human. [Q8IY49-2 ]
    uc003sno.4. human. [Q8IY49-1 ]
    uc010ksq.3. human.

    Organism-specific databases

    CTDi 221938.
    GeneCardsi GC07M004945.
    H-InvDB HIX0201148.
    HGNCi HGNC:30133. MMD2.
    HPAi HPA048714.
    MIMi 614581. gene.
    neXtProti NX_Q8IY49.
    PharmGKBi PA134910250.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1272.
    HOGENOMi HOG000039440.
    HOVERGENi HBG053507.
    InParanoidi Q8IY49.
    KOi K11064.
    OMAi MNHRVPS.
    OrthoDBi EOG7SJD5B.
    PhylomeDBi Q8IY49.
    TreeFami TF313370.

    Miscellaneous databases

    GenomeRNAii 221938.
    NextBioi 91508.
    PROi Q8IY49.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8IY49.
    CleanExi HS_MMD2.
    Genevestigatori Q8IY49.

    Family and domain databases

    InterProi IPR004254. HlyIII-related.
    [Graphical view ]
    PANTHERi PTHR20855. PTHR20855. 1 hit.
    Pfami PF03006. HlyIII. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif."
      Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C., Funk W.D.
      J. Mol. Evol. 61:372-380(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
    2. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
      Tissue: Brain and Retinoblastoma.
    5. "Identification of the topology and functional domains of PAQR10."
      Jin T., Xu D., Ding Q., Zhang Y., Mao C., Pan Y., Wang Z., Chen Y.
      Biochem. J. 443:643-653(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, MEMBRANE TOPOLOGY.

    Entry informationi

    Entry nameiPAQRA_HUMAN
    AccessioniPrimary (citable) accession number: Q8IY49
    Secondary accession number(s): B5MBW4, Q6NVU5, Q6TCH0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: August 31, 2004
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3