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Protein

Monocyte to macrophage differentiation factor 2

Gene

MMD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • protein kinase activity Source: CACAO

GO - Biological processi

  • positive regulation of neuron differentiation Source: CACAO
  • positive regulation of protein kinase activity Source: CACAO
  • positive regulation of Ras protein signal transduction Source: CACAO
  • regulation of protein localization Source: CACAO
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Protein family/group databases

TCDBi1.C.113.2.3. 1.c.113 the hly iii (hly iii) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Monocyte to macrophage differentiation factor 2
Alternative name(s):
Progestin and adipoQ receptor family member 10
Progestin and adipoQ receptor family member X
Gene namesi
Name:MMD2
Synonyms:PAQR10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:30133. MMD2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38CytoplasmicSequence analysisAdd BLAST38
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Topological domaini60 – 65LumenalSequence analysis6
Transmembranei66 – 86HelicalSequence analysisAdd BLAST21
Topological domaini87 – 102CytoplasmicSequence analysisAdd BLAST16
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Topological domaini124 – 132LumenalSequence analysis9
Transmembranei133 – 153HelicalSequence analysisAdd BLAST21
Topological domaini154 – 182CytoplasmicSequence analysisAdd BLAST29
Transmembranei183 – 203HelicalSequence analysisAdd BLAST21
Topological domaini204 – 205LumenalSequence analysis2
Transmembranei206 – 226HelicalSequence analysisAdd BLAST21
Topological domaini227 – 233CytoplasmicSequence analysis7
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Topological domaini255 – 270LumenalSequence analysisAdd BLAST16

GO - Cellular componenti

  • Golgi membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • perinuclear region of cytoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi221938.
MalaCardsiMMD2.
OpenTargetsiENSG00000136297.
PharmGKBiPA134910250.

Polymorphism and mutation databases

BioMutaiMMD2.
DMDMi51701810.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002188571 – 270Monocyte to macrophage differentiation factor 2Add BLAST270

Proteomic databases

PaxDbiQ8IY49.
PRIDEiQ8IY49.

PTM databases

PhosphoSitePlusiQ8IY49.

Expressioni

Tissue specificityi

Shows restricted expression with highest levels in brain and testis.1 Publication

Gene expression databases

BgeeiENSG00000136297.
CleanExiHS_MMD2.
GenevisibleiQ8IY49. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000384690.

Structurei

3D structure databases

ProteinModelPortaliQ8IY49.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ADIPOR family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4243. Eukaryota.
COG1272. LUCA.
GeneTreeiENSGT00390000001574.
HOGENOMiHOG000039440.
HOVERGENiHBG053507.
InParanoidiQ8IY49.
KOiK11064.
OMAiMSHEKPL.
OrthoDBiEOG091G0QEG.
PhylomeDBiQ8IY49.
TreeFamiTF313370.

Family and domain databases

InterProiIPR004254. AdipoR/HlyIII-related.
[Graphical view]
PANTHERiPTHR20855. PTHR20855. 2 hits.
PfamiPF03006. HlyIII. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IY49-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFAPRLLDFQ KTKYARFMNH RVPAHKRYQP TEYEHAANCA THAFWIIPSI
60 70 80 90 100
LGSSNLYFLS DDDWETISAW IYGLGLCGLF VVSTVFHTIS WKKSHLRMVE
110 120 130 140 150
HCLHMFDRMV IYFFIAASYA PWLNLRELGP WASHMRWLVW IMASVGTIYV
160 170 180 190 200
FFFHERTGSC VQFLRGEACP KAGTACLPAR YKLVELLCYV VMGFFPALVI
210 220 230 240 250
LSMPNTEGIW ELVTGGVFYC LGMVFFKSDG RIPFAHAIWH LFVAFGAGTH
260 270
YYAIWRYLYL PSTLQTKVSK
Length:270
Mass (Da):31,264
Last modified:August 31, 2004 - v2
Checksum:iA726231D6283A2DA
GO
Isoform 2 (identifier: Q8IY49-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     156-179: Missing.

Show »
Length:246
Mass (Da):28,845
Checksum:iF944D5B94B7E68A9
GO
Isoform 3 (identifier: Q8IY49-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     156-179: Missing.
     204-270: PNTEGIWELV...PSTLQTKVSK → AGKLRPGMTCLKRQ

Note: No experimental confirmation available.
Show »
Length:193
Mass (Da):22,730
Checksum:i14147EF0A8A50C78
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9F → L in AAR08376 (PubMed:16044242).Curated1
Sequence conflicti99V → L in AAH37881 (PubMed:15489334).Curated1
Sequence conflicti103L → I in AAH67905 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011486156 – 179Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST24
Alternative sequenceiVSP_045589204 – 270PNTEG…TKVSK → AGKLRPGMTCLKRQ in isoform 3. 1 PublicationAdd BLAST67

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY424288 mRNA. Translation: AAR08376.1.
AC053546 Genomic DNA. No translation available.
AC092032 Genomic DNA. No translation available.
CH471144 Genomic DNA. Translation: EAW87307.1.
BC037881 mRNA. Translation: AAH37881.2.
BC048346 mRNA. No translation available.
BC067905 mRNA. Translation: AAH67905.1.
CCDSiCCDS47529.1. [Q8IY49-1]
CCDS47530.1. [Q8IY49-2]
CCDS59047.1. [Q8IY49-3]
RefSeqiNP_001094070.1. NM_001100600.1. [Q8IY49-1]
NP_001257304.1. NM_001270375.1. [Q8IY49-3]
NP_940685.3. NM_198403.3. [Q8IY49-2]
UniGeneiHs.558694.

Genome annotation databases

EnsembliENST00000401401; ENSP00000384141; ENSG00000136297. [Q8IY49-2]
ENST00000404774; ENSP00000384690; ENSG00000136297. [Q8IY49-1]
ENST00000406755; ENSP00000385963; ENSG00000136297. [Q8IY49-3]
ENST00000612910; ENSP00000484193; ENSG00000136297. [Q8IY49-3]
GeneIDi221938.
KEGGihsa:221938.
UCSCiuc003snn.5. human. [Q8IY49-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY424288 mRNA. Translation: AAR08376.1.
AC053546 Genomic DNA. No translation available.
AC092032 Genomic DNA. No translation available.
CH471144 Genomic DNA. Translation: EAW87307.1.
BC037881 mRNA. Translation: AAH37881.2.
BC048346 mRNA. No translation available.
BC067905 mRNA. Translation: AAH67905.1.
CCDSiCCDS47529.1. [Q8IY49-1]
CCDS47530.1. [Q8IY49-2]
CCDS59047.1. [Q8IY49-3]
RefSeqiNP_001094070.1. NM_001100600.1. [Q8IY49-1]
NP_001257304.1. NM_001270375.1. [Q8IY49-3]
NP_940685.3. NM_198403.3. [Q8IY49-2]
UniGeneiHs.558694.

3D structure databases

ProteinModelPortaliQ8IY49.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000384690.

Protein family/group databases

TCDBi1.C.113.2.3. 1.c.113 the hly iii (hly iii) family.

PTM databases

PhosphoSitePlusiQ8IY49.

Polymorphism and mutation databases

BioMutaiMMD2.
DMDMi51701810.

Proteomic databases

PaxDbiQ8IY49.
PRIDEiQ8IY49.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000401401; ENSP00000384141; ENSG00000136297. [Q8IY49-2]
ENST00000404774; ENSP00000384690; ENSG00000136297. [Q8IY49-1]
ENST00000406755; ENSP00000385963; ENSG00000136297. [Q8IY49-3]
ENST00000612910; ENSP00000484193; ENSG00000136297. [Q8IY49-3]
GeneIDi221938.
KEGGihsa:221938.
UCSCiuc003snn.5. human. [Q8IY49-1]

Organism-specific databases

CTDi221938.
DisGeNETi221938.
GeneCardsiMMD2.
H-InvDBHIX0201148.
HGNCiHGNC:30133. MMD2.
MalaCardsiMMD2.
MIMi614581. gene.
neXtProtiNX_Q8IY49.
OpenTargetsiENSG00000136297.
PharmGKBiPA134910250.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4243. Eukaryota.
COG1272. LUCA.
GeneTreeiENSGT00390000001574.
HOGENOMiHOG000039440.
HOVERGENiHBG053507.
InParanoidiQ8IY49.
KOiK11064.
OMAiMSHEKPL.
OrthoDBiEOG091G0QEG.
PhylomeDBiQ8IY49.
TreeFamiTF313370.

Miscellaneous databases

ChiTaRSiMMD2. human.
GenomeRNAii221938.
PROiQ8IY49.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136297.
CleanExiHS_MMD2.
GenevisibleiQ8IY49. HS.

Family and domain databases

InterProiIPR004254. AdipoR/HlyIII-related.
[Graphical view]
PANTHERiPTHR20855. PTHR20855. 2 hits.
PfamiPF03006. HlyIII. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPAQRA_HUMAN
AccessioniPrimary (citable) accession number: Q8IY49
Secondary accession number(s): B5MBW4, Q6NVU5, Q6TCH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: November 2, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.