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Q8IY49

- PAQRA_HUMAN

UniProt

Q8IY49 - PAQRA_HUMAN

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Protein
Monocyte to macrophage differentiation factor 2
Gene
MMD2, PAQR10
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Monocyte to macrophage differentiation factor 2
Alternative name(s):
Progestin and adipoQ receptor family member 10
Progestin and adipoQ receptor family member X
Gene namesi
Name:MMD2
Synonyms:PAQR10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:30133. MMD2.

Subcellular locationi

Golgi apparatus membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei39 – 5921Helical; Reviewed prediction
Add
BLAST
Topological domaini60 – 656Lumenal Reviewed prediction
Transmembranei66 – 8621Helical; Reviewed prediction
Add
BLAST
Topological domaini87 – 10216Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei103 – 12321Helical; Reviewed prediction
Add
BLAST
Topological domaini124 – 1329Lumenal Reviewed prediction
Transmembranei133 – 15321Helical; Reviewed prediction
Add
BLAST
Topological domaini154 – 18229Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei183 – 20321Helical; Reviewed prediction
Add
BLAST
Topological domaini204 – 2052Lumenal Reviewed prediction
Transmembranei206 – 22621Helical; Reviewed prediction
Add
BLAST
Topological domaini227 – 2337Cytoplasmic Reviewed prediction
Transmembranei234 – 25421Helical; Reviewed prediction
Add
BLAST
Topological domaini255 – 27016Lumenal Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. perinuclear region of cytoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134910250.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 270270Monocyte to macrophage differentiation factor 2
PRO_0000218857Add
BLAST

Proteomic databases

PaxDbiQ8IY49.
PRIDEiQ8IY49.

Expressioni

Tissue specificityi

Shows restricted expression with highest levels in brain and testis.1 Publication

Gene expression databases

BgeeiQ8IY49.
CleanExiHS_MMD2.
GenevestigatoriQ8IY49.

Organism-specific databases

HPAiHPA048714.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000384690.

Structurei

3D structure databases

ProteinModelPortaliQ8IY49.

Family & Domainsi

Sequence similaritiesi

Belongs to the ADIPOR family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1272.
HOGENOMiHOG000039440.
HOVERGENiHBG053507.
InParanoidiQ8IY49.
KOiK11064.
OMAiMNHRVPS.
OrthoDBiEOG7SJD5B.
PhylomeDBiQ8IY49.
TreeFamiTF313370.

Family and domain databases

InterProiIPR004254. HlyIII-related.
[Graphical view]
PANTHERiPTHR20855. PTHR20855. 1 hit.
PfamiPF03006. HlyIII. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IY49-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MFAPRLLDFQ KTKYARFMNH RVPAHKRYQP TEYEHAANCA THAFWIIPSI    50
LGSSNLYFLS DDDWETISAW IYGLGLCGLF VVSTVFHTIS WKKSHLRMVE 100
HCLHMFDRMV IYFFIAASYA PWLNLRELGP WASHMRWLVW IMASVGTIYV 150
FFFHERTGSC VQFLRGEACP KAGTACLPAR YKLVELLCYV VMGFFPALVI 200
LSMPNTEGIW ELVTGGVFYC LGMVFFKSDG RIPFAHAIWH LFVAFGAGTH 250
YYAIWRYLYL PSTLQTKVSK 270
Length:270
Mass (Da):31,264
Last modified:August 31, 2004 - v2
Checksum:iA726231D6283A2DA
GO
Isoform 2 (identifier: Q8IY49-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     156-179: Missing.

Show »
Length:246
Mass (Da):28,845
Checksum:iF944D5B94B7E68A9
GO
Isoform 3 (identifier: Q8IY49-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     156-179: Missing.
     204-270: PNTEGIWELV...PSTLQTKVSK → AGKLRPGMTCLKRQ

Note: No experimental confirmation available.

Show »
Length:193
Mass (Da):22,730
Checksum:i14147EF0A8A50C78
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei156 – 17924Missing in isoform 2 and isoform 3.
VSP_011486Add
BLAST
Alternative sequencei204 – 27067PNTEG…TKVSK → AGKLRPGMTCLKRQ in isoform 3.
VSP_045589Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91F → L in AAR08376. 1 Publication
Sequence conflicti99 – 991V → L in AAH37881. 1 Publication
Sequence conflicti103 – 1031L → I in AAH67905. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY424288 mRNA. Translation: AAR08376.1.
AC053546 Genomic DNA. No translation available.
AC092032 Genomic DNA. No translation available.
CH471144 Genomic DNA. Translation: EAW87307.1.
BC037881 mRNA. Translation: AAH37881.2.
BC048346 mRNA. No translation available.
BC067905 mRNA. Translation: AAH67905.1.
CCDSiCCDS47529.1. [Q8IY49-1]
CCDS47530.1. [Q8IY49-2]
CCDS59047.1. [Q8IY49-3]
RefSeqiNP_001094070.1. NM_001100600.1. [Q8IY49-1]
NP_001257304.1. NM_001270375.1. [Q8IY49-3]
NP_940685.3. NM_198403.3. [Q8IY49-2]
UniGeneiHs.558694.

Genome annotation databases

EnsembliENST00000401401; ENSP00000384141; ENSG00000136297. [Q8IY49-2]
ENST00000404774; ENSP00000384690; ENSG00000136297. [Q8IY49-1]
ENST00000406755; ENSP00000385963; ENSG00000136297. [Q8IY49-3]
GeneIDi221938.
KEGGihsa:221938.
UCSCiuc003snn.4. human. [Q8IY49-2]
uc003sno.4. human. [Q8IY49-1]
uc010ksq.3. human.

Polymorphism databases

DMDMi51701810.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY424288 mRNA. Translation: AAR08376.1 .
AC053546 Genomic DNA. No translation available.
AC092032 Genomic DNA. No translation available.
CH471144 Genomic DNA. Translation: EAW87307.1 .
BC037881 mRNA. Translation: AAH37881.2 .
BC048346 mRNA. No translation available.
BC067905 mRNA. Translation: AAH67905.1 .
CCDSi CCDS47529.1. [Q8IY49-1 ]
CCDS47530.1. [Q8IY49-2 ]
CCDS59047.1. [Q8IY49-3 ]
RefSeqi NP_001094070.1. NM_001100600.1. [Q8IY49-1 ]
NP_001257304.1. NM_001270375.1. [Q8IY49-3 ]
NP_940685.3. NM_198403.3. [Q8IY49-2 ]
UniGenei Hs.558694.

3D structure databases

ProteinModelPortali Q8IY49.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000384690.

Polymorphism databases

DMDMi 51701810.

Proteomic databases

PaxDbi Q8IY49.
PRIDEi Q8IY49.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000401401 ; ENSP00000384141 ; ENSG00000136297 . [Q8IY49-2 ]
ENST00000404774 ; ENSP00000384690 ; ENSG00000136297 . [Q8IY49-1 ]
ENST00000406755 ; ENSP00000385963 ; ENSG00000136297 . [Q8IY49-3 ]
GeneIDi 221938.
KEGGi hsa:221938.
UCSCi uc003snn.4. human. [Q8IY49-2 ]
uc003sno.4. human. [Q8IY49-1 ]
uc010ksq.3. human.

Organism-specific databases

CTDi 221938.
GeneCardsi GC07M004945.
H-InvDB HIX0201148.
HGNCi HGNC:30133. MMD2.
HPAi HPA048714.
MIMi 614581. gene.
neXtProti NX_Q8IY49.
PharmGKBi PA134910250.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1272.
HOGENOMi HOG000039440.
HOVERGENi HBG053507.
InParanoidi Q8IY49.
KOi K11064.
OMAi MNHRVPS.
OrthoDBi EOG7SJD5B.
PhylomeDBi Q8IY49.
TreeFami TF313370.

Miscellaneous databases

GenomeRNAii 221938.
NextBioi 91508.
PROi Q8IY49.
SOURCEi Search...

Gene expression databases

Bgeei Q8IY49.
CleanExi HS_MMD2.
Genevestigatori Q8IY49.

Family and domain databases

InterProi IPR004254. HlyIII-related.
[Graphical view ]
PANTHERi PTHR20855. PTHR20855. 1 hit.
Pfami PF03006. HlyIII. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif."
    Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C., Funk W.D.
    J. Mol. Evol. 61:372-380(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Brain and Retinoblastoma.
  5. "Identification of the topology and functional domains of PAQR10."
    Jin T., Xu D., Ding Q., Zhang Y., Mao C., Pan Y., Wang Z., Chen Y.
    Biochem. J. 443:643-653(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, MEMBRANE TOPOLOGY.

Entry informationi

Entry nameiPAQRA_HUMAN
AccessioniPrimary (citable) accession number: Q8IY49
Secondary accession number(s): B5MBW4, Q6NVU5, Q6TCH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: September 3, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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