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Q8IY49 (PAQRA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Monocyte to macrophage differentiation factor 2
Alternative name(s):
Progestin and adipoQ receptor family member 10
Progestin and adipoQ receptor family member X
Gene names
Name:MMD2
Synonyms:PAQR10
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length270 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Golgi apparatus membrane; Multi-pass membrane protein Ref.5.

Tissue specificity

Shows restricted expression with highest levels in brain and testis. Ref.1

Sequence similarities

Belongs to the ADIPOR family.

Ontologies

Keywords
   Cellular componentGolgi apparatus
Membrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   Molecular functionReceptor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentGolgi membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

perinuclear region of cytoplasm

Inferred from direct assay PubMed 22500632. Source: MGI

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8IY49-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8IY49-2)

The sequence of this isoform differs from the canonical sequence as follows:
     156-179: Missing.
Isoform 3 (identifier: Q8IY49-3)

The sequence of this isoform differs from the canonical sequence as follows:
     156-179: Missing.
     204-270: PNTEGIWELV...PSTLQTKVSK → AGKLRPGMTCLKRQ
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 270270Monocyte to macrophage differentiation factor 2
PRO_0000218857

Regions

Topological domain1 – 3838Cytoplasmic Potential
Transmembrane39 – 5921Helical; Potential
Topological domain60 – 656Lumenal Potential
Transmembrane66 – 8621Helical; Potential
Topological domain87 – 10216Cytoplasmic Potential
Transmembrane103 – 12321Helical; Potential
Topological domain124 – 1329Lumenal Potential
Transmembrane133 – 15321Helical; Potential
Topological domain154 – 18229Cytoplasmic Potential
Transmembrane183 – 20321Helical; Potential
Topological domain204 – 2052Lumenal Potential
Transmembrane206 – 22621Helical; Potential
Topological domain227 – 2337Cytoplasmic Potential
Transmembrane234 – 25421Helical; Potential
Topological domain255 – 27016Lumenal Potential

Natural variations

Alternative sequence156 – 17924Missing in isoform 2 and isoform 3.
VSP_011486
Alternative sequence204 – 27067PNTEG…TKVSK → AGKLRPGMTCLKRQ in isoform 3.
VSP_045589

Experimental info

Sequence conflict91F → L in AAR08376. Ref.1
Sequence conflict991V → L in AAH37881. Ref.4
Sequence conflict1031L → I in AAH67905. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified August 31, 2004. Version 2.
Checksum: A726231D6283A2DA

FASTA27031,264
        10         20         30         40         50         60 
MFAPRLLDFQ KTKYARFMNH RVPAHKRYQP TEYEHAANCA THAFWIIPSI LGSSNLYFLS 

        70         80         90        100        110        120 
DDDWETISAW IYGLGLCGLF VVSTVFHTIS WKKSHLRMVE HCLHMFDRMV IYFFIAASYA 

       130        140        150        160        170        180 
PWLNLRELGP WASHMRWLVW IMASVGTIYV FFFHERTGSC VQFLRGEACP KAGTACLPAR 

       190        200        210        220        230        240 
YKLVELLCYV VMGFFPALVI LSMPNTEGIW ELVTGGVFYC LGMVFFKSDG RIPFAHAIWH 

       250        260        270 
LFVAFGAGTH YYAIWRYLYL PSTLQTKVSK 

« Hide

Isoform 2 [UniParc].

Checksum: F944D5B94B7E68A9
Show »

FASTA24628,845
Isoform 3 [UniParc].

Checksum: 14147EF0A8A50C78
Show »

FASTA19322,730

References

« Hide 'large scale' references
[1]"PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif."
Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C., Funk W.D.
J. Mol. Evol. 61:372-380(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
[2]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
Tissue: Brain and Retinoblastoma.
[5]"Identification of the topology and functional domains of PAQR10."
Jin T., Xu D., Ding Q., Zhang Y., Mao C., Pan Y., Wang Z., Chen Y.
Biochem. J. 443:643-653(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, MEMBRANE TOPOLOGY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY424288 mRNA. Translation: AAR08376.1.
AC053546 Genomic DNA. No translation available.
AC092032 Genomic DNA. No translation available.
CH471144 Genomic DNA. Translation: EAW87307.1.
BC037881 mRNA. Translation: AAH37881.2.
BC048346 mRNA. No translation available.
BC067905 mRNA. Translation: AAH67905.1.
CCDSCCDS47529.1. [Q8IY49-1]
CCDS47530.1. [Q8IY49-2]
CCDS59047.1. [Q8IY49-3]
RefSeqNP_001094070.1. NM_001100600.1. [Q8IY49-1]
NP_001257304.1. NM_001270375.1. [Q8IY49-3]
NP_940685.3. NM_198403.3. [Q8IY49-2]
UniGeneHs.558694.

3D structure databases

ProteinModelPortalQ8IY49.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000384690.

Polymorphism databases

DMDM51701810.

Proteomic databases

PaxDbQ8IY49.
PRIDEQ8IY49.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000401401; ENSP00000384141; ENSG00000136297. [Q8IY49-2]
ENST00000404774; ENSP00000384690; ENSG00000136297. [Q8IY49-1]
ENST00000406755; ENSP00000385963; ENSG00000136297. [Q8IY49-3]
GeneID221938.
KEGGhsa:221938.
UCSCuc003snn.4. human. [Q8IY49-2]
uc003sno.4. human. [Q8IY49-1]

Organism-specific databases

CTD221938.
GeneCardsGC07M004945.
H-InvDBHIX0201148.
HGNCHGNC:30133. MMD2.
HPAHPA048714.
MIM614581. gene.
neXtProtNX_Q8IY49.
PharmGKBPA134910250.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1272.
HOGENOMHOG000039440.
HOVERGENHBG053507.
InParanoidQ8IY49.
KOK11064.
OMAMNHRVPS.
OrthoDBEOG7SJD5B.
PhylomeDBQ8IY49.
TreeFamTF313370.

Gene expression databases

BgeeQ8IY49.
CleanExHS_MMD2.
GenevestigatorQ8IY49.

Family and domain databases

InterProIPR004254. HlyIII-related.
[Graphical view]
PANTHERPTHR20855. PTHR20855. 1 hit.
PfamPF03006. HlyIII. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi221938.
NextBio91508.
PROQ8IY49.
SOURCESearch...

Entry information

Entry namePAQRA_HUMAN
AccessionPrimary (citable) accession number: Q8IY49
Secondary accession number(s): B5MBW4, Q6NVU5, Q6TCH0
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: July 9, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM