Q8IY49 (PAQRA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Monocyte to macrophage differentiation factor 2

Alternative name(s):
Progestin and adipoQ receptor family member 10
Progestin and adipoQ receptor family member X

Gene names

Name:	MMD2
Synonyms:	PAQR10

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	270 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Golgi apparatus membrane; Multi-pass membrane protein Ref.5.
Tissue specificity	Shows restricted expression with highest levels in brain and testis. Ref.1
Sequence similarities	Belongs to the ADIPOR family.

Ontologies

Keywords
Cellular component	Golgi apparatus Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Molecular function	Receptor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW perinuclear region of cytoplasm Inferred from direct assay PubMed 22500632. Source: MGI
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IY49-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8IY49-2)

The sequence of this isoform differs from the canonical sequence as follows:
     156-179: Missing.

Isoform 3 (identifier: Q8IY49-3)

The sequence of this isoform differs from the canonical sequence as follows:
     156-179: Missing.
     204-270: PNTEGIWELV...PSTLQTKVSK → AGKLRPGMTCLKRQ

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 270	270	Monocyte to macrophage differentiation factor 2		PRO_0000218857
Regions
	Topological domain	1 – 38	38	Cytoplasmic Potential
	Transmembrane	39 – 59	21	Helical; Potential
	Topological domain	60 – 65	6	Lumenal Potential
	Transmembrane	66 – 86	21	Helical; Potential
	Topological domain	87 – 102	16	Cytoplasmic Potential
	Transmembrane	103 – 123	21	Helical; Potential
	Topological domain	124 – 132	9	Lumenal Potential
	Transmembrane	133 – 153	21	Helical; Potential
	Topological domain	154 – 182	29	Cytoplasmic Potential
	Transmembrane	183 – 203	21	Helical; Potential
	Topological domain	204 – 205	2	Lumenal Potential
	Transmembrane	206 – 226	21	Helical; Potential
	Topological domain	227 – 233	7	Cytoplasmic Potential
	Transmembrane	234 – 254	21	Helical; Potential
	Topological domain	255 – 270	16	Lumenal Potential
Natural variations
	Alternative sequence	156 – 179	24	Missing in isoform 2 and isoform 3.		VSP_011486
	Alternative sequence	204 – 270	67	PNTEG…TKVSK → AGKLRPGMTCLKRQ in isoform 3.		VSP_045589
Experimental info
	Sequence conflict	9	1	F → L in AAR08376. Ref.1
	Sequence conflict	99	1	V → L in AAH37881. Ref.4
	Sequence conflict	103	1	L → I in AAH67905. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified August 31, 2004. Version 2. Checksum: A726231D6283A2DA	FASTA	270	31,264
	10 20 30 40 50 60 MFAPRLLDFQ KTKYARFMNH RVPAHKRYQP TEYEHAANCA THAFWIIPSI LGSSNLYFLS 70 80 90 100 110 120 DDDWETISAW IYGLGLCGLF VVSTVFHTIS WKKSHLRMVE HCLHMFDRMV IYFFIAASYA 130 140 150 160 170 180 PWLNLRELGP WASHMRWLVW IMASVGTIYV FFFHERTGSC VQFLRGEACP KAGTACLPAR 190 200 210 220 230 240 YKLVELLCYV VMGFFPALVI LSMPNTEGIW ELVTGGVFYC LGMVFFKSDG RIPFAHAIWH 250 260 270 LFVAFGAGTH YYAIWRYLYL PSTLQTKVSK
	Isoform 2 [UniParc]. Checksum: F944D5B94B7E68A9	FASTA	246	28,845
	10 20 30 40 50 60 MFAPRLLDFQ KTKYARFMNH RVPAHKRYQP TEYEHAANCA THAFWIIPSI LGSSNLYFLS 70 80 90 100 110 120 DDDWETISAW IYGLGLCGLF VVSTVFHTIS WKKSHLRMVE HCLHMFDRMV IYFFIAASYA 130 140 150 160 170 180 PWLNLRELGP WASHMRWLVW IMASVGTIYV FFFHERYKLV ELLCYVVMGF FPALVILSMP 190 200 210 220 230 240 NTEGIWELVT GGVFYCLGMV FFKSDGRIPF AHAIWHLFVA FGAGTHYYAI WRYLYLPSTL QTKVSK
	Isoform 3 [UniParc]. Checksum: 14147EF0A8A50C78	FASTA	193	22,730
	10 20 30 40 50 60 MFAPRLLDFQ KTKYARFMNH RVPAHKRYQP TEYEHAANCA THAFWIIPSI LGSSNLYFLS 70 80 90 100 110 120 DDDWETISAW IYGLGLCGLF VVSTVFHTIS WKKSHLRMVE HCLHMFDRMV IYFFIAASYA 130 140 150 160 170 180 PWLNLRELGP WASHMRWLVW IMASVGTIYV FFFHERYKLV ELLCYVVMGF FPALVILSMA 190 GKLRPGMTCL KRQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif." Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C., Funk W.D. J. Mol. Evol. 61:372-380(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
[2]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3). Tissue: Brain and Retinoblastoma.
[5]	"Identification of the topology and functional domains of PAQR10." Jin T., Xu D., Ding Q., Zhang Y., Mao C., Pan Y., Wang Z., Chen Y. Biochem. J. 443:643-653(2012) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, MEMBRANE TOPOLOGY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY424288 mRNA. Translation: AAR08376.1. AC053546 Genomic DNA. No translation available. AC092032 Genomic DNA. No translation available. CH471144 Genomic DNA. Translation: EAW87307.1. BC037881 mRNA. Translation: AAH37881.2. BC048346 mRNA. No translation available. BC067905 mRNA. Translation: AAH67905.1.
IPI	IPI00217645. IPI00455214. IPI00892673.
RefSeq	NP_001094070.1. NM_001100600.1. NP_001257304.1. NM_001270375.1. NP_940685.3. NM_198403.3.
UniGene	Hs.558694.
3D structure databases
ProteinModelPortal	Q8IY49.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000384690.
Polymorphism databases
DMDM	51701810.
Proteomic databases
PaxDb	Q8IY49.
PRIDE	Q8IY49.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000401401; ENSP00000384141; ENSG00000136297. ENST00000404774; ENSP00000384690; ENSG00000136297. ENST00000406755; ENSP00000385963; ENSG00000136297.
GeneID	221938.
KEGG	hsa:221938.
UCSC	uc003snn.4. human. uc003sno.4. human.
Organism-specific databases
CTD	221938.
GeneCards	GC07M004945.
H-InvDB	HIX0201148.
HGNC	HGNC:30133. MMD2.
HPA	HPA048714.
MIM	614581. gene.
neXtProt	NX_Q8IY49.
PharmGKB	PA134910250.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1272.
HOGENOM	HOG000039440.
HOVERGEN	HBG053507.
InParanoid	Q8IY49.
KO	K11064.
OMA	WAEEIAN.
OrthoDB	EOG4HDSV7.
Gene expression databases
ArrayExpress	Q8IY49.
Bgee	Q8IY49.
CleanEx	HS_MMD2.
Genevestigator	Q8IY49.
GermOnline	ENSG00000136297. Homo sapiens.
Family and domain databases
InterPro	IPR004254. HlyIII-related. [Graphical view]
PANTHER	PTHR20855. PTHR20855. 1 hit.
Pfam	PF03006. HlyIII. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	221938.
NextBio	91508.
SOURCE	Search...

Entry information

Entry name

PAQRA_HUMAN

Accession

Primary (citable) accession number: Q8IY49
Secondary accession number(s): B5MBW4, Q6NVU5, Q6TCH0

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
Last sequence update:	August 31, 2004
Last modified:	April 3, 2013
This is version 85 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.