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Protein

Monocyte to macrophage differentiation factor 2

Gene

MMD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Monocyte to macrophage differentiation factor 2
Alternative name(s):
Progestin and adipoQ receptor family member 10
Progestin and adipoQ receptor family member X
Gene namesi
Name:MMD2
Synonyms:PAQR10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:30133. MMD2.

Subcellular locationi

Golgi apparatus membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei39 – 5921HelicalSequence AnalysisAdd
BLAST
Topological domaini60 – 656LumenalSequence Analysis
Transmembranei66 – 8621HelicalSequence AnalysisAdd
BLAST
Topological domaini87 – 10216CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei103 – 12321HelicalSequence AnalysisAdd
BLAST
Topological domaini124 – 1329LumenalSequence Analysis
Transmembranei133 – 15321HelicalSequence AnalysisAdd
BLAST
Topological domaini154 – 18229CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei183 – 20321HelicalSequence AnalysisAdd
BLAST
Topological domaini204 – 2052LumenalSequence Analysis
Transmembranei206 – 22621HelicalSequence AnalysisAdd
BLAST
Topological domaini227 – 2337CytoplasmicSequence Analysis
Transmembranei234 – 25421HelicalSequence AnalysisAdd
BLAST
Topological domaini255 – 27016LumenalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. perinuclear region of cytoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134910250.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 270270Monocyte to macrophage differentiation factor 2PRO_0000218857Add
BLAST

Proteomic databases

PaxDbiQ8IY49.
PRIDEiQ8IY49.

Expressioni

Tissue specificityi

Shows restricted expression with highest levels in brain and testis.1 Publication

Gene expression databases

BgeeiQ8IY49.
CleanExiHS_MMD2.
GenevestigatoriQ8IY49.

Organism-specific databases

HPAiHPA048714.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000384690.

Structurei

3D structure databases

ProteinModelPortaliQ8IY49.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ADIPOR family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1272.
GeneTreeiENSGT00390000001574.
HOGENOMiHOG000039440.
HOVERGENiHBG053507.
InParanoidiQ8IY49.
KOiK11064.
OMAiMSHEKPL.
OrthoDBiEOG7SJD5B.
PhylomeDBiQ8IY49.
TreeFamiTF313370.

Family and domain databases

InterProiIPR004254. AdipoR/HlyIII-related.
[Graphical view]
PANTHERiPTHR20855. PTHR20855. 1 hit.
PfamiPF03006. HlyIII. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IY49-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFAPRLLDFQ KTKYARFMNH RVPAHKRYQP TEYEHAANCA THAFWIIPSI
60 70 80 90 100
LGSSNLYFLS DDDWETISAW IYGLGLCGLF VVSTVFHTIS WKKSHLRMVE
110 120 130 140 150
HCLHMFDRMV IYFFIAASYA PWLNLRELGP WASHMRWLVW IMASVGTIYV
160 170 180 190 200
FFFHERTGSC VQFLRGEACP KAGTACLPAR YKLVELLCYV VMGFFPALVI
210 220 230 240 250
LSMPNTEGIW ELVTGGVFYC LGMVFFKSDG RIPFAHAIWH LFVAFGAGTH
260 270
YYAIWRYLYL PSTLQTKVSK
Length:270
Mass (Da):31,264
Last modified:August 31, 2004 - v2
Checksum:iA726231D6283A2DA
GO
Isoform 2 (identifier: Q8IY49-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     156-179: Missing.

Show »
Length:246
Mass (Da):28,845
Checksum:iF944D5B94B7E68A9
GO
Isoform 3 (identifier: Q8IY49-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     156-179: Missing.
     204-270: PNTEGIWELV...PSTLQTKVSK → AGKLRPGMTCLKRQ

Note: No experimental confirmation available.

Show »
Length:193
Mass (Da):22,730
Checksum:i14147EF0A8A50C78
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91F → L in AAR08376 (PubMed:16044242).Curated
Sequence conflicti99 – 991V → L in AAH37881 (PubMed:15489334).Curated
Sequence conflicti103 – 1031L → I in AAH67905 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei156 – 17924Missing in isoform 2 and isoform 3. 2 PublicationsVSP_011486Add
BLAST
Alternative sequencei204 – 27067PNTEG…TKVSK → AGKLRPGMTCLKRQ in isoform 3. 1 PublicationVSP_045589Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY424288 mRNA. Translation: AAR08376.1.
AC053546 Genomic DNA. No translation available.
AC092032 Genomic DNA. No translation available.
CH471144 Genomic DNA. Translation: EAW87307.1.
BC037881 mRNA. Translation: AAH37881.2.
BC048346 mRNA. No translation available.
BC067905 mRNA. Translation: AAH67905.1.
CCDSiCCDS47529.1. [Q8IY49-1]
CCDS47530.1. [Q8IY49-2]
CCDS59047.1. [Q8IY49-3]
RefSeqiNP_001094070.1. NM_001100600.1. [Q8IY49-1]
NP_001257304.1. NM_001270375.1. [Q8IY49-3]
NP_940685.3. NM_198403.3. [Q8IY49-2]
UniGeneiHs.558694.

Genome annotation databases

EnsembliENST00000401401; ENSP00000384141; ENSG00000136297. [Q8IY49-2]
ENST00000404774; ENSP00000384690; ENSG00000136297. [Q8IY49-1]
ENST00000406755; ENSP00000385963; ENSG00000136297. [Q8IY49-3]
ENST00000612910; ENSP00000484193; ENSG00000136297. [Q8IY49-3]
GeneIDi221938.
KEGGihsa:221938.
UCSCiuc003snn.4. human. [Q8IY49-2]
uc003sno.4. human. [Q8IY49-1]
uc010ksq.3. human.

Polymorphism databases

DMDMi51701810.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY424288 mRNA. Translation: AAR08376.1.
AC053546 Genomic DNA. No translation available.
AC092032 Genomic DNA. No translation available.
CH471144 Genomic DNA. Translation: EAW87307.1.
BC037881 mRNA. Translation: AAH37881.2.
BC048346 mRNA. No translation available.
BC067905 mRNA. Translation: AAH67905.1.
CCDSiCCDS47529.1. [Q8IY49-1]
CCDS47530.1. [Q8IY49-2]
CCDS59047.1. [Q8IY49-3]
RefSeqiNP_001094070.1. NM_001100600.1. [Q8IY49-1]
NP_001257304.1. NM_001270375.1. [Q8IY49-3]
NP_940685.3. NM_198403.3. [Q8IY49-2]
UniGeneiHs.558694.

3D structure databases

ProteinModelPortaliQ8IY49.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000384690.

Polymorphism databases

DMDMi51701810.

Proteomic databases

PaxDbiQ8IY49.
PRIDEiQ8IY49.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000401401; ENSP00000384141; ENSG00000136297. [Q8IY49-2]
ENST00000404774; ENSP00000384690; ENSG00000136297. [Q8IY49-1]
ENST00000406755; ENSP00000385963; ENSG00000136297. [Q8IY49-3]
ENST00000612910; ENSP00000484193; ENSG00000136297. [Q8IY49-3]
GeneIDi221938.
KEGGihsa:221938.
UCSCiuc003snn.4. human. [Q8IY49-2]
uc003sno.4. human. [Q8IY49-1]
uc010ksq.3. human.

Organism-specific databases

CTDi221938.
GeneCardsiGC07M004945.
H-InvDBHIX0201148.
HGNCiHGNC:30133. MMD2.
HPAiHPA048714.
MIMi614581. gene.
neXtProtiNX_Q8IY49.
PharmGKBiPA134910250.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1272.
GeneTreeiENSGT00390000001574.
HOGENOMiHOG000039440.
HOVERGENiHBG053507.
InParanoidiQ8IY49.
KOiK11064.
OMAiMSHEKPL.
OrthoDBiEOG7SJD5B.
PhylomeDBiQ8IY49.
TreeFamiTF313370.

Miscellaneous databases

ChiTaRSiMMD2. human.
GenomeRNAii221938.
NextBioi91508.
PROiQ8IY49.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IY49.
CleanExiHS_MMD2.
GenevestigatoriQ8IY49.

Family and domain databases

InterProiIPR004254. AdipoR/HlyIII-related.
[Graphical view]
PANTHERiPTHR20855. PTHR20855. 1 hit.
PfamiPF03006. HlyIII. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif."
    Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C., Funk W.D.
    J. Mol. Evol. 61:372-380(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Brain and Retinoblastoma.
  5. "Identification of the topology and functional domains of PAQR10."
    Jin T., Xu D., Ding Q., Zhang Y., Mao C., Pan Y., Wang Z., Chen Y.
    Biochem. J. 443:643-653(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, MEMBRANE TOPOLOGY.

Entry informationi

Entry nameiPAQRA_HUMAN
AccessioniPrimary (citable) accession number: Q8IY49
Secondary accession number(s): B5MBW4, Q6NVU5, Q6TCH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: August 31, 2004
Last modified: January 7, 2015
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.