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Protein

Protein AMN1 homolog

Gene

AMN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein AMN1 homolog
Gene namesi
Name:AMN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:27281. AMN1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162376371.

Polymorphism and mutation databases

BioMutaiAMN1.
DMDMi156630575.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258Protein AMN1 homologPRO_0000289273Add
BLAST

Proteomic databases

EPDiQ8IY45.
MaxQBiQ8IY45.
PaxDbiQ8IY45.
PeptideAtlasiQ8IY45.
PRIDEiQ8IY45.

PTM databases

iPTMnetiQ8IY45.
PhosphoSiteiQ8IY45.

Expressioni

Gene expression databases

BgeeiENSG00000151743.
CleanExiHS_AMN1.
ExpressionAtlasiQ8IY45. baseline and differential.
GenevisibleiQ8IY45. HS.

Organism-specific databases

HPAiHPA046157.
HPA062290.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000281471.

Structurei

3D structure databases

ProteinModelPortaliQ8IY45.
SMRiQ8IY45. Positions 62-126, 167-216.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AMN1 family.Curated

Phylogenomic databases

eggNOGiENOG410IT1V. Eukaryota.
ENOG410ZYWH. LUCA.
GeneTreeiENSGT00730000111305.
HOGENOMiHOG000007165.
HOVERGENiHBG106876.
InParanoidiQ8IY45.
OMAiCRLLKII.
OrthoDBiEOG091G0G98.
PhylomeDBiQ8IY45.
TreeFamiTF331575.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF13516. LRR_6. 3 hits.
[Graphical view]
SMARTiSM00367. LRR_CC. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IY45-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPRPRRVSQL LDLCLWCFMK NISRYLTDIK PLPPNIKDRL IKIMSMQGQI
60 70 80 90 100
TDSNISEILH PEVQTLDLRS CDISDAALLH LSNCRKLKKL NLNASKGNRV
110 120 130 140 150
SVTSEGIKAV ASSCSYLHEA SLKRCCNLTD EGVVALALNC QLLKIIDLGG
160 170 180 190 200
CLSITDVSLH ALGKNCPFLQ CVDFSATQVS DSGVIALVSG PCAKKLEEIH
210 220 230 240 250
MGHCVNLTDG AVEAVLTYCP QIRILLFHGC PLITDHSREV LEQLVGPNKL

KQVTWTVY
Length:258
Mass (Da):28,408
Last modified:May 29, 2007 - v4
Checksum:i845276D49BA6646B
GO
Isoform 2 (identifier: Q8IY45-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: Missing.

Note: No experimental confirmation available.
Show »
Length:240
Mass (Da):26,193
Checksum:i1772C166162E6192
GO

Sequence cautioni

The sequence AAH37897 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH45831 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH67906 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1818Missing in isoform 2. 1 PublicationVSP_054567Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK302112 mRNA. Translation: BAH13629.1.
AC023157 Genomic DNA. No translation available.
CH471116 Genomic DNA. Translation: EAW88544.1.
BC037897 mRNA. Translation: AAH37897.3. Different initiation.
BC045831 mRNA. Translation: AAH45831.2. Different initiation.
BC067906 mRNA. Translation: AAH67906.1. Different initiation.
CCDSiCCDS44858.1. [Q8IY45-1]
CCDS61089.1. [Q8IY45-2]
RefSeqiNP_001106873.1. NM_001113402.1. [Q8IY45-1]
NP_001265340.1. NM_001278411.1. [Q8IY45-2]
NP_001265341.1. NM_001278412.1. [Q8IY45-2]
UniGeneiHs.585084.
Hs.740628.

Genome annotation databases

EnsembliENST00000281471; ENSP00000281471; ENSG00000151743. [Q8IY45-1]
ENST00000536761; ENSP00000440967; ENSG00000151743. [Q8IY45-2]
ENST00000537562; ENSP00000441419; ENSG00000151743. [Q8IY45-2]
GeneIDi196394.
KEGGihsa:196394.
UCSCiuc001rkq.4. human. [Q8IY45-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK302112 mRNA. Translation: BAH13629.1.
AC023157 Genomic DNA. No translation available.
CH471116 Genomic DNA. Translation: EAW88544.1.
BC037897 mRNA. Translation: AAH37897.3. Different initiation.
BC045831 mRNA. Translation: AAH45831.2. Different initiation.
BC067906 mRNA. Translation: AAH67906.1. Different initiation.
CCDSiCCDS44858.1. [Q8IY45-1]
CCDS61089.1. [Q8IY45-2]
RefSeqiNP_001106873.1. NM_001113402.1. [Q8IY45-1]
NP_001265340.1. NM_001278411.1. [Q8IY45-2]
NP_001265341.1. NM_001278412.1. [Q8IY45-2]
UniGeneiHs.585084.
Hs.740628.

3D structure databases

ProteinModelPortaliQ8IY45.
SMRiQ8IY45. Positions 62-126, 167-216.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000281471.

PTM databases

iPTMnetiQ8IY45.
PhosphoSiteiQ8IY45.

Polymorphism and mutation databases

BioMutaiAMN1.
DMDMi156630575.

Proteomic databases

EPDiQ8IY45.
MaxQBiQ8IY45.
PaxDbiQ8IY45.
PeptideAtlasiQ8IY45.
PRIDEiQ8IY45.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281471; ENSP00000281471; ENSG00000151743. [Q8IY45-1]
ENST00000536761; ENSP00000440967; ENSG00000151743. [Q8IY45-2]
ENST00000537562; ENSP00000441419; ENSG00000151743. [Q8IY45-2]
GeneIDi196394.
KEGGihsa:196394.
UCSCiuc001rkq.4. human. [Q8IY45-1]

Organism-specific databases

CTDi196394.
GeneCardsiAMN1.
HGNCiHGNC:27281. AMN1.
HPAiHPA046157.
HPA062290.
neXtProtiNX_Q8IY45.
PharmGKBiPA162376371.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IT1V. Eukaryota.
ENOG410ZYWH. LUCA.
GeneTreeiENSGT00730000111305.
HOGENOMiHOG000007165.
HOVERGENiHBG106876.
InParanoidiQ8IY45.
OMAiCRLLKII.
OrthoDBiEOG091G0G98.
PhylomeDBiQ8IY45.
TreeFamiTF331575.

Miscellaneous databases

ChiTaRSiAMN1. human.
GenomeRNAii196394.
PROiQ8IY45.

Gene expression databases

BgeeiENSG00000151743.
CleanExiHS_AMN1.
ExpressionAtlasiQ8IY45. baseline and differential.
GenevisibleiQ8IY45. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
[Graphical view]
PfamiPF13516. LRR_6. 3 hits.
[Graphical view]
SMARTiSM00367. LRR_CC. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAMN1_HUMAN
AccessioniPrimary (citable) accession number: Q8IY45
Secondary accession number(s): B7Z7J3, Q6NVU4, Q86X98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: September 7, 2016
This is version 92 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.