ID CD019_HUMAN Reviewed; 314 AA. AC Q8IY42; Q9NV03; DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2003, sequence version 1. DT 24-JAN-2024, entry version 128. DE RecName: Full=Uncharacterized protein C4orf19; GN Name=C4orf19; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLY-274. RC TISSUE=Placenta; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [3] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-30 AND SER-238, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., RA Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver RT phosphoproteome."; RL J. Proteomics 96:253-262(2014). CC -!- INTERACTION: CC Q8IY42; Q9NX38: ABITRAM; NbExp=3; IntAct=EBI-10216552, EBI-9105722; CC Q8IY42; Q96LK0: CEP19; NbExp=3; IntAct=EBI-10216552, EBI-741885; CC Q8IY42; P60228: EIF3E; NbExp=4; IntAct=EBI-10216552, EBI-347740; CC Q8IY42; Q9BUL8: PDCD10; NbExp=8; IntAct=EBI-10216552, EBI-740195; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK001879; BAA91958.1; -; mRNA. DR EMBL; BC037906; AAH37906.1; -; mRNA. DR CCDS; CCDS3442.1; -. DR RefSeq; NP_001098099.1; NM_001104629.1. DR RefSeq; NP_060772.2; NM_018302.2. DR RefSeq; XP_011512014.1; XM_011513712.2. DR RefSeq; XP_011512015.1; XM_011513713.2. DR RefSeq; XP_016863850.1; XM_017008361.1. DR AlphaFoldDB; Q8IY42; -. DR BioGRID; 120574; 9. DR IntAct; Q8IY42; 9. DR MINT; Q8IY42; -. DR STRING; 9606.ENSP00000371408; -. DR GlyGen; Q8IY42; 1 site, 1 O-linked glycan (1 site). DR iPTMnet; Q8IY42; -. DR PhosphoSitePlus; Q8IY42; -. DR BioMuta; C4orf19; -. DR DMDM; 74728286; -. DR MassIVE; Q8IY42; -. DR PaxDb; 9606-ENSP00000284437; -. DR PeptideAtlas; Q8IY42; -. DR ProteomicsDB; 71104; -. DR Antibodypedia; 43802; 77 antibodies from 16 providers. DR DNASU; 55286; -. DR Ensembl; ENST00000284437.6; ENSP00000284437.6; ENSG00000154274.15. DR Ensembl; ENST00000381980.9; ENSP00000371408.4; ENSG00000154274.15. DR GeneID; 55286; -. DR KEGG; hsa:55286; -. DR MANE-Select; ENST00000381980.9; ENSP00000371408.4; NM_001104629.2; NP_001098099.1. DR UCSC; uc003gsw.5; human. DR AGR; HGNC:25618; -. DR CTD; 55286; -. DR DisGeNET; 55286; -. DR GeneCards; C4orf19; -. DR HGNC; HGNC:25618; C4orf19. DR HPA; ENSG00000154274; Tissue enhanced (liver). DR neXtProt; NX_Q8IY42; -. DR OpenTargets; ENSG00000154274; -. DR PharmGKB; PA144596500; -. DR VEuPathDB; HostDB:ENSG00000154274; -. DR eggNOG; ENOG502S5D9; Eukaryota. DR GeneTree; ENSGT00390000013778; -. DR HOGENOM; CLU_076375_0_0_1; -. DR InParanoid; Q8IY42; -. DR OMA; GNYVEKD; -. DR OrthoDB; 5305438at2759; -. DR PhylomeDB; Q8IY42; -. DR TreeFam; TF337421; -. DR PathwayCommons; Q8IY42; -. DR SignaLink; Q8IY42; -. DR BioGRID-ORCS; 55286; 15 hits in 1117 CRISPR screens. DR ChiTaRS; C4orf19; human. DR GenomeRNAi; 55286; -. DR Pharos; Q8IY42; Tdark. DR PRO; PR:Q8IY42; -. DR Proteomes; UP000005640; Chromosome 4. DR RNAct; Q8IY42; Protein. DR Bgee; ENSG00000154274; Expressed in amniotic fluid and 161 other cell types or tissues. DR ExpressionAtlas; Q8IY42; baseline and differential. DR InterPro; IPR031528; DUF4699. DR PANTHER; PTHR16106; CHROMOSOME 4 OPEN READING FRAME 19; 1. DR PANTHER; PTHR16106:SF3; CHROMOSOME 4 OPEN READING FRAME 19; 1. DR Pfam; PF15770; DUF4699; 1. DR Genevisible; Q8IY42; HS. PE 1: Evidence at protein level; KW Phosphoprotein; Reference proteome. FT CHAIN 1..314 FT /note="Uncharacterized protein C4orf19" FT /id="PRO_0000286561" FT REGION 36..142 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 267..291 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 50..71 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 105..135 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 30 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:24275569" FT MOD_RES 106 FT /note="Phosphothreonine" FT /evidence="ECO:0000250|UniProtKB:Q99K99" FT MOD_RES 238 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:24275569" FT MOD_RES 241 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:Q99K99" FT VARIANT 39 FT /note="D -> E (in dbSNP:rs6852908)" FT /id="VAR_050770" FT VARIANT 151 FT /note="A -> T (in dbSNP:rs2973275)" FT /id="VAR_032118" FT VARIANT 274 FT /note="E -> G (in dbSNP:rs3733500)" FT /evidence="ECO:0000269|PubMed:14702039" FT /id="VAR_032119" SQ SEQUENCE 314 AA; 33742 MW; 65A8FEBD0F1B08EA CRC64; MGCRCCKIIQ SYLFDPVQVP SPGYVNEVNS CKLDEDDTDK LKGKWSSEVL VQKNDPQRQG SKKTESSSRT ADPWEPCWPH QGPLPQGDAG GEHHACGVNG IGPAATPQPT GNSSPTQDDR GSWASTANTV PPTQPFLEGG GTRKQDCVLL ASEGTQVMRN GDSRAPSEAE SFALEVQDHV FQIPAPDYLQ HWGPAGDNVD HNEKDCVFKN HTEDESLEGI QPPVGEHGLN TPFSVRRSWD SLNEDVETEV LSICFNEKGP VHAMPVVDSG NRQEDTHGSD GDGDGEIVDE DAAVAEALAA LEAATAGEDL DETD //