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Protein

Uncharacterized protein C4orf19

Gene

C4orf19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C4orf19
Gene namesi
Name:C4orf19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:25618. C4orf19.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000154274.
PharmGKBiPA144596500.

Polymorphism and mutation databases

BioMutaiC4orf19.
DMDMi74728286.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002865611 – 314Uncharacterized protein C4orf19Add BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei30PhosphoserineCombined sources1
Modified residuei106PhosphothreonineBy similarity1
Modified residuei238PhosphoserineCombined sources1
Modified residuei241PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8IY42.
PeptideAtlasiQ8IY42.
PRIDEiQ8IY42.

PTM databases

iPTMnetiQ8IY42.
PhosphoSitePlusiQ8IY42.

Expressioni

Gene expression databases

BgeeiENSG00000154274.
CleanExiHS_C4orf19.
ExpressionAtlasiQ8IY42. baseline and differential.
GenevisibleiQ8IY42. HS.

Organism-specific databases

HPAiHPA043458.
HPA052894.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
EIF3EP602283EBI-10216552,EBI-347740
PDCD10Q9BUL85EBI-10216552,EBI-740195

Protein-protein interaction databases

BioGridi120574. 6 interactors.
IntActiQ8IY42. 5 interactors.
STRINGi9606.ENSP00000284437.

Structurei

3D structure databases

ProteinModelPortaliQ8IY42.
SMRiQ8IY42.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IIR8. Eukaryota.
ENOG4111ADT. LUCA.
GeneTreeiENSGT00390000013778.
HOGENOMiHOG000111464.
HOVERGENiHBG099521.
InParanoidiQ8IY42.
OMAiQIPAPDY.
OrthoDBiEOG091G0CJ1.
PhylomeDBiQ8IY42.
TreeFamiTF337421.

Family and domain databases

InterProiIPR031528. DUF4699.
[Graphical view]
PfamiPF15770. DUF4699. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IY42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCRCCKIIQ SYLFDPVQVP SPGYVNEVNS CKLDEDDTDK LKGKWSSEVL
60 70 80 90 100
VQKNDPQRQG SKKTESSSRT ADPWEPCWPH QGPLPQGDAG GEHHACGVNG
110 120 130 140 150
IGPAATPQPT GNSSPTQDDR GSWASTANTV PPTQPFLEGG GTRKQDCVLL
160 170 180 190 200
ASEGTQVMRN GDSRAPSEAE SFALEVQDHV FQIPAPDYLQ HWGPAGDNVD
210 220 230 240 250
HNEKDCVFKN HTEDESLEGI QPPVGEHGLN TPFSVRRSWD SLNEDVETEV
260 270 280 290 300
LSICFNEKGP VHAMPVVDSG NRQEDTHGSD GDGDGEIVDE DAAVAEALAA
310
LEAATAGEDL DETD
Length:314
Mass (Da):33,742
Last modified:March 1, 2003 - v1
Checksum:i65A8FEBD0F1B08EA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05077039D → E.Corresponds to variant rs6852908dbSNPEnsembl.1
Natural variantiVAR_032118151A → T.Corresponds to variant rs2973275dbSNPEnsembl.1
Natural variantiVAR_032119274E → G.1 PublicationCorresponds to variant rs3733500dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001879 mRNA. Translation: BAA91958.1.
BC037906 mRNA. Translation: AAH37906.1.
CCDSiCCDS3442.1.
RefSeqiNP_001098099.1. NM_001104629.1.
NP_060772.2. NM_018302.2.
XP_011512014.1. XM_011513712.2.
XP_011512015.1. XM_011513713.2.
XP_016863850.1. XM_017008361.1.
UniGeneiHs.107527.

Genome annotation databases

EnsembliENST00000284437; ENSP00000284437; ENSG00000154274.
ENST00000381980; ENSP00000371408; ENSG00000154274.
GeneIDi55286.
KEGGihsa:55286.
UCSCiuc003gsw.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001879 mRNA. Translation: BAA91958.1.
BC037906 mRNA. Translation: AAH37906.1.
CCDSiCCDS3442.1.
RefSeqiNP_001098099.1. NM_001104629.1.
NP_060772.2. NM_018302.2.
XP_011512014.1. XM_011513712.2.
XP_011512015.1. XM_011513713.2.
XP_016863850.1. XM_017008361.1.
UniGeneiHs.107527.

3D structure databases

ProteinModelPortaliQ8IY42.
SMRiQ8IY42.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120574. 6 interactors.
IntActiQ8IY42. 5 interactors.
STRINGi9606.ENSP00000284437.

PTM databases

iPTMnetiQ8IY42.
PhosphoSitePlusiQ8IY42.

Polymorphism and mutation databases

BioMutaiC4orf19.
DMDMi74728286.

Proteomic databases

PaxDbiQ8IY42.
PeptideAtlasiQ8IY42.
PRIDEiQ8IY42.

Protocols and materials databases

DNASUi55286.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000284437; ENSP00000284437; ENSG00000154274.
ENST00000381980; ENSP00000371408; ENSG00000154274.
GeneIDi55286.
KEGGihsa:55286.
UCSCiuc003gsw.5. human.

Organism-specific databases

CTDi55286.
GeneCardsiC4orf19.
HGNCiHGNC:25618. C4orf19.
HPAiHPA043458.
HPA052894.
neXtProtiNX_Q8IY42.
OpenTargetsiENSG00000154274.
PharmGKBiPA144596500.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIR8. Eukaryota.
ENOG4111ADT. LUCA.
GeneTreeiENSGT00390000013778.
HOGENOMiHOG000111464.
HOVERGENiHBG099521.
InParanoidiQ8IY42.
OMAiQIPAPDY.
OrthoDBiEOG091G0CJ1.
PhylomeDBiQ8IY42.
TreeFamiTF337421.

Miscellaneous databases

ChiTaRSiC4orf19. human.
GenomeRNAii55286.
PROiQ8IY42.

Gene expression databases

BgeeiENSG00000154274.
CleanExiHS_C4orf19.
ExpressionAtlasiQ8IY42. baseline and differential.
GenevisibleiQ8IY42. HS.

Family and domain databases

InterProiIPR031528. DUF4699.
[Graphical view]
PfamiPF15770. DUF4699. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD019_HUMAN
AccessioniPrimary (citable) accession number: Q8IY42
Secondary accession number(s): Q9NV03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.