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Q8IY37 (DHX37_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable ATP-dependent RNA helicase DHX37

EC=3.6.4.13
Alternative name(s):
DEAH box protein 37
Gene names
Name:DHX37
Synonyms:DDX37, KIAA1517
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1157 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + H2O = ADP + phosphate.

Sequence similarities

Belongs to the DEAD box helicase family. DEAH subfamily.

Contains 1 helicase ATP-binding domain.

Contains 1 helicase C-terminal domain.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   LigandATP-binding
Nucleotide-binding
   Molecular functionHelicase
Hydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ATP-dependent helicase activity

Inferred from electronic annotation. Source: InterPro

nucleic acid binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11571157Probable ATP-dependent RNA helicase DHX37
PRO_0000055172

Regions

Domain262 – 429168Helicase ATP-binding
Domain459 – 716258Helicase C-terminal
Nucleotide binding275 – 2828ATP By similarity
Motif372 – 3754DEAH box

Natural variations

Natural variant961M → I.
Corresponds to variant rs11558556 [ dbSNP | Ensembl ].
VAR_061826
Natural variant4581R → Q.
Corresponds to variant rs11057939 [ dbSNP | Ensembl ].
VAR_052185
Natural variant5081K → N.
Corresponds to variant rs35165507 [ dbSNP | Ensembl ].
VAR_052186
Natural variant7171V → I.
Corresponds to variant rs35016004 [ dbSNP | Ensembl ].
VAR_052187
Natural variant8691S → G. Ref.1
Corresponds to variant rs4516060 [ dbSNP | Ensembl ].
VAR_052188
Natural variant10811R → Q. Ref.1
Corresponds to variant rs4447263 [ dbSNP | Ensembl ].
VAR_052189

Experimental info

Sequence conflict1741E → R in AAH02575. Ref.1
Sequence conflict8981A → S in BAA96041. Ref.2
Sequence conflict1130 – 115728YLLAE…PTTVH → CEFDQGQGVGVDRMGSLRQG LCALCTVSPGLAEGSGPTAA GQLFAT Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q8IY37 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 49332175221B30C5

FASTA1,157129,545
        10         20         30         40         50         60 
MGKLRRRYNI KGRQQAGPGP SKGPPEPPPV QLELEDKDTL KGVDASNALV LPGKKKKKTK 

        70         80         90        100        110        120 
APPLSKKEKK PLTKKEKKVL QKILEQKEKK SQRAEMLQKL SEVQASEAEM RLFYTTSKLG 

       130        140        150        160        170        180 
TGNRMYHTKE KADEVVAPGQ EKISSLSGAH RKRRRWPSAE EEEEEEEESE SELEEESELD 

       190        200        210        220        230        240 
EDPAAEPAEA GVGTTVAPLP PAPAPSSQPV PAGMTVPPPP AAAPPLPRAL AKPAVFIPVN 

       250        260        270        280        290        300 
RSPEMQEERL KLPILSEEQV IMEAVAEHPI VIVCGETGSG KTTQVPQFLY EAGFSSEDSI 

       310        320        330        340        350        360 
IGVTEPRRVA AVAMSQRVAK EMNLSQRVVS YQIRYEGNVT EETRIKFMTD GVLLKEIQKD 

       370        380        390        400        410        420 
FLLLRYKVVI IDEAHERSVY TDILIGLLSR IVTLRAKRNL PLKLLIMSAT LRVEDFTQNP 

       430        440        450        460        470        480 
RLFAKPPPVI KVESRQFPVT VHFNKRTPLE DYSGECFRKV CKIHRMLPAG GILVFLTGQA 

       490        500        510        520        530        540 
EVHALCRRLR KAFPPSRARP QEKDDDQKDS VEEMRKFKKS RARAKKARAE VLPQINLDHY 

       550        560        570        580        590        600 
SVLPAGEGDE DREAEVDEEE GALDSDLDLD LGDGGQDGGE QPDASLPLHV LPLYSLLAPE 

       610        620        630        640        650        660 
KQAQVFKPPP EGTRLCVVAT NVAETSLTIP GIKYVVDCGK VKKRYYDRVT GVSSFRVTWV 

       670        680        690        700        710        720 
SQASADQRAG RAGRTEPGHC YRLYSSAVFG DFEQFPPPEI TRRPVEDLIL QMKALNVEKV 

       730        740        750        760        770        780 
INFPFPTPPS VEALLAAEEL LIALGALQPP QKAERVKQLQ ENRLSCPITA LGRTMATFPV 

       790        800        810        820        830        840 
APRYAKMLAL SRQHGCLPYA ITIVASMTVR ELFEELDRPA ASDEELTRLK SKRARVAQMK 

       850        860        870        880        890        900 
RTWAGQGASL KLGDLMVLLG AVGACEYASC TPQFCEANGL RYKAMMEIRR LRGQLTTAVN 

       910        920        930        940        950        960 
AVCPEAELFV DPKMQPPTES QVTYLRQIVT AGLGDHLARR VQSEEMLEDK WRNAYKTPLL 

       970        980        990       1000       1010       1020 
DDPVFIHPSS VLFKELPEFV VYQEIVETTK MYMKGVSSVE VQWIPALLPS YCQFDKPLEE 

      1030       1040       1050       1060       1070       1080 
PAPTYCPERG RVLCHRASVF YRVGWPLPAI EVDFPEGIDR YKHFARFLLE GQVFRKLASY 

      1090       1100       1110       1120       1130       1140 
RSCLLSSPGT MLKTWARLQP RTESLLRALV AEKADCHEAL LAAWKKNPKY LLAEYCEWLP 

      1150 
QAMHPDIEKA WPPTTVH 

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References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLY-869 AND GLN-1081.
Tissue: Brain and Duodenum.
[2]"Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 178-1157.
Tissue: Brain.
[3]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC002575 mRNA. Translation: AAH02575.2.
BC037964 mRNA. Translation: AAH37964.1.
AB040950 mRNA. Translation: BAA96041.1.
CCDSCCDS9261.1.
RefSeqNP_116045.2. NM_032656.3.
UniGeneHs.107382.

3D structure databases

ProteinModelPortalQ8IY37.
SMRQ8IY37. Positions 249-489, 731-1011.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121684. 8 interactions.
IntActQ8IY37. 2 interactions.
MINTMINT-3038283.
STRING9606.ENSP00000311135.

PTM databases

PhosphoSiteQ8IY37.

Polymorphism databases

DMDM38257651.

Proteomic databases

MaxQBQ8IY37.
PaxDbQ8IY37.
PRIDEQ8IY37.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000308736; ENSP00000311135; ENSG00000150990.
GeneID57647.
KEGGhsa:57647.
UCSCuc001ugy.3. human.

Organism-specific databases

CTD57647.
GeneCardsGC12M125431.
HGNCHGNC:17210. DHX37.
HPAHPA047607.
neXtProtNX_Q8IY37.
PharmGKBPA27224.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1643.
HOGENOMHOG000201240.
HOVERGENHBG051356.
InParanoidQ8IY37.
KOK14780.
OMAHNWKGRQ.
PhylomeDBQ8IY37.
TreeFamTF105654.

Gene expression databases

ArrayExpressQ8IY37.
BgeeQ8IY37.
CleanExHS_DHX37.
GenevestigatorQ8IY37.

Family and domain databases

Gene3D3.40.50.300. 3 hits.
InterProIPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR011709. DUF1605.
IPR007502. Helicase-assoc_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00270. DEAD. 1 hit.
PF04408. HA2. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07717. OB_NTP_bind. 1 hit.
[Graphical view]
SMARTSM00487. DEXDc. 1 hit.
SM00847. HA2. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 2 hits.
PROSITEPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi57647.
NextBio64382.
PROQ8IY37.

Entry information

Entry nameDHX37_HUMAN
AccessionPrimary (citable) accession number: Q8IY37
Secondary accession number(s): Q9BUI7, Q9P211
Entry history
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM