SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8IY37

- DHX37_HUMAN

UniProt

Q8IY37 - DHX37_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Probable ATP-dependent RNA helicase DHX37
Gene
DHX37, DDX37, KIAA1517
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi275 – 2828ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. helicase activity Source: UniProtKB-KW
  3. nucleic acid binding Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Helicase, Hydrolase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable ATP-dependent RNA helicase DHX37 (EC:3.6.4.13)
    Alternative name(s):
    DEAH box protein 37
    Gene namesi
    Name:DHX37
    Synonyms:DDX37, KIAA1517
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:17210. DHX37.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27224.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11571157Probable ATP-dependent RNA helicase DHX37
    PRO_0000055172Add
    BLAST

    Proteomic databases

    MaxQBiQ8IY37.
    PaxDbiQ8IY37.
    PRIDEiQ8IY37.

    PTM databases

    PhosphoSiteiQ8IY37.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8IY37.
    BgeeiQ8IY37.
    CleanExiHS_DHX37.
    GenevestigatoriQ8IY37.

    Organism-specific databases

    HPAiHPA047607.

    Interactioni

    Protein-protein interaction databases

    BioGridi121684. 8 interactions.
    IntActiQ8IY37. 2 interactions.
    MINTiMINT-3038283.
    STRINGi9606.ENSP00000311135.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IY37.
    SMRiQ8IY37. Positions 249-489, 731-1011.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini262 – 429168Helicase ATP-binding
    Add
    BLAST
    Domaini459 – 716258Helicase C-terminal
    Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi372 – 3754DEAH box

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1643.
    HOGENOMiHOG000201240.
    HOVERGENiHBG051356.
    InParanoidiQ8IY37.
    KOiK14780.
    OMAiHNWKGRQ.
    PhylomeDBiQ8IY37.
    TreeFamiTF105654.

    Family and domain databases

    Gene3Di3.40.50.300. 3 hits.
    InterProiIPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
    IPR011709. DUF1605.
    IPR007502. Helicase-assoc_dom.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00270. DEAD. 1 hit.
    PF04408. HA2. 1 hit.
    PF00271. Helicase_C. 1 hit.
    PF07717. OB_NTP_bind. 1 hit.
    [Graphical view]
    SMARTiSM00487. DEXDc. 1 hit.
    SM00847. HA2. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8IY37-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKLRRRYNI KGRQQAGPGP SKGPPEPPPV QLELEDKDTL KGVDASNALV     50
    LPGKKKKKTK APPLSKKEKK PLTKKEKKVL QKILEQKEKK SQRAEMLQKL 100
    SEVQASEAEM RLFYTTSKLG TGNRMYHTKE KADEVVAPGQ EKISSLSGAH 150
    RKRRRWPSAE EEEEEEEESE SELEEESELD EDPAAEPAEA GVGTTVAPLP 200
    PAPAPSSQPV PAGMTVPPPP AAAPPLPRAL AKPAVFIPVN RSPEMQEERL 250
    KLPILSEEQV IMEAVAEHPI VIVCGETGSG KTTQVPQFLY EAGFSSEDSI 300
    IGVTEPRRVA AVAMSQRVAK EMNLSQRVVS YQIRYEGNVT EETRIKFMTD 350
    GVLLKEIQKD FLLLRYKVVI IDEAHERSVY TDILIGLLSR IVTLRAKRNL 400
    PLKLLIMSAT LRVEDFTQNP RLFAKPPPVI KVESRQFPVT VHFNKRTPLE 450
    DYSGECFRKV CKIHRMLPAG GILVFLTGQA EVHALCRRLR KAFPPSRARP 500
    QEKDDDQKDS VEEMRKFKKS RARAKKARAE VLPQINLDHY SVLPAGEGDE 550
    DREAEVDEEE GALDSDLDLD LGDGGQDGGE QPDASLPLHV LPLYSLLAPE 600
    KQAQVFKPPP EGTRLCVVAT NVAETSLTIP GIKYVVDCGK VKKRYYDRVT 650
    GVSSFRVTWV SQASADQRAG RAGRTEPGHC YRLYSSAVFG DFEQFPPPEI 700
    TRRPVEDLIL QMKALNVEKV INFPFPTPPS VEALLAAEEL LIALGALQPP 750
    QKAERVKQLQ ENRLSCPITA LGRTMATFPV APRYAKMLAL SRQHGCLPYA 800
    ITIVASMTVR ELFEELDRPA ASDEELTRLK SKRARVAQMK RTWAGQGASL 850
    KLGDLMVLLG AVGACEYASC TPQFCEANGL RYKAMMEIRR LRGQLTTAVN 900
    AVCPEAELFV DPKMQPPTES QVTYLRQIVT AGLGDHLARR VQSEEMLEDK 950
    WRNAYKTPLL DDPVFIHPSS VLFKELPEFV VYQEIVETTK MYMKGVSSVE 1000
    VQWIPALLPS YCQFDKPLEE PAPTYCPERG RVLCHRASVF YRVGWPLPAI 1050
    EVDFPEGIDR YKHFARFLLE GQVFRKLASY RSCLLSSPGT MLKTWARLQP 1100
    RTESLLRALV AEKADCHEAL LAAWKKNPKY LLAEYCEWLP QAMHPDIEKA 1150
    WPPTTVH 1157
    Length:1,157
    Mass (Da):129,545
    Last modified:March 1, 2003 - v1
    Checksum:i49332175221B30C5
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti96 – 961M → I.
    Corresponds to variant rs11558556 [ dbSNP | Ensembl ].
    VAR_061826
    Natural varianti458 – 4581R → Q.
    Corresponds to variant rs11057939 [ dbSNP | Ensembl ].
    VAR_052185
    Natural varianti508 – 5081K → N.
    Corresponds to variant rs35165507 [ dbSNP | Ensembl ].
    VAR_052186
    Natural varianti717 – 7171V → I.
    Corresponds to variant rs35016004 [ dbSNP | Ensembl ].
    VAR_052187
    Natural varianti869 – 8691S → G.1 Publication
    Corresponds to variant rs4516060 [ dbSNP | Ensembl ].
    VAR_052188
    Natural varianti1081 – 10811R → Q.1 Publication
    Corresponds to variant rs4447263 [ dbSNP | Ensembl ].
    VAR_052189

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti174 – 1741E → R in AAH02575. 1 Publication
    Sequence conflicti898 – 8981A → S in BAA96041. 1 Publication
    Sequence conflicti1130 – 115728YLLAE…PTTVH → CEFDQGQGVGVDRMGSLRQG LCALCTVSPGLAEGSGPTAA GQLFAT1 Publication
    Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC002575 mRNA. Translation: AAH02575.2.
    BC037964 mRNA. Translation: AAH37964.1.
    AB040950 mRNA. Translation: BAA96041.1.
    CCDSiCCDS9261.1.
    RefSeqiNP_116045.2. NM_032656.3.
    UniGeneiHs.107382.

    Genome annotation databases

    EnsembliENST00000308736; ENSP00000311135; ENSG00000150990.
    GeneIDi57647.
    KEGGihsa:57647.
    UCSCiuc001ugy.3. human.

    Polymorphism databases

    DMDMi38257651.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC002575 mRNA. Translation: AAH02575.2 .
    BC037964 mRNA. Translation: AAH37964.1 .
    AB040950 mRNA. Translation: BAA96041.1 .
    CCDSi CCDS9261.1.
    RefSeqi NP_116045.2. NM_032656.3.
    UniGenei Hs.107382.

    3D structure databases

    ProteinModelPortali Q8IY37.
    SMRi Q8IY37. Positions 249-489, 731-1011.
    ModBasei Search...

    Protein-protein interaction databases

    BioGridi 121684. 8 interactions.
    IntActi Q8IY37. 2 interactions.
    MINTi MINT-3038283.
    STRINGi 9606.ENSP00000311135.

    PTM databases

    PhosphoSitei Q8IY37.

    Polymorphism databases

    DMDMi 38257651.

    Proteomic databases

    MaxQBi Q8IY37.
    PaxDbi Q8IY37.
    PRIDEi Q8IY37.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000308736 ; ENSP00000311135 ; ENSG00000150990 .
    GeneIDi 57647.
    KEGGi hsa:57647.
    UCSCi uc001ugy.3. human.

    Organism-specific databases

    CTDi 57647.
    GeneCardsi GC12M125431.
    HGNCi HGNC:17210. DHX37.
    HPAi HPA047607.
    neXtProti NX_Q8IY37.
    PharmGKBi PA27224.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1643.
    HOGENOMi HOG000201240.
    HOVERGENi HBG051356.
    InParanoidi Q8IY37.
    KOi K14780.
    OMAi HNWKGRQ.
    PhylomeDBi Q8IY37.
    TreeFami TF105654.

    Miscellaneous databases

    GenomeRNAii 57647.
    NextBioi 64382.
    PROi Q8IY37.

    Gene expression databases

    ArrayExpressi Q8IY37.
    Bgeei Q8IY37.
    CleanExi HS_DHX37.
    Genevestigatori Q8IY37.

    Family and domain databases

    Gene3Di 3.40.50.300. 3 hits.
    InterProi IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
    IPR011709. DUF1605.
    IPR007502. Helicase-assoc_dom.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00270. DEAD. 1 hit.
    PF04408. HA2. 1 hit.
    PF00271. Helicase_C. 1 hit.
    PF07717. OB_NTP_bind. 1 hit.
    [Graphical view ]
    SMARTi SM00487. DEXDc. 1 hit.
    SM00847. HA2. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLY-869 AND GLN-1081.
      Tissue: Brain and Duodenum.
    2. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
      DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 178-1157.
      Tissue: Brain.
    3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiDHX37_HUMAN
    AccessioniPrimary (citable) accession number: Q8IY37
    Secondary accession number(s): Q9BUI7, Q9P211
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 7, 2003
    Last sequence update: March 1, 2003
    Last modified: September 3, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi