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Q8IY37

- DHX37_HUMAN

UniProt

Q8IY37 - DHX37_HUMAN

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Protein

Probable ATP-dependent RNA helicase DHX37

Gene

DHX37

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi275 – 2828ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. helicase activity Source: UniProtKB-KW
  3. nucleic acid binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ATP-dependent RNA helicase DHX37 (EC:3.6.4.13)
Alternative name(s):
DEAH box protein 37
Gene namesi
Name:DHX37
Synonyms:DDX37, KIAA1517
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:17210. DHX37.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27224.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11571157Probable ATP-dependent RNA helicase DHX37PRO_0000055172Add
BLAST

Proteomic databases

MaxQBiQ8IY37.
PaxDbiQ8IY37.
PRIDEiQ8IY37.

PTM databases

PhosphoSiteiQ8IY37.

Expressioni

Gene expression databases

BgeeiQ8IY37.
CleanExiHS_DHX37.
ExpressionAtlasiQ8IY37. baseline and differential.
GenevestigatoriQ8IY37.

Organism-specific databases

HPAiHPA047607.

Interactioni

Protein-protein interaction databases

BioGridi121684. 9 interactions.
IntActiQ8IY37. 2 interactions.
MINTiMINT-3038283.
STRINGi9606.ENSP00000311135.

Structurei

3D structure databases

ProteinModelPortaliQ8IY37.
SMRiQ8IY37. Positions 249-489, 731-1011.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini262 – 429168Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini459 – 716258Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi372 – 3754DEAH box

Sequence similaritiesi

Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1643.
GeneTreeiENSGT00550000074985.
HOGENOMiHOG000201240.
HOVERGENiHBG051356.
InParanoidiQ8IY37.
KOiK14780.
OMAiHNWKGRQ.
PhylomeDBiQ8IY37.
TreeFamiTF105654.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR011709. DUF1605.
IPR007502. Helicase-assoc_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF04408. HA2. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07717. OB_NTP_bind. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00847. HA2. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IY37-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGKLRRRYNI KGRQQAGPGP SKGPPEPPPV QLELEDKDTL KGVDASNALV
60 70 80 90 100
LPGKKKKKTK APPLSKKEKK PLTKKEKKVL QKILEQKEKK SQRAEMLQKL
110 120 130 140 150
SEVQASEAEM RLFYTTSKLG TGNRMYHTKE KADEVVAPGQ EKISSLSGAH
160 170 180 190 200
RKRRRWPSAE EEEEEEEESE SELEEESELD EDPAAEPAEA GVGTTVAPLP
210 220 230 240 250
PAPAPSSQPV PAGMTVPPPP AAAPPLPRAL AKPAVFIPVN RSPEMQEERL
260 270 280 290 300
KLPILSEEQV IMEAVAEHPI VIVCGETGSG KTTQVPQFLY EAGFSSEDSI
310 320 330 340 350
IGVTEPRRVA AVAMSQRVAK EMNLSQRVVS YQIRYEGNVT EETRIKFMTD
360 370 380 390 400
GVLLKEIQKD FLLLRYKVVI IDEAHERSVY TDILIGLLSR IVTLRAKRNL
410 420 430 440 450
PLKLLIMSAT LRVEDFTQNP RLFAKPPPVI KVESRQFPVT VHFNKRTPLE
460 470 480 490 500
DYSGECFRKV CKIHRMLPAG GILVFLTGQA EVHALCRRLR KAFPPSRARP
510 520 530 540 550
QEKDDDQKDS VEEMRKFKKS RARAKKARAE VLPQINLDHY SVLPAGEGDE
560 570 580 590 600
DREAEVDEEE GALDSDLDLD LGDGGQDGGE QPDASLPLHV LPLYSLLAPE
610 620 630 640 650
KQAQVFKPPP EGTRLCVVAT NVAETSLTIP GIKYVVDCGK VKKRYYDRVT
660 670 680 690 700
GVSSFRVTWV SQASADQRAG RAGRTEPGHC YRLYSSAVFG DFEQFPPPEI
710 720 730 740 750
TRRPVEDLIL QMKALNVEKV INFPFPTPPS VEALLAAEEL LIALGALQPP
760 770 780 790 800
QKAERVKQLQ ENRLSCPITA LGRTMATFPV APRYAKMLAL SRQHGCLPYA
810 820 830 840 850
ITIVASMTVR ELFEELDRPA ASDEELTRLK SKRARVAQMK RTWAGQGASL
860 870 880 890 900
KLGDLMVLLG AVGACEYASC TPQFCEANGL RYKAMMEIRR LRGQLTTAVN
910 920 930 940 950
AVCPEAELFV DPKMQPPTES QVTYLRQIVT AGLGDHLARR VQSEEMLEDK
960 970 980 990 1000
WRNAYKTPLL DDPVFIHPSS VLFKELPEFV VYQEIVETTK MYMKGVSSVE
1010 1020 1030 1040 1050
VQWIPALLPS YCQFDKPLEE PAPTYCPERG RVLCHRASVF YRVGWPLPAI
1060 1070 1080 1090 1100
EVDFPEGIDR YKHFARFLLE GQVFRKLASY RSCLLSSPGT MLKTWARLQP
1110 1120 1130 1140 1150
RTESLLRALV AEKADCHEAL LAAWKKNPKY LLAEYCEWLP QAMHPDIEKA

WPPTTVH
Length:1,157
Mass (Da):129,545
Last modified:March 1, 2003 - v1
Checksum:i49332175221B30C5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti174 – 1741E → R in AAH02575. (PubMed:15489334)Curated
Sequence conflicti898 – 8981A → S in BAA96041. (PubMed:10819331)Curated
Sequence conflicti1130 – 115728YLLAE…PTTVH → CEFDQGQGVGVDRMGSLRQG LCALCTVSPGLAEGSGPTAA GQLFAT(PubMed:10819331)CuratedAdd
BLAST

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti96 – 961M → I.
Corresponds to variant rs11558556 [ dbSNP | Ensembl ].
VAR_061826
Natural varianti458 – 4581R → Q.
Corresponds to variant rs11057939 [ dbSNP | Ensembl ].
VAR_052185
Natural varianti508 – 5081K → N.
Corresponds to variant rs35165507 [ dbSNP | Ensembl ].
VAR_052186
Natural varianti717 – 7171V → I.
Corresponds to variant rs35016004 [ dbSNP | Ensembl ].
VAR_052187
Natural varianti869 – 8691S → G.1 Publication
Corresponds to variant rs4516060 [ dbSNP | Ensembl ].
VAR_052188
Natural varianti1081 – 10811R → Q.1 Publication
Corresponds to variant rs4447263 [ dbSNP | Ensembl ].
VAR_052189

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC002575 mRNA. Translation: AAH02575.2.
BC037964 mRNA. Translation: AAH37964.1.
AB040950 mRNA. Translation: BAA96041.1.
CCDSiCCDS9261.1.
RefSeqiNP_116045.2. NM_032656.3.
UniGeneiHs.107382.

Genome annotation databases

EnsembliENST00000308736; ENSP00000311135; ENSG00000150990.
GeneIDi57647.
KEGGihsa:57647.
UCSCiuc001ugy.3. human.

Polymorphism databases

DMDMi38257651.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC002575 mRNA. Translation: AAH02575.2 .
BC037964 mRNA. Translation: AAH37964.1 .
AB040950 mRNA. Translation: BAA96041.1 .
CCDSi CCDS9261.1.
RefSeqi NP_116045.2. NM_032656.3.
UniGenei Hs.107382.

3D structure databases

ProteinModelPortali Q8IY37.
SMRi Q8IY37. Positions 249-489, 731-1011.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121684. 9 interactions.
IntActi Q8IY37. 2 interactions.
MINTi MINT-3038283.
STRINGi 9606.ENSP00000311135.

PTM databases

PhosphoSitei Q8IY37.

Polymorphism databases

DMDMi 38257651.

Proteomic databases

MaxQBi Q8IY37.
PaxDbi Q8IY37.
PRIDEi Q8IY37.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000308736 ; ENSP00000311135 ; ENSG00000150990 .
GeneIDi 57647.
KEGGi hsa:57647.
UCSCi uc001ugy.3. human.

Organism-specific databases

CTDi 57647.
GeneCardsi GC12M125431.
HGNCi HGNC:17210. DHX37.
HPAi HPA047607.
neXtProti NX_Q8IY37.
PharmGKBi PA27224.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1643.
GeneTreei ENSGT00550000074985.
HOGENOMi HOG000201240.
HOVERGENi HBG051356.
InParanoidi Q8IY37.
KOi K14780.
OMAi HNWKGRQ.
PhylomeDBi Q8IY37.
TreeFami TF105654.

Miscellaneous databases

GenomeRNAii 57647.
NextBioi 64382.
PROi Q8IY37.

Gene expression databases

Bgeei Q8IY37.
CleanExi HS_DHX37.
ExpressionAtlasi Q8IY37. baseline and differential.
Genevestigatori Q8IY37.

Family and domain databases

Gene3Di 3.40.50.300. 3 hits.
InterProi IPR011545. DEAD/DEAH_box_helicase_dom.
IPR011709. DUF1605.
IPR007502. Helicase-assoc_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00270. DEAD. 1 hit.
PF04408. HA2. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07717. OB_NTP_bind. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00847. HA2. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLY-869 AND GLN-1081.
    Tissue: Brain and Duodenum.
  2. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 178-1157.
    Tissue: Brain.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDHX37_HUMAN
AccessioniPrimary (citable) accession number: Q8IY37
Secondary accession number(s): Q9BUI7, Q9P211
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3