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Protein

Probable ATP-dependent RNA helicase DHX37

Gene

DHX37

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi275 – 282ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-6790901. rRNA modification in the nucleus and cytosol.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ATP-dependent RNA helicase DHX37 (EC:3.6.4.13)
Alternative name(s):
DEAH box protein 37
Gene namesi
Name:DHX37
Synonyms:DDX37, KIAA1517
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:17210. DHX37.

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000150990.
PharmGKBiPA27224.

Polymorphism and mutation databases

BioMutaiDHX37.
DMDMi38257651.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000551721 – 1157Probable ATP-dependent RNA helicase DHX37Add BLAST1157

Proteomic databases

EPDiQ8IY37.
MaxQBiQ8IY37.
PaxDbiQ8IY37.
PeptideAtlasiQ8IY37.
PRIDEiQ8IY37.

PTM databases

iPTMnetiQ8IY37.
PhosphoSitePlusiQ8IY37.

Expressioni

Gene expression databases

BgeeiENSG00000150990.
CleanExiHS_DHX37.
ExpressionAtlasiQ8IY37. baseline and differential.
GenevisibleiQ8IY37. HS.

Organism-specific databases

HPAiHPA047607.

Interactioni

Protein-protein interaction databases

BioGridi121684. 25 interactors.
IntActiQ8IY37. 5 interactors.
MINTiMINT-3038283.
STRINGi9606.ENSP00000311135.

Structurei

3D structure databases

ProteinModelPortaliQ8IY37.
SMRiQ8IY37.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini262 – 429Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST168
Domaini459 – 716Helicase C-terminalPROSITE-ProRule annotationAdd BLAST258

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi372 – 375DEAH box4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0926. Eukaryota.
COG1643. LUCA.
GeneTreeiENSGT00550000074985.
HOGENOMiHOG000201240.
HOVERGENiHBG051356.
InParanoidiQ8IY37.
KOiK14780.
OMAiKIHRMLP.
OrthoDBiEOG091G02IP.
PhylomeDBiQ8IY37.
TreeFamiTF105654.

Family and domain databases

InterProiView protein in InterPro
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR011709. DUF1605.
IPR007502. Helicase-assoc_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00270. DEAD. 1 hit.
PF04408. HA2. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07717. OB_NTP_bind. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00847. HA2. 1 hit.
SM00490. HELICc. 1 hit.
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiView protein in PROSITE
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8IY37-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKLRRRYNI KGRQQAGPGP SKGPPEPPPV QLELEDKDTL KGVDASNALV
60 70 80 90 100
LPGKKKKKTK APPLSKKEKK PLTKKEKKVL QKILEQKEKK SQRAEMLQKL
110 120 130 140 150
SEVQASEAEM RLFYTTSKLG TGNRMYHTKE KADEVVAPGQ EKISSLSGAH
160 170 180 190 200
RKRRRWPSAE EEEEEEEESE SELEEESELD EDPAAEPAEA GVGTTVAPLP
210 220 230 240 250
PAPAPSSQPV PAGMTVPPPP AAAPPLPRAL AKPAVFIPVN RSPEMQEERL
260 270 280 290 300
KLPILSEEQV IMEAVAEHPI VIVCGETGSG KTTQVPQFLY EAGFSSEDSI
310 320 330 340 350
IGVTEPRRVA AVAMSQRVAK EMNLSQRVVS YQIRYEGNVT EETRIKFMTD
360 370 380 390 400
GVLLKEIQKD FLLLRYKVVI IDEAHERSVY TDILIGLLSR IVTLRAKRNL
410 420 430 440 450
PLKLLIMSAT LRVEDFTQNP RLFAKPPPVI KVESRQFPVT VHFNKRTPLE
460 470 480 490 500
DYSGECFRKV CKIHRMLPAG GILVFLTGQA EVHALCRRLR KAFPPSRARP
510 520 530 540 550
QEKDDDQKDS VEEMRKFKKS RARAKKARAE VLPQINLDHY SVLPAGEGDE
560 570 580 590 600
DREAEVDEEE GALDSDLDLD LGDGGQDGGE QPDASLPLHV LPLYSLLAPE
610 620 630 640 650
KQAQVFKPPP EGTRLCVVAT NVAETSLTIP GIKYVVDCGK VKKRYYDRVT
660 670 680 690 700
GVSSFRVTWV SQASADQRAG RAGRTEPGHC YRLYSSAVFG DFEQFPPPEI
710 720 730 740 750
TRRPVEDLIL QMKALNVEKV INFPFPTPPS VEALLAAEEL LIALGALQPP
760 770 780 790 800
QKAERVKQLQ ENRLSCPITA LGRTMATFPV APRYAKMLAL SRQHGCLPYA
810 820 830 840 850
ITIVASMTVR ELFEELDRPA ASDEELTRLK SKRARVAQMK RTWAGQGASL
860 870 880 890 900
KLGDLMVLLG AVGACEYASC TPQFCEANGL RYKAMMEIRR LRGQLTTAVN
910 920 930 940 950
AVCPEAELFV DPKMQPPTES QVTYLRQIVT AGLGDHLARR VQSEEMLEDK
960 970 980 990 1000
WRNAYKTPLL DDPVFIHPSS VLFKELPEFV VYQEIVETTK MYMKGVSSVE
1010 1020 1030 1040 1050
VQWIPALLPS YCQFDKPLEE PAPTYCPERG RVLCHRASVF YRVGWPLPAI
1060 1070 1080 1090 1100
EVDFPEGIDR YKHFARFLLE GQVFRKLASY RSCLLSSPGT MLKTWARLQP
1110 1120 1130 1140 1150
RTESLLRALV AEKADCHEAL LAAWKKNPKY LLAEYCEWLP QAMHPDIEKA

WPPTTVH
Length:1,157
Mass (Da):129,545
Last modified:March 1, 2003 - v1
Checksum:i49332175221B30C5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti174E → R in AAH02575 (PubMed:15489334).Curated1
Sequence conflicti898A → S in BAA96041 (PubMed:10819331).Curated1
Sequence conflicti1130 – 1157YLLAE…PTTVH → CEFDQGQGVGVDRMGSLRQG LCALCTVSPGLAEGSGPTAA GQLFAT (PubMed:10819331).CuratedAdd BLAST28

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06182696M → I. Corresponds to variant dbSNP:rs11558556Ensembl.1
Natural variantiVAR_052185458R → Q. Corresponds to variant dbSNP:rs11057939Ensembl.1
Natural variantiVAR_052186508K → N. Corresponds to variant dbSNP:rs35165507Ensembl.1
Natural variantiVAR_052187717V → I. Corresponds to variant dbSNP:rs35016004Ensembl.1
Natural variantiVAR_052188869S → G1 PublicationCorresponds to variant dbSNP:rs4516060Ensembl.1
Natural variantiVAR_0521891081R → Q1 PublicationCorresponds to variant dbSNP:rs4447263Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC002575 mRNA. Translation: AAH02575.2.
BC037964 mRNA. Translation: AAH37964.1.
AB040950 mRNA. Translation: BAA96041.1.
CCDSiCCDS9261.1.
RefSeqiNP_116045.2. NM_032656.3.
UniGeneiHs.107382.

Genome annotation databases

EnsembliENST00000308736; ENSP00000311135; ENSG00000150990.
GeneIDi57647.
KEGGihsa:57647.
UCSCiuc001ugy.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDHX37_HUMAN
AccessioniPrimary (citable) accession number: Q8IY37
Secondary accession number(s): Q9BUI7, Q9P211
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: March 1, 2003
Last modified: August 30, 2017
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families