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Q8IY37

- DHX37_HUMAN

UniProt

Q8IY37 - DHX37_HUMAN

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Protein

Probable ATP-dependent RNA helicase DHX37

Gene
DHX37, DDX37, KIAA1517
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi275 – 2828ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. helicase activity Source: UniProtKB-KW
  3. nucleic acid binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ATP-dependent RNA helicase DHX37 (EC:3.6.4.13)
Alternative name(s):
DEAH box protein 37
Gene namesi
Name:DHX37
Synonyms:DDX37, KIAA1517
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:17210. DHX37.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27224.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11571157Probable ATP-dependent RNA helicase DHX37PRO_0000055172Add
BLAST

Proteomic databases

MaxQBiQ8IY37.
PaxDbiQ8IY37.
PRIDEiQ8IY37.

PTM databases

PhosphoSiteiQ8IY37.

Expressioni

Gene expression databases

ArrayExpressiQ8IY37.
BgeeiQ8IY37.
CleanExiHS_DHX37.
GenevestigatoriQ8IY37.

Organism-specific databases

HPAiHPA047607.

Interactioni

Protein-protein interaction databases

BioGridi121684. 8 interactions.
IntActiQ8IY37. 2 interactions.
MINTiMINT-3038283.
STRINGi9606.ENSP00000311135.

Structurei

3D structure databases

ProteinModelPortaliQ8IY37.
SMRiQ8IY37. Positions 249-489, 731-1011.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini262 – 429168Helicase ATP-bindingAdd
BLAST
Domaini459 – 716258Helicase C-terminalAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi372 – 3754DEAH box

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1643.
HOGENOMiHOG000201240.
HOVERGENiHBG051356.
InParanoidiQ8IY37.
KOiK14780.
OMAiHNWKGRQ.
PhylomeDBiQ8IY37.
TreeFamiTF105654.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR011709. DUF1605.
IPR007502. Helicase-assoc_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF04408. HA2. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07717. OB_NTP_bind. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00847. HA2. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IY37-1 [UniParc]FASTAAdd to Basket

« Hide

MGKLRRRYNI KGRQQAGPGP SKGPPEPPPV QLELEDKDTL KGVDASNALV     50
LPGKKKKKTK APPLSKKEKK PLTKKEKKVL QKILEQKEKK SQRAEMLQKL 100
SEVQASEAEM RLFYTTSKLG TGNRMYHTKE KADEVVAPGQ EKISSLSGAH 150
RKRRRWPSAE EEEEEEEESE SELEEESELD EDPAAEPAEA GVGTTVAPLP 200
PAPAPSSQPV PAGMTVPPPP AAAPPLPRAL AKPAVFIPVN RSPEMQEERL 250
KLPILSEEQV IMEAVAEHPI VIVCGETGSG KTTQVPQFLY EAGFSSEDSI 300
IGVTEPRRVA AVAMSQRVAK EMNLSQRVVS YQIRYEGNVT EETRIKFMTD 350
GVLLKEIQKD FLLLRYKVVI IDEAHERSVY TDILIGLLSR IVTLRAKRNL 400
PLKLLIMSAT LRVEDFTQNP RLFAKPPPVI KVESRQFPVT VHFNKRTPLE 450
DYSGECFRKV CKIHRMLPAG GILVFLTGQA EVHALCRRLR KAFPPSRARP 500
QEKDDDQKDS VEEMRKFKKS RARAKKARAE VLPQINLDHY SVLPAGEGDE 550
DREAEVDEEE GALDSDLDLD LGDGGQDGGE QPDASLPLHV LPLYSLLAPE 600
KQAQVFKPPP EGTRLCVVAT NVAETSLTIP GIKYVVDCGK VKKRYYDRVT 650
GVSSFRVTWV SQASADQRAG RAGRTEPGHC YRLYSSAVFG DFEQFPPPEI 700
TRRPVEDLIL QMKALNVEKV INFPFPTPPS VEALLAAEEL LIALGALQPP 750
QKAERVKQLQ ENRLSCPITA LGRTMATFPV APRYAKMLAL SRQHGCLPYA 800
ITIVASMTVR ELFEELDRPA ASDEELTRLK SKRARVAQMK RTWAGQGASL 850
KLGDLMVLLG AVGACEYASC TPQFCEANGL RYKAMMEIRR LRGQLTTAVN 900
AVCPEAELFV DPKMQPPTES QVTYLRQIVT AGLGDHLARR VQSEEMLEDK 950
WRNAYKTPLL DDPVFIHPSS VLFKELPEFV VYQEIVETTK MYMKGVSSVE 1000
VQWIPALLPS YCQFDKPLEE PAPTYCPERG RVLCHRASVF YRVGWPLPAI 1050
EVDFPEGIDR YKHFARFLLE GQVFRKLASY RSCLLSSPGT MLKTWARLQP 1100
RTESLLRALV AEKADCHEAL LAAWKKNPKY LLAEYCEWLP QAMHPDIEKA 1150
WPPTTVH 1157
Length:1,157
Mass (Da):129,545
Last modified:March 1, 2003 - v1
Checksum:i49332175221B30C5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti96 – 961M → I.
Corresponds to variant rs11558556 [ dbSNP | Ensembl ].
VAR_061826
Natural varianti458 – 4581R → Q.
Corresponds to variant rs11057939 [ dbSNP | Ensembl ].
VAR_052185
Natural varianti508 – 5081K → N.
Corresponds to variant rs35165507 [ dbSNP | Ensembl ].
VAR_052186
Natural varianti717 – 7171V → I.
Corresponds to variant rs35016004 [ dbSNP | Ensembl ].
VAR_052187
Natural varianti869 – 8691S → G.1 Publication
Corresponds to variant rs4516060 [ dbSNP | Ensembl ].
VAR_052188
Natural varianti1081 – 10811R → Q.1 Publication
Corresponds to variant rs4447263 [ dbSNP | Ensembl ].
VAR_052189

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti174 – 1741E → R in AAH02575. 1 Publication
Sequence conflicti898 – 8981A → S in BAA96041. 1 Publication
Sequence conflicti1130 – 115728YLLAE…PTTVH → CEFDQGQGVGVDRMGSLRQG LCALCTVSPGLAEGSGPTAA GQLFAT1 PublicationAdd
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC002575 mRNA. Translation: AAH02575.2.
BC037964 mRNA. Translation: AAH37964.1.
AB040950 mRNA. Translation: BAA96041.1.
CCDSiCCDS9261.1.
RefSeqiNP_116045.2. NM_032656.3.
UniGeneiHs.107382.

Genome annotation databases

EnsembliENST00000308736; ENSP00000311135; ENSG00000150990.
GeneIDi57647.
KEGGihsa:57647.
UCSCiuc001ugy.3. human.

Polymorphism databases

DMDMi38257651.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC002575 mRNA. Translation: AAH02575.2 .
BC037964 mRNA. Translation: AAH37964.1 .
AB040950 mRNA. Translation: BAA96041.1 .
CCDSi CCDS9261.1.
RefSeqi NP_116045.2. NM_032656.3.
UniGenei Hs.107382.

3D structure databases

ProteinModelPortali Q8IY37.
SMRi Q8IY37. Positions 249-489, 731-1011.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121684. 8 interactions.
IntActi Q8IY37. 2 interactions.
MINTi MINT-3038283.
STRINGi 9606.ENSP00000311135.

PTM databases

PhosphoSitei Q8IY37.

Polymorphism databases

DMDMi 38257651.

Proteomic databases

MaxQBi Q8IY37.
PaxDbi Q8IY37.
PRIDEi Q8IY37.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000308736 ; ENSP00000311135 ; ENSG00000150990 .
GeneIDi 57647.
KEGGi hsa:57647.
UCSCi uc001ugy.3. human.

Organism-specific databases

CTDi 57647.
GeneCardsi GC12M125431.
HGNCi HGNC:17210. DHX37.
HPAi HPA047607.
neXtProti NX_Q8IY37.
PharmGKBi PA27224.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1643.
HOGENOMi HOG000201240.
HOVERGENi HBG051356.
InParanoidi Q8IY37.
KOi K14780.
OMAi HNWKGRQ.
PhylomeDBi Q8IY37.
TreeFami TF105654.

Miscellaneous databases

GenomeRNAii 57647.
NextBioi 64382.
PROi Q8IY37.

Gene expression databases

ArrayExpressi Q8IY37.
Bgeei Q8IY37.
CleanExi HS_DHX37.
Genevestigatori Q8IY37.

Family and domain databases

Gene3Di 3.40.50.300. 3 hits.
InterProi IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR011709. DUF1605.
IPR007502. Helicase-assoc_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00270. DEAD. 1 hit.
PF04408. HA2. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07717. OB_NTP_bind. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00847. HA2. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLY-869 AND GLN-1081.
    Tissue: Brain and Duodenum.
  2. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 178-1157.
    Tissue: Brain.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDHX37_HUMAN
AccessioniPrimary (citable) accession number: Q8IY37
Secondary accession number(s): Q9BUI7, Q9P211
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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