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Q8IY34

- S15A3_HUMAN

UniProt

Q8IY34 - S15A3_HUMAN

Protein

Solute carrier family 15 member 3

Gene

SLC15A3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides By similarity.By similarity

    GO - Molecular functioni

    1. symporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. ion transport Source: Reactome
    2. peptide transport Source: UniProtKB-KW
    3. protein transport Source: UniProtKB-KW
    4. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Peptide transport, Protein transport, Symport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_19328. Proton/oligonucleotide cotransporters.

    Protein family/group databases

    TCDBi2.A.17.3.9. the proton-dependent oligopeptide transporter (pot/ptr) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 15 member 3
    Alternative name(s):
    Osteoclast transporter
    Peptide transporter 3
    Peptide/histidine transporter 2
    Gene namesi
    Name:SLC15A3
    Synonyms:OCTP, PHT2, PTR3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:18068. SLC15A3.

    Subcellular locationi

    Lysosome membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. lysosomal membrane Source: UniProtKB

    Keywords - Cellular componenti

    Lysosome, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134919658.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 581581Solute carrier family 15 member 3PRO_0000295912Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi61 – 611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi66 – 661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi223 – 2231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi356 – 3561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi439 – 4391N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ8IY34.
    PaxDbiQ8IY34.
    PRIDEiQ8IY34.

    PTM databases

    PhosphoSiteiQ8IY34.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8IY34.
    BgeeiQ8IY34.
    CleanExiHS_SLC15A3.
    GenevestigatoriQ8IY34.

    Organism-specific databases

    HPAiHPA047880.

    Interactioni

    Protein-protein interaction databases

    BioGridi119447. 1 interaction.
    DIPiDIP-60838N.
    STRINGi9606.ENSP00000227880.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IY34.
    SMRiQ8IY34. Positions 33-563.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei38 – 5821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei76 – 9621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei103 – 12321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei155 – 17521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei200 – 22021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei232 – 25221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei310 – 33021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei369 – 38921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei411 – 43121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei458 – 47821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei497 – 51721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei540 – 56021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi165 – 1706Poly-Leu
    Compositional biasi380 – 3834Poly-Val

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG3104.
    HOGENOMiHOG000143436.
    HOVERGENiHBG108431.
    InParanoidiQ8IY34.
    KOiK14638.
    OMAiHYIHHNE.
    OrthoDBiEOG7FNC8C.
    PhylomeDBiQ8IY34.
    TreeFamiTF330897.

    Family and domain databases

    InterProiIPR016196. MFS_dom_general_subst_transpt.
    IPR000109. POT_fam.
    [Graphical view]
    PANTHERiPTHR11654. PTHR11654. 1 hit.
    PfamiPF00854. PTR2. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 3 hits.

    Sequencei

    Sequence statusi: Complete.

    Q8IY34-1 [UniParc]FASTAAdd to Basket

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    MPAPRAREQP RVPGERQPLL PRGARGPRRW RRAAGAAVLL VEMLERAAFF    50
    GVTANLVLYL NSTNFNWTGE QATRAALVFL GASYLLAPVG GWLADVYLGR 100
    YRAVALSLLL YLAASGLLPA TAFPDGRSSF CGEMPASPLG PACPSAGCPR 150
    SSPSPYCAPV LYAGLLLLGL AASSVRSNLT SFGADQVMDL GRDATRRFFN 200
    WFYWSINLGA VLSLLVVAFI QQNISFLLGY SIPVGCVGLA FFIFLFATPV 250
    FITKPPMGSQ VSSMLKLALQ NCCPQLWQRH SARDRQCARV LADERSPQPG 300
    ASPQEDIANF QVLVKILPVM VTLVPYWMVY FQMQSTYVLQ GLHLHIPNIF 350
    PANPANISVA LRAQGSSYTI PEAWLLLANV VVVLILVPLK DRLIDPLLLR 400
    CKLLPSALQK MALGMFFGFT SVIVAGVLEM ERLHYIHHNE TVSQQIGEVL 450
    YNAAPLSIWW QIPQYLLIGI SEIFASIPGL EFAYSEAPRS MQGAIMGIFF 500
    CLSGVGSLLG SSLVALLSLP GGWLHCPKDF GNINNCRMDL YFFLLAGIQA 550
    VTALLFVWIA GRYERASQGP ASHSRFSRDR G 581
    Length:581
    Mass (Da):63,560
    Last modified:May 18, 2010 - v2
    Checksum:i56768D2963DB13D4
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti349 – 3491I → F.1 Publication
    Corresponds to variant rs17855607 [ dbSNP | Ensembl ].
    VAR_034592

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB020598 mRNA. Translation: BAA93432.1.
    AF135600 mRNA. Translation: AAQ13565.1.
    AP003721 Genomic DNA. No translation available.
    BC037974 mRNA. Translation: AAH37974.1.
    CCDSiCCDS7998.1.
    RefSeqiNP_057666.1. NM_016582.2.
    UniGeneiHs.237856.

    Genome annotation databases

    EnsembliENST00000227880; ENSP00000227880; ENSG00000110446.
    GeneIDi51296.
    KEGGihsa:51296.
    UCSCiuc001nqn.2. human.

    Polymorphism databases

    DMDMi296452890.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB020598 mRNA. Translation: BAA93432.1 .
    AF135600 mRNA. Translation: AAQ13565.1 .
    AP003721 Genomic DNA. No translation available.
    BC037974 mRNA. Translation: AAH37974.1 .
    CCDSi CCDS7998.1.
    RefSeqi NP_057666.1. NM_016582.2.
    UniGenei Hs.237856.

    3D structure databases

    ProteinModelPortali Q8IY34.
    SMRi Q8IY34. Positions 33-563.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119447. 1 interaction.
    DIPi DIP-60838N.
    STRINGi 9606.ENSP00000227880.

    Chemistry

    GuidetoPHARMACOLOGYi 986.

    Protein family/group databases

    TCDBi 2.A.17.3.9. the proton-dependent oligopeptide transporter (pot/ptr) family.

    PTM databases

    PhosphoSitei Q8IY34.

    Polymorphism databases

    DMDMi 296452890.

    Proteomic databases

    MaxQBi Q8IY34.
    PaxDbi Q8IY34.
    PRIDEi Q8IY34.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000227880 ; ENSP00000227880 ; ENSG00000110446 .
    GeneIDi 51296.
    KEGGi hsa:51296.
    UCSCi uc001nqn.2. human.

    Organism-specific databases

    CTDi 51296.
    GeneCardsi GC11M060704.
    HGNCi HGNC:18068. SLC15A3.
    HPAi HPA047880.
    MIMi 610408. gene.
    neXtProti NX_Q8IY34.
    PharmGKBi PA134919658.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG3104.
    HOGENOMi HOG000143436.
    HOVERGENi HBG108431.
    InParanoidi Q8IY34.
    KOi K14638.
    OMAi HYIHHNE.
    OrthoDBi EOG7FNC8C.
    PhylomeDBi Q8IY34.
    TreeFami TF330897.

    Enzyme and pathway databases

    Reactomei REACT_19328. Proton/oligonucleotide cotransporters.

    Miscellaneous databases

    GenomeRNAii 51296.
    NextBioi 54577.
    PROi Q8IY34.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8IY34.
    Bgeei Q8IY34.
    CleanExi HS_SLC15A3.
    Genevestigatori Q8IY34.

    Family and domain databases

    InterProi IPR016196. MFS_dom_general_subst_transpt.
    IPR000109. POT_fam.
    [Graphical view ]
    PANTHERi PTHR11654. PTHR11654. 1 hit.
    Pfami PF00854. PTR2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 3 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a new member of peptide transporter."
      Ishiabshi K., Imai M.
      Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Placenta.
    2. "Cloning of a novel gene of peptide transporter from human osteoclast."
      Yamane S., Toyosaki-Maeda T., Tsuruta Y., Suzuki R., Ochi T.
      Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Synovial fluid.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-349.
      Tissue: Blood and Pancreas.
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Tissue: Placenta.

    Entry informationi

    Entry nameiS15A3_HUMAN
    AccessioniPrimary (citable) accession number: Q8IY34
    Secondary accession number(s): Q9P2X9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 92 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3