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Q8IY34

- S15A3_HUMAN

UniProt

Q8IY34 - S15A3_HUMAN

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Protein

Solute carrier family 15 member 3

Gene
SLC15A3, OCTP, PHT2, PTR3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides By similarity.

GO - Molecular functioni

  1. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. ion transport Source: Reactome
  2. peptide transport Source: UniProtKB-KW
  3. protein transport Source: UniProtKB-KW
  4. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Peptide transport, Protein transport, Symport, Transport

Enzyme and pathway databases

ReactomeiREACT_19328. Proton/oligonucleotide cotransporters.

Protein family/group databases

TCDBi2.A.17.3.9. the proton-dependent oligopeptide transporter (pot/ptr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 15 member 3
Alternative name(s):
Osteoclast transporter
Peptide transporter 3
Peptide/histidine transporter 2
Gene namesi
Name:SLC15A3
Synonyms:OCTP, PHT2, PTR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:18068. SLC15A3.

Subcellular locationi

Lysosome membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei38 – 5821Helical; Reviewed predictionAdd
BLAST
Transmembranei76 – 9621Helical; Reviewed predictionAdd
BLAST
Transmembranei103 – 12321Helical; Reviewed predictionAdd
BLAST
Transmembranei155 – 17521Helical; Reviewed predictionAdd
BLAST
Transmembranei200 – 22021Helical; Reviewed predictionAdd
BLAST
Transmembranei232 – 25221Helical; Reviewed predictionAdd
BLAST
Transmembranei310 – 33021Helical; Reviewed predictionAdd
BLAST
Transmembranei369 – 38921Helical; Reviewed predictionAdd
BLAST
Transmembranei411 – 43121Helical; Reviewed predictionAdd
BLAST
Transmembranei458 – 47821Helical; Reviewed predictionAdd
BLAST
Transmembranei497 – 51721Helical; Reviewed predictionAdd
BLAST
Transmembranei540 – 56021Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. lysosomal membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134919658.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 581581Solute carrier family 15 member 3PRO_0000295912Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi61 – 611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi66 – 661N-linked (GlcNAc...) Reviewed prediction
Glycosylationi178 – 1781N-linked (GlcNAc...) Reviewed prediction
Glycosylationi223 – 2231N-linked (GlcNAc...) Reviewed prediction
Glycosylationi356 – 3561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi439 – 4391N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8IY34.
PaxDbiQ8IY34.
PRIDEiQ8IY34.

PTM databases

PhosphoSiteiQ8IY34.

Expressioni

Gene expression databases

ArrayExpressiQ8IY34.
BgeeiQ8IY34.
CleanExiHS_SLC15A3.
GenevestigatoriQ8IY34.

Organism-specific databases

HPAiHPA047880.

Interactioni

Protein-protein interaction databases

BioGridi119447. 1 interaction.
STRINGi9606.ENSP00000227880.

Structurei

3D structure databases

ProteinModelPortaliQ8IY34.
SMRiQ8IY34. Positions 33-563.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi165 – 1706Poly-Leu
Compositional biasi380 – 3834Poly-Val

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG3104.
HOGENOMiHOG000143436.
HOVERGENiHBG108431.
InParanoidiQ8IY34.
KOiK14638.
OMAiHYIHHNE.
OrthoDBiEOG7FNC8C.
PhylomeDBiQ8IY34.
TreeFamiTF330897.

Family and domain databases

InterProiIPR016196. MFS_dom_general_subst_transpt.
IPR000109. POT_fam.
[Graphical view]
PANTHERiPTHR11654. PTHR11654. 1 hit.
PfamiPF00854. PTR2. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.

Sequencei

Sequence statusi: Complete.

Q8IY34-1 [UniParc]FASTAAdd to Basket

« Hide

MPAPRAREQP RVPGERQPLL PRGARGPRRW RRAAGAAVLL VEMLERAAFF    50
GVTANLVLYL NSTNFNWTGE QATRAALVFL GASYLLAPVG GWLADVYLGR 100
YRAVALSLLL YLAASGLLPA TAFPDGRSSF CGEMPASPLG PACPSAGCPR 150
SSPSPYCAPV LYAGLLLLGL AASSVRSNLT SFGADQVMDL GRDATRRFFN 200
WFYWSINLGA VLSLLVVAFI QQNISFLLGY SIPVGCVGLA FFIFLFATPV 250
FITKPPMGSQ VSSMLKLALQ NCCPQLWQRH SARDRQCARV LADERSPQPG 300
ASPQEDIANF QVLVKILPVM VTLVPYWMVY FQMQSTYVLQ GLHLHIPNIF 350
PANPANISVA LRAQGSSYTI PEAWLLLANV VVVLILVPLK DRLIDPLLLR 400
CKLLPSALQK MALGMFFGFT SVIVAGVLEM ERLHYIHHNE TVSQQIGEVL 450
YNAAPLSIWW QIPQYLLIGI SEIFASIPGL EFAYSEAPRS MQGAIMGIFF 500
CLSGVGSLLG SSLVALLSLP GGWLHCPKDF GNINNCRMDL YFFLLAGIQA 550
VTALLFVWIA GRYERASQGP ASHSRFSRDR G 581
Length:581
Mass (Da):63,560
Last modified:May 18, 2010 - v2
Checksum:i56768D2963DB13D4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti349 – 3491I → F.1 Publication
Corresponds to variant rs17855607 [ dbSNP | Ensembl ].
VAR_034592

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB020598 mRNA. Translation: BAA93432.1.
AF135600 mRNA. Translation: AAQ13565.1.
AP003721 Genomic DNA. No translation available.
BC037974 mRNA. Translation: AAH37974.1.
CCDSiCCDS7998.1.
RefSeqiNP_057666.1. NM_016582.2.
UniGeneiHs.237856.

Genome annotation databases

EnsembliENST00000227880; ENSP00000227880; ENSG00000110446.
GeneIDi51296.
KEGGihsa:51296.
UCSCiuc001nqn.2. human.

Polymorphism databases

DMDMi296452890.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB020598 mRNA. Translation: BAA93432.1 .
AF135600 mRNA. Translation: AAQ13565.1 .
AP003721 Genomic DNA. No translation available.
BC037974 mRNA. Translation: AAH37974.1 .
CCDSi CCDS7998.1.
RefSeqi NP_057666.1. NM_016582.2.
UniGenei Hs.237856.

3D structure databases

ProteinModelPortali Q8IY34.
SMRi Q8IY34. Positions 33-563.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119447. 1 interaction.
STRINGi 9606.ENSP00000227880.

Chemistry

GuidetoPHARMACOLOGYi 986.

Protein family/group databases

TCDBi 2.A.17.3.9. the proton-dependent oligopeptide transporter (pot/ptr) family.

PTM databases

PhosphoSitei Q8IY34.

Polymorphism databases

DMDMi 296452890.

Proteomic databases

MaxQBi Q8IY34.
PaxDbi Q8IY34.
PRIDEi Q8IY34.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000227880 ; ENSP00000227880 ; ENSG00000110446 .
GeneIDi 51296.
KEGGi hsa:51296.
UCSCi uc001nqn.2. human.

Organism-specific databases

CTDi 51296.
GeneCardsi GC11M060704.
HGNCi HGNC:18068. SLC15A3.
HPAi HPA047880.
MIMi 610408. gene.
neXtProti NX_Q8IY34.
PharmGKBi PA134919658.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG3104.
HOGENOMi HOG000143436.
HOVERGENi HBG108431.
InParanoidi Q8IY34.
KOi K14638.
OMAi HYIHHNE.
OrthoDBi EOG7FNC8C.
PhylomeDBi Q8IY34.
TreeFami TF330897.

Enzyme and pathway databases

Reactomei REACT_19328. Proton/oligonucleotide cotransporters.

Miscellaneous databases

GenomeRNAii 51296.
NextBioi 54577.
PROi Q8IY34.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8IY34.
Bgeei Q8IY34.
CleanExi HS_SLC15A3.
Genevestigatori Q8IY34.

Family and domain databases

InterProi IPR016196. MFS_dom_general_subst_transpt.
IPR000109. POT_fam.
[Graphical view ]
PANTHERi PTHR11654. PTHR11654. 1 hit.
Pfami PF00854. PTR2. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 3 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a new member of peptide transporter."
    Ishiabshi K., Imai M.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  2. "Cloning of a novel gene of peptide transporter from human osteoclast."
    Yamane S., Toyosaki-Maeda T., Tsuruta Y., Suzuki R., Ochi T.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Synovial fluid.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-349.
    Tissue: Blood and Pancreas.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Placenta.

Entry informationi

Entry nameiS15A3_HUMAN
AccessioniPrimary (citable) accession number: Q8IY34
Secondary accession number(s): Q9P2X9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: May 18, 2010
Last modified: September 3, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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