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Q8IY34

- S15A3_HUMAN

UniProt

Q8IY34 - S15A3_HUMAN

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Protein

Solute carrier family 15 member 3

Gene

SLC15A3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides (By similarity).By similarity

GO - Molecular functioni

  1. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. ion transport Source: Reactome
  2. peptide transport Source: UniProtKB-KW
  3. protein transport Source: UniProtKB-KW
  4. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Peptide transport, Protein transport, Symport, Transport

Enzyme and pathway databases

ReactomeiREACT_19328. Proton/oligonucleotide cotransporters.

Protein family/group databases

TCDBi2.A.17.3.9. the proton-dependent oligopeptide transporter (pot/ptr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 15 member 3
Alternative name(s):
Osteoclast transporter
Peptide transporter 3
Peptide/histidine transporter 2
Gene namesi
Name:SLC15A3
Synonyms:OCTP, PHT2, PTR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:18068. SLC15A3.

Subcellular locationi

Lysosome membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei38 – 5821HelicalSequence AnalysisAdd
BLAST
Transmembranei76 – 9621HelicalSequence AnalysisAdd
BLAST
Transmembranei103 – 12321HelicalSequence AnalysisAdd
BLAST
Transmembranei155 – 17521HelicalSequence AnalysisAdd
BLAST
Transmembranei200 – 22021HelicalSequence AnalysisAdd
BLAST
Transmembranei232 – 25221HelicalSequence AnalysisAdd
BLAST
Transmembranei310 – 33021HelicalSequence AnalysisAdd
BLAST
Transmembranei369 – 38921HelicalSequence AnalysisAdd
BLAST
Transmembranei411 – 43121HelicalSequence AnalysisAdd
BLAST
Transmembranei458 – 47821HelicalSequence AnalysisAdd
BLAST
Transmembranei497 – 51721HelicalSequence AnalysisAdd
BLAST
Transmembranei540 – 56021HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. lysosomal membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134919658.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 581581Solute carrier family 15 member 3PRO_0000295912Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi61 – 611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi66 – 661N-linked (GlcNAc...)Sequence Analysis
Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence Analysis
Glycosylationi223 – 2231N-linked (GlcNAc...)Sequence Analysis
Glycosylationi356 – 3561N-linked (GlcNAc...)Sequence Analysis
Glycosylationi439 – 4391N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8IY34.
PaxDbiQ8IY34.
PRIDEiQ8IY34.

PTM databases

PhosphoSiteiQ8IY34.

Expressioni

Gene expression databases

BgeeiQ8IY34.
CleanExiHS_SLC15A3.
ExpressionAtlasiQ8IY34. baseline and differential.
GenevestigatoriQ8IY34.

Organism-specific databases

HPAiHPA047880.

Interactioni

Protein-protein interaction databases

BioGridi119447. 1 interaction.
DIPiDIP-60838N.
STRINGi9606.ENSP00000227880.

Structurei

3D structure databases

ProteinModelPortaliQ8IY34.
SMRiQ8IY34. Positions 33-563.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi165 – 1706Poly-Leu
Compositional biasi380 – 3834Poly-Val

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG3104.
GeneTreeiENSGT00530000062961.
HOGENOMiHOG000143436.
HOVERGENiHBG108431.
InParanoidiQ8IY34.
KOiK14638.
OMAiHYIHHNE.
OrthoDBiEOG7FNC8C.
PhylomeDBiQ8IY34.
TreeFamiTF330897.

Family and domain databases

InterProiIPR016196. MFS_dom_general_subst_transpt.
IPR000109. POT_fam.
[Graphical view]
PANTHERiPTHR11654. PTHR11654. 1 hit.
PfamiPF00854. PTR2. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.

Sequencei

Sequence statusi: Complete.

Q8IY34-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPAPRAREQP RVPGERQPLL PRGARGPRRW RRAAGAAVLL VEMLERAAFF
60 70 80 90 100
GVTANLVLYL NSTNFNWTGE QATRAALVFL GASYLLAPVG GWLADVYLGR
110 120 130 140 150
YRAVALSLLL YLAASGLLPA TAFPDGRSSF CGEMPASPLG PACPSAGCPR
160 170 180 190 200
SSPSPYCAPV LYAGLLLLGL AASSVRSNLT SFGADQVMDL GRDATRRFFN
210 220 230 240 250
WFYWSINLGA VLSLLVVAFI QQNISFLLGY SIPVGCVGLA FFIFLFATPV
260 270 280 290 300
FITKPPMGSQ VSSMLKLALQ NCCPQLWQRH SARDRQCARV LADERSPQPG
310 320 330 340 350
ASPQEDIANF QVLVKILPVM VTLVPYWMVY FQMQSTYVLQ GLHLHIPNIF
360 370 380 390 400
PANPANISVA LRAQGSSYTI PEAWLLLANV VVVLILVPLK DRLIDPLLLR
410 420 430 440 450
CKLLPSALQK MALGMFFGFT SVIVAGVLEM ERLHYIHHNE TVSQQIGEVL
460 470 480 490 500
YNAAPLSIWW QIPQYLLIGI SEIFASIPGL EFAYSEAPRS MQGAIMGIFF
510 520 530 540 550
CLSGVGSLLG SSLVALLSLP GGWLHCPKDF GNINNCRMDL YFFLLAGIQA
560 570 580
VTALLFVWIA GRYERASQGP ASHSRFSRDR G
Length:581
Mass (Da):63,560
Last modified:May 18, 2010 - v2
Checksum:i56768D2963DB13D4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti349 – 3491I → F.1 Publication
Corresponds to variant rs17855607 [ dbSNP | Ensembl ].
VAR_034592

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020598 mRNA. Translation: BAA93432.1.
AF135600 mRNA. Translation: AAQ13565.1.
AP003721 Genomic DNA. No translation available.
BC037974 mRNA. Translation: AAH37974.1.
CCDSiCCDS7998.1.
RefSeqiNP_057666.1. NM_016582.2.
UniGeneiHs.237856.

Genome annotation databases

EnsembliENST00000227880; ENSP00000227880; ENSG00000110446.
GeneIDi51296.
KEGGihsa:51296.
UCSCiuc001nqn.2. human.

Polymorphism databases

DMDMi296452890.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020598 mRNA. Translation: BAA93432.1 .
AF135600 mRNA. Translation: AAQ13565.1 .
AP003721 Genomic DNA. No translation available.
BC037974 mRNA. Translation: AAH37974.1 .
CCDSi CCDS7998.1.
RefSeqi NP_057666.1. NM_016582.2.
UniGenei Hs.237856.

3D structure databases

ProteinModelPortali Q8IY34.
SMRi Q8IY34. Positions 33-563.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119447. 1 interaction.
DIPi DIP-60838N.
STRINGi 9606.ENSP00000227880.

Chemistry

GuidetoPHARMACOLOGYi 986.

Protein family/group databases

TCDBi 2.A.17.3.9. the proton-dependent oligopeptide transporter (pot/ptr) family.

PTM databases

PhosphoSitei Q8IY34.

Polymorphism databases

DMDMi 296452890.

Proteomic databases

MaxQBi Q8IY34.
PaxDbi Q8IY34.
PRIDEi Q8IY34.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000227880 ; ENSP00000227880 ; ENSG00000110446 .
GeneIDi 51296.
KEGGi hsa:51296.
UCSCi uc001nqn.2. human.

Organism-specific databases

CTDi 51296.
GeneCardsi GC11M060704.
HGNCi HGNC:18068. SLC15A3.
HPAi HPA047880.
MIMi 610408. gene.
neXtProti NX_Q8IY34.
PharmGKBi PA134919658.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG3104.
GeneTreei ENSGT00530000062961.
HOGENOMi HOG000143436.
HOVERGENi HBG108431.
InParanoidi Q8IY34.
KOi K14638.
OMAi HYIHHNE.
OrthoDBi EOG7FNC8C.
PhylomeDBi Q8IY34.
TreeFami TF330897.

Enzyme and pathway databases

Reactomei REACT_19328. Proton/oligonucleotide cotransporters.

Miscellaneous databases

GenomeRNAii 51296.
NextBioi 54577.
PROi Q8IY34.
SOURCEi Search...

Gene expression databases

Bgeei Q8IY34.
CleanExi HS_SLC15A3.
ExpressionAtlasi Q8IY34. baseline and differential.
Genevestigatori Q8IY34.

Family and domain databases

InterProi IPR016196. MFS_dom_general_subst_transpt.
IPR000109. POT_fam.
[Graphical view ]
PANTHERi PTHR11654. PTHR11654. 1 hit.
Pfami PF00854. PTR2. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 3 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a new member of peptide transporter."
    Ishiabshi K., Imai M.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  2. "Cloning of a novel gene of peptide transporter from human osteoclast."
    Yamane S., Toyosaki-Maeda T., Tsuruta Y., Suzuki R., Ochi T.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Synovial fluid.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-349.
    Tissue: Blood and Pancreas.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Placenta.

Entry informationi

Entry nameiS15A3_HUMAN
AccessioniPrimary (citable) accession number: Q8IY34
Secondary accession number(s): Q9P2X9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3