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Protein

Solute carrier family 15 member 3

Gene

SLC15A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Peptide transport, Protein transport, Symport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-427975. Proton/oligopeptide cotransporters.

Protein family/group databases

TCDBi2.A.17.3.9. the proton-dependent oligopeptide transporter (pot/ptr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 15 member 3
Alternative name(s):
Osteoclast transporter
Peptide transporter 3
Peptide/histidine transporter 2
Gene namesi
Name:SLC15A3
Synonyms:OCTP, PHT2, PTR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:18068. SLC15A3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei38 – 58HelicalSequence analysisAdd BLAST21
Transmembranei76 – 96HelicalSequence analysisAdd BLAST21
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Transmembranei155 – 175HelicalSequence analysisAdd BLAST21
Transmembranei200 – 220HelicalSequence analysisAdd BLAST21
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21
Transmembranei310 – 330HelicalSequence analysisAdd BLAST21
Transmembranei369 – 389HelicalSequence analysisAdd BLAST21
Transmembranei411 – 431HelicalSequence analysisAdd BLAST21
Transmembranei458 – 478HelicalSequence analysisAdd BLAST21
Transmembranei497 – 517HelicalSequence analysisAdd BLAST21
Transmembranei540 – 560HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000110446.
PharmGKBiPA134919658.

Polymorphism and mutation databases

BioMutaiSLC15A3.
DMDMi296452890.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002959121 – 581Solute carrier family 15 member 3Add BLAST581

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi61N-linked (GlcNAc...)Sequence analysis1
Glycosylationi66N-linked (GlcNAc...)Sequence analysis1
Glycosylationi178N-linked (GlcNAc...)Sequence analysis1
Glycosylationi223N-linked (GlcNAc...)Sequence analysis1
Glycosylationi356N-linked (GlcNAc...)Sequence analysis1
Glycosylationi439N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8IY34.
PaxDbiQ8IY34.
PeptideAtlasiQ8IY34.
PRIDEiQ8IY34.

PTM databases

PhosphoSitePlusiQ8IY34.

Expressioni

Gene expression databases

BgeeiENSG00000110446.
CleanExiHS_SLC15A3.
ExpressionAtlasiQ8IY34. baseline and differential.
GenevisibleiQ8IY34. HS.

Organism-specific databases

HPAiHPA047880.
HPA057642.

Interactioni

Protein-protein interaction databases

BioGridi119447. 8 interactors.
DIPiDIP-60838N.
IntActiQ8IY34. 3 interactors.
STRINGi9606.ENSP00000227880.

Structurei

3D structure databases

ProteinModelPortaliQ8IY34.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi165 – 170Poly-Leu6
Compositional biasi380 – 383Poly-Val4

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1237. Eukaryota.
COG3104. LUCA.
GeneTreeiENSGT00530000062961.
HOGENOMiHOG000143436.
HOVERGENiHBG108431.
InParanoidiQ8IY34.
KOiK14638.
OMAiHYIHRNE.
OrthoDBiEOG091G0GF9.
PhylomeDBiQ8IY34.
TreeFamiTF330897.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR000109. POT_fam.
[Graphical view]
PANTHERiPTHR11654. PTHR11654. 2 hits.
PfamiPF00854. PTR2. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.

Sequencei

Sequence statusi: Complete.

Q8IY34-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAPRAREQP RVPGERQPLL PRGARGPRRW RRAAGAAVLL VEMLERAAFF
60 70 80 90 100
GVTANLVLYL NSTNFNWTGE QATRAALVFL GASYLLAPVG GWLADVYLGR
110 120 130 140 150
YRAVALSLLL YLAASGLLPA TAFPDGRSSF CGEMPASPLG PACPSAGCPR
160 170 180 190 200
SSPSPYCAPV LYAGLLLLGL AASSVRSNLT SFGADQVMDL GRDATRRFFN
210 220 230 240 250
WFYWSINLGA VLSLLVVAFI QQNISFLLGY SIPVGCVGLA FFIFLFATPV
260 270 280 290 300
FITKPPMGSQ VSSMLKLALQ NCCPQLWQRH SARDRQCARV LADERSPQPG
310 320 330 340 350
ASPQEDIANF QVLVKILPVM VTLVPYWMVY FQMQSTYVLQ GLHLHIPNIF
360 370 380 390 400
PANPANISVA LRAQGSSYTI PEAWLLLANV VVVLILVPLK DRLIDPLLLR
410 420 430 440 450
CKLLPSALQK MALGMFFGFT SVIVAGVLEM ERLHYIHHNE TVSQQIGEVL
460 470 480 490 500
YNAAPLSIWW QIPQYLLIGI SEIFASIPGL EFAYSEAPRS MQGAIMGIFF
510 520 530 540 550
CLSGVGSLLG SSLVALLSLP GGWLHCPKDF GNINNCRMDL YFFLLAGIQA
560 570 580
VTALLFVWIA GRYERASQGP ASHSRFSRDR G
Length:581
Mass (Da):63,560
Last modified:May 18, 2010 - v2
Checksum:i56768D2963DB13D4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034592349I → F.1 PublicationCorresponds to variant rs17855607dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020598 mRNA. Translation: BAA93432.1.
AF135600 mRNA. Translation: AAQ13565.1.
AP003721 Genomic DNA. No translation available.
BC037974 mRNA. Translation: AAH37974.1.
CCDSiCCDS7998.1.
RefSeqiNP_057666.1. NM_016582.2.
UniGeneiHs.237856.

Genome annotation databases

EnsembliENST00000227880; ENSP00000227880; ENSG00000110446.
GeneIDi51296.
KEGGihsa:51296.
UCSCiuc001nqn.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020598 mRNA. Translation: BAA93432.1.
AF135600 mRNA. Translation: AAQ13565.1.
AP003721 Genomic DNA. No translation available.
BC037974 mRNA. Translation: AAH37974.1.
CCDSiCCDS7998.1.
RefSeqiNP_057666.1. NM_016582.2.
UniGeneiHs.237856.

3D structure databases

ProteinModelPortaliQ8IY34.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119447. 8 interactors.
DIPiDIP-60838N.
IntActiQ8IY34. 3 interactors.
STRINGi9606.ENSP00000227880.

Protein family/group databases

TCDBi2.A.17.3.9. the proton-dependent oligopeptide transporter (pot/ptr) family.

PTM databases

PhosphoSitePlusiQ8IY34.

Polymorphism and mutation databases

BioMutaiSLC15A3.
DMDMi296452890.

Proteomic databases

MaxQBiQ8IY34.
PaxDbiQ8IY34.
PeptideAtlasiQ8IY34.
PRIDEiQ8IY34.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000227880; ENSP00000227880; ENSG00000110446.
GeneIDi51296.
KEGGihsa:51296.
UCSCiuc001nqn.3. human.

Organism-specific databases

CTDi51296.
GeneCardsiSLC15A3.
HGNCiHGNC:18068. SLC15A3.
HPAiHPA047880.
HPA057642.
MIMi610408. gene.
neXtProtiNX_Q8IY34.
OpenTargetsiENSG00000110446.
PharmGKBiPA134919658.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1237. Eukaryota.
COG3104. LUCA.
GeneTreeiENSGT00530000062961.
HOGENOMiHOG000143436.
HOVERGENiHBG108431.
InParanoidiQ8IY34.
KOiK14638.
OMAiHYIHRNE.
OrthoDBiEOG091G0GF9.
PhylomeDBiQ8IY34.
TreeFamiTF330897.

Enzyme and pathway databases

ReactomeiR-HSA-427975. Proton/oligopeptide cotransporters.

Miscellaneous databases

GenomeRNAii51296.
PROiQ8IY34.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000110446.
CleanExiHS_SLC15A3.
ExpressionAtlasiQ8IY34. baseline and differential.
GenevisibleiQ8IY34. HS.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR000109. POT_fam.
[Graphical view]
PANTHERiPTHR11654. PTHR11654. 2 hits.
PfamiPF00854. PTR2. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiS15A3_HUMAN
AccessioniPrimary (citable) accession number: Q8IY34
Secondary accession number(s): Q9P2X9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.