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Q8IY34 (S15A3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 15 member 3
Alternative name(s):
Osteoclast transporter
Peptide transporter 3
Peptide/histidine transporter 2
Gene names
Name:SLC15A3
Synonyms:OCTP, PHT2, PTR3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length581 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides By similarity.

Subcellular location

Lysosome membrane; Multi-pass membrane protein Ref.5.

Sequence similarities

Belongs to the PTR2/POT transporter (TC 2.A.17) family. [View classification]

Ontologies

Keywords
   Biological processPeptide transport
Protein transport
Symport
Transport
   Cellular componentLysosome
Membrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_procession transport

Traceable author statement. Source: Reactome

peptide transport

Inferred from electronic annotation. Source: UniProtKB-KW

protein transport

Inferred from electronic annotation. Source: UniProtKB-KW

transmembrane transport

Traceable author statement. Source: Reactome

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

lysosomal membrane

Inferred from direct assay Ref.5. Source: UniProtKB

   Molecular_functionsymporter activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 581581Solute carrier family 15 member 3
PRO_0000295912

Regions

Transmembrane38 – 5821Helical; Potential
Transmembrane76 – 9621Helical; Potential
Transmembrane103 – 12321Helical; Potential
Transmembrane155 – 17521Helical; Potential
Transmembrane200 – 22021Helical; Potential
Transmembrane232 – 25221Helical; Potential
Transmembrane310 – 33021Helical; Potential
Transmembrane369 – 38921Helical; Potential
Transmembrane411 – 43121Helical; Potential
Transmembrane458 – 47821Helical; Potential
Transmembrane497 – 51721Helical; Potential
Transmembrane540 – 56021Helical; Potential
Compositional bias165 – 1706Poly-Leu
Compositional bias380 – 3834Poly-Val

Amino acid modifications

Glycosylation611N-linked (GlcNAc...) Potential
Glycosylation661N-linked (GlcNAc...) Potential
Glycosylation1781N-linked (GlcNAc...) Potential
Glycosylation2231N-linked (GlcNAc...) Potential
Glycosylation3561N-linked (GlcNAc...) Potential
Glycosylation4391N-linked (GlcNAc...) Potential

Natural variations

Natural variant3491I → F. Ref.4
Corresponds to variant rs17855607 [ dbSNP | Ensembl ].
VAR_034592

Sequences

Sequence LengthMass (Da)Tools
Q8IY34 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: 56768D2963DB13D4

FASTA58163,560
        10         20         30         40         50         60 
MPAPRAREQP RVPGERQPLL PRGARGPRRW RRAAGAAVLL VEMLERAAFF GVTANLVLYL 

        70         80         90        100        110        120 
NSTNFNWTGE QATRAALVFL GASYLLAPVG GWLADVYLGR YRAVALSLLL YLAASGLLPA 

       130        140        150        160        170        180 
TAFPDGRSSF CGEMPASPLG PACPSAGCPR SSPSPYCAPV LYAGLLLLGL AASSVRSNLT 

       190        200        210        220        230        240 
SFGADQVMDL GRDATRRFFN WFYWSINLGA VLSLLVVAFI QQNISFLLGY SIPVGCVGLA 

       250        260        270        280        290        300 
FFIFLFATPV FITKPPMGSQ VSSMLKLALQ NCCPQLWQRH SARDRQCARV LADERSPQPG 

       310        320        330        340        350        360 
ASPQEDIANF QVLVKILPVM VTLVPYWMVY FQMQSTYVLQ GLHLHIPNIF PANPANISVA 

       370        380        390        400        410        420 
LRAQGSSYTI PEAWLLLANV VVVLILVPLK DRLIDPLLLR CKLLPSALQK MALGMFFGFT 

       430        440        450        460        470        480 
SVIVAGVLEM ERLHYIHHNE TVSQQIGEVL YNAAPLSIWW QIPQYLLIGI SEIFASIPGL 

       490        500        510        520        530        540 
EFAYSEAPRS MQGAIMGIFF CLSGVGSLLG SSLVALLSLP GGWLHCPKDF GNINNCRMDL 

       550        560        570        580 
YFFLLAGIQA VTALLFVWIA GRYERASQGP ASHSRFSRDR G 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of a new member of peptide transporter."
Ishiabshi K., Imai M.
Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Placenta.
[2]"Cloning of a novel gene of peptide transporter from human osteoclast."
Yamane S., Toyosaki-Maeda T., Tsuruta Y., Suzuki R., Ochi T.
Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Synovial fluid.
[3]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-349.
Tissue: Blood and Pancreas.
[5]"Integral and associated lysosomal membrane proteins."
Schroeder B., Wrocklage C., Pan C., Jaeger R., Koesters B., Schaefer H., Elsaesser H.-P., Mann M., Hasilik A.
Traffic 8:1676-1686(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
Tissue: Placenta.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB020598 mRNA. Translation: BAA93432.1.
AF135600 mRNA. Translation: AAQ13565.1.
AP003721 Genomic DNA. No translation available.
BC037974 mRNA. Translation: AAH37974.1.
CCDSCCDS7998.1.
RefSeqNP_057666.1. NM_016582.2.
UniGeneHs.237856.

3D structure databases

ProteinModelPortalQ8IY34.
SMRQ8IY34. Positions 33-563.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119447. 1 interaction.
STRING9606.ENSP00000227880.

Chemistry

GuidetoPHARMACOLOGY986.

Protein family/group databases

TCDB2.A.17.3.9. the proton-dependent oligopeptide transporter (pot) family.

PTM databases

PhosphoSiteQ8IY34.

Polymorphism databases

DMDM296452890.

Proteomic databases

MaxQBQ8IY34.
PaxDbQ8IY34.
PRIDEQ8IY34.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000227880; ENSP00000227880; ENSG00000110446.
GeneID51296.
KEGGhsa:51296.
UCSCuc001nqn.2. human.

Organism-specific databases

CTD51296.
GeneCardsGC11M060704.
HGNCHGNC:18068. SLC15A3.
HPAHPA047880.
MIM610408. gene.
neXtProtNX_Q8IY34.
PharmGKBPA134919658.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG3104.
HOGENOMHOG000143436.
HOVERGENHBG108431.
InParanoidQ8IY34.
KOK14638.
OMAHYIHHNE.
OrthoDBEOG7FNC8C.
PhylomeDBQ8IY34.
TreeFamTF330897.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.
REACT_19419. Amino acid and oligopeptide SLC transporters.

Gene expression databases

ArrayExpressQ8IY34.
BgeeQ8IY34.
CleanExHS_SLC15A3.
GenevestigatorQ8IY34.

Family and domain databases

InterProIPR016196. MFS_dom_general_subst_transpt.
IPR000109. POT_fam.
[Graphical view]
PANTHERPTHR11654. PTHR11654. 1 hit.
PfamPF00854. PTR2. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 3 hits.
ProtoNetSearch...

Other

GenomeRNAi51296.
NextBio54577.
PROQ8IY34.
SOURCESearch...

Entry information

Entry nameS15A3_HUMAN
AccessionPrimary (citable) accession number: Q8IY34
Secondary accession number(s): Q9P2X9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM