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Protein

Intraflagellar transport protein 20 homolog

Gene

IFT20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Part of intraflagellar transport (IFT) particles involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment.1 Publication

GO - Molecular functioni

  • Rab GTPase binding Source: ParkinsonsUK-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation

Enzyme and pathway databases

ReactomeiR-HSA-5620924. Intraflagellar transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Intraflagellar transport protein 20 homolog
Short name:
hIFT20
Gene namesi
Name:IFT20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:30989. IFT20.

Subcellular locationi

  • Golgi apparatuscis-Golgi network By similarity
  • Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriole By similarity
  • Cytoplasmcytoskeletoncilium basal body By similarity
  • Cell projectioncilium By similarity

  • Note: Present at the centrosomes during the cell cycle and associated with the proximal portion of the mother centriole and the lateral aspect of the daughter centriole. Associated with basal body at the base of primary cilia (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Golgi apparatus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000109083.
PharmGKBiPA142671663.

Polymorphism and mutation databases

BioMutaiIFT20.
DMDMi74728279.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002493031 – 132Intraflagellar transport protein 20 homologAdd BLAST132

Proteomic databases

EPDiQ8IY31.
MaxQBiQ8IY31.
PaxDbiQ8IY31.
PeptideAtlasiQ8IY31.
PRIDEiQ8IY31.
TopDownProteomicsiQ8IY31-3. [Q8IY31-3]

PTM databases

iPTMnetiQ8IY31.
PhosphoSitePlusiQ8IY31.

Expressioni

Tissue specificityi

Expressed in almost all tissues.1 Publication

Gene expression databases

BgeeiENSG00000109083.
CleanExiHS_IFT20.
ExpressionAtlasiQ8IY31. baseline and differential.
GenevisibleiQ8IY31. HS.

Organism-specific databases

HPAiHPA021376.

Interactioni

Subunit structurei

Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts directly with IFT57 and KIF3B/Kinesin II subunit. Interacts with IFT88 (By similarity). Interacts with CEP83.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ABI2Q9NYB94EBI-744203,EBI-743598
CCDC53Q9Y3C03EBI-744203,EBI-712969
CCDC67E9PJR53EBI-744203,EBI-10177066
CROCCP2Q86T233EBI-744203,EBI-2872397
DTNBP1Q96EV83EBI-744203,EBI-465804
EMILIN1Q9Y6C26EBI-744203,EBI-744586
EXOC7Q9UPT54EBI-744203,EBI-720048
FSD2A1L4K13EBI-744203,EBI-5661036
GOLGA2Q083793EBI-744203,EBI-618309
HAUS1Q96CS25EBI-744203,EBI-2514791
KRT13A1A4E93EBI-744203,EBI-10171552
KXD1Q9BQD35EBI-744203,EBI-739657
MED4Q9NPJ63EBI-744203,EBI-394607
NDC80O147775EBI-744203,EBI-715849
NUP54Q7Z3B43EBI-744203,EBI-741048
NUP62P371983EBI-744203,EBI-347978
PSMA1P257863EBI-744203,EBI-359352
USHBP1Q8N6Y03EBI-744203,EBI-739895
ZDHHC17Q8IUH53EBI-9091197,EBI-524753

GO - Molecular functioni

  • Rab GTPase binding Source: ParkinsonsUK-UCL

Protein-protein interaction databases

BioGridi124711. 36 interactors.
IntActiQ8IY31. 50 interactors.
MINTiMINT-1193441.
STRINGi9606.ENSP00000350570.

Structurei

3D structure databases

ProteinModelPortaliQ8IY31.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni70 – 132IFT57-bindingBy similarityAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili74 – 114Sequence analysisAdd BLAST41

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410KC8U. Eukaryota.
ENOG4110P7T. LUCA.
GeneTreeiENSGT00390000003413.
HOGENOMiHOG000230527.
HOVERGENiHBG081781.
InParanoidiQ8IY31.
KOiK16473.
OMAiQYEIFEQ.
OrthoDBiEOG091G0VSN.
PhylomeDBiQ8IY31.
TreeFamiTF319434.

Family and domain databases

InterProiIPR028172. FT20.
[Graphical view]
PfamiPF14931. IFT20. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IY31-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKDILGEAG LHFDELNKLR VLDPEVTQQT IELKEECKDF VDKIGQFQKI
60 70 80 90 100
VGGLIELVDQ LAKEAENEKM KAIGARNLLK SIAKQREAQQ QQLQALIAEK
110 120 130
KMQLERYRVE YEALCKVEAE QNEFIDQFIF QK
Length:132
Mass (Da):15,281
Last modified:March 1, 2003 - v1
Checksum:i8C751DE18FEEB30F
GO
Isoform 2 (identifier: Q8IY31-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MTHLLLTATVTPSEQNSSREPGWETAM

Show »
Length:158
Mass (Da):18,120
Checksum:i8CB5C24AC62F22D1
GO
Isoform 3 (identifier: Q8IY31-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     72-132: AIGARNLLKS...EFIDQFIFQK → SLAVSPRLEC...KENAARKVSG

Show »
Length:148
Mass (Da):15,964
Checksum:iC19CC3F33BC56CA8
GO
Isoform 4 (identifier: Q8IY31-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     107-132: YRVEYEALCKVEAEQNEFIDQFIFQK → NELKISLL

Note: No experimental confirmation available.
Show »
Length:114
Mass (Da):12,969
Checksum:i80A74AE1A98303BA
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0203901M → MTHLLLTATVTPSEQNSSRE PGWETAM in isoform 2. 1 Publication1
Alternative sequenceiVSP_02039172 – 132AIGAR…FIFQK → SLAVSPRLECTGAISAHCKL CLSDSSDSPTSPSRVGGTTG HRCSELAQIYSKAERSSTAA TSSPNSRKENAARKVSG in isoform 3. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_046026107 – 132YRVEY…FIFQK → NELKISLL in isoform 4. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY224601 mRNA. Translation: AAP50265.1.
BQ639919 mRNA. No translation available.
AC002094 Genomic DNA. No translation available.
BC002640 mRNA. Translation: AAH02640.1.
BC038094 mRNA. Translation: AAH38094.1.
CCDSiCCDS32593.1. [Q8IY31-3]
CCDS58533.1. [Q8IY31-4]
CCDS58534.1. [Q8IY31-1]
CCDS58535.1. [Q8IY31-2]
RefSeqiNP_001254703.1. NM_001267774.1. [Q8IY31-2]
NP_001254704.1. NM_001267775.1. [Q8IY31-1]
NP_001254705.1. NM_001267776.1. [Q8IY31-1]
NP_001254706.1. NM_001267777.1. [Q8IY31-4]
NP_001254707.1. NM_001267778.1.
NP_777547.1. NM_174887.3. [Q8IY31-3]
UniGeneiHs.705431.
Hs.744876.

Genome annotation databases

EnsembliENST00000357896; ENSP00000350570; ENSG00000109083. [Q8IY31-3]
ENST00000395418; ENSP00000378809; ENSG00000109083. [Q8IY31-1]
ENST00000579419; ENSP00000463322; ENSG00000109083. [Q8IY31-4]
ENST00000585089; ENSP00000464443; ENSG00000109083. [Q8IY31-2]
ENST00000585313; ENSP00000463138; ENSG00000109083. [Q8IY31-1]
GeneIDi90410.
KEGGihsa:90410.
UCSCiuc002hau.3. human. [Q8IY31-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY224601 mRNA. Translation: AAP50265.1.
BQ639919 mRNA. No translation available.
AC002094 Genomic DNA. No translation available.
BC002640 mRNA. Translation: AAH02640.1.
BC038094 mRNA. Translation: AAH38094.1.
CCDSiCCDS32593.1. [Q8IY31-3]
CCDS58533.1. [Q8IY31-4]
CCDS58534.1. [Q8IY31-1]
CCDS58535.1. [Q8IY31-2]
RefSeqiNP_001254703.1. NM_001267774.1. [Q8IY31-2]
NP_001254704.1. NM_001267775.1. [Q8IY31-1]
NP_001254705.1. NM_001267776.1. [Q8IY31-1]
NP_001254706.1. NM_001267777.1. [Q8IY31-4]
NP_001254707.1. NM_001267778.1.
NP_777547.1. NM_174887.3. [Q8IY31-3]
UniGeneiHs.705431.
Hs.744876.

3D structure databases

ProteinModelPortaliQ8IY31.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124711. 36 interactors.
IntActiQ8IY31. 50 interactors.
MINTiMINT-1193441.
STRINGi9606.ENSP00000350570.

PTM databases

iPTMnetiQ8IY31.
PhosphoSitePlusiQ8IY31.

Polymorphism and mutation databases

BioMutaiIFT20.
DMDMi74728279.

Proteomic databases

EPDiQ8IY31.
MaxQBiQ8IY31.
PaxDbiQ8IY31.
PeptideAtlasiQ8IY31.
PRIDEiQ8IY31.
TopDownProteomicsiQ8IY31-3. [Q8IY31-3]

Protocols and materials databases

DNASUi90410.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357896; ENSP00000350570; ENSG00000109083. [Q8IY31-3]
ENST00000395418; ENSP00000378809; ENSG00000109083. [Q8IY31-1]
ENST00000579419; ENSP00000463322; ENSG00000109083. [Q8IY31-4]
ENST00000585089; ENSP00000464443; ENSG00000109083. [Q8IY31-2]
ENST00000585313; ENSP00000463138; ENSG00000109083. [Q8IY31-1]
GeneIDi90410.
KEGGihsa:90410.
UCSCiuc002hau.3. human. [Q8IY31-1]

Organism-specific databases

CTDi90410.
GeneCardsiIFT20.
HGNCiHGNC:30989. IFT20.
HPAiHPA021376.
MIMi614394. gene.
neXtProtiNX_Q8IY31.
OpenTargetsiENSG00000109083.
PharmGKBiPA142671663.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KC8U. Eukaryota.
ENOG4110P7T. LUCA.
GeneTreeiENSGT00390000003413.
HOGENOMiHOG000230527.
HOVERGENiHBG081781.
InParanoidiQ8IY31.
KOiK16473.
OMAiQYEIFEQ.
OrthoDBiEOG091G0VSN.
PhylomeDBiQ8IY31.
TreeFamiTF319434.

Enzyme and pathway databases

ReactomeiR-HSA-5620924. Intraflagellar transport.

Miscellaneous databases

ChiTaRSiIFT20. human.
GeneWikiiIFT20.
GenomeRNAii90410.
PROiQ8IY31.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000109083.
CleanExiHS_IFT20.
ExpressionAtlasiQ8IY31. baseline and differential.
GenevisibleiQ8IY31. HS.

Family and domain databases

InterProiIPR028172. FT20.
[Graphical view]
PfamiPF14931. IFT20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIFT20_HUMAN
AccessioniPrimary (citable) accession number: Q8IY31
Secondary accession number(s): J3QL09, Q5GLZ2, Q9BUG5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.