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Q8IY31

- IFT20_HUMAN

UniProt

Q8IY31 - IFT20_HUMAN

Protein

Intraflagellar transport protein 20 homolog

Gene

IFT20

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Part of intraflagellar transport (IFT) particles involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. centrosome localization Source: RefGenome
    2. cilium assembly Source: MGI
    3. intraciliary transport Source: RefGenome
    4. protein localization to cilium Source: RefGenome
    5. protein localization to Golgi apparatus Source: MGI
    6. regulation of autophagic vacuole assembly Source: UniProtKB
    7. regulation of cilium assembly Source: UniProtKB

    Keywords - Biological processi

    Cilium biogenesis/degradation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Intraflagellar transport protein 20 homolog
    Short name:
    hIFT20
    Gene namesi
    Name:IFT20
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:30989. IFT20.

    Subcellular locationi

    Golgi apparatuscis-Golgi network By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriole By similarity. Cytoplasmcytoskeletoncilium basal body By similarity
    Note: Present at the centrosomes during the cell cycle and associated with the proximal portion of the mother centriole and the lateral aspect of the daughter centriole. Associated with basal body at the base of primary cilia By similarity.By similarity

    GO - Cellular componenti

    1. centriole Source: UniProtKB-SubCell
    2. centrosome Source: MGI
    3. cilium Source: RefGenome
    4. dendrite terminus Source: Ensembl
    5. extracellular vesicular exosome Source: UniProt
    6. Golgi apparatus Source: RefGenome
    7. intraciliary transport particle B Source: RefGenome

    Keywords - Cellular componenti

    Cell projection, Cilium, Cytoplasm, Cytoskeleton, Golgi apparatus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671663.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 132132Intraflagellar transport protein 20 homologPRO_0000249303Add
    BLAST

    Proteomic databases

    MaxQBiQ8IY31.
    PaxDbiQ8IY31.
    PRIDEiQ8IY31.

    Expressioni

    Tissue specificityi

    Expressed in almost all tissues.1 Publication

    Gene expression databases

    ArrayExpressiQ8IY31.
    BgeeiQ8IY31.
    CleanExiHS_IFT20.
    GenevestigatoriQ8IY31.

    Organism-specific databases

    HPAiHPA021376.

    Interactioni

    Subunit structurei

    Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts directly with IFT57 and KIF3B/Kinesin II subunit. Interacts with IFT88 By similarity. Interacts with CEP83.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    KXD1Q9BQD32EBI-744203,EBI-739657
    ZDHHC17Q8IUH53EBI-9091197,EBI-524753

    Protein-protein interaction databases

    BioGridi124711. 12 interactions.
    IntActiQ8IY31. 13 interactions.
    MINTiMINT-1193441.
    STRINGi9606.ENSP00000350570.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IY31.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni70 – 13263IFT57-bindingBy similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili74 – 11441Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG41943.
    HOGENOMiHOG000230527.
    HOVERGENiHBG081781.
    InParanoidiQ8IY31.
    KOiK16473.
    OMAiFIDQFIL.
    PhylomeDBiQ8IY31.
    TreeFamiTF319434.

    Family and domain databases

    InterProiIPR028172. FT20.
    [Graphical view]
    PfamiPF14931. IFT20. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8IY31-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAKDILGEAG LHFDELNKLR VLDPEVTQQT IELKEECKDF VDKIGQFQKI    50
    VGGLIELVDQ LAKEAENEKM KAIGARNLLK SIAKQREAQQ QQLQALIAEK 100
    KMQLERYRVE YEALCKVEAE QNEFIDQFIF QK 132
    Length:132
    Mass (Da):15,281
    Last modified:March 1, 2003 - v1
    Checksum:i8C751DE18FEEB30F
    GO
    Isoform 2 (identifier: Q8IY31-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MTHLLLTATVTPSEQNSSREPGWETAM

    Show »
    Length:158
    Mass (Da):18,120
    Checksum:i8CB5C24AC62F22D1
    GO
    Isoform 3 (identifier: Q8IY31-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         72-132: AIGARNLLKS...EFIDQFIFQK → SLAVSPRLEC...KENAARKVSG

    Show »
    Length:148
    Mass (Da):15,964
    Checksum:iC19CC3F33BC56CA8
    GO
    Isoform 4 (identifier: Q8IY31-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         107-132: YRVEYEALCKVEAEQNEFIDQFIFQK → NELKISLL

    Note: No experimental confirmation available.

    Show »
    Length:114
    Mass (Da):12,969
    Checksum:i80A74AE1A98303BA
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 11M → MTHLLLTATVTPSEQNSSRE PGWETAM in isoform 2. 1 PublicationVSP_020390
    Alternative sequencei72 – 13261AIGAR…FIFQK → SLAVSPRLECTGAISAHCKL CLSDSSDSPTSPSRVGGTTG HRCSELAQIYSKAERSSTAA TSSPNSRKENAARKVSG in isoform 3. 1 PublicationVSP_020391Add
    BLAST
    Alternative sequencei107 – 13226YRVEY…FIFQK → NELKISLL in isoform 4. 1 PublicationVSP_046026Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY224601 mRNA. Translation: AAP50265.1.
    BQ639919 mRNA. No translation available.
    AC002094 Genomic DNA. No translation available.
    BC002640 mRNA. Translation: AAH02640.1.
    BC038094 mRNA. Translation: AAH38094.1.
    CCDSiCCDS32593.1. [Q8IY31-3]
    CCDS58533.1. [Q8IY31-4]
    CCDS58534.1. [Q8IY31-1]
    CCDS58535.1. [Q8IY31-2]
    RefSeqiNP_001254703.1. NM_001267774.1. [Q8IY31-2]
    NP_001254704.1. NM_001267775.1. [Q8IY31-1]
    NP_001254705.1. NM_001267776.1. [Q8IY31-1]
    NP_001254706.1. NM_001267777.1. [Q8IY31-4]
    NP_001254707.1. NM_001267778.1.
    NP_777547.1. NM_174887.3. [Q8IY31-3]
    UniGeneiHs.705431.
    Hs.744876.

    Genome annotation databases

    GeneIDi90410.
    KEGGihsa:90410.
    UCSCiuc002hau.2. human. [Q8IY31-3]
    uc002hav.2. human. [Q8IY31-2]
    uc002haw.2. human. [Q8IY31-1]

    Polymorphism databases

    DMDMi74728279.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY224601 mRNA. Translation: AAP50265.1 .
    BQ639919 mRNA. No translation available.
    AC002094 Genomic DNA. No translation available.
    BC002640 mRNA. Translation: AAH02640.1 .
    BC038094 mRNA. Translation: AAH38094.1 .
    CCDSi CCDS32593.1. [Q8IY31-3 ]
    CCDS58533.1. [Q8IY31-4 ]
    CCDS58534.1. [Q8IY31-1 ]
    CCDS58535.1. [Q8IY31-2 ]
    RefSeqi NP_001254703.1. NM_001267774.1. [Q8IY31-2 ]
    NP_001254704.1. NM_001267775.1. [Q8IY31-1 ]
    NP_001254705.1. NM_001267776.1. [Q8IY31-1 ]
    NP_001254706.1. NM_001267777.1. [Q8IY31-4 ]
    NP_001254707.1. NM_001267778.1.
    NP_777547.1. NM_174887.3. [Q8IY31-3 ]
    UniGenei Hs.705431.
    Hs.744876.

    3D structure databases

    ProteinModelPortali Q8IY31.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124711. 12 interactions.
    IntActi Q8IY31. 13 interactions.
    MINTi MINT-1193441.
    STRINGi 9606.ENSP00000350570.

    Polymorphism databases

    DMDMi 74728279.

    Proteomic databases

    MaxQBi Q8IY31.
    PaxDbi Q8IY31.
    PRIDEi Q8IY31.

    Protocols and materials databases

    DNASUi 90410.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 90410.
    KEGGi hsa:90410.
    UCSCi uc002hau.2. human. [Q8IY31-3 ]
    uc002hav.2. human. [Q8IY31-2 ]
    uc002haw.2. human. [Q8IY31-1 ]

    Organism-specific databases

    CTDi 90410.
    GeneCardsi GC17M026655.
    HGNCi HGNC:30989. IFT20.
    HPAi HPA021376.
    MIMi 614394. gene.
    neXtProti NX_Q8IY31.
    PharmGKBi PA142671663.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG41943.
    HOGENOMi HOG000230527.
    HOVERGENi HBG081781.
    InParanoidi Q8IY31.
    KOi K16473.
    OMAi FIDQFIL.
    PhylomeDBi Q8IY31.
    TreeFami TF319434.

    Miscellaneous databases

    ChiTaRSi IFT20. human.
    GeneWikii IFT20.
    GenomeRNAii 90410.
    NextBioi 35536454.
    PROi Q8IY31.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8IY31.
    Bgeei Q8IY31.
    CleanExi HS_IFT20.
    Genevestigatori Q8IY31.

    Family and domain databases

    InterProi IPR028172. FT20.
    [Graphical view ]
    Pfami PF14931. IFT20. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of the human IFT20 gene."
      Yin G., Dai J., Ji C., Ni X., Shu G., Ye X., Dai J., Wu Q., Gu S., Xie Y., Zhao R.C., Mao Y.
      Mol. Biol. Rep. 30:255-260(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
    2. "Expressed sequence tag analysis of human retina for the NEIBank project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts."
      Wistow G., Berstein S.L., Wyatt M.K., Ray S., Behal A., Touchman J.W., Bouffard G., Smith D., Peterson K.
      Mol. Vis. 8:196-204(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Uterus.
    5. "The intraflagellar transport protein IFT20 is associated with the Golgi complex and is required for cilia assembly."
      Follit J.A., Tuft R.A., Fogarty K.E., Pazour G.J.
      Mol. Biol. Cell 17:3781-3792(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. Cited for: INTERACTION WITH CEP83.

    Entry informationi

    Entry nameiIFT20_HUMAN
    AccessioniPrimary (citable) accession number: Q8IY31
    Secondary accession number(s): J3QL09, Q5GLZ2, Q9BUG5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 5, 2006
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3