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Protein

Phospholipid phosphatase 6

Gene

PLPP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Phosphatase that dephosphorylates presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP), suggesting that it may be indirectly involved in innate immunity. PSDP is a bioactive lipid that rapidly remodels to presqualene monophosphate PSMP upon cell activation. Displays diphosphate phosphatase activity with a substrate preference for PSDP > FDP > phosphatidic acid.1 Publication

pH dependencei

Optimum pH is 7-8.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

ReactomeiR-HSA-191273. Cholesterol biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid phosphatase 6Imported (EC:3.1.3.-)
Alternative name(s):
Phosphatidic acid phosphatase type 2 domain-containing protein 2
Short name:
PPAP2 domain-containing protein 2
Presqualene diphosphate phosphatase
Gene namesi
Name:PLPP6Imported
Synonyms:PPAPDC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:23682. PLPP6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei133 – 153HelicalSequence analysisAdd BLAST21
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Transmembranei229 – 249HelicalSequence analysisAdd BLAST21
Transmembranei261 – 281HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi403313.
OpenTargetsiENSG00000205808.
PharmGKBiPA142671155.

Polymorphism and mutation databases

BioMutaiPPAPDC2.
DMDMi108860900.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002393961 – 295Phospholipid phosphatase 6Add BLAST295

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei26PhosphoserineCombined sources1
Modified residuei36PhosphoserineCombined sources1
Modified residuei70PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IY26.
MaxQBiQ8IY26.
PaxDbiQ8IY26.
PeptideAtlasiQ8IY26.
PRIDEiQ8IY26.

PTM databases

DEPODiQ8IY26.
iPTMnetiQ8IY26.
PhosphoSitePlusiQ8IY26.

Expressioni

Tissue specificityi

Widely expressed. Expressed in most organs, in particular gastrointestinal organs, spleen, placenta, kidney, thymus and brain.1 Publication

Gene expression databases

BgeeiENSG00000205808.
CleanExiHS_PPAPDC2.
GenevisibleiQ8IY26. HS.

Organism-specific databases

HPAiHPA018096.

Interactioni

Protein-protein interaction databases

BioGridi135624. 2 interactors.
IntActiQ8IY26. 20 interactors.
STRINGi9606.ENSP00000371307.

Structurei

3D structure databases

ProteinModelPortaliQ8IY26.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4268. Eukaryota.
ENOG410ZVFK. LUCA.
GeneTreeiENSGT00390000012789.
HOGENOMiHOG000231931.
HOVERGENiHBG054746.
InParanoidiQ8IY26.
OMAiLGYMQYS.
OrthoDBiEOG091G0STF.
PhylomeDBiQ8IY26.
TreeFamiTF323272.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiView protein in InterPro
IPR000326. P_Acid_Pase_2/haloperoxidase.
PfamiView protein in Pfam
PF01569. PAP2. 1 hit.
SMARTiView protein in SMART
SM00014. acidPPc. 1 hit.
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8IY26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSPRRSMEG RPLGVSASSS SSSPGSPAHG GGGGGSRFEF QSLLSSRATA
60 70 80 90 100
VDPTCARLRA SESPVHRRGS FPLAAAGPSQ SPAPPLPEED RMDLNPSFLG
110 120 130 140 150
IALRSLLAID LWLSKKLGVC AGESSSWGSV RPLMKLLEIS GHGIPWLLGT
160 170 180 190 200
LYCLCRSDSW AGREVLMNLL FALLLDLLLV ALIKGLVRRR RPAHNQMDMF
210 220 230 240 250
VTLSVDKYSF PSGHATRAAL MSRFILNHLV LAIPLRVLVV LWAFVLGLSR
260 270 280 290
VMLGRHNVTD VAFGFFLGYM QYSIVDYCWL SPHNAPVLFL LWSQR
Length:295
Mass (Da):32,194
Last modified:June 13, 2006 - v3
Checksum:i92024580CE727AED
GO

Sequence cautioni

The sequence AK074672 differs from that shown. Reason: Frameshift at position 267.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0506167S → G. Corresponds to variant dbSNP:rs34250374Ensembl.1
Natural variantiVAR_0506178M → T. Corresponds to variant dbSNP:rs35791393Ensembl.1
Natural variantiVAR_026645140S → W1 PublicationCorresponds to variant dbSNP:rs17857157Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074672 mRNA. No translation available.
AK128369 mRNA. Translation: BAG54667.1.
AL136231 Genomic DNA. No translation available.
BC038108 mRNA. Translation: AAH38108.2.
CCDSiCCDS34981.1.
RefSeqiNP_982278.3. NM_203453.3.
UniGeneiHs.107510.
Hs.741406.

Genome annotation databases

EnsembliENST00000381883; ENSP00000371307; ENSG00000205808.
GeneIDi403313.
KEGGihsa:403313.
UCSCiuc003zin.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPLPP6_HUMAN
AccessioniPrimary (citable) accession number: Q8IY26
Secondary accession number(s): B3KY05, Q5JVJ6, Q8NCK9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: July 5, 2017
This is version 117 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families