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Protein

Phospholipid phosphatase 6

Gene

PLPP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Phosphatase that dephosphorylates presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP), suggesting that it may be indirectly involved in innate immunity. PSDP is a bioactive lipid that rapidly remodels to presqualene monophosphate PSMP upon cell activation. Displays diphosphate phosphatase activity with a substrate preference for PSDP > FDP > phosphatidic acid.1 Publication

pH dependencei

Optimum pH is 7-8.1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid phosphatase 6Imported (EC:3.1.3.-)
Alternative name(s):
Phosphatidic acid phosphatase type 2 domain-containing protein 2
Short name:
PPAP2 domain-containing protein 2
Presqualene diphosphate phosphatase
Gene namesi
Name:PLPP6Imported
Synonyms:PPAPDC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:23682. PLPP6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei133 – 15321HelicalSequence analysisAdd
BLAST
Transmembranei165 – 18521HelicalSequence analysisAdd
BLAST
Transmembranei229 – 24921HelicalSequence analysisAdd
BLAST
Transmembranei261 – 28121HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671155.

Polymorphism and mutation databases

BioMutaiPPAPDC2.
DMDMi108860900.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 295295Phospholipid phosphatase 6PRO_0000239396Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei26 – 261PhosphoserineCombined sources
Modified residuei36 – 361PhosphoserineCombined sources
Modified residuei70 – 701PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IY26.
MaxQBiQ8IY26.
PaxDbiQ8IY26.
PeptideAtlasiQ8IY26.
PRIDEiQ8IY26.

PTM databases

DEPODiQ8IY26.
iPTMnetiQ8IY26.
PhosphoSiteiQ8IY26.

Expressioni

Tissue specificityi

Widely expressed. Expressed in most organs, in particular gastrointestinal organs, spleen, placenta, kidney, thymus and brain.1 Publication

Gene expression databases

BgeeiQ8IY26.
CleanExiHS_PPAPDC2.
GenevisibleiQ8IY26. HS.

Organism-specific databases

HPAiHPA018096.

Interactioni

Protein-protein interaction databases

BioGridi135624. 2 interactions.
STRINGi9606.ENSP00000371307.

Structurei

3D structure databases

ProteinModelPortaliQ8IY26.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4268. Eukaryota.
ENOG410ZVFK. LUCA.
GeneTreeiENSGT00390000012789.
HOGENOMiHOG000231931.
HOVERGENiHBG054746.
InParanoidiQ8IY26.
OMAiLGYMQYS.
OrthoDBiEOG7BW0MW.
PhylomeDBiQ8IY26.
TreeFamiTF323272.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8IY26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSPRRSMEG RPLGVSASSS SSSPGSPAHG GGGGGSRFEF QSLLSSRATA
60 70 80 90 100
VDPTCARLRA SESPVHRRGS FPLAAAGPSQ SPAPPLPEED RMDLNPSFLG
110 120 130 140 150
IALRSLLAID LWLSKKLGVC AGESSSWGSV RPLMKLLEIS GHGIPWLLGT
160 170 180 190 200
LYCLCRSDSW AGREVLMNLL FALLLDLLLV ALIKGLVRRR RPAHNQMDMF
210 220 230 240 250
VTLSVDKYSF PSGHATRAAL MSRFILNHLV LAIPLRVLVV LWAFVLGLSR
260 270 280 290
VMLGRHNVTD VAFGFFLGYM QYSIVDYCWL SPHNAPVLFL LWSQR
Length:295
Mass (Da):32,194
Last modified:June 13, 2006 - v3
Checksum:i92024580CE727AED
GO

Sequence cautioni

The sequence AK074672 differs from that shown. Reason: Frameshift at position 267. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 71S → G.
Corresponds to variant rs34250374 [ dbSNP | Ensembl ].
VAR_050616
Natural varianti8 – 81M → T.
Corresponds to variant rs35791393 [ dbSNP | Ensembl ].
VAR_050617
Natural varianti140 – 1401S → W.1 Publication
Corresponds to variant rs17857157 [ dbSNP | Ensembl ].
VAR_026645

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074672 mRNA. No translation available.
AK128369 mRNA. Translation: BAG54667.1.
AL136231 Genomic DNA. Translation: CAI41266.1.
BC038108 mRNA. Translation: AAH38108.2.
CCDSiCCDS34981.1.
RefSeqiNP_982278.3. NM_203453.3.
UniGeneiHs.107510.
Hs.741406.

Genome annotation databases

EnsembliENST00000381883; ENSP00000371307; ENSG00000205808.
GeneIDi403313.
KEGGihsa:403313.
UCSCiuc003zin.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074672 mRNA. No translation available.
AK128369 mRNA. Translation: BAG54667.1.
AL136231 Genomic DNA. Translation: CAI41266.1.
BC038108 mRNA. Translation: AAH38108.2.
CCDSiCCDS34981.1.
RefSeqiNP_982278.3. NM_203453.3.
UniGeneiHs.107510.
Hs.741406.

3D structure databases

ProteinModelPortaliQ8IY26.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi135624. 2 interactions.
STRINGi9606.ENSP00000371307.

PTM databases

DEPODiQ8IY26.
iPTMnetiQ8IY26.
PhosphoSiteiQ8IY26.

Polymorphism and mutation databases

BioMutaiPPAPDC2.
DMDMi108860900.

Proteomic databases

EPDiQ8IY26.
MaxQBiQ8IY26.
PaxDbiQ8IY26.
PeptideAtlasiQ8IY26.
PRIDEiQ8IY26.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381883; ENSP00000371307; ENSG00000205808.
GeneIDi403313.
KEGGihsa:403313.
UCSCiuc003zin.5. human.

Organism-specific databases

CTDi403313.
GeneCardsiPPAPDC2.
HGNCiHGNC:23682. PLPP6.
HPAiHPA018096.
MIMi611666. gene.
neXtProtiNX_Q8IY26.
PharmGKBiPA142671155.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4268. Eukaryota.
ENOG410ZVFK. LUCA.
GeneTreeiENSGT00390000012789.
HOGENOMiHOG000231931.
HOVERGENiHBG054746.
InParanoidiQ8IY26.
OMAiLGYMQYS.
OrthoDBiEOG7BW0MW.
PhylomeDBiQ8IY26.
TreeFamiTF323272.

Miscellaneous databases

GenomeRNAii403313.
PROiQ8IY26.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IY26.
CleanExiHS_PPAPDC2.
GenevisibleiQ8IY26. HS.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland and Thymus.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT TRP-140.
    Tissue: Testis.
  4. "Identification and functional characterization of a presqualene diphosphate phosphatase."
    Fukunaga K., Arita M., Takahashi M., Morris A.J., Pfeffer M., Levy B.D.
    J. Biol. Chem. 281:9490-9497(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 76-91, FUNCTION, ENZYME ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26 AND SER-36, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiPLPP6_HUMAN
AccessioniPrimary (citable) accession number: Q8IY26
Secondary accession number(s): B3KY05, Q5JVJ6, Q8NCK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: July 6, 2016
This is version 106 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.