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Protein

C-Maf-inducing protein

Gene

CMIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor.2 Publications

Names & Taxonomyi

Protein namesi
Recommended name:
C-Maf-inducing protein
Short name:
c-Mip
Alternative name(s):
Truncated c-Maf-inducing protein
Short name:
Tc-Mip
Gene namesi
Name:CMIP
Synonyms:KIAA1694, TCMIP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:24319. CMIP.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi80790.
OpenTargetsiENSG00000153815.

Polymorphism and mutation databases

BioMutaiCMIP.
DMDMi353526341.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003176281 – 773C-Maf-inducing proteinAdd BLAST773

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei349PhosphoserineCombined sources1
Modified residuei377PhosphoserineCombined sources1
Modified residuei382PhosphoserineCombined sources1
Modified residuei660PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IY22.
MaxQBiQ8IY22.
PaxDbiQ8IY22.
PeptideAtlasiQ8IY22.
PRIDEiQ8IY22.

PTM databases

iPTMnetiQ8IY22.
PhosphoSitePlusiQ8IY22.

Expressioni

Tissue specificityi

Isoform 1 is expressed in peripheral blood mononuclear cells and kidney. Lower expression in brain and liver. Expression is down-regulated in activated cells. Isoform 2 is expressed in lymphocyte precursors, however, expression shuts down during maturation and differentiation in thymus and fetal liver.1 Publication

Developmental stagei

Expressed in fetal liver.1 Publication

Gene expression databases

BgeeiENSG00000153815.
ExpressionAtlasiQ8IY22. baseline and differential.
GenevisibleiQ8IY22. HS.

Organism-specific databases

HPAiHPA054424.
HPA066710.

Interactioni

Subunit structurei

Interacts with FLNA.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi123313. 8 interactors.
IntActiQ8IY22. 5 interactors.
MINTiMINT-7383621.
STRINGi9606.ENSP00000446100.

Structurei

3D structure databases

ProteinModelPortaliQ8IY22.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 163PHAdd BLAST110
Repeati663 – 686LRR 1Add BLAST24
Repeati687 – 707LRR 2Add BLAST21
Repeati712 – 732LRR 3Add BLAST21
Repeati736 – 756LRR 4Add BLAST21

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IJT4. Eukaryota.
ENOG410XSJQ. LUCA.
GeneTreeiENSGT00390000018220.
HOGENOMiHOG000111809.
HOVERGENiHBG107725.
InParanoidiQ8IY22.
OMAiCLMVSPT.
OrthoDBiEOG091G05SH.
PhylomeDBiQ8IY22.
TreeFamiTF328575.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.80.10.10. 1 hit.
InterProiView protein in InterPro
IPR032675. L_dom-like.
IPR011993. PH_dom-like.
SUPFAMiSSF50729. SSF50729. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IY22-1) [UniParc]FASTAAdd to basket
Also known as: C-Mip

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDVTSSSGGG GDPRQIEETK PLLGGDVSAP EGTKMGAVPC RRALLLCNGM
60 70 80 90 100
RYKLLQEGDI QVCVIRHPRT FLSKILTSKF LRRWEPHHLT LADNSLASAT
110 120 130 140 150
PTGYMENSVS YSAIEDVQLL SWENAPKYCL QLTIPGGTVL LQAANSYLRD
160 170 180 190 200
QWFHSLQWKK KIYKYKKVLS NPSRWEVVLK EIRTLVDMAL TSPLQDDSIN
210 220 230 240 250
QAPLEIVSKL LSENTNLTTQ EHENIIVAIA PLLENNHPPP DLCEFFCKHC
260 270 280 290 300
RERPRSMVVI EVFTPVVQRI LKHNMDFGKC PRLRLFTQEY ILALNELNAG
310 320 330 340 350
MEVVKKFIQS MHGPTGHCPH PRVLPNLVAV CLAAIYSCYE EFINSRDNSP
360 370 380 390 400
SLKEIRNGCQ QPCDRKPTLP LRLLHPSPDL VSQEATLSEA RLKSVVVASS
410 420 430 440 450
EIHVEVERTS TAKPALTASA GNDSEPNLID CLMVSPACST MSIELGPQAD
460 470 480 490 500
RTLGCYVEIL KLLSDYDDWR PSLASLLQPI PFPKEALAHE KFTKELKYVI
510 520 530 540 550
QRFAEDPRQE VHSCLLSVRA GKDGWFQLYS PGGVACDDDG ELFASMVHIL
560 570 580 590 600
MGSCYKTKKF LLSLAENKLG PCMLLALRGN QTMVEILCLM LEYNIIDNND
610 620 630 640 650
TQLQIISTLE STDVGKRMYE QLCDRQRELK ELQRKGGPTR LTLPSKSTDA
660 670 680 690 700
DLARLLSSGS FGNLENLSLA FTNVTSACAE HLIKLPSLKQ LNLWSTQFGD
710 720 730 740 750
AGLRLLSEHL TMLQVLNLCE TPVTDAGLLA LSSMKSLCSL NMNSTKLSAD
760 770
TYEDLKAKLP NLKEVDVRYT EAW
Length:773
Mass (Da):86,331
Last modified:October 19, 2011 - v3
Checksum:iD8C25A853A93E9DD
GO
Isoform 2 (identifier: Q8IY22-2) [UniParc]FASTAAdd to basket
Also known as: Tc-Mip

The sequence of this isoform differs from the canonical sequence as follows:
     1-94: Missing.
     95-100: SLASAT → MGQAAE

Show »
Length:679
Mass (Da):76,033
Checksum:i7FC78A2ABE8504CE
GO
Isoform 3 (identifier: Q8IY22-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-153: Missing.
     154-159: HSLQWK → MASVAQ

Note: No experimental confirmation available.
Show »
Length:620
Mass (Da):69,288
Checksum:iF84064C435ADAA62
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0311081 – 153Missing in isoform 3. 1 PublicationAdd BLAST153
Alternative sequenceiVSP_0311091 – 94Missing in isoform 2. 1 PublicationAdd BLAST94
Alternative sequenceiVSP_03111095 – 100SLASAT → MGQAAE in isoform 2. 1 Publication6
Alternative sequenceiVSP_031111154 – 159HSLQWK → MASVAQ in isoform 3. 1 Publication6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY172689 mRNA. Translation: AAO17720.1.
AC092135 Genomic DNA. No translation available.
AC092139 Genomic DNA. No translation available.
AC099480 Genomic DNA. No translation available.
AC099524 Genomic DNA. No translation available.
BC038113 mRNA. Translation: AAH38113.1.
AB051481 mRNA. Translation: BAB21785.1.
CCDSiCCDS54044.1. [Q8IY22-1]
CCDS54045.1. [Q8IY22-2]
RefSeqiNP_085132.1. NM_030629.2. [Q8IY22-2]
NP_938204.2. NM_198390.2. [Q8IY22-1]
UniGeneiHs.594095.
Hs.662343.

Genome annotation databases

EnsembliENST00000398040; ENSP00000381120; ENSG00000153815. [Q8IY22-3]
ENST00000537098; ENSP00000446100; ENSG00000153815. [Q8IY22-1]
ENST00000539778; ENSP00000440401; ENSG00000153815. [Q8IY22-2]
GeneIDi80790.
KEGGihsa:80790.
UCSCiuc002fgp.5. human. [Q8IY22-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCMIP_HUMAN
AccessioniPrimary (citable) accession number: Q8IY22
Secondary accession number(s): Q9C0G9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 19, 2011
Last modified: August 30, 2017
This is version 126 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot