Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

C-Maf-inducing protein

Gene

CMIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor.2 Publications

Names & Taxonomyi

Protein namesi
Recommended name:
C-Maf-inducing protein
Short name:
c-Mip
Alternative name(s):
Truncated c-Maf-inducing protein
Short name:
Tc-Mip
Gene namesi
Name:CMIP
Synonyms:KIAA1694, TCMIP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:24319. CMIP.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiCMIP.
DMDMi353526341.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 773773C-Maf-inducing proteinPRO_0000317628Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei349 – 3491PhosphoserineCombined sources
Modified residuei377 – 3771PhosphoserineCombined sources
Modified residuei660 – 6601PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IY22.
MaxQBiQ8IY22.
PaxDbiQ8IY22.
PRIDEiQ8IY22.

PTM databases

iPTMnetiQ8IY22.
PhosphoSiteiQ8IY22.

Expressioni

Tissue specificityi

Isoform 1 is expressed in peripheral blood mononuclear cells and kidney. Lower expression in brain and liver. Expression is down-regulated in activated cells. Isoform 2 is expressed in lymphocyte precursors, however, expression shuts down during maturation and differentiation in thymus and fetal liver.1 Publication

Developmental stagei

Expressed in fetal liver.1 Publication

Gene expression databases

BgeeiQ8IY22.
ExpressionAtlasiQ8IY22. baseline and differential.
GenevisibleiQ8IY22. HS.

Interactioni

Subunit structurei

Interacts with FLNA.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Mib1Q80SY42EBI-7689652,EBI-645227From a different organism.
PIK3R1P279862EBI-7689652,EBI-79464

Protein-protein interaction databases

BioGridi123313. 4 interactions.
IntActiQ8IY22. 3 interactions.
MINTiMINT-7383621.
STRINGi9606.ENSP00000446100.

Structurei

3D structure databases

ProteinModelPortaliQ8IY22.
SMRiQ8IY22. Positions 639-769.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 163110PHAdd
BLAST
Repeati663 – 68624LRR 1Add
BLAST
Repeati687 – 70721LRR 2Add
BLAST
Repeati712 – 73221LRR 3Add
BLAST
Repeati736 – 75621LRR 4Add
BLAST

Sequence similaritiesi

Contains 4 LRR (leucine-rich) repeats.Curated
Contains 1 PH domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IJT4. Eukaryota.
ENOG410XSJQ. LUCA.
GeneTreeiENSGT00390000018220.
HOGENOMiHOG000111809.
HOVERGENiHBG107725.
InParanoidiQ8IY22.
OMAiCLMVSPT.
OrthoDBiEOG71G9TG.
PhylomeDBiQ8IY22.
TreeFamiTF328575.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR011993. PH_dom-like.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IY22-1) [UniParc]FASTAAdd to basket

Also known as: C-Mip

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDVTSSSGGG GDPRQIEETK PLLGGDVSAP EGTKMGAVPC RRALLLCNGM
60 70 80 90 100
RYKLLQEGDI QVCVIRHPRT FLSKILTSKF LRRWEPHHLT LADNSLASAT
110 120 130 140 150
PTGYMENSVS YSAIEDVQLL SWENAPKYCL QLTIPGGTVL LQAANSYLRD
160 170 180 190 200
QWFHSLQWKK KIYKYKKVLS NPSRWEVVLK EIRTLVDMAL TSPLQDDSIN
210 220 230 240 250
QAPLEIVSKL LSENTNLTTQ EHENIIVAIA PLLENNHPPP DLCEFFCKHC
260 270 280 290 300
RERPRSMVVI EVFTPVVQRI LKHNMDFGKC PRLRLFTQEY ILALNELNAG
310 320 330 340 350
MEVVKKFIQS MHGPTGHCPH PRVLPNLVAV CLAAIYSCYE EFINSRDNSP
360 370 380 390 400
SLKEIRNGCQ QPCDRKPTLP LRLLHPSPDL VSQEATLSEA RLKSVVVASS
410 420 430 440 450
EIHVEVERTS TAKPALTASA GNDSEPNLID CLMVSPACST MSIELGPQAD
460 470 480 490 500
RTLGCYVEIL KLLSDYDDWR PSLASLLQPI PFPKEALAHE KFTKELKYVI
510 520 530 540 550
QRFAEDPRQE VHSCLLSVRA GKDGWFQLYS PGGVACDDDG ELFASMVHIL
560 570 580 590 600
MGSCYKTKKF LLSLAENKLG PCMLLALRGN QTMVEILCLM LEYNIIDNND
610 620 630 640 650
TQLQIISTLE STDVGKRMYE QLCDRQRELK ELQRKGGPTR LTLPSKSTDA
660 670 680 690 700
DLARLLSSGS FGNLENLSLA FTNVTSACAE HLIKLPSLKQ LNLWSTQFGD
710 720 730 740 750
AGLRLLSEHL TMLQVLNLCE TPVTDAGLLA LSSMKSLCSL NMNSTKLSAD
760 770
TYEDLKAKLP NLKEVDVRYT EAW
Length:773
Mass (Da):86,331
Last modified:October 19, 2011 - v3
Checksum:iD8C25A853A93E9DD
GO
Isoform 2 (identifier: Q8IY22-2) [UniParc]FASTAAdd to basket

Also known as: Tc-Mip

The sequence of this isoform differs from the canonical sequence as follows:
     1-94: Missing.
     95-100: SLASAT → MGQAAE

Show »
Length:679
Mass (Da):76,033
Checksum:i7FC78A2ABE8504CE
GO
Isoform 3 (identifier: Q8IY22-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-153: Missing.
     154-159: HSLQWK → MASVAQ

Note: No experimental confirmation available.
Show »
Length:620
Mass (Da):69,288
Checksum:iF84064C435ADAA62
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 153153Missing in isoform 3. 1 PublicationVSP_031108Add
BLAST
Alternative sequencei1 – 9494Missing in isoform 2. 1 PublicationVSP_031109Add
BLAST
Alternative sequencei95 – 1006SLASAT → MGQAAE in isoform 2. 1 PublicationVSP_031110
Alternative sequencei154 – 1596HSLQWK → MASVAQ in isoform 3. 1 PublicationVSP_031111

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY172689 mRNA. Translation: AAO17720.1.
AC092135 Genomic DNA. No translation available.
AC092139 Genomic DNA. No translation available.
AC099480 Genomic DNA. No translation available.
AC099524 Genomic DNA. No translation available.
BC038113 mRNA. Translation: AAH38113.1.
AB051481 mRNA. Translation: BAB21785.1.
CCDSiCCDS54044.1. [Q8IY22-1]
CCDS54045.1. [Q8IY22-2]
RefSeqiNP_085132.1. NM_030629.2. [Q8IY22-2]
NP_938204.2. NM_198390.2. [Q8IY22-1]
UniGeneiHs.594095.

Genome annotation databases

EnsembliENST00000398040; ENSP00000381120; ENSG00000153815. [Q8IY22-3]
ENST00000537098; ENSP00000446100; ENSG00000153815. [Q8IY22-1]
ENST00000539778; ENSP00000440401; ENSG00000153815. [Q8IY22-2]
GeneIDi80790.
KEGGihsa:80790.
UCSCiuc002fgp.5. human. [Q8IY22-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY172689 mRNA. Translation: AAO17720.1.
AC092135 Genomic DNA. No translation available.
AC092139 Genomic DNA. No translation available.
AC099480 Genomic DNA. No translation available.
AC099524 Genomic DNA. No translation available.
BC038113 mRNA. Translation: AAH38113.1.
AB051481 mRNA. Translation: BAB21785.1.
CCDSiCCDS54044.1. [Q8IY22-1]
CCDS54045.1. [Q8IY22-2]
RefSeqiNP_085132.1. NM_030629.2. [Q8IY22-2]
NP_938204.2. NM_198390.2. [Q8IY22-1]
UniGeneiHs.594095.

3D structure databases

ProteinModelPortaliQ8IY22.
SMRiQ8IY22. Positions 639-769.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123313. 4 interactions.
IntActiQ8IY22. 3 interactions.
MINTiMINT-7383621.
STRINGi9606.ENSP00000446100.

PTM databases

iPTMnetiQ8IY22.
PhosphoSiteiQ8IY22.

Polymorphism and mutation databases

BioMutaiCMIP.
DMDMi353526341.

Proteomic databases

EPDiQ8IY22.
MaxQBiQ8IY22.
PaxDbiQ8IY22.
PRIDEiQ8IY22.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398040; ENSP00000381120; ENSG00000153815. [Q8IY22-3]
ENST00000537098; ENSP00000446100; ENSG00000153815. [Q8IY22-1]
ENST00000539778; ENSP00000440401; ENSG00000153815. [Q8IY22-2]
GeneIDi80790.
KEGGihsa:80790.
UCSCiuc002fgp.5. human. [Q8IY22-1]

Organism-specific databases

CTDi80790.
GeneCardsiCMIP.
H-InvDBHIX0013273.
HGNCiHGNC:24319. CMIP.
MIMi610112. gene.
neXtProtiNX_Q8IY22.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJT4. Eukaryota.
ENOG410XSJQ. LUCA.
GeneTreeiENSGT00390000018220.
HOGENOMiHOG000111809.
HOVERGENiHBG107725.
InParanoidiQ8IY22.
OMAiCLMVSPT.
OrthoDBiEOG71G9TG.
PhylomeDBiQ8IY22.
TreeFamiTF328575.

Miscellaneous databases

ChiTaRSiCMIP. human.
GenomeRNAii80790.
PROiQ8IY22.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IY22.
ExpressionAtlasiQ8IY22. baseline and differential.
GenevisibleiQ8IY22. HS.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR011993. PH_dom-like.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Truncation of C-mip (Tc-mip), a new proximal signaling protein, induces c-maf Th2 transcription factor and cytoskeleton reorganization."
    Grimbert P., Valanciute A., Audard V., Pawlak A., Le gouvelo S., Lang P., Niaudet P., Bensman A., Guellaen G., Sahali D.
    J. Exp. Med. 198:797-807(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  2. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain.
  4. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
    DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 17-773 (ISOFORM 1).
    Tissue: Brain.
  5. "The Filamin-A is a partner of Tc-mip, a new adapter protein involved in c-maf-dependent Th2 signaling pathway."
    Grimbert P., Valanciute A., Audard V., Lang P., Guellaen G., Sahali D.
    Mol. Immunol. 40:1257-1261(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH FLNA, SUBCELLULAR LOCATION.
  6. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-377, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-349, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-660, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCMIP_HUMAN
AccessioniPrimary (citable) accession number: Q8IY22
Secondary accession number(s): Q9C0G9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 19, 2011
Last modified: June 8, 2016
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.