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Q8IXZ2

- ZC3H3_HUMAN

UniProt

Q8IXZ2 - ZC3H3_HUMAN

Protein

Zinc finger CCCH domain-containing protein 3

Gene

ZC3H3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 3 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri667 – 69529C3H1-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri699 – 72224C3H1-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri723 – 74927C3H1-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri750 – 77728C3H1-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri778 – 80023C3H1-type 5PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. mRNA polyadenylation Source: UniProtKB
    2. poly(A)+ mRNA export from nucleus Source: UniProtKB
    3. regulation of mRNA export from nucleus Source: UniProtKB

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger CCCH domain-containing protein 3
    Gene namesi
    Name:ZC3H3
    Synonyms:KIAA0150, ZC3HDC3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:28972. ZC3H3.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134933089.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 948948Zinc finger CCCH domain-containing protein 3PRO_0000213896Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei408 – 4081Phosphoserine1 Publication
    Modified residuei918 – 9181Phosphoserine1 Publication
    Modified residuei920 – 9201Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8IXZ2.
    PaxDbiQ8IXZ2.
    PRIDEiQ8IXZ2.

    PTM databases

    PhosphoSiteiQ8IXZ2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8IXZ2.
    BgeeiQ8IXZ2.
    CleanExiHS_ZC3H3.
    GenevestigatoriQ8IXZ2.

    Organism-specific databases

    HPAiHPA023658.
    HPA050577.

    Interactioni

    Protein-protein interaction databases

    BioGridi116761. 3 interactions.
    IntActiQ8IXZ2. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IXZ2.
    SMRiQ8IXZ2. Positions 695-747.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi382 – 39110Poly-Ser
    Compositional biasi873 – 8819Poly-Ser

    Sequence similaritiesi

    Contains 5 C3H1-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri667 – 69529C3H1-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri699 – 72224C3H1-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri723 – 74927C3H1-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri750 – 77728C3H1-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri778 – 80023C3H1-type 5PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5084.
    HOGENOMiHOG000133053.
    HOVERGENiHBG055611.
    InParanoidiQ8IXZ2.
    OMAiRCPYIHD.
    OrthoDBiEOG725DGQ.
    PhylomeDBiQ8IXZ2.
    TreeFamiTF324375.

    Family and domain databases

    Gene3Di4.10.1000.10. 1 hit.
    InterProiIPR000571. Znf_CCCH.
    [Graphical view]
    PfamiPF00642. zf-CCCH. 2 hits.
    [Graphical view]
    SMARTiSM00356. ZnF_C3H1. 5 hits.
    [Graphical view]
    PROSITEiPS50103. ZF_C3H1. 5 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8IXZ2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEEKEILRRQ IRLLQGLIDD YKTLHGNAPA PGTPAASGWQ PPTYHSGRAF    50
    SARYPRPSRR GYSSHHGPSW RKKYSLVNRP PGPSDPPADH AVRPLHGARG 100
    GQPPVPQQHV LERQVQLSQG QNVVIKVKPP SKSGSASASG AQRGSLEEFE 150
    ETPWSDQRPR EGEGEPPRGQ LQPSRPTRAR GTCSVEDPLL VCQKEPGKPR 200
    MVKSVGSVGD SPREPRRTVS ESVIAVKASF PSSALPPRTG VALGRKLGSH 250
    SVASCAPQLL GDRRVDAGHT DQPVPSGSVG GPARPASGPR QAREASLVVT 300
    CRTNKFRKNN YKWVAASSKS PRVARRALSP RVAAENVCKA SAGMANKVEK 350
    PQLIADPEPK PRKPATSSKP GSAPSKYKWK ASSPSASSSS SFRWQSEASS 400
    KDHASQLSPV LSRSPSGDRP AVGHSGLKPL SGETPLSAYK VKSRTKIIRR 450
    RSSTSLPGDK KSGTSPAATA KSHLSLRRRQ ALRGKSSPVL KKTPNKGLVQ 500
    VTTHRLCRLP PSRAHLPTKE ASSLHAVRTA PTSKVIKTRY RIVKKTPASP 550
    LSAPPFPLSL PSWRARRLSL SRSLVLNRLR PVASGGGKAQ PGSPWWRSKG 600
    YRCIGGVLYK VSANKLSKTS GQPSDAGSRP LLRTGRLDPA GSCSRSLASR 650
    AVQRSLAIIR QARQRREKRK EYCMYYNRFG RCNRGERCPY IHDPEKVAVC 700
    TRFVRGTCKK TDGTCPFSHH VSKEKMPVCS YFLKGICSNS NCPYSHVYVS 750
    RKAEVCSDFL KGYCPLGAKC KKKHTLLCPD FARRGACPRG AQCQLLHRTQ 800
    KRHSRRAATS PAPGPSDATA RSRVSASHGP RKPSASQRPT RQTPSSAALT 850
    AAAVAAPPHC PGGSASPSSS KASSSSSSSS SPPASLDHEA PSLQEAALAA 900
    ACSNRLCKLP SFISLQSSPS PGAQPRVRAP RAPLTKDSGK PLHIKPRL 948
    Length:948
    Mass (Da):101,941
    Last modified:October 5, 2010 - v3
    Checksum:i9CDD4F29EE40946B
    GO
    Isoform 2 (identifier: Q8IXZ2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-613: Missing.
         614-634: NKLSKTSGQPSDAGSRPLLRT → MEPGGEPTGAKESSTLMESLA

    Show »
    Length:335
    Mass (Da):35,929
    Checksum:iB5FE8363BA91A4C3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti572 – 5721R → G in AAH38670. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti6 – 61I → M.1 Publication
    Corresponds to variant rs2242093 [ dbSNP | Ensembl ].
    VAR_018457
    Natural varianti102 – 1021Q → R.1 Publication
    Corresponds to variant rs17857167 [ dbSNP | Ensembl ].
    VAR_060402
    Natural varianti149 – 1491F → Y.
    Corresponds to variant rs3750206 [ dbSNP | Ensembl ].
    VAR_018458
    Natural varianti151 – 1511E → D.1 Publication
    Corresponds to variant rs3750207 [ dbSNP | Ensembl ].
    VAR_018459
    Natural varianti165 – 1651E → K.1 Publication
    Corresponds to variant rs17853852 [ dbSNP | Ensembl ].
    VAR_060403
    Natural varianti168 – 1681R → W.
    Corresponds to variant rs3750208 [ dbSNP | Ensembl ].
    VAR_057484
    Natural varianti228 – 2281A → S.
    Corresponds to variant rs4873802 [ dbSNP | Ensembl ].
    VAR_057485
    Natural varianti231 – 2311P → A.1 Publication
    Corresponds to variant rs17853853 [ dbSNP | Ensembl ].
    VAR_060404
    Natural varianti351 – 3511P → L.
    Corresponds to variant rs34674128 [ dbSNP | Ensembl ].
    VAR_057486
    Natural varianti399 – 3991S → G.1 Publication
    Corresponds to variant rs1318196 [ dbSNP | Ensembl ].
    VAR_018460
    Natural varianti415 – 4151P → L.
    Corresponds to variant rs36008851 [ dbSNP | Ensembl ].
    VAR_057487
    Natural varianti452 – 4521S → G.2 Publications
    Corresponds to variant rs4874147 [ dbSNP | Ensembl ].
    VAR_018461
    Natural varianti503 – 5031T → K.
    Corresponds to variant rs11548254 [ dbSNP | Ensembl ].
    VAR_057488
    Natural varianti578 – 5781R → H.1 Publication
    Corresponds to variant rs17855618 [ dbSNP | Ensembl ].
    VAR_060405
    Natural varianti636 – 6361R → W.1 Publication
    Corresponds to variant rs17857164 [ dbSNP | Ensembl ].
    VAR_060406
    Natural varianti727 – 7271P → R.1 Publication
    Corresponds to variant rs17857168 [ dbSNP | Ensembl ].
    VAR_060407

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 613613Missing in isoform 2. 1 PublicationVSP_010272Add
    BLAST
    Alternative sequencei614 – 63421NKLSK…PLLRT → MEPGGEPTGAKESSTLMESL A in isoform 2. 1 PublicationVSP_010273Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC067930 Genomic DNA. No translation available.
    AC105118 Genomic DNA. No translation available.
    BC034435 mRNA. Translation: AAH34435.1.
    BC038670 mRNA. Translation: AAH38670.1.
    D63484 mRNA. Translation: BAA09771.1.
    CCDSiCCDS6402.1. [Q8IXZ2-1]
    RefSeqiNP_055932.2. NM_015117.2. [Q8IXZ2-1]
    UniGeneiHs.521915.

    Genome annotation databases

    EnsembliENST00000262577; ENSP00000262577; ENSG00000014164. [Q8IXZ2-1]
    GeneIDi23144.
    KEGGihsa:23144.
    UCSCiuc003yyd.2. human. [Q8IXZ2-1]

    Polymorphism databases

    DMDMi308153538.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC067930 Genomic DNA. No translation available.
    AC105118 Genomic DNA. No translation available.
    BC034435 mRNA. Translation: AAH34435.1 .
    BC038670 mRNA. Translation: AAH38670.1 .
    D63484 mRNA. Translation: BAA09771.1 .
    CCDSi CCDS6402.1. [Q8IXZ2-1 ]
    RefSeqi NP_055932.2. NM_015117.2. [Q8IXZ2-1 ]
    UniGenei Hs.521915.

    3D structure databases

    ProteinModelPortali Q8IXZ2.
    SMRi Q8IXZ2. Positions 695-747.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116761. 3 interactions.
    IntActi Q8IXZ2. 1 interaction.

    PTM databases

    PhosphoSitei Q8IXZ2.

    Polymorphism databases

    DMDMi 308153538.

    Proteomic databases

    MaxQBi Q8IXZ2.
    PaxDbi Q8IXZ2.
    PRIDEi Q8IXZ2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000262577 ; ENSP00000262577 ; ENSG00000014164 . [Q8IXZ2-1 ]
    GeneIDi 23144.
    KEGGi hsa:23144.
    UCSCi uc003yyd.2. human. [Q8IXZ2-1 ]

    Organism-specific databases

    CTDi 23144.
    GeneCardsi GC08M144519.
    H-InvDB HIX0022677.
    HGNCi HGNC:28972. ZC3H3.
    HPAi HPA023658.
    HPA050577.
    neXtProti NX_Q8IXZ2.
    PharmGKBi PA134933089.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5084.
    HOGENOMi HOG000133053.
    HOVERGENi HBG055611.
    InParanoidi Q8IXZ2.
    OMAi RCPYIHD.
    OrthoDBi EOG725DGQ.
    PhylomeDBi Q8IXZ2.
    TreeFami TF324375.

    Miscellaneous databases

    ChiTaRSi ZC3H3. human.
    GenomeRNAii 23144.
    NextBioi 44434.
    PROi Q8IXZ2.

    Gene expression databases

    ArrayExpressi Q8IXZ2.
    Bgeei Q8IXZ2.
    CleanExi HS_ZC3H3.
    Genevestigatori Q8IXZ2.

    Family and domain databases

    Gene3Di 4.10.1000.10. 1 hit.
    InterProi IPR000571. Znf_CCCH.
    [Graphical view ]
    Pfami PF00642. zf-CCCH. 2 hits.
    [Graphical view ]
    SMARTi SM00356. ZnF_C3H1. 5 hits.
    [Graphical view ]
    PROSITEi PS50103. ZF_C3H1. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS MET-6; ARG-102; LYS-165; ALA-231; GLY-452; HIS-578; TRP-636 AND ARG-727.
      Tissue: Brain.
    3. "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1."
      Nagase T., Seki N., Tanaka A., Ishikawa K., Nomura N.
      DNA Res. 2:167-174(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-948 (ISOFORM 1), VARIANTS ASP-151; GLY-399 AND GLY-452.
      Tissue: Bone marrow.
    4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-918 AND SER-920, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-408, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiZC3H3_HUMAN
    AccessioniPrimary (citable) accession number: Q8IXZ2
    Secondary accession number(s): Q14163, Q8N4E2, Q9BUS4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 96 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3