Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8IXZ2 (ZC3H3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger CCCH domain-containing protein 3
Gene names
Name:ZC3H3
Synonyms:KIAA0150, ZC3HDC3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length948 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Contains 5 C3H1-type zinc fingers.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8IXZ2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8IXZ2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-613: Missing.
     614-634: NKLSKTSGQPSDAGSRPLLRT → MEPGGEPTGAKESSTLMESLA

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 948948Zinc finger CCCH domain-containing protein 3
PRO_0000213896

Regions

Zinc finger667 – 69529C3H1-type 1
Zinc finger699 – 72224C3H1-type 2
Zinc finger723 – 74927C3H1-type 3
Zinc finger750 – 77728C3H1-type 4
Zinc finger778 – 80023C3H1-type 5
Compositional bias382 – 39110Poly-Ser
Compositional bias873 – 8819Poly-Ser

Amino acid modifications

Modified residue4081Phosphoserine Ref.6
Modified residue9181Phosphoserine Ref.5
Modified residue9201Phosphoserine Ref.5

Natural variations

Alternative sequence1 – 613613Missing in isoform 2.
VSP_010272
Alternative sequence614 – 63421NKLSK…PLLRT → MEPGGEPTGAKESSTLMESL A in isoform 2.
VSP_010273
Natural variant61I → M. Ref.2
Corresponds to variant rs2242093 [ dbSNP | Ensembl ].
VAR_018457
Natural variant1021Q → R. Ref.2
Corresponds to variant rs17857167 [ dbSNP | Ensembl ].
VAR_060402
Natural variant1491F → Y.
Corresponds to variant rs3750206 [ dbSNP | Ensembl ].
VAR_018458
Natural variant1511E → D. Ref.3
Corresponds to variant rs3750207 [ dbSNP | Ensembl ].
VAR_018459
Natural variant1651E → K. Ref.2
Corresponds to variant rs17853852 [ dbSNP | Ensembl ].
VAR_060403
Natural variant1681R → W.
Corresponds to variant rs3750208 [ dbSNP | Ensembl ].
VAR_057484
Natural variant2281A → S.
Corresponds to variant rs4873802 [ dbSNP | Ensembl ].
VAR_057485
Natural variant2311P → A. Ref.2
Corresponds to variant rs17853853 [ dbSNP | Ensembl ].
VAR_060404
Natural variant3511P → L.
Corresponds to variant rs34674128 [ dbSNP | Ensembl ].
VAR_057486
Natural variant3991S → G. Ref.3
Corresponds to variant rs1318196 [ dbSNP | Ensembl ].
VAR_018460
Natural variant4151P → L.
Corresponds to variant rs36008851 [ dbSNP | Ensembl ].
VAR_057487
Natural variant4521S → G. Ref.2 Ref.3
Corresponds to variant rs4874147 [ dbSNP | Ensembl ].
VAR_018461
Natural variant5031T → K.
Corresponds to variant rs11548254 [ dbSNP | Ensembl ].
VAR_057488
Natural variant5781R → H. Ref.2
Corresponds to variant rs17855618 [ dbSNP | Ensembl ].
VAR_060405
Natural variant6361R → W. Ref.2
Corresponds to variant rs17857164 [ dbSNP | Ensembl ].
VAR_060406
Natural variant7271P → R. Ref.2
Corresponds to variant rs17857168 [ dbSNP | Ensembl ].
VAR_060407

Experimental info

Sequence conflict5721R → G in AAH38670. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 5, 2010. Version 3.
Checksum: 9CDD4F29EE40946B

FASTA948101,941
        10         20         30         40         50         60 
MEEKEILRRQ IRLLQGLIDD YKTLHGNAPA PGTPAASGWQ PPTYHSGRAF SARYPRPSRR 

        70         80         90        100        110        120 
GYSSHHGPSW RKKYSLVNRP PGPSDPPADH AVRPLHGARG GQPPVPQQHV LERQVQLSQG 

       130        140        150        160        170        180 
QNVVIKVKPP SKSGSASASG AQRGSLEEFE ETPWSDQRPR EGEGEPPRGQ LQPSRPTRAR 

       190        200        210        220        230        240 
GTCSVEDPLL VCQKEPGKPR MVKSVGSVGD SPREPRRTVS ESVIAVKASF PSSALPPRTG 

       250        260        270        280        290        300 
VALGRKLGSH SVASCAPQLL GDRRVDAGHT DQPVPSGSVG GPARPASGPR QAREASLVVT 

       310        320        330        340        350        360 
CRTNKFRKNN YKWVAASSKS PRVARRALSP RVAAENVCKA SAGMANKVEK PQLIADPEPK 

       370        380        390        400        410        420 
PRKPATSSKP GSAPSKYKWK ASSPSASSSS SFRWQSEASS KDHASQLSPV LSRSPSGDRP 

       430        440        450        460        470        480 
AVGHSGLKPL SGETPLSAYK VKSRTKIIRR RSSTSLPGDK KSGTSPAATA KSHLSLRRRQ 

       490        500        510        520        530        540 
ALRGKSSPVL KKTPNKGLVQ VTTHRLCRLP PSRAHLPTKE ASSLHAVRTA PTSKVIKTRY 

       550        560        570        580        590        600 
RIVKKTPASP LSAPPFPLSL PSWRARRLSL SRSLVLNRLR PVASGGGKAQ PGSPWWRSKG 

       610        620        630        640        650        660 
YRCIGGVLYK VSANKLSKTS GQPSDAGSRP LLRTGRLDPA GSCSRSLASR AVQRSLAIIR 

       670        680        690        700        710        720 
QARQRREKRK EYCMYYNRFG RCNRGERCPY IHDPEKVAVC TRFVRGTCKK TDGTCPFSHH 

       730        740        750        760        770        780 
VSKEKMPVCS YFLKGICSNS NCPYSHVYVS RKAEVCSDFL KGYCPLGAKC KKKHTLLCPD 

       790        800        810        820        830        840 
FARRGACPRG AQCQLLHRTQ KRHSRRAATS PAPGPSDATA RSRVSASHGP RKPSASQRPT 

       850        860        870        880        890        900 
RQTPSSAALT AAAVAAPPHC PGGSASPSSS KASSSSSSSS SPPASLDHEA PSLQEAALAA 

       910        920        930        940 
ACSNRLCKLP SFISLQSSPS PGAQPRVRAP RAPLTKDSGK PLHIKPRL 

« Hide

Isoform 2 [UniParc].

Checksum: B5FE8363BA91A4C3
Show »

FASTA33535,929

References

[1]"DNA sequence and analysis of human chromosome 8."
Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. expand/collapse author list , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS MET-6; ARG-102; LYS-165; ALA-231; GLY-452; HIS-578; TRP-636 AND ARG-727.
Tissue: Brain.
[3]"Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1."
Nagase T., Seki N., Tanaka A., Ishikawa K., Nomura N.
DNA Res. 2:167-174(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-948 (ISOFORM 1), VARIANTS ASP-151; GLY-399 AND GLY-452.
Tissue: Bone marrow.
[4]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[5]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-918 AND SER-920, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-408, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC067930 Genomic DNA. No translation available.
AC105118 Genomic DNA. No translation available.
BC034435 mRNA. Translation: AAH34435.1.
BC038670 mRNA. Translation: AAH38670.1.
D63484 mRNA. Translation: BAA09771.1.
RefSeqNP_055932.2. NM_015117.2.
UniGeneHs.521915.

3D structure databases

ProteinModelPortalQ8IXZ2.
SMRQ8IXZ2. Positions 668-804.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116761. 3 interactions.
IntActQ8IXZ2. 1 interaction.

PTM databases

PhosphoSiteQ8IXZ2.

Polymorphism databases

DMDM308153538.

Proteomic databases

PaxDbQ8IXZ2.
PRIDEQ8IXZ2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000262577; ENSP00000262577; ENSG00000014164. [Q8IXZ2-1]
GeneID23144.
KEGGhsa:23144.
UCSCuc003yyd.2. human. [Q8IXZ2-1]

Organism-specific databases

CTD23144.
GeneCardsGC08M144519.
H-InvDBHIX0022677.
HGNCHGNC:28972. ZC3H3.
HPAHPA023658.
HPA050577.
neXtProtNX_Q8IXZ2.
PharmGKBPA134933089.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5084.
HOGENOMHOG000133053.
HOVERGENHBG055611.
InParanoidQ8IXZ2.
OMARCPYIHD.
OrthoDBEOG725DGQ.
PhylomeDBQ8IXZ2.
TreeFamTF324375.

Gene expression databases

ArrayExpressQ8IXZ2.
BgeeQ8IXZ2.
CleanExHS_ZC3H3.
GenevestigatorQ8IXZ2.

Family and domain databases

Gene3D4.10.1000.10. 1 hit.
InterProIPR000571. Znf_CCCH.
[Graphical view]
PfamPF00642. zf-CCCH. 2 hits.
[Graphical view]
SMARTSM00356. ZnF_C3H1. 5 hits.
[Graphical view]
PROSITEPS50103. ZF_C3H1. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSZC3H3. human.
GenomeRNAi23144.
NextBio44434.
PROQ8IXZ2.

Entry information

Entry nameZC3H3_HUMAN
AccessionPrimary (citable) accession number: Q8IXZ2
Secondary accession number(s): Q14163, Q8N4E2, Q9BUS4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 5, 2010
Last modified: March 19, 2014
This is version 92 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM