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Q8IXZ2

- ZC3H3_HUMAN

UniProt

Q8IXZ2 - ZC3H3_HUMAN

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Protein

Zinc finger CCCH domain-containing protein 3

Gene

ZC3H3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri667 – 69529C3H1-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri699 – 72224C3H1-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri723 – 74927C3H1-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri750 – 77728C3H1-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri778 – 80023C3H1-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. mRNA polyadenylation Source: UniProtKB
  2. poly(A)+ mRNA export from nucleus Source: UniProtKB
  3. regulation of mRNA export from nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CCCH domain-containing protein 3
Gene namesi
Name:ZC3H3
Synonyms:KIAA0150, ZC3HDC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:28972. ZC3H3.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134933089.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 948948Zinc finger CCCH domain-containing protein 3PRO_0000213896Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei408 – 4081Phosphoserine1 Publication
Modified residuei918 – 9181Phosphoserine1 Publication
Modified residuei920 – 9201Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8IXZ2.
PaxDbiQ8IXZ2.
PRIDEiQ8IXZ2.

PTM databases

PhosphoSiteiQ8IXZ2.

Expressioni

Gene expression databases

BgeeiQ8IXZ2.
CleanExiHS_ZC3H3.
ExpressionAtlasiQ8IXZ2. baseline and differential.
GenevestigatoriQ8IXZ2.

Organism-specific databases

HPAiHPA023658.
HPA050577.

Interactioni

Protein-protein interaction databases

BioGridi116761. 102 interactions.
IntActiQ8IXZ2. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8IXZ2.
SMRiQ8IXZ2. Positions 695-747.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi382 – 39110Poly-Ser
Compositional biasi873 – 8819Poly-Ser

Sequence similaritiesi

Contains 5 C3H1-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri667 – 69529C3H1-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri699 – 72224C3H1-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri723 – 74927C3H1-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri750 – 77728C3H1-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri778 – 80023C3H1-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5084.
GeneTreeiENSGT00390000009627.
HOGENOMiHOG000133053.
HOVERGENiHBG055611.
InParanoidiQ8IXZ2.
OMAiRCPYIHD.
OrthoDBiEOG725DGQ.
PhylomeDBiQ8IXZ2.
TreeFamiTF324375.

Family and domain databases

Gene3Di4.10.1000.10. 1 hit.
InterProiIPR000571. Znf_CCCH.
[Graphical view]
PfamiPF00642. zf-CCCH. 2 hits.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 5 hits.
[Graphical view]
PROSITEiPS50103. ZF_C3H1. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IXZ2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEKEILRRQ IRLLQGLIDD YKTLHGNAPA PGTPAASGWQ PPTYHSGRAF
60 70 80 90 100
SARYPRPSRR GYSSHHGPSW RKKYSLVNRP PGPSDPPADH AVRPLHGARG
110 120 130 140 150
GQPPVPQQHV LERQVQLSQG QNVVIKVKPP SKSGSASASG AQRGSLEEFE
160 170 180 190 200
ETPWSDQRPR EGEGEPPRGQ LQPSRPTRAR GTCSVEDPLL VCQKEPGKPR
210 220 230 240 250
MVKSVGSVGD SPREPRRTVS ESVIAVKASF PSSALPPRTG VALGRKLGSH
260 270 280 290 300
SVASCAPQLL GDRRVDAGHT DQPVPSGSVG GPARPASGPR QAREASLVVT
310 320 330 340 350
CRTNKFRKNN YKWVAASSKS PRVARRALSP RVAAENVCKA SAGMANKVEK
360 370 380 390 400
PQLIADPEPK PRKPATSSKP GSAPSKYKWK ASSPSASSSS SFRWQSEASS
410 420 430 440 450
KDHASQLSPV LSRSPSGDRP AVGHSGLKPL SGETPLSAYK VKSRTKIIRR
460 470 480 490 500
RSSTSLPGDK KSGTSPAATA KSHLSLRRRQ ALRGKSSPVL KKTPNKGLVQ
510 520 530 540 550
VTTHRLCRLP PSRAHLPTKE ASSLHAVRTA PTSKVIKTRY RIVKKTPASP
560 570 580 590 600
LSAPPFPLSL PSWRARRLSL SRSLVLNRLR PVASGGGKAQ PGSPWWRSKG
610 620 630 640 650
YRCIGGVLYK VSANKLSKTS GQPSDAGSRP LLRTGRLDPA GSCSRSLASR
660 670 680 690 700
AVQRSLAIIR QARQRREKRK EYCMYYNRFG RCNRGERCPY IHDPEKVAVC
710 720 730 740 750
TRFVRGTCKK TDGTCPFSHH VSKEKMPVCS YFLKGICSNS NCPYSHVYVS
760 770 780 790 800
RKAEVCSDFL KGYCPLGAKC KKKHTLLCPD FARRGACPRG AQCQLLHRTQ
810 820 830 840 850
KRHSRRAATS PAPGPSDATA RSRVSASHGP RKPSASQRPT RQTPSSAALT
860 870 880 890 900
AAAVAAPPHC PGGSASPSSS KASSSSSSSS SPPASLDHEA PSLQEAALAA
910 920 930 940
ACSNRLCKLP SFISLQSSPS PGAQPRVRAP RAPLTKDSGK PLHIKPRL
Length:948
Mass (Da):101,941
Last modified:October 5, 2010 - v3
Checksum:i9CDD4F29EE40946B
GO
Isoform 2 (identifier: Q8IXZ2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-613: Missing.
     614-634: NKLSKTSGQPSDAGSRPLLRT → MEPGGEPTGAKESSTLMESLA

Show »
Length:335
Mass (Da):35,929
Checksum:iB5FE8363BA91A4C3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti572 – 5721R → G in AAH38670. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61I → M.1 Publication
Corresponds to variant rs2242093 [ dbSNP | Ensembl ].
VAR_018457
Natural varianti102 – 1021Q → R.1 Publication
Corresponds to variant rs17857167 [ dbSNP | Ensembl ].
VAR_060402
Natural varianti149 – 1491F → Y.
Corresponds to variant rs3750206 [ dbSNP | Ensembl ].
VAR_018458
Natural varianti151 – 1511E → D.1 Publication
Corresponds to variant rs3750207 [ dbSNP | Ensembl ].
VAR_018459
Natural varianti165 – 1651E → K.1 Publication
Corresponds to variant rs17853852 [ dbSNP | Ensembl ].
VAR_060403
Natural varianti168 – 1681R → W.
Corresponds to variant rs3750208 [ dbSNP | Ensembl ].
VAR_057484
Natural varianti228 – 2281A → S.
Corresponds to variant rs4873802 [ dbSNP | Ensembl ].
VAR_057485
Natural varianti231 – 2311P → A.1 Publication
Corresponds to variant rs17853853 [ dbSNP | Ensembl ].
VAR_060404
Natural varianti351 – 3511P → L.
Corresponds to variant rs34674128 [ dbSNP | Ensembl ].
VAR_057486
Natural varianti399 – 3991S → G.1 Publication
Corresponds to variant rs1318196 [ dbSNP | Ensembl ].
VAR_018460
Natural varianti415 – 4151P → L.
Corresponds to variant rs36008851 [ dbSNP | Ensembl ].
VAR_057487
Natural varianti452 – 4521S → G.2 Publications
Corresponds to variant rs4874147 [ dbSNP | Ensembl ].
VAR_018461
Natural varianti503 – 5031T → K.
Corresponds to variant rs11548254 [ dbSNP | Ensembl ].
VAR_057488
Natural varianti578 – 5781R → H.1 Publication
Corresponds to variant rs17855618 [ dbSNP | Ensembl ].
VAR_060405
Natural varianti636 – 6361R → W.1 Publication
Corresponds to variant rs17857164 [ dbSNP | Ensembl ].
VAR_060406
Natural varianti727 – 7271P → R.1 Publication
Corresponds to variant rs17857168 [ dbSNP | Ensembl ].
VAR_060407

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 613613Missing in isoform 2. 1 PublicationVSP_010272Add
BLAST
Alternative sequencei614 – 63421NKLSK…PLLRT → MEPGGEPTGAKESSTLMESL A in isoform 2. 1 PublicationVSP_010273Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC067930 Genomic DNA. No translation available.
AC105118 Genomic DNA. No translation available.
BC034435 mRNA. Translation: AAH34435.1.
BC038670 mRNA. Translation: AAH38670.1.
D63484 mRNA. Translation: BAA09771.1.
CCDSiCCDS6402.1. [Q8IXZ2-1]
RefSeqiNP_055932.2. NM_015117.2. [Q8IXZ2-1]
UniGeneiHs.521915.

Genome annotation databases

EnsembliENST00000262577; ENSP00000262577; ENSG00000014164. [Q8IXZ2-1]
GeneIDi23144.
KEGGihsa:23144.
UCSCiuc003yyd.2. human. [Q8IXZ2-1]

Polymorphism databases

DMDMi308153538.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC067930 Genomic DNA. No translation available.
AC105118 Genomic DNA. No translation available.
BC034435 mRNA. Translation: AAH34435.1 .
BC038670 mRNA. Translation: AAH38670.1 .
D63484 mRNA. Translation: BAA09771.1 .
CCDSi CCDS6402.1. [Q8IXZ2-1 ]
RefSeqi NP_055932.2. NM_015117.2. [Q8IXZ2-1 ]
UniGenei Hs.521915.

3D structure databases

ProteinModelPortali Q8IXZ2.
SMRi Q8IXZ2. Positions 695-747.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116761. 102 interactions.
IntActi Q8IXZ2. 1 interaction.

PTM databases

PhosphoSitei Q8IXZ2.

Polymorphism databases

DMDMi 308153538.

Proteomic databases

MaxQBi Q8IXZ2.
PaxDbi Q8IXZ2.
PRIDEi Q8IXZ2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000262577 ; ENSP00000262577 ; ENSG00000014164 . [Q8IXZ2-1 ]
GeneIDi 23144.
KEGGi hsa:23144.
UCSCi uc003yyd.2. human. [Q8IXZ2-1 ]

Organism-specific databases

CTDi 23144.
GeneCardsi GC08M144519.
H-InvDB HIX0022677.
HGNCi HGNC:28972. ZC3H3.
HPAi HPA023658.
HPA050577.
neXtProti NX_Q8IXZ2.
PharmGKBi PA134933089.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5084.
GeneTreei ENSGT00390000009627.
HOGENOMi HOG000133053.
HOVERGENi HBG055611.
InParanoidi Q8IXZ2.
OMAi RCPYIHD.
OrthoDBi EOG725DGQ.
PhylomeDBi Q8IXZ2.
TreeFami TF324375.

Miscellaneous databases

ChiTaRSi ZC3H3. human.
GenomeRNAii 23144.
NextBioi 44434.
PROi Q8IXZ2.

Gene expression databases

Bgeei Q8IXZ2.
CleanExi HS_ZC3H3.
ExpressionAtlasi Q8IXZ2. baseline and differential.
Genevestigatori Q8IXZ2.

Family and domain databases

Gene3Di 4.10.1000.10. 1 hit.
InterProi IPR000571. Znf_CCCH.
[Graphical view ]
Pfami PF00642. zf-CCCH. 2 hits.
[Graphical view ]
SMARTi SM00356. ZnF_C3H1. 5 hits.
[Graphical view ]
PROSITEi PS50103. ZF_C3H1. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS MET-6; ARG-102; LYS-165; ALA-231; GLY-452; HIS-578; TRP-636 AND ARG-727.
    Tissue: Brain.
  3. "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1."
    Nagase T., Seki N., Tanaka A., Ishikawa K., Nomura N.
    DNA Res. 2:167-174(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-948 (ISOFORM 1), VARIANTS ASP-151; GLY-399 AND GLY-452.
    Tissue: Bone marrow.
  4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-918 AND SER-920, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-408, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZC3H3_HUMAN
AccessioniPrimary (citable) accession number: Q8IXZ2
Secondary accession number(s): Q14163, Q8N4E2, Q9BUS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 5, 2010
Last modified: October 29, 2014
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3