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Protein

Zinc finger CCCH domain-containing protein 3

Gene

ZC3H3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for the export of polyadenylated mRNAs from the nucleus (PubMed:19364924). Enhances ACVR1B-induced SMAD-dependent transcription. Binds to single-stranded DNA but not to double-stranded DNA in vitro. Involved in RNA cleavage (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri667 – 695C3H1-type 1PROSITE-ProRule annotationAdd BLAST29
Zinc fingeri699 – 722C3H1-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri723 – 749C3H1-type 3PROSITE-ProRule annotationAdd BLAST27
Zinc fingeri750 – 777C3H1-type 4PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri778 – 800C3H1-type 5PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • mRNA polyadenylation Source: UniProtKB
  • poly(A)+ mRNA export from nucleus Source: UniProtKB
  • positive regulation of activin receptor signaling pathway Source: Ensembl
  • regulation of mRNA export from nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

mRNA transport, Transport

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CCCH domain-containing protein 3
Alternative name(s):
Smad-interacting CPSF-like factorBy similarity
Gene namesi
Name:ZC3H3
Synonyms:KIAA0150, SMICLBy similarity, ZC3HDC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:28972. ZC3H3.

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

  • mRNA cleavage and polyadenylation specificity factor complex Source: GO_Central
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23144.
OpenTargetsiENSG00000014164.
PharmGKBiPA134933089.

Polymorphism and mutation databases

BioMutaiZC3H3.
DMDMi308153538.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002138961 – 948Zinc finger CCCH domain-containing protein 3Add BLAST948

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei408PhosphoserineCombined sources1
Modified residuei918PhosphoserineCombined sources1
Modified residuei920PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IXZ2.
MaxQBiQ8IXZ2.
PaxDbiQ8IXZ2.
PeptideAtlasiQ8IXZ2.
PRIDEiQ8IXZ2.

PTM databases

iPTMnetiQ8IXZ2.
PhosphoSitePlusiQ8IXZ2.

Expressioni

Gene expression databases

BgeeiENSG00000014164.
CleanExiHS_ZC3H3.
ExpressionAtlasiQ8IXZ2. baseline and differential.
GenevisibleiQ8IXZ2. HS.

Organism-specific databases

HPAiHPA023658.
HPA050577.

Interactioni

Subunit structurei

Interacts with SMAD1, SMAD3, SMAD4, CPSF2 and CPSF3 (By similarity).By similarity

Protein-protein interaction databases

BioGridi116761. 124 interactors.
IntActiQ8IXZ2. 16 interactors.
STRINGi9606.ENSP00000262577.

Structurei

3D structure databases

ProteinModelPortaliQ8IXZ2.
SMRiQ8IXZ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi382 – 391Poly-Ser10
Compositional biasi873 – 881Poly-Ser9

Sequence similaritiesi

Contains 5 C3H1-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri667 – 695C3H1-type 1PROSITE-ProRule annotationAdd BLAST29
Zinc fingeri699 – 722C3H1-type 2PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri723 – 749C3H1-type 3PROSITE-ProRule annotationAdd BLAST27
Zinc fingeri750 – 777C3H1-type 4PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri778 – 800C3H1-type 5PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1492. Eukaryota.
COG5084. LUCA.
GeneTreeiENSGT00390000009627.
HOGENOMiHOG000133053.
HOVERGENiHBG055611.
InParanoidiQ8IXZ2.
OMAiGRCNRGE.
OrthoDBiEOG091G038R.
PhylomeDBiQ8IXZ2.
TreeFamiTF324375.

Family and domain databases

Gene3Di4.10.1000.10. 2 hits.
InterProiIPR000571. Znf_CCCH.
[Graphical view]
PfamiPF00642. zf-CCCH. 2 hits.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 5 hits.
[Graphical view]
SUPFAMiSSF90229. SSF90229. 2 hits.
PROSITEiPS50103. ZF_C3H1. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IXZ2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEKEILRRQ IRLLQGLIDD YKTLHGNAPA PGTPAASGWQ PPTYHSGRAF
60 70 80 90 100
SARYPRPSRR GYSSHHGPSW RKKYSLVNRP PGPSDPPADH AVRPLHGARG
110 120 130 140 150
GQPPVPQQHV LERQVQLSQG QNVVIKVKPP SKSGSASASG AQRGSLEEFE
160 170 180 190 200
ETPWSDQRPR EGEGEPPRGQ LQPSRPTRAR GTCSVEDPLL VCQKEPGKPR
210 220 230 240 250
MVKSVGSVGD SPREPRRTVS ESVIAVKASF PSSALPPRTG VALGRKLGSH
260 270 280 290 300
SVASCAPQLL GDRRVDAGHT DQPVPSGSVG GPARPASGPR QAREASLVVT
310 320 330 340 350
CRTNKFRKNN YKWVAASSKS PRVARRALSP RVAAENVCKA SAGMANKVEK
360 370 380 390 400
PQLIADPEPK PRKPATSSKP GSAPSKYKWK ASSPSASSSS SFRWQSEASS
410 420 430 440 450
KDHASQLSPV LSRSPSGDRP AVGHSGLKPL SGETPLSAYK VKSRTKIIRR
460 470 480 490 500
RSSTSLPGDK KSGTSPAATA KSHLSLRRRQ ALRGKSSPVL KKTPNKGLVQ
510 520 530 540 550
VTTHRLCRLP PSRAHLPTKE ASSLHAVRTA PTSKVIKTRY RIVKKTPASP
560 570 580 590 600
LSAPPFPLSL PSWRARRLSL SRSLVLNRLR PVASGGGKAQ PGSPWWRSKG
610 620 630 640 650
YRCIGGVLYK VSANKLSKTS GQPSDAGSRP LLRTGRLDPA GSCSRSLASR
660 670 680 690 700
AVQRSLAIIR QARQRREKRK EYCMYYNRFG RCNRGERCPY IHDPEKVAVC
710 720 730 740 750
TRFVRGTCKK TDGTCPFSHH VSKEKMPVCS YFLKGICSNS NCPYSHVYVS
760 770 780 790 800
RKAEVCSDFL KGYCPLGAKC KKKHTLLCPD FARRGACPRG AQCQLLHRTQ
810 820 830 840 850
KRHSRRAATS PAPGPSDATA RSRVSASHGP RKPSASQRPT RQTPSSAALT
860 870 880 890 900
AAAVAAPPHC PGGSASPSSS KASSSSSSSS SPPASLDHEA PSLQEAALAA
910 920 930 940
ACSNRLCKLP SFISLQSSPS PGAQPRVRAP RAPLTKDSGK PLHIKPRL
Length:948
Mass (Da):101,941
Last modified:October 5, 2010 - v3
Checksum:i9CDD4F29EE40946B
GO
Isoform 2 (identifier: Q8IXZ2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-613: Missing.
     614-634: NKLSKTSGQPSDAGSRPLLRT → MEPGGEPTGAKESSTLMESLA

Show »
Length:335
Mass (Da):35,929
Checksum:iB5FE8363BA91A4C3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti572R → G in AAH38670 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0184576I → M.1 PublicationCorresponds to variant rs2242093dbSNPEnsembl.1
Natural variantiVAR_060402102Q → R.1 PublicationCorresponds to variant rs17857167dbSNPEnsembl.1
Natural variantiVAR_018458149F → Y.Corresponds to variant rs3750206dbSNPEnsembl.1
Natural variantiVAR_018459151E → D.1 PublicationCorresponds to variant rs3750207dbSNPEnsembl.1
Natural variantiVAR_060403165E → K.1 PublicationCorresponds to variant rs17853852dbSNPEnsembl.1
Natural variantiVAR_057484168R → W.Corresponds to variant rs3750208dbSNPEnsembl.1
Natural variantiVAR_057485228A → S.Corresponds to variant rs4873802dbSNPEnsembl.1
Natural variantiVAR_060404231P → A.1 PublicationCorresponds to variant rs17853853dbSNPEnsembl.1
Natural variantiVAR_057486351P → L.Corresponds to variant rs34674128dbSNPEnsembl.1
Natural variantiVAR_018460399S → G.1 PublicationCorresponds to variant rs1318196dbSNPEnsembl.1
Natural variantiVAR_057487415P → L.Corresponds to variant rs36008851dbSNPEnsembl.1
Natural variantiVAR_018461452S → G.2 PublicationsCorresponds to variant rs4874147dbSNPEnsembl.1
Natural variantiVAR_057488503T → K.Corresponds to variant rs11548254dbSNPEnsembl.1
Natural variantiVAR_060405578R → H.1 PublicationCorresponds to variant rs17855618dbSNPEnsembl.1
Natural variantiVAR_060406636R → W.1 PublicationCorresponds to variant rs17857164dbSNPEnsembl.1
Natural variantiVAR_060407727P → R.1 PublicationCorresponds to variant rs17857168dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0102721 – 613Missing in isoform 2. 1 PublicationAdd BLAST613
Alternative sequenceiVSP_010273614 – 634NKLSK…PLLRT → MEPGGEPTGAKESSTLMESL A in isoform 2. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC067930 Genomic DNA. No translation available.
AC105118 Genomic DNA. No translation available.
BC034435 mRNA. Translation: AAH34435.1.
BC038670 mRNA. Translation: AAH38670.1.
D63484 mRNA. Translation: BAA09771.1.
CCDSiCCDS6402.1. [Q8IXZ2-1]
RefSeqiNP_055932.2. NM_015117.2. [Q8IXZ2-1]
UniGeneiHs.521915.

Genome annotation databases

EnsembliENST00000262577; ENSP00000262577; ENSG00000014164. [Q8IXZ2-1]
GeneIDi23144.
KEGGihsa:23144.
UCSCiuc003yyd.3. human. [Q8IXZ2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC067930 Genomic DNA. No translation available.
AC105118 Genomic DNA. No translation available.
BC034435 mRNA. Translation: AAH34435.1.
BC038670 mRNA. Translation: AAH38670.1.
D63484 mRNA. Translation: BAA09771.1.
CCDSiCCDS6402.1. [Q8IXZ2-1]
RefSeqiNP_055932.2. NM_015117.2. [Q8IXZ2-1]
UniGeneiHs.521915.

3D structure databases

ProteinModelPortaliQ8IXZ2.
SMRiQ8IXZ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116761. 124 interactors.
IntActiQ8IXZ2. 16 interactors.
STRINGi9606.ENSP00000262577.

PTM databases

iPTMnetiQ8IXZ2.
PhosphoSitePlusiQ8IXZ2.

Polymorphism and mutation databases

BioMutaiZC3H3.
DMDMi308153538.

Proteomic databases

EPDiQ8IXZ2.
MaxQBiQ8IXZ2.
PaxDbiQ8IXZ2.
PeptideAtlasiQ8IXZ2.
PRIDEiQ8IXZ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262577; ENSP00000262577; ENSG00000014164. [Q8IXZ2-1]
GeneIDi23144.
KEGGihsa:23144.
UCSCiuc003yyd.3. human. [Q8IXZ2-1]

Organism-specific databases

CTDi23144.
DisGeNETi23144.
GeneCardsiZC3H3.
H-InvDBHIX0022677.
HGNCiHGNC:28972. ZC3H3.
HPAiHPA023658.
HPA050577.
neXtProtiNX_Q8IXZ2.
OpenTargetsiENSG00000014164.
PharmGKBiPA134933089.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1492. Eukaryota.
COG5084. LUCA.
GeneTreeiENSGT00390000009627.
HOGENOMiHOG000133053.
HOVERGENiHBG055611.
InParanoidiQ8IXZ2.
OMAiGRCNRGE.
OrthoDBiEOG091G038R.
PhylomeDBiQ8IXZ2.
TreeFamiTF324375.

Miscellaneous databases

ChiTaRSiZC3H3. human.
GenomeRNAii23144.
PROiQ8IXZ2.

Gene expression databases

BgeeiENSG00000014164.
CleanExiHS_ZC3H3.
ExpressionAtlasiQ8IXZ2. baseline and differential.
GenevisibleiQ8IXZ2. HS.

Family and domain databases

Gene3Di4.10.1000.10. 2 hits.
InterProiIPR000571. Znf_CCCH.
[Graphical view]
PfamiPF00642. zf-CCCH. 2 hits.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 5 hits.
[Graphical view]
SUPFAMiSSF90229. SSF90229. 2 hits.
PROSITEiPS50103. ZF_C3H1. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZC3H3_HUMAN
AccessioniPrimary (citable) accession number: Q8IXZ2
Secondary accession number(s): Q14163, Q8N4E2, Q9BUS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 5, 2010
Last modified: November 30, 2016
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.