ID   PPIL6_HUMAN             Reviewed;         311 AA.
AC   Q8IXY8; A9NIU0; A9NIU9; E7EX15;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   27-MAR-2024, entry version 169.
DE   RecName: Full=Probable inactive peptidyl-prolyl cis-trans isomerase-like 6 {ECO:0000305|PubMed:20676357};
DE            Short=PPIase {ECO:0000305|PubMed:20676357};
DE   AltName: Full=Cyclophilin-like protein PPIL6 {ECO:0000312|EMBL:ABC88651.1};
DE   AltName: Full=Rotamase PPIL6;
GN   Name=PPIL6 {ECO:0000312|HGNC:HGNC:21557};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RA   Chen S., Yu L.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   FUNCTION, AND CAUTION.
RX   PubMed=20676357; DOI=10.1371/journal.pbio.1000439;
RA   Davis T.L., Walker J.R., Campagna-Slater V., Finerty P.J., Paramanathan R.,
RA   Bernstein G., MacKenzie F., Tempel W., Ouyang H., Lee W.H.,
RA   Eisenmesser E.Z., Dhe-Paganon S.;
RT   "Structural and biochemical characterization of the human cyclophilin
RT   family of peptidyl-prolyl isomerases.";
RL   PLoS Biol. 8:E1000439-E1000439(2010).
CC   -!- FUNCTION: Probable inactive PPIase with no peptidyl-prolyl cis-trans
CC       isomerase activity. {ECO:0000269|PubMed:20676357}.
CC   -!- INTERACTION:
CC       Q8IXY8; Q92624: APPBP2; NbExp=3; IntAct=EBI-12226639, EBI-743771;
CC       Q8IXY8; O95429: BAG4; NbExp=3; IntAct=EBI-12226639, EBI-2949658;
CC       Q8IXY8; Q86UB2: BIVM; NbExp=3; IntAct=EBI-12226639, EBI-12191873;
CC       Q8IXY8; O60504: SORBS3; NbExp=3; IntAct=EBI-12226639, EBI-741237;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q8IXY8-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8IXY8-2; Sequence=VSP_043036;
CC       Name=3;
CC         IsoId=Q8IXY8-3; Sequence=VSP_055658;
CC   -!- SIMILARITY: Belongs to the cyclophilin-type PPIase family.
CC       {ECO:0000305}.
CC   -!- CAUTION: Despite the fact that it belongs to the cyclophilin-type
CC       PPIase family, a report has shown that it has probably no peptidyl-
CC       prolyl cis-trans isomerase activity. {ECO:0000269|PubMed:20676357}.
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DR   EMBL; DQ363562; ABC88651.1; -; mRNA.
DR   EMBL; DQ423529; ABD83948.1; -; mRNA.
DR   EMBL; AL109947; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL359711; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471051; EAW48347.1; -; Genomic_DNA.
DR   EMBL; BC038716; AAH38716.1; -; mRNA.
DR   CCDS; CCDS47466.2; -. [Q8IXY8-2]
DR   CCDS; CCDS5074.1; -. [Q8IXY8-1]
DR   CCDS; CCDS69169.1; -. [Q8IXY8-3]
DR   RefSeq; NP_001104768.2; NM_001111298.2. [Q8IXY8-2]
DR   RefSeq; NP_001273289.1; NM_001286360.1. [Q8IXY8-3]
DR   RefSeq; NP_001273290.1; NM_001286361.1.
DR   RefSeq; NP_775943.1; NM_173672.4. [Q8IXY8-1]
DR   PDB; 8J07; EM; 4.10 A; S/s=1-311.
DR   PDBsum; 8J07; -.
DR   AlphaFoldDB; Q8IXY8; -.
DR   EMDB; EMD-35888; -.
DR   SMR; Q8IXY8; -.
DR   BioGRID; 130200; 6.
DR   IntAct; Q8IXY8; 4.
DR   STRING; 9606.ENSP00000392257; -.
DR   iPTMnet; Q8IXY8; -.
DR   PhosphoSitePlus; Q8IXY8; -.
DR   BioMuta; PPIL6; -.
DR   DMDM; 74762491; -.
DR   jPOST; Q8IXY8; -.
DR   MassIVE; Q8IXY8; -.
DR   PaxDb; 9606-ENSP00000392257; -.
DR   PeptideAtlas; Q8IXY8; -.
DR   ProteomicsDB; 18957; -.
DR   ProteomicsDB; 71076; -. [Q8IXY8-1]
DR   ProteomicsDB; 71077; -. [Q8IXY8-2]
DR   Antibodypedia; 32250; 200 antibodies from 19 providers.
DR   DNASU; 285755; -.
DR   Ensembl; ENST00000424445.6; ENSP00000407731.2; ENSG00000185250.16. [Q8IXY8-3]
DR   Ensembl; ENST00000440797.6; ENSP00000392257.2; ENSG00000185250.16. [Q8IXY8-2]
DR   Ensembl; ENST00000521072.7; ENSP00000427929.1; ENSG00000185250.16. [Q8IXY8-1]
DR   GeneID; 285755; -.
DR   KEGG; hsa:285755; -.
DR   MANE-Select; ENST00000521072.7; ENSP00000427929.1; NM_173672.5; NP_775943.1.
DR   UCSC; uc003ptg.4; human. [Q8IXY8-1]
DR   AGR; HGNC:21557; -.
DR   CTD; 285755; -.
DR   DisGeNET; 285755; -.
DR   GeneCards; PPIL6; -.
DR   HGNC; HGNC:21557; PPIL6.
DR   HPA; ENSG00000185250; Tissue enhanced (fallopian tube, testis).
DR   neXtProt; NX_Q8IXY8; -.
DR   OpenTargets; ENSG00000185250; -.
DR   PharmGKB; PA134939571; -.
DR   VEuPathDB; HostDB:ENSG00000185250; -.
DR   eggNOG; KOG0546; Eukaryota.
DR   GeneTree; ENSGT00940000159634; -.
DR   HOGENOM; CLU_058893_1_0_1; -.
DR   InParanoid; Q8IXY8; -.
DR   OMA; ERPVVEC; -.
DR   OrthoDB; 2902006at2759; -.
DR   PhylomeDB; Q8IXY8; -.
DR   TreeFam; TF351326; -.
DR   PathwayCommons; Q8IXY8; -.
DR   SignaLink; Q8IXY8; -.
DR   BioGRID-ORCS; 285755; 10 hits in 1145 CRISPR screens.
DR   ChiTaRS; PPIL6; human.
DR   GenomeRNAi; 285755; -.
DR   Pharos; Q8IXY8; Tdark.
DR   PRO; PR:Q8IXY8; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   RNAct; Q8IXY8; Protein.
DR   Bgee; ENSG00000185250; Expressed in right uterine tube and 110 other cell types or tissues.
DR   ExpressionAtlas; Q8IXY8; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR   Gene3D; 2.40.100.10; Cyclophilin-like; 1.
DR   InterPro; IPR029000; Cyclophilin-like_dom_sf.
DR   InterPro; IPR002130; Cyclophilin-type_PPIase_dom.
DR   PANTHER; PTHR11071; PEPTIDYL-PROLYL CIS-TRANS ISOMERASE; 1.
DR   PANTHER; PTHR11071:SF561; PEPTIDYL-PROLYL CIS-TRANS ISOMERASE H; 1.
DR   Pfam; PF00160; Pro_isomerase; 1.
DR   PRINTS; PR00153; CSAPPISMRASE.
DR   SUPFAM; SSF50891; Cyclophilin-like; 1.
DR   PROSITE; PS50072; CSA_PPIASE_2; 1.
DR   Genevisible; Q8IXY8; HS.
PE   1: Evidence at protein level;
KW   3D-structure; Alternative splicing; Reference proteome.
FT   CHAIN           1..311
FT                   /note="Probable inactive peptidyl-prolyl cis-trans
FT                   isomerase-like 6"
FT                   /id="PRO_0000263755"
FT   DOMAIN          145..308
FT                   /note="PPIase cyclophilin-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00156"
FT   VAR_SEQ         46..77
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_055658"
FT   VAR_SEQ         229
FT                   /note="E -> EELYGSLKRSVKRQKESRGVGKIEKYR (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_043036"
FT   VARIANT         110
FT                   /note="H -> R (in dbSNP:rs9398200)"
FT                   /id="VAR_029620"
SQ   SEQUENCE   311 AA;  35228 MW;  034E81BD5D077148 CRC64;
     MARPQPCGPP HARCGSPSLP ERPLQVKVVG LFSCPNFQIA KSAAENLKNN HPSKFEDPIL
     VPLQEFAWHQ YLQEKKRELK NETWEYSSSV ISFVNGQFLG DALDLQKWAH EVWDIVDIKP
     SALYDALTED FSAKFLRDTK HDFVFLDICI DSSPIGRLIF ELYCDVCPKT CKNFQVLCTG
     KAGFSQRGIR LHYKNSIFHR IVQNGWIQGG DIVYGKGDNG ESIYGPTFED ENFSVPHNKR
     GVLGMANKGR HSNGSQFYIT LQATPYLDRK FVAFGQLIEG TEVLKQLELV PTQNERPIHM
     CRITDSGDPY A
//