Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8IXY8

- PPIL6_HUMAN

UniProt

Q8IXY8 - PPIL6_HUMAN

Protein

Peptidyl-prolyl cis-trans isomerase-like 6

Gene

PPIL6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

    Catalytic activityi

    Peptidylproline (omega=180) = peptidylproline (omega=0).

    GO - Molecular functioni

    1. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. protein folding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Isomerase, Rotamase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase-like 6 (EC:5.2.1.8)
    Short name:
    PPIase
    Alternative name(s):
    Cyclophilin-like protein PPIL6
    Rotamase PPIL6
    Gene namesi
    Name:PPIL6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:21557. PPIL6.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134939571.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 311311Peptidyl-prolyl cis-trans isomerase-like 6PRO_0000263755Add
    BLAST

    Proteomic databases

    PaxDbiQ8IXY8.
    PRIDEiQ8IXY8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8IXY8.
    BgeeiQ8IXY8.
    CleanExiHS_PPIL6.
    GenevestigatoriQ8IXY8.

    Organism-specific databases

    HPAiHPA036717.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000389292.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IXY8.
    SMRiQ8IXY8. Positions 145-308.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini145 – 308164PPIase cyclophilin-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the cyclophilin-type PPIase family.Curated
    Contains 1 PPIase cyclophilin-type domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0652.
    HOGENOMiHOG000065981.
    HOVERGENiHBG056776.
    InParanoidiQ8IXY8.
    KOiK12739.
    OMAiGMANKGR.
    PhylomeDBiQ8IXY8.
    TreeFamiTF351326.

    Family and domain databases

    Gene3Di2.40.100.10. 1 hit.
    InterProiIPR029000. Cyclophilin-like_dom.
    IPR002130. Cyclophilin-type_PPIase_dom.
    [Graphical view]
    PfamiPF00160. Pro_isomerase. 1 hit.
    [Graphical view]
    PRINTSiPR00153. CSAPPISMRASE.
    SUPFAMiSSF50891. SSF50891. 1 hit.
    PROSITEiPS50072. CSA_PPIASE_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8IXY8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MARPQPCGPP HARCGSPSLP ERPLQVKVVG LFSCPNFQIA KSAAENLKNN    50
    HPSKFEDPIL VPLQEFAWHQ YLQEKKRELK NETWEYSSSV ISFVNGQFLG 100
    DALDLQKWAH EVWDIVDIKP SALYDALTED FSAKFLRDTK HDFVFLDICI 150
    DSSPIGRLIF ELYCDVCPKT CKNFQVLCTG KAGFSQRGIR LHYKNSIFHR 200
    IVQNGWIQGG DIVYGKGDNG ESIYGPTFED ENFSVPHNKR GVLGMANKGR 250
    HSNGSQFYIT LQATPYLDRK FVAFGQLIEG TEVLKQLELV PTQNERPIHM 300
    CRITDSGDPY A 311
    Length:311
    Mass (Da):35,228
    Last modified:March 1, 2003 - v1
    Checksum:i034E81BD5D077148
    GO
    Isoform 2 (identifier: Q8IXY8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         229-229: E → EELYGSLKRSVKRQKESRGVGKIEKYR

    Note: No experimental confirmation available.

    Show »
    Length:337
    Mass (Da):38,306
    Checksum:i367792C3788259C5
    GO
    Isoform 3 (identifier: Q8IXY8-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         46-77: Missing.

    Note: No experimental confirmation available. Gene prediction based on partial EST data.

    Show »
    Length:279
    Mass (Da):31,298
    Checksum:i990B706D9590BE4E
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti110 – 1101H → R.
    Corresponds to variant rs9398200 [ dbSNP | Ensembl ].
    VAR_029620

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei46 – 7732Missing in isoform 3. CuratedVSP_055658Add
    BLAST
    Alternative sequencei229 – 2291E → EELYGSLKRSVKRQKESRGV GKIEKYR in isoform 2. 1 PublicationVSP_043036

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ363562 mRNA. Translation: ABC88651.1.
    DQ423529 mRNA. Translation: ABD83948.1.
    AL109947, AL359711 Genomic DNA. Translation: CAI23335.1.
    AL359711, AL109947 Genomic DNA. Translation: CAI40695.1.
    CH471051 Genomic DNA. Translation: EAW48347.1.
    BC038716 mRNA. Translation: AAH38716.1.
    CCDSiCCDS47466.2. [Q8IXY8-2]
    CCDS5074.1. [Q8IXY8-1]
    RefSeqiNP_001104768.2. NM_001111298.2. [Q8IXY8-2]
    NP_001273289.1. NM_001286360.1.
    NP_001273290.1. NM_001286361.1.
    NP_775943.1. NM_173672.4. [Q8IXY8-1]
    UniGeneiHs.32234.

    Genome annotation databases

    EnsembliENST00000424445; ENSP00000407731; ENSG00000185250. [Q8IXY8-3]
    ENST00000440797; ENSP00000392257; ENSG00000185250. [Q8IXY8-2]
    ENST00000521072; ENSP00000427929; ENSG00000185250. [Q8IXY8-1]
    GeneIDi285755.
    KEGGihsa:285755.
    UCSCiuc003ptg.4. human. [Q8IXY8-1]
    uc010kdp.3. human. [Q8IXY8-2]

    Polymorphism databases

    DMDMi74762491.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ363562 mRNA. Translation: ABC88651.1 .
    DQ423529 mRNA. Translation: ABD83948.1 .
    AL109947 , AL359711 Genomic DNA. Translation: CAI23335.1 .
    AL359711 , AL109947 Genomic DNA. Translation: CAI40695.1 .
    CH471051 Genomic DNA. Translation: EAW48347.1 .
    BC038716 mRNA. Translation: AAH38716.1 .
    CCDSi CCDS47466.2. [Q8IXY8-2 ]
    CCDS5074.1. [Q8IXY8-1 ]
    RefSeqi NP_001104768.2. NM_001111298.2. [Q8IXY8-2 ]
    NP_001273289.1. NM_001286360.1.
    NP_001273290.1. NM_001286361.1.
    NP_775943.1. NM_173672.4. [Q8IXY8-1 ]
    UniGenei Hs.32234.

    3D structure databases

    ProteinModelPortali Q8IXY8.
    SMRi Q8IXY8. Positions 145-308.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000389292.

    Polymorphism databases

    DMDMi 74762491.

    Proteomic databases

    PaxDbi Q8IXY8.
    PRIDEi Q8IXY8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000424445 ; ENSP00000407731 ; ENSG00000185250 . [Q8IXY8-3 ]
    ENST00000440797 ; ENSP00000392257 ; ENSG00000185250 . [Q8IXY8-2 ]
    ENST00000521072 ; ENSP00000427929 ; ENSG00000185250 . [Q8IXY8-1 ]
    GeneIDi 285755.
    KEGGi hsa:285755.
    UCSCi uc003ptg.4. human. [Q8IXY8-1 ]
    uc010kdp.3. human. [Q8IXY8-2 ]

    Organism-specific databases

    CTDi 285755.
    GeneCardsi GC06M109711.
    HGNCi HGNC:21557. PPIL6.
    HPAi HPA036717.
    neXtProti NX_Q8IXY8.
    PharmGKBi PA134939571.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0652.
    HOGENOMi HOG000065981.
    HOVERGENi HBG056776.
    InParanoidi Q8IXY8.
    KOi K12739.
    OMAi GMANKGR.
    PhylomeDBi Q8IXY8.
    TreeFami TF351326.

    Miscellaneous databases

    ChiTaRSi PPIL6. human.
    GenomeRNAii 285755.
    NextBioi 95753.
    PROi Q8IXY8.

    Gene expression databases

    ArrayExpressi Q8IXY8.
    Bgeei Q8IXY8.
    CleanExi HS_PPIL6.
    Genevestigatori Q8IXY8.

    Family and domain databases

    Gene3Di 2.40.100.10. 1 hit.
    InterProi IPR029000. Cyclophilin-like_dom.
    IPR002130. Cyclophilin-type_PPIase_dom.
    [Graphical view ]
    Pfami PF00160. Pro_isomerase. 1 hit.
    [Graphical view ]
    PRINTSi PR00153. CSAPPISMRASE.
    SUPFAMi SSF50891. SSF50891. 1 hit.
    PROSITEi PS50072. CSA_PPIASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Chen S., Yu L.
      Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    2. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.

    Entry informationi

    Entry nameiPPIL6_HUMAN
    AccessioniPrimary (citable) accession number: Q8IXY8
    Secondary accession number(s): A9NIU0, A9NIU9, E7EX15
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3