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Protein

Peptidyl-prolyl cis-trans isomerase-like 6

Gene

PPIL6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Enzyme and pathway databases

BioCyciZFISH:HS11954-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase-like 6 (EC:5.2.1.8)
Short name:
PPIase
Alternative name(s):
Cyclophilin-like protein PPIL6
Rotamase PPIL6
Gene namesi
Name:PPIL6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21557. PPIL6.

Pathology & Biotechi

Organism-specific databases

DisGeNETi285755.
OpenTargetsiENSG00000185250.
PharmGKBiPA134939571.

Polymorphism and mutation databases

BioMutaiPPIL6.
DMDMi74762491.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002637551 – 311Peptidyl-prolyl cis-trans isomerase-like 6Add BLAST311

Proteomic databases

PeptideAtlasiQ8IXY8.
PRIDEiQ8IXY8.

PTM databases

iPTMnetiQ8IXY8.
PhosphoSitePlusiQ8IXY8.

Expressioni

Gene expression databases

BgeeiENSG00000185250.
CleanExiHS_PPIL6.
ExpressionAtlasiQ8IXY8. baseline and differential.
GenevisibleiQ8IXY8. HS.

Organism-specific databases

HPAiHPA036717.

Interactioni

Protein-protein interaction databases

IntActiQ8IXY8. 3 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ8IXY8.
SMRiQ8IXY8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini145 – 308PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST164

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.Curated
Contains 1 PPIase cyclophilin-type domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000119072.
HOGENOMiHOG000065981.
HOVERGENiHBG056776.
InParanoidiQ8IXY8.
KOiK12739.
OMAiYRDENFS.
OrthoDBiEOG091G0BGL.
PhylomeDBiQ8IXY8.
TreeFamiTF351326.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IXY8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARPQPCGPP HARCGSPSLP ERPLQVKVVG LFSCPNFQIA KSAAENLKNN
60 70 80 90 100
HPSKFEDPIL VPLQEFAWHQ YLQEKKRELK NETWEYSSSV ISFVNGQFLG
110 120 130 140 150
DALDLQKWAH EVWDIVDIKP SALYDALTED FSAKFLRDTK HDFVFLDICI
160 170 180 190 200
DSSPIGRLIF ELYCDVCPKT CKNFQVLCTG KAGFSQRGIR LHYKNSIFHR
210 220 230 240 250
IVQNGWIQGG DIVYGKGDNG ESIYGPTFED ENFSVPHNKR GVLGMANKGR
260 270 280 290 300
HSNGSQFYIT LQATPYLDRK FVAFGQLIEG TEVLKQLELV PTQNERPIHM
310
CRITDSGDPY A
Length:311
Mass (Da):35,228
Last modified:March 1, 2003 - v1
Checksum:i034E81BD5D077148
GO
Isoform 2 (identifier: Q8IXY8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     229-229: E → EELYGSLKRSVKRQKESRGVGKIEKYR

Note: No experimental confirmation available.
Show »
Length:337
Mass (Da):38,306
Checksum:i367792C3788259C5
GO
Isoform 3 (identifier: Q8IXY8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     46-77: Missing.

Note: No experimental confirmation available. Gene prediction based on partial EST data.
Show »
Length:279
Mass (Da):31,298
Checksum:i990B706D9590BE4E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_029620110H → R.Corresponds to variant rs9398200dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05565846 – 77Missing in isoform 3. CuratedAdd BLAST32
Alternative sequenceiVSP_043036229E → EELYGSLKRSVKRQKESRGV GKIEKYR in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ363562 mRNA. Translation: ABC88651.1.
DQ423529 mRNA. Translation: ABD83948.1.
AL109947, AL359711 Genomic DNA. Translation: CAI23335.1.
AL359711, AL109947 Genomic DNA. Translation: CAI40695.1.
CH471051 Genomic DNA. Translation: EAW48347.1.
BC038716 mRNA. Translation: AAH38716.1.
CCDSiCCDS47466.2. [Q8IXY8-2]
CCDS5074.1. [Q8IXY8-1]
CCDS69169.1. [Q8IXY8-3]
RefSeqiNP_001104768.2. NM_001111298.2. [Q8IXY8-2]
NP_001273289.1. NM_001286360.1. [Q8IXY8-3]
NP_001273290.1. NM_001286361.1.
NP_775943.1. NM_173672.4. [Q8IXY8-1]
UniGeneiHs.32234.

Genome annotation databases

EnsembliENST00000424445; ENSP00000407731; ENSG00000185250. [Q8IXY8-3]
ENST00000440797; ENSP00000392257; ENSG00000185250. [Q8IXY8-2]
ENST00000521072; ENSP00000427929; ENSG00000185250. [Q8IXY8-1]
GeneIDi285755.
KEGGihsa:285755.
UCSCiuc003ptg.4. human. [Q8IXY8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ363562 mRNA. Translation: ABC88651.1.
DQ423529 mRNA. Translation: ABD83948.1.
AL109947, AL359711 Genomic DNA. Translation: CAI23335.1.
AL359711, AL109947 Genomic DNA. Translation: CAI40695.1.
CH471051 Genomic DNA. Translation: EAW48347.1.
BC038716 mRNA. Translation: AAH38716.1.
CCDSiCCDS47466.2. [Q8IXY8-2]
CCDS5074.1. [Q8IXY8-1]
CCDS69169.1. [Q8IXY8-3]
RefSeqiNP_001104768.2. NM_001111298.2. [Q8IXY8-2]
NP_001273289.1. NM_001286360.1. [Q8IXY8-3]
NP_001273290.1. NM_001286361.1.
NP_775943.1. NM_173672.4. [Q8IXY8-1]
UniGeneiHs.32234.

3D structure databases

ProteinModelPortaliQ8IXY8.
SMRiQ8IXY8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8IXY8. 3 interactors.

PTM databases

iPTMnetiQ8IXY8.
PhosphoSitePlusiQ8IXY8.

Polymorphism and mutation databases

BioMutaiPPIL6.
DMDMi74762491.

Proteomic databases

PeptideAtlasiQ8IXY8.
PRIDEiQ8IXY8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000424445; ENSP00000407731; ENSG00000185250. [Q8IXY8-3]
ENST00000440797; ENSP00000392257; ENSG00000185250. [Q8IXY8-2]
ENST00000521072; ENSP00000427929; ENSG00000185250. [Q8IXY8-1]
GeneIDi285755.
KEGGihsa:285755.
UCSCiuc003ptg.4. human. [Q8IXY8-1]

Organism-specific databases

CTDi285755.
DisGeNETi285755.
GeneCardsiPPIL6.
HGNCiHGNC:21557. PPIL6.
HPAiHPA036717.
neXtProtiNX_Q8IXY8.
OpenTargetsiENSG00000185250.
PharmGKBiPA134939571.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000119072.
HOGENOMiHOG000065981.
HOVERGENiHBG056776.
InParanoidiQ8IXY8.
KOiK12739.
OMAiYRDENFS.
OrthoDBiEOG091G0BGL.
PhylomeDBiQ8IXY8.
TreeFamiTF351326.

Enzyme and pathway databases

BioCyciZFISH:HS11954-MONOMER.

Miscellaneous databases

ChiTaRSiPPIL6. human.
GenomeRNAii285755.
PROiQ8IXY8.

Gene expression databases

BgeeiENSG00000185250.
CleanExiHS_PPIL6.
ExpressionAtlasiQ8IXY8. baseline and differential.
GenevisibleiQ8IXY8. HS.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPIL6_HUMAN
AccessioniPrimary (citable) accession number: Q8IXY8
Secondary accession number(s): A9NIU0, A9NIU9, E7EX15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.