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Q8IXY8

- PPIL6_HUMAN

UniProt

Q8IXY8 - PPIL6_HUMAN

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Protein

Peptidyl-prolyl cis-trans isomerase-like 6

Gene
PPIL6
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

  1. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-KW

GO - Biological processi

  1. protein folding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase-like 6 (EC:5.2.1.8)
Short name:
PPIase
Alternative name(s):
Cyclophilin-like protein PPIL6
Rotamase PPIL6
Gene namesi
Name:PPIL6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:21557. PPIL6.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134939571.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 311311Peptidyl-prolyl cis-trans isomerase-like 6PRO_0000263755Add
BLAST

Proteomic databases

PaxDbiQ8IXY8.
PRIDEiQ8IXY8.

Expressioni

Gene expression databases

ArrayExpressiQ8IXY8.
BgeeiQ8IXY8.
CleanExiHS_PPIL6.
GenevestigatoriQ8IXY8.

Organism-specific databases

HPAiHPA036717.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000389292.

Structurei

3D structure databases

ProteinModelPortaliQ8IXY8.
SMRiQ8IXY8. Positions 145-308.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini145 – 308164PPIase cyclophilin-typeAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0652.
HOGENOMiHOG000065981.
HOVERGENiHBG056776.
InParanoidiQ8IXY8.
KOiK12739.
OMAiGMANKGR.
PhylomeDBiQ8IXY8.
TreeFamiTF351326.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IXY8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MARPQPCGPP HARCGSPSLP ERPLQVKVVG LFSCPNFQIA KSAAENLKNN    50
HPSKFEDPIL VPLQEFAWHQ YLQEKKRELK NETWEYSSSV ISFVNGQFLG 100
DALDLQKWAH EVWDIVDIKP SALYDALTED FSAKFLRDTK HDFVFLDICI 150
DSSPIGRLIF ELYCDVCPKT CKNFQVLCTG KAGFSQRGIR LHYKNSIFHR 200
IVQNGWIQGG DIVYGKGDNG ESIYGPTFED ENFSVPHNKR GVLGMANKGR 250
HSNGSQFYIT LQATPYLDRK FVAFGQLIEG TEVLKQLELV PTQNERPIHM 300
CRITDSGDPY A 311
Length:311
Mass (Da):35,228
Last modified:March 1, 2003 - v1
Checksum:i034E81BD5D077148
GO
Isoform 2 (identifier: Q8IXY8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     229-229: E → EELYGSLKRSVKRQKESRGVGKIEKYR

Note: No experimental confirmation available.

Show »
Length:337
Mass (Da):38,306
Checksum:i367792C3788259C5
GO
Isoform 3 (identifier: Q8IXY8-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     46-77: Missing.

Note: No experimental confirmation available. Gene prediction based on partial EST data.

Show »
Length:279
Mass (Da):31,298
Checksum:i990B706D9590BE4E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti110 – 1101H → R.
Corresponds to variant rs9398200 [ dbSNP | Ensembl ].
VAR_029620

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei46 – 7732Missing in isoform 3. VSP_055658Add
BLAST
Alternative sequencei229 – 2291E → EELYGSLKRSVKRQKESRGV GKIEKYR in isoform 2. VSP_043036

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ363562 mRNA. Translation: ABC88651.1.
DQ423529 mRNA. Translation: ABD83948.1.
AL109947, AL359711 Genomic DNA. Translation: CAI23335.1.
AL359711, AL109947 Genomic DNA. Translation: CAI40695.1.
CH471051 Genomic DNA. Translation: EAW48347.1.
BC038716 mRNA. Translation: AAH38716.1.
CCDSiCCDS47466.2. [Q8IXY8-2]
CCDS5074.1. [Q8IXY8-1]
RefSeqiNP_001104768.2. NM_001111298.2. [Q8IXY8-2]
NP_001273289.1. NM_001286360.1.
NP_001273290.1. NM_001286361.1.
NP_775943.1. NM_173672.4. [Q8IXY8-1]
UniGeneiHs.32234.

Genome annotation databases

EnsembliENST00000424445; ENSP00000407731; ENSG00000185250.
ENST00000440797; ENSP00000392257; ENSG00000185250. [Q8IXY8-2]
ENST00000521072; ENSP00000427929; ENSG00000185250. [Q8IXY8-1]
GeneIDi285755.
KEGGihsa:285755.
UCSCiuc003ptg.4. human. [Q8IXY8-1]
uc010kdp.3. human. [Q8IXY8-2]

Polymorphism databases

DMDMi74762491.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ363562 mRNA. Translation: ABC88651.1 .
DQ423529 mRNA. Translation: ABD83948.1 .
AL109947 , AL359711 Genomic DNA. Translation: CAI23335.1 .
AL359711 , AL109947 Genomic DNA. Translation: CAI40695.1 .
CH471051 Genomic DNA. Translation: EAW48347.1 .
BC038716 mRNA. Translation: AAH38716.1 .
CCDSi CCDS47466.2. [Q8IXY8-2 ]
CCDS5074.1. [Q8IXY8-1 ]
RefSeqi NP_001104768.2. NM_001111298.2. [Q8IXY8-2 ]
NP_001273289.1. NM_001286360.1.
NP_001273290.1. NM_001286361.1.
NP_775943.1. NM_173672.4. [Q8IXY8-1 ]
UniGenei Hs.32234.

3D structure databases

ProteinModelPortali Q8IXY8.
SMRi Q8IXY8. Positions 145-308.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000389292.

Polymorphism databases

DMDMi 74762491.

Proteomic databases

PaxDbi Q8IXY8.
PRIDEi Q8IXY8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000424445 ; ENSP00000407731 ; ENSG00000185250 .
ENST00000440797 ; ENSP00000392257 ; ENSG00000185250 . [Q8IXY8-2 ]
ENST00000521072 ; ENSP00000427929 ; ENSG00000185250 . [Q8IXY8-1 ]
GeneIDi 285755.
KEGGi hsa:285755.
UCSCi uc003ptg.4. human. [Q8IXY8-1 ]
uc010kdp.3. human. [Q8IXY8-2 ]

Organism-specific databases

CTDi 285755.
GeneCardsi GC06M109711.
HGNCi HGNC:21557. PPIL6.
HPAi HPA036717.
neXtProti NX_Q8IXY8.
PharmGKBi PA134939571.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0652.
HOGENOMi HOG000065981.
HOVERGENi HBG056776.
InParanoidi Q8IXY8.
KOi K12739.
OMAi GMANKGR.
PhylomeDBi Q8IXY8.
TreeFami TF351326.

Miscellaneous databases

ChiTaRSi PPIL6. human.
GenomeRNAii 285755.
NextBioi 95753.
PROi Q8IXY8.

Gene expression databases

ArrayExpressi Q8IXY8.
Bgeei Q8IXY8.
CleanExi HS_PPIL6.
Genevestigatori Q8IXY8.

Family and domain databases

Gene3Di 2.40.100.10. 1 hit.
InterProi IPR029000. Cyclophilin-like_dom.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view ]
Pfami PF00160. Pro_isomerase. 1 hit.
[Graphical view ]
PRINTSi PR00153. CSAPPISMRASE.
SUPFAMi SSF50891. SSF50891. 1 hit.
PROSITEi PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Chen S., Yu L.
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.

Entry informationi

Entry nameiPPIL6_HUMAN
AccessioniPrimary (citable) accession number: Q8IXY8
Secondary accession number(s): A9NIU0, A9NIU9, E7EX15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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