Q8IXY8 (PPIL6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptidyl-prolyl cis-trans isomerase-like 6
Short name=PPIase
EC=5.2.1.8

Alternative name(s):
Cyclophilin-like protein PPIL6
Rotamase PPIL6

Gene names

Name:

PPIL6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	311 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Sequence similarities	Belongs to the cyclophilin-type PPIase family. Contains 1 PPIase cyclophilin-type domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Molecular function	Isomerase Rotamase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein folding Inferred from electronic annotation. Source: UniProtKB-KW protein peptidyl-prolyl isomerization Inferred from electronic annotation. Source: GOC
Molecular_function	peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IXY8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8IXY8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     229-229: E → EELYGSLKRSVKRQKESRGVGKIEKYR

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 311	311	Peptidyl-prolyl cis-trans isomerase-like 6		PRO_0000263755
Regions
	Domain	145 – 308	164	PPIase cyclophilin-type
Natural variations
	Alternative sequence	229	1	E → EELYGSLKRSVKRQKESRGV GKIEKYR in isoform 2.		VSP_043036
	Natural variant	110	1	H → R. Corresponds to variant rs9398200 [ dbSNP | Ensembl ].		VAR_029620

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 034E81BD5D077148	FASTA	311	35,228
	10 20 30 40 50 60 MARPQPCGPP HARCGSPSLP ERPLQVKVVG LFSCPNFQIA KSAAENLKNN HPSKFEDPIL 70 80 90 100 110 120 VPLQEFAWHQ YLQEKKRELK NETWEYSSSV ISFVNGQFLG DALDLQKWAH EVWDIVDIKP 130 140 150 160 170 180 SALYDALTED FSAKFLRDTK HDFVFLDICI DSSPIGRLIF ELYCDVCPKT CKNFQVLCTG 190 200 210 220 230 240 KAGFSQRGIR LHYKNSIFHR IVQNGWIQGG DIVYGKGDNG ESIYGPTFED ENFSVPHNKR 250 260 270 280 290 300 GVLGMANKGR HSNGSQFYIT LQATPYLDRK FVAFGQLIEG TEVLKQLELV PTQNERPIHM 310 CRITDSGDPY A
	Isoform 2 [UniParc]. Checksum: 367792C3788259C5	FASTA	337	38,306
	10 20 30 40 50 60 MARPQPCGPP HARCGSPSLP ERPLQVKVVG LFSCPNFQIA KSAAENLKNN HPSKFEDPIL 70 80 90 100 110 120 VPLQEFAWHQ YLQEKKRELK NETWEYSSSV ISFVNGQFLG DALDLQKWAH EVWDIVDIKP 130 140 150 160 170 180 SALYDALTED FSAKFLRDTK HDFVFLDICI DSSPIGRLIF ELYCDVCPKT CKNFQVLCTG 190 200 210 220 230 240 KAGFSQRGIR LHYKNSIFHR IVQNGWIQGG DIVYGKGDNG ESIYGPTFEE LYGSLKRSVK 250 260 270 280 290 300 RQKESRGVGK IEKYRDENFS VPHNKRGVLG MANKGRHSNG SQFYITLQAT PYLDRKFVAF 310 320 330 GQLIEGTEVL KQLELVPTQN ERPIHMCRIT DSGDPYA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Chen S., Yu L. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[2]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ363562 mRNA. Translation: ABC88651.1. DQ423529 mRNA. Translation: ABD83948.1. AL109947, AL359711 Genomic DNA. Translation: CAI23335.1. AL359711, AL109947 Genomic DNA. Translation: CAI40695.1. CH471051 Genomic DNA. Translation: EAW48347.1. BC038716 mRNA. Translation: AAH38716.1.
IPI	IPI00217696. IPI00514884.
RefSeq	NP_001104768.2. NM_001111298.2. NP_775943.1. NM_173672.4.
UniGene	Hs.32234.
3D structure databases
ProteinModelPortal	Q8IXY8.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000389292.
Polymorphism databases
DMDM	74762491.
Proteomic databases
PaxDb	Q8IXY8.
PRIDE	Q8IXY8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000440797; ENSP00000392257; ENSG00000185250. ENST00000521072; ENSP00000427929; ENSG00000185250.
GeneID	285755.
KEGG	hsa:285755.
UCSC	uc003ptg.4. human. uc010kdp.3. human.
Organism-specific databases
CTD	285755.
GeneCards	GC06M109711.
HGNC	HGNC:21557. PPIL6.
HPA	HPA036717.
neXtProt	NX_Q8IXY8.
PharmGKB	PA134939571.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0652.
HOGENOM	HOG000065981.
HOVERGEN	HBG056776.
InParanoid	Q8IXY8.
KO	K12739.
OMA	GMANKGR.
OrthoDB	EOG41RPVF.
PhylomeDB	Q8IXY8.
Gene expression databases
ArrayExpress	Q8IXY8.
Bgee	Q8IXY8.
CleanEx	HS_PPIL6.
Genevestigator	Q8IXY8.
GermOnline	ENSG00000185250. Homo sapiens.
Family and domain databases
InterPro	IPR002130. Cyclophilin-like_PPIase_dom. [Graphical view]
Pfam	PF00160. Pro_isomerase. 1 hit. [Graphical view]
PRINTS	PR00153. CSAPPISMRASE.
SUPFAM	SSF50891. CSA_PPIase. 1 hit.
PROSITE	PS00170. CSA_PPIASE_1. False negative. PS50072. CSA_PPIASE_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PPIL6. human.
GenomeRNAi	285755.
NextBio	95753.

Entry information

Entry name

PPIL6_HUMAN

Accession

Primary (citable) accession number: Q8IXY8
Secondary accession number(s): A9NIU0, A9NIU9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	March 1, 2003
Last modified:	May 29, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.