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Protein

Solute carrier family 35 member F2

Gene

SLC35F2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Putative solute transporter.Curated

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.7.24.10. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member F2
Gene namesi
Name:SLC35F2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:23615. SLC35F2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21
Transmembranei108 – 126HelicalSequence analysisAdd BLAST19
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Transmembranei195 – 215HelicalSequence analysisAdd BLAST21
Transmembranei227 – 247HelicalSequence analysisAdd BLAST21
Transmembranei263 – 283HelicalSequence analysisAdd BLAST21
Transmembranei291 – 311HelicalSequence analysisAdd BLAST21
Transmembranei314 – 334HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi54733.
OpenTargetsiENSG00000110660.
PharmGKBiPA134945023.

Polymorphism and mutation databases

BioMutaiSLC35F2.
DMDMi74728243.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003073091 – 374Solute carrier family 35 member F2Add BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei5PhosphoserineCombined sources1
Modified residuei25PhosphoserineBy similarity1
Modified residuei371PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8IXU6.
MaxQBiQ8IXU6.
PaxDbiQ8IXU6.
PeptideAtlasiQ8IXU6.
PRIDEiQ8IXU6.

PTM databases

iPTMnetiQ8IXU6.
PhosphoSitePlusiQ8IXU6.

Expressioni

Gene expression databases

BgeeiENSG00000110660.
CleanExiHS_SLC35F2.
ExpressionAtlasiQ8IXU6. baseline and differential.
GenevisibleiQ8IXU6. HS.

Organism-specific databases

HPAiHPA048185.
HPA050695.

Interactioni

Protein-protein interaction databases

BioGridi120116. 12 interactors.
IntActiQ8IXU6. 1 interactor.
STRINGi9606.ENSP00000393571.

Structurei

3D structure databases

ProteinModelPortaliQ8IXU6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SLC35F solute transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2766. Eukaryota.
COG0697. LUCA.
GeneTreeiENSGT00390000015655.
HOGENOMiHOG000241333.
HOVERGENiHBG058983.
InParanoidiQ8IXU6.
KOiK15287.
OMAiFILHARY.
OrthoDBiEOG091G0O0G.
PhylomeDBiQ8IXU6.
TreeFamiTF313645.

Family and domain databases

InterProiIPR009262. SLC35_F1/F2/F6.
[Graphical view]
PfamiPF06027. SLC35F. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IXU6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEADSPAGPG APEPLAEGAA AEFSSLLRRI KGKLFTWNIL KTIALGQMLS
60 70 80 90 100
LCICGTAITS QYLAERYKVN TPMLQSFINY CLLFLIYTVM LAFRSGSDNL
110 120 130 140 150
LVILKRKWWK YILLGLADVE ANYVIVRAYQ YTTLTSVQLL DCFGIPVLMA
160 170 180 190 200
LSWFILHARY RVIHFIAVAV CLLGVGTMVG ADILAGREDN SGSDVLIGDI
210 220 230 240 250
LVLLGASLYA ISNVCEEYIV KKLSRQEFLG MVGLFGTIIS GIQLLIVEYK
260 270 280 290 300
DIASIHWDWK IALLFVAFAL CMFCLYSFMP LVIKVTSATS VNLGILTADL
310 320 330 340 350
YSLFVGLFLF GYKFSGLYIL SFTVIMVGFI LYCSTPTRTA EPAESSVPPV
360 370
TSIGIDNLGL KLEENLQETH SAVL
Length:374
Mass (Da):41,212
Last modified:March 1, 2003 - v1
Checksum:iADBF0F42F2DC7998
GO
Isoform 2 (identifier: Q8IXU6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     314-358: FSGLYILSFT...PVTSIGIDNL → DSTSCPSLSS...QSPALGLTTW
     360-374: Missing.

Note: No experimental confirmation available.
Show »
Length:357
Mass (Da):39,229
Checksum:i5C31F073D3E2E7C7
GO
Isoform 3 (identifier: Q8IXU6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: Missing.

Note: No experimental confirmation available.
Show »
Length:327
Mass (Da):36,305
Checksum:iD0737B61B9E583F8
GO

Sequence cautioni

The sequence CAA68226 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48M → T in BAB14394 (PubMed:14702039).Curated1
Sequence conflicti133T → A in CAA68226 (PubMed:9119394).Curated1
Sequence conflicti191S → SG in CAI46204 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0286991 – 47Missing in isoform 3. 1 PublicationAdd BLAST47
Alternative sequenceiVSP_028700314 – 358FSGLY…GIDNL → DSTSCPSLSSWWGLSCTAPP LLARPSRLKAACLQSPALGL TTW in isoform 2. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_028701360 – 374Missing in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023080 mRNA. Translation: BAB14394.1.
AK128062 mRNA. Translation: BAC87256.1.
BC039195 mRNA. Translation: AAH39195.1.
BC048302 mRNA. Translation: AAH48302.1.
AL833969 Transcribed RNA. Translation: CAI46204.1.
X99961 mRNA. Translation: CAA68226.1. Different initiation.
CCDSiCCDS41709.1. [Q8IXU6-1]
RefSeqiNP_059985.2. NM_017515.4. [Q8IXU6-1]
UniGeneiHs.524014.

Genome annotation databases

EnsembliENST00000375682; ENSP00000364834; ENSG00000110660. [Q8IXU6-3]
ENST00000525071; ENSP00000434307; ENSG00000110660. [Q8IXU6-2]
ENST00000525815; ENSP00000436785; ENSG00000110660. [Q8IXU6-1]
GeneIDi54733.
KEGGihsa:54733.
UCSCiuc001pjq.3. human. [Q8IXU6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023080 mRNA. Translation: BAB14394.1.
AK128062 mRNA. Translation: BAC87256.1.
BC039195 mRNA. Translation: AAH39195.1.
BC048302 mRNA. Translation: AAH48302.1.
AL833969 Transcribed RNA. Translation: CAI46204.1.
X99961 mRNA. Translation: CAA68226.1. Different initiation.
CCDSiCCDS41709.1. [Q8IXU6-1]
RefSeqiNP_059985.2. NM_017515.4. [Q8IXU6-1]
UniGeneiHs.524014.

3D structure databases

ProteinModelPortaliQ8IXU6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120116. 12 interactors.
IntActiQ8IXU6. 1 interactor.
STRINGi9606.ENSP00000393571.

Protein family/group databases

TCDBi2.A.7.24.10. the drug/metabolite transporter (dmt) superfamily.

PTM databases

iPTMnetiQ8IXU6.
PhosphoSitePlusiQ8IXU6.

Polymorphism and mutation databases

BioMutaiSLC35F2.
DMDMi74728243.

Proteomic databases

EPDiQ8IXU6.
MaxQBiQ8IXU6.
PaxDbiQ8IXU6.
PeptideAtlasiQ8IXU6.
PRIDEiQ8IXU6.

Protocols and materials databases

DNASUi54733.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375682; ENSP00000364834; ENSG00000110660. [Q8IXU6-3]
ENST00000525071; ENSP00000434307; ENSG00000110660. [Q8IXU6-2]
ENST00000525815; ENSP00000436785; ENSG00000110660. [Q8IXU6-1]
GeneIDi54733.
KEGGihsa:54733.
UCSCiuc001pjq.3. human. [Q8IXU6-1]

Organism-specific databases

CTDi54733.
DisGeNETi54733.
GeneCardsiSLC35F2.
H-InvDBHIX0010087.
HGNCiHGNC:23615. SLC35F2.
HPAiHPA048185.
HPA050695.
neXtProtiNX_Q8IXU6.
OpenTargetsiENSG00000110660.
PharmGKBiPA134945023.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2766. Eukaryota.
COG0697. LUCA.
GeneTreeiENSGT00390000015655.
HOGENOMiHOG000241333.
HOVERGENiHBG058983.
InParanoidiQ8IXU6.
KOiK15287.
OMAiFILHARY.
OrthoDBiEOG091G0O0G.
PhylomeDBiQ8IXU6.
TreeFamiTF313645.

Miscellaneous databases

ChiTaRSiSLC35F2. human.
GenomeRNAii54733.
PROiQ8IXU6.

Gene expression databases

BgeeiENSG00000110660.
CleanExiHS_SLC35F2.
ExpressionAtlasiQ8IXU6. baseline and differential.
GenevisibleiQ8IXU6. HS.

Family and domain databases

InterProiIPR009262. SLC35_F1/F2/F6.
[Graphical view]
PfamiPF06027. SLC35F. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS35F2_HUMAN
AccessioniPrimary (citable) accession number: Q8IXU6
Secondary accession number(s): Q14963
, Q5JPA8, Q6ZRQ3, Q9H947
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.