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Protein

Solute carrier family 35 member F2

Gene

SLC35F2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Putative solute transporter.Curated

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.7.24.10. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member F2
Gene namesi
Name:SLC35F2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:23615. SLC35F2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei39 – 5921HelicalSequence analysisAdd
BLAST
Transmembranei73 – 9321HelicalSequence analysisAdd
BLAST
Transmembranei108 – 12619HelicalSequence analysisAdd
BLAST
Transmembranei136 – 15621HelicalSequence analysisAdd
BLAST
Transmembranei165 – 18521HelicalSequence analysisAdd
BLAST
Transmembranei195 – 21521HelicalSequence analysisAdd
BLAST
Transmembranei227 – 24721HelicalSequence analysisAdd
BLAST
Transmembranei263 – 28321HelicalSequence analysisAdd
BLAST
Transmembranei291 – 31121HelicalSequence analysisAdd
BLAST
Transmembranei314 – 33421HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134945023.

Polymorphism and mutation databases

BioMutaiSLC35F2.
DMDMi74728243.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 374374Solute carrier family 35 member F2PRO_0000307309Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Modified residuei5 – 51PhosphoserineCombined sources
Modified residuei25 – 251PhosphoserineBy similarity
Modified residuei371 – 3711PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8IXU6.
MaxQBiQ8IXU6.
PaxDbiQ8IXU6.
PeptideAtlasiQ8IXU6.
PRIDEiQ8IXU6.

PTM databases

iPTMnetiQ8IXU6.
PhosphoSiteiQ8IXU6.

Expressioni

Gene expression databases

BgeeiENSG00000110660.
CleanExiHS_SLC35F2.
ExpressionAtlasiQ8IXU6. baseline and differential.
GenevisibleiQ8IXU6. HS.

Organism-specific databases

HPAiHPA048185.
HPA050695.

Interactioni

Protein-protein interaction databases

BioGridi120116. 12 interactions.
IntActiQ8IXU6. 1 interaction.
STRINGi9606.ENSP00000393571.

Structurei

3D structure databases

ProteinModelPortaliQ8IXU6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SLC35F solute transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2766. Eukaryota.
COG0697. LUCA.
GeneTreeiENSGT00390000015655.
HOGENOMiHOG000241333.
HOVERGENiHBG058983.
InParanoidiQ8IXU6.
KOiK15287.
OMAiFILHARY.
OrthoDBiEOG091G0O0G.
PhylomeDBiQ8IXU6.
TreeFamiTF313645.

Family and domain databases

InterProiIPR009262. SLC35_F1/F2/F6.
[Graphical view]
PfamiPF06027. SLC35F. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IXU6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEADSPAGPG APEPLAEGAA AEFSSLLRRI KGKLFTWNIL KTIALGQMLS
60 70 80 90 100
LCICGTAITS QYLAERYKVN TPMLQSFINY CLLFLIYTVM LAFRSGSDNL
110 120 130 140 150
LVILKRKWWK YILLGLADVE ANYVIVRAYQ YTTLTSVQLL DCFGIPVLMA
160 170 180 190 200
LSWFILHARY RVIHFIAVAV CLLGVGTMVG ADILAGREDN SGSDVLIGDI
210 220 230 240 250
LVLLGASLYA ISNVCEEYIV KKLSRQEFLG MVGLFGTIIS GIQLLIVEYK
260 270 280 290 300
DIASIHWDWK IALLFVAFAL CMFCLYSFMP LVIKVTSATS VNLGILTADL
310 320 330 340 350
YSLFVGLFLF GYKFSGLYIL SFTVIMVGFI LYCSTPTRTA EPAESSVPPV
360 370
TSIGIDNLGL KLEENLQETH SAVL
Length:374
Mass (Da):41,212
Last modified:March 1, 2003 - v1
Checksum:iADBF0F42F2DC7998
GO
Isoform 2 (identifier: Q8IXU6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     314-358: FSGLYILSFT...PVTSIGIDNL → DSTSCPSLSS...QSPALGLTTW
     360-374: Missing.

Note: No experimental confirmation available.
Show »
Length:357
Mass (Da):39,229
Checksum:i5C31F073D3E2E7C7
GO
Isoform 3 (identifier: Q8IXU6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: Missing.

Note: No experimental confirmation available.
Show »
Length:327
Mass (Da):36,305
Checksum:iD0737B61B9E583F8
GO

Sequence cautioni

The sequence CAA68226 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti48 – 481M → T in BAB14394 (PubMed:14702039).Curated
Sequence conflicti133 – 1331T → A in CAA68226 (PubMed:9119394).Curated
Sequence conflicti191 – 1911S → SG in CAI46204 (PubMed:17974005).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4747Missing in isoform 3. 1 PublicationVSP_028699Add
BLAST
Alternative sequencei314 – 35845FSGLY…GIDNL → DSTSCPSLSSWWGLSCTAPP LLARPSRLKAACLQSPALGL TTW in isoform 2. 1 PublicationVSP_028700Add
BLAST
Alternative sequencei360 – 37415Missing in isoform 2. 1 PublicationVSP_028701Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023080 mRNA. Translation: BAB14394.1.
AK128062 mRNA. Translation: BAC87256.1.
BC039195 mRNA. Translation: AAH39195.1.
BC048302 mRNA. Translation: AAH48302.1.
AL833969 Transcribed RNA. Translation: CAI46204.1.
X99961 mRNA. Translation: CAA68226.1. Different initiation.
CCDSiCCDS41709.1. [Q8IXU6-1]
RefSeqiNP_059985.2. NM_017515.4. [Q8IXU6-1]
UniGeneiHs.524014.

Genome annotation databases

EnsembliENST00000375682; ENSP00000364834; ENSG00000110660. [Q8IXU6-3]
ENST00000525071; ENSP00000434307; ENSG00000110660. [Q8IXU6-2]
ENST00000525815; ENSP00000436785; ENSG00000110660. [Q8IXU6-1]
GeneIDi54733.
KEGGihsa:54733.
UCSCiuc001pjq.3. human. [Q8IXU6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023080 mRNA. Translation: BAB14394.1.
AK128062 mRNA. Translation: BAC87256.1.
BC039195 mRNA. Translation: AAH39195.1.
BC048302 mRNA. Translation: AAH48302.1.
AL833969 Transcribed RNA. Translation: CAI46204.1.
X99961 mRNA. Translation: CAA68226.1. Different initiation.
CCDSiCCDS41709.1. [Q8IXU6-1]
RefSeqiNP_059985.2. NM_017515.4. [Q8IXU6-1]
UniGeneiHs.524014.

3D structure databases

ProteinModelPortaliQ8IXU6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120116. 12 interactions.
IntActiQ8IXU6. 1 interaction.
STRINGi9606.ENSP00000393571.

Protein family/group databases

TCDBi2.A.7.24.10. the drug/metabolite transporter (dmt) superfamily.

PTM databases

iPTMnetiQ8IXU6.
PhosphoSiteiQ8IXU6.

Polymorphism and mutation databases

BioMutaiSLC35F2.
DMDMi74728243.

Proteomic databases

EPDiQ8IXU6.
MaxQBiQ8IXU6.
PaxDbiQ8IXU6.
PeptideAtlasiQ8IXU6.
PRIDEiQ8IXU6.

Protocols and materials databases

DNASUi54733.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375682; ENSP00000364834; ENSG00000110660. [Q8IXU6-3]
ENST00000525071; ENSP00000434307; ENSG00000110660. [Q8IXU6-2]
ENST00000525815; ENSP00000436785; ENSG00000110660. [Q8IXU6-1]
GeneIDi54733.
KEGGihsa:54733.
UCSCiuc001pjq.3. human. [Q8IXU6-1]

Organism-specific databases

CTDi54733.
GeneCardsiSLC35F2.
H-InvDBHIX0010087.
HGNCiHGNC:23615. SLC35F2.
HPAiHPA048185.
HPA050695.
neXtProtiNX_Q8IXU6.
PharmGKBiPA134945023.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2766. Eukaryota.
COG0697. LUCA.
GeneTreeiENSGT00390000015655.
HOGENOMiHOG000241333.
HOVERGENiHBG058983.
InParanoidiQ8IXU6.
KOiK15287.
OMAiFILHARY.
OrthoDBiEOG091G0O0G.
PhylomeDBiQ8IXU6.
TreeFamiTF313645.

Miscellaneous databases

ChiTaRSiSLC35F2. human.
GenomeRNAii54733.
PROiQ8IXU6.

Gene expression databases

BgeeiENSG00000110660.
CleanExiHS_SLC35F2.
ExpressionAtlasiQ8IXU6. baseline and differential.
GenevisibleiQ8IXU6. HS.

Family and domain databases

InterProiIPR009262. SLC35_F1/F2/F6.
[Graphical view]
PfamiPF06027. SLC35F. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS35F2_HUMAN
AccessioniPrimary (citable) accession number: Q8IXU6
Secondary accession number(s): Q14963
, Q5JPA8, Q6ZRQ3, Q9H947
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2003
Last modified: September 7, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.