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Protein

DNA damage-induced apoptosis suppressor protein

Gene

DDIAS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be an anti-apoptotic protein involved in DNA repair or cell survival.1 Publication

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • cell cycle arrest Source: UniProtKB-KW
  • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: UniProtKB
  • regulation of DNA stability Source: UniProtKB

Keywordsi

Biological processApoptosis, Cell cycle, Growth arrest

Names & Taxonomyi

Protein namesi
Recommended name:
DNA damage-induced apoptosis suppressor protein
Alternative name(s):
Nitric oxide-inducible gene protein
Gene namesi
Name:DDIAS
Synonyms:C11orf82, NOXIN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000165490.12
HGNCiHGNC:26351 DDIAS
neXtProtiNX_Q8IXT1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi220042
OpenTargetsiENSG00000165490
PharmGKBiPA162377743

Polymorphism and mutation databases

BioMutaiNOXIN
DMDMi162416238

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003118381 – 998DNA damage-induced apoptosis suppressor proteinAdd BLAST998

Proteomic databases

MaxQBiQ8IXT1
PaxDbiQ8IXT1
PeptideAtlasiQ8IXT1
PRIDEiQ8IXT1

PTM databases

iPTMnetiQ8IXT1
PhosphoSitePlusiQ8IXT1

Expressioni

Tissue specificityi

Highly expressed in colorectal and lung cancer tissues.1 Publication

Inductioni

Induced by UV irradiation. Expression starts to increase in early S phase and is steady high until late S phase in both cancer and normal cells.1 Publication

Gene expression databases

BgeeiENSG00000165490
CleanExiHS_C11orf82
ExpressionAtlasiQ8IXT1 baseline and differential
GenevisibleiQ8IXT1 HS

Organism-specific databases

HPAiHPA038540
HPA038541

Interactioni

Protein-protein interaction databases

BioGridi12862013 interactors.
STRINGi9606.ENSP00000414687

Structurei

3D structure databases

ProteinModelPortaliQ8IXT1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi543 – 546Poly-Ser4

Phylogenomic databases

eggNOGiENOG410IGF0 Eukaryota
ENOG41122YI LUCA
GeneTreeiENSGT00390000014932
HOGENOMiHOG000057281
HOVERGENiHBG102847
InParanoidiQ8IXT1
OMAiDFVPCSQ
OrthoDBiEOG091G02XK
PhylomeDBiQ8IXT1
TreeFamiTF332740

Family and domain databases

InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR013955 Rep_factor-A_C
PfamiView protein in Pfam
PF08646 Rep_fac-A_C, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IXT1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNRRRKFLLA SVLALQNSSF IYPSCQKCFS RIILVSKRSN CPKCGSTGES
60 70 80 90 100
GNANYRYKLS LKVAESNKLF VITVFGSCLD TFFGLTATGL HRYIQDPNKI
110 120 130 140 150
PETLDNDTTQ NLLTKAVETC FVGQSFIFGV TNFENQPGQG SDASNFLQQC
160 170 180 190 200
SDHKRKAKAL VACQIVLPDP GIAGFTVIDY FHQLLQTFNF RKLQCDSQAP
210 220 230 240 250
NNHLLALDHS NSDLSSIYTS DSTSDFFKSC SKDTFSKFWQ PSLEFTCIVS
260 270 280 290 300
QLTDNDDFSA SEQSKAFGTL QQNRKSISIA EATGSSSCHD PIQDSWSLVS
310 320 330 340 350
YMDKKSTAEK LGKELGLQAK ELSAVHSSHH EIGVNDSNLF SLEMREPLES
360 370 380 390 400
SNTKSFHSAV EIKNRSQHEL PCFQHHGIDT PTSLQKRSAC CPPSLLRLEE
410 420 430 440 450
TASSSQDGDP QIWDDLPFSE SLNKFLAVLE SEIAVTQADV SSRKHHVDND
460 470 480 490 500
IDKFHADHSR LSVTPQRTTG ALHTPPIALR SSQVIVKANC SKDDFLFNCK
510 520 530 540 550
GNLSPSVEKE SQPDNKVEAV SVNHNGRDMS EYFLPNPYLS ALSSSSKDLE
560 570 580 590 600
TIVTLKKTIR ISPHRESDHS SLNNKYLNGC GEISVSEMNE KLTTLCYRKY
610 620 630 640 650
NDVSDLCKLE NKQYCRWSKN QDDSFTICRK LTYPLETLCN SPNRSTNTLK
660 670 680 690 700
EMPWGHINNN VTQSYSIGYE GSYDASADLF DDIAKEMDIA TEITKKSQDI
710 720 730 740 750
LLKWGTSLAE SHPSESDFSL RSLSEDFIQP SQKLSLQSLS DSRHSRTCSP
760 770 780 790 800
TPHFQSDSEY NFENSQDFVP CSQSTPISGF HQTRIHGINR AFKKPVFYSD
810 820 830 840 850
LDGNYEKIRI FPENDKQQAS PSCPKNIKTP SQKIRSPIVS GVSQPDVFNH
860 870 880 890 900
YPFAECHETD SDEWVPPTTQ KIFPSDMLGF QGIGLGKCLA AYHFPDQQEL
910 920 930 940 950
PRKKLKHIRQ GTNKGLIKKK LKNMLAAVVT KKKTHKYNCK SSGWISKCPD
960 970 980 990
IQVLAAPQLH PILGPDSCSE VKCCLPFSEK GPPSVCETRS AWSPELFS
Length:998
Mass (Da):111,616
Last modified:December 4, 2007 - v2
Checksum:iC1BAEB360CD04559
GO
Isoform 2 (identifier: Q8IXT1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     171-178: GIAGFTVI → ATQDAKTK
     179-998: Missing.

Show »
Length:178
Mass (Da):19,688
Checksum:i9FCE06E4D9A71413
GO

Sequence cautioni

The sequence BAB14764 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti153H → R in BAB71685 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037326217I → T1 PublicationCorresponds to variant dbSNP:rs17853911Ensembl.1
Natural variantiVAR_037327460R → S2 PublicationsCorresponds to variant dbSNP:rs7947780Ensembl.1
Natural variantiVAR_037328757D → N. Corresponds to variant dbSNP:rs35711622Ensembl.1
Natural variantiVAR_037329795P → R. Corresponds to variant dbSNP:rs11826199Ensembl.1
Natural variantiVAR_037330842V → I1 PublicationCorresponds to variant dbSNP:rs7130899Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_029606171 – 178GIAGFTVI → ATQDAKTK in isoform 2. 1 Publication8
Alternative sequenceiVSP_029607179 – 998Missing in isoform 2. 1 PublicationAdd BLAST820

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023998 mRNA Translation: BAB14764.1 Different initiation.
AK058145 mRNA Translation: BAB71685.1
AP001646 Genomic DNA No translation available.
BC039268 mRNA Translation: AAH39268.1
CCDSiCCDS8263.1 [Q8IXT1-1]
RefSeqiNP_659455.3, NM_145018.3 [Q8IXT1-1]
XP_011543137.1, XM_011544835.1 [Q8IXT1-1]
XP_011543138.1, XM_011544836.2 [Q8IXT1-1]
UniGeneiHs.165607

Genome annotation databases

EnsembliENST00000329143; ENSP00000329930; ENSG00000165490 [Q8IXT1-1]
ENST00000525361; ENSP00000435424; ENSG00000165490 [Q8IXT1-2]
ENST00000533655; ENSP00000435421; ENSG00000165490 [Q8IXT1-1]
GeneIDi220042
KEGGihsa:220042
UCSCiuc001ozt.4 human [Q8IXT1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDDIAS_HUMAN
AccessioniPrimary (citable) accession number: Q8IXT1
Secondary accession number(s): Q96LK6, Q9H856
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: February 28, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome