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Protein

DNA damage-induced apoptosis suppressor protein

Gene

DDIAS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be an anti-apoptotic protein involved in DNA repair or cell survival.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, Cell cycle, Growth arrest

Names & Taxonomyi

Protein namesi
Recommended name:
DNA damage-induced apoptosis suppressor protein
Alternative name(s):
Nitric oxide-inducible gene protein
Gene namesi
Name:DDIAS
Synonyms:C11orf82, NOXIN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:26351. DDIAS.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Accumulates in the nucleus in response to stress.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162377743.

Polymorphism and mutation databases

BioMutaiNOXIN.
DMDMi162416238.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 998998DNA damage-induced apoptosis suppressor proteinPRO_0000311838Add
BLAST

Proteomic databases

EPDiQ8IXT1.
MaxQBiQ8IXT1.
PaxDbiQ8IXT1.
PRIDEiQ8IXT1.

PTM databases

iPTMnetiQ8IXT1.
PhosphoSiteiQ8IXT1.

Expressioni

Tissue specificityi

Highly expressed in colorectal and lung cancer tissues.1 Publication

Inductioni

Induced by UV irradiation. Expression starts to increase in early S phase and is steady high until late S phase in both cancer and normal cells.1 Publication

Gene expression databases

BgeeiENSG00000165490.
CleanExiHS_C11orf82.
ExpressionAtlasiQ8IXT1. baseline and differential.
GenevisibleiQ8IXT1. HS.

Organism-specific databases

HPAiHPA038540.
HPA038541.

Interactioni

Protein-protein interaction databases

BioGridi128620. 1 interaction.
STRINGi9606.ENSP00000414687.

Structurei

3D structure databases

ProteinModelPortaliQ8IXT1.
SMRiQ8IXT1. Positions 8-132.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi543 – 5464Poly-Ser

Phylogenomic databases

eggNOGiENOG410IGF0. Eukaryota.
ENOG41122YI. LUCA.
GeneTreeiENSGT00390000014932.
HOGENOMiHOG000057281.
HOVERGENiHBG102847.
InParanoidiQ8IXT1.
OMAiPCSQSTP.
OrthoDBiEOG091G02XK.
PhylomeDBiQ8IXT1.
TreeFamiTF332740.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR013955. Rep_factor-A_C.
[Graphical view]
PfamiPF08646. Rep_fac-A_C. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IXT1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNRRRKFLLA SVLALQNSSF IYPSCQKCFS RIILVSKRSN CPKCGSTGES
60 70 80 90 100
GNANYRYKLS LKVAESNKLF VITVFGSCLD TFFGLTATGL HRYIQDPNKI
110 120 130 140 150
PETLDNDTTQ NLLTKAVETC FVGQSFIFGV TNFENQPGQG SDASNFLQQC
160 170 180 190 200
SDHKRKAKAL VACQIVLPDP GIAGFTVIDY FHQLLQTFNF RKLQCDSQAP
210 220 230 240 250
NNHLLALDHS NSDLSSIYTS DSTSDFFKSC SKDTFSKFWQ PSLEFTCIVS
260 270 280 290 300
QLTDNDDFSA SEQSKAFGTL QQNRKSISIA EATGSSSCHD PIQDSWSLVS
310 320 330 340 350
YMDKKSTAEK LGKELGLQAK ELSAVHSSHH EIGVNDSNLF SLEMREPLES
360 370 380 390 400
SNTKSFHSAV EIKNRSQHEL PCFQHHGIDT PTSLQKRSAC CPPSLLRLEE
410 420 430 440 450
TASSSQDGDP QIWDDLPFSE SLNKFLAVLE SEIAVTQADV SSRKHHVDND
460 470 480 490 500
IDKFHADHSR LSVTPQRTTG ALHTPPIALR SSQVIVKANC SKDDFLFNCK
510 520 530 540 550
GNLSPSVEKE SQPDNKVEAV SVNHNGRDMS EYFLPNPYLS ALSSSSKDLE
560 570 580 590 600
TIVTLKKTIR ISPHRESDHS SLNNKYLNGC GEISVSEMNE KLTTLCYRKY
610 620 630 640 650
NDVSDLCKLE NKQYCRWSKN QDDSFTICRK LTYPLETLCN SPNRSTNTLK
660 670 680 690 700
EMPWGHINNN VTQSYSIGYE GSYDASADLF DDIAKEMDIA TEITKKSQDI
710 720 730 740 750
LLKWGTSLAE SHPSESDFSL RSLSEDFIQP SQKLSLQSLS DSRHSRTCSP
760 770 780 790 800
TPHFQSDSEY NFENSQDFVP CSQSTPISGF HQTRIHGINR AFKKPVFYSD
810 820 830 840 850
LDGNYEKIRI FPENDKQQAS PSCPKNIKTP SQKIRSPIVS GVSQPDVFNH
860 870 880 890 900
YPFAECHETD SDEWVPPTTQ KIFPSDMLGF QGIGLGKCLA AYHFPDQQEL
910 920 930 940 950
PRKKLKHIRQ GTNKGLIKKK LKNMLAAVVT KKKTHKYNCK SSGWISKCPD
960 970 980 990
IQVLAAPQLH PILGPDSCSE VKCCLPFSEK GPPSVCETRS AWSPELFS
Length:998
Mass (Da):111,616
Last modified:December 4, 2007 - v2
Checksum:iC1BAEB360CD04559
GO
Isoform 2 (identifier: Q8IXT1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     171-178: GIAGFTVI → ATQDAKTK
     179-998: Missing.

Show »
Length:178
Mass (Da):19,688
Checksum:i9FCE06E4D9A71413
GO

Sequence cautioni

The sequence BAB14764 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti153 – 1531H → R in BAB71685 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti217 – 2171I → T.1 Publication
Corresponds to variant rs17853911 [ dbSNP | Ensembl ].
VAR_037326
Natural varianti460 – 4601R → S.2 Publications
Corresponds to variant rs7947780 [ dbSNP | Ensembl ].
VAR_037327
Natural varianti757 – 7571D → N.
Corresponds to variant rs35711622 [ dbSNP | Ensembl ].
VAR_037328
Natural varianti795 – 7951P → R.
Corresponds to variant rs11826199 [ dbSNP | Ensembl ].
VAR_037329
Natural varianti842 – 8421V → I.1 Publication
Corresponds to variant rs7130899 [ dbSNP | Ensembl ].
VAR_037330

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei171 – 1788GIAGFTVI → ATQDAKTK in isoform 2. 1 PublicationVSP_029606
Alternative sequencei179 – 998820Missing in isoform 2. 1 PublicationVSP_029607Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023998 mRNA. Translation: BAB14764.1. Different initiation.
AK058145 mRNA. Translation: BAB71685.1.
AP001646 Genomic DNA. No translation available.
BC039268 mRNA. Translation: AAH39268.1.
CCDSiCCDS8263.1. [Q8IXT1-1]
RefSeqiNP_659455.3. NM_145018.3. [Q8IXT1-1]
XP_011543137.1. XM_011544835.1. [Q8IXT1-1]
XP_011543138.1. XM_011544836.2. [Q8IXT1-1]
UniGeneiHs.165607.

Genome annotation databases

EnsembliENST00000329143; ENSP00000329930; ENSG00000165490. [Q8IXT1-1]
ENST00000525361; ENSP00000435424; ENSG00000165490. [Q8IXT1-2]
ENST00000533655; ENSP00000435421; ENSG00000165490. [Q8IXT1-1]
GeneIDi220042.
KEGGihsa:220042.
UCSCiuc001ozt.4. human. [Q8IXT1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023998 mRNA. Translation: BAB14764.1. Different initiation.
AK058145 mRNA. Translation: BAB71685.1.
AP001646 Genomic DNA. No translation available.
BC039268 mRNA. Translation: AAH39268.1.
CCDSiCCDS8263.1. [Q8IXT1-1]
RefSeqiNP_659455.3. NM_145018.3. [Q8IXT1-1]
XP_011543137.1. XM_011544835.1. [Q8IXT1-1]
XP_011543138.1. XM_011544836.2. [Q8IXT1-1]
UniGeneiHs.165607.

3D structure databases

ProteinModelPortaliQ8IXT1.
SMRiQ8IXT1. Positions 8-132.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128620. 1 interaction.
STRINGi9606.ENSP00000414687.

PTM databases

iPTMnetiQ8IXT1.
PhosphoSiteiQ8IXT1.

Polymorphism and mutation databases

BioMutaiNOXIN.
DMDMi162416238.

Proteomic databases

EPDiQ8IXT1.
MaxQBiQ8IXT1.
PaxDbiQ8IXT1.
PRIDEiQ8IXT1.

Protocols and materials databases

DNASUi220042.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329143; ENSP00000329930; ENSG00000165490. [Q8IXT1-1]
ENST00000525361; ENSP00000435424; ENSG00000165490. [Q8IXT1-2]
ENST00000533655; ENSP00000435421; ENSG00000165490. [Q8IXT1-1]
GeneIDi220042.
KEGGihsa:220042.
UCSCiuc001ozt.4. human. [Q8IXT1-1]

Organism-specific databases

CTDi220042.
GeneCardsiDDIAS.
HGNCiHGNC:26351. DDIAS.
HPAiHPA038540.
HPA038541.
neXtProtiNX_Q8IXT1.
PharmGKBiPA162377743.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGF0. Eukaryota.
ENOG41122YI. LUCA.
GeneTreeiENSGT00390000014932.
HOGENOMiHOG000057281.
HOVERGENiHBG102847.
InParanoidiQ8IXT1.
OMAiPCSQSTP.
OrthoDBiEOG091G02XK.
PhylomeDBiQ8IXT1.
TreeFamiTF332740.

Miscellaneous databases

ChiTaRSiC11orf82. human.
GenomeRNAii220042.
PROiQ8IXT1.

Gene expression databases

BgeeiENSG00000165490.
CleanExiHS_C11orf82.
ExpressionAtlasiQ8IXT1. baseline and differential.
GenevisibleiQ8IXT1. HS.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR013955. Rep_factor-A_C.
[Graphical view]
PfamiPF08646. Rep_fac-A_C. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDDIAS_HUMAN
AccessioniPrimary (citable) accession number: Q8IXT1
Secondary accession number(s): Q96LK6, Q9H856
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: September 7, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.