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Protein

Protein FAM126B

Gene

FAM126B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM126B
Gene namesi
Name:FAM126B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000155744.9
HGNCiHGNC:28593 FAM126B
neXtProtiNX_Q8IXS8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi285172
OpenTargetsiENSG00000155744
PharmGKBiPA162385879

Polymorphism and mutation databases

BioMutaiFAM126B
DMDMi74728235

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002780941 – 530Protein FAM126BAdd BLAST530

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei30PhosphothreonineCombined sources1
Modified residuei306PhosphothreonineCombined sources1
Modified residuei321PhosphoserineCombined sources1
Modified residuei341PhosphoserineBy similarity1
Modified residuei430PhosphoserineCombined sources1
Modified residuei442PhosphoserineCombined sources1
Modified residuei444PhosphoserineCombined sources1
Modified residuei491PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IXS8
MaxQBiQ8IXS8
PaxDbiQ8IXS8
PeptideAtlasiQ8IXS8
PRIDEiQ8IXS8

PTM databases

iPTMnetiQ8IXS8
PhosphoSitePlusiQ8IXS8

Expressioni

Gene expression databases

BgeeiENSG00000155744
CleanExiHS_FAM126B
ExpressionAtlasiQ8IXS8 baseline and differential
GenevisibleiQ8IXS8 HS

Organism-specific databases

HPAiHPA036166
HPA036167
HPA067307

Interactioni

Subunit structurei

Component of a phosphatidylinositol 4-kinase (PI4K) complex, composed of PI4KA, EFR3 (EFR3A or EFR3B), TTC7 (TTC7A or TTC7B) and FAM126 (FAM126A or FAM126B).1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi130030, 6 interactors
IntActiQ8IXS8, 5 interactors

Structurei

3D structure databases

ProteinModelPortaliQ8IXS8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM126 family.Curated

Phylogenomic databases

eggNOGiKOG4688 Eukaryota
ENOG410ZXRB LUCA
GeneTreeiENSGT00390000011295
HOGENOMiHOG000252938
HOVERGENiHBG057270
InParanoidiQ8IXS8
KOiK21844
OMAiHRWRRED
OrthoDBiEOG091G03RR
PhylomeDBiQ8IXS8
TreeFamiTF317153

Family and domain databases

InterProiView protein in InterPro
IPR018619 Hyccin
PANTHERiPTHR31220 PTHR31220, 1 hit
PfamiView protein in Pfam
PF09790 Hyccin, 1 hit

Sequencei

Sequence statusi: Complete.

Q8IXS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGTDRCVVE EWLSEFKALP DTQITSYAAT LHRKKTLVPA LYKVIQDSNN
60 70 80 90 100
ELLEPVCHQL FELYRSSEVR LKRFTLQFLP ELMWVYLRLT VSRDRQSNGC
110 120 130 140 150
IEALLLGIYN LEIADKDGNN KVLSFTIPSL SKPSIYHEPS TIGSMALTEG
160 170 180 190 200
ALCQHDLIRV VYSDLHPQRE TFTAQNRFEV LSFLMLCYNS AIVYMPASSY
210 220 230 240 250
QSLCRMGSRV CVSGFPRQHE KHWKELCGRI VLDPEFMVQL LTGVYYAMYN
260 270 280 290 300
GQWDLGQEVL DDIIYRAQLE LFSQPLLVAN AMKNSLPFDA PDSTQEGQKV
310 320 330 340 350
LKVEVTPTVP RISRTAITTA SIRRHRWRRE GAEGVNGGEE SVNLNDADEG
360 370 380 390 400
FSSGASLSSQ PIGTKPSSSS QRGSLRKVAT GRSAKDKETA SAIKSSESPR
410 420 430 440 450
DSVVRKQYVQ QPTDLSVDSV ELTPMKKHLS LPAGQVVPKI NSLSLIRTAS
460 470 480 490 500
ASSSKSFDYV NGSQASTSIG VGTEGGTNLA ANNANRYSTV SLQEDRLGQA
510 520 530
GEGKELLSPG APLTKQSRSP SFNMQLISQV
Length:530
Mass (Da):58,647
Last modified:March 1, 2003 - v1
Checksum:iFD448E6AAB39D5AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315104 mRNA Translation: BAG37564.1
AL833403 mRNA No translation available.
AC005037 Genomic DNA Translation: AAY14726.1
AC007272 Genomic DNA Translation: AAX88971.1
CH471063 Genomic DNA Translation: EAW70232.1
BC039295 mRNA Translation: AAH39295.1
CCDSiCCDS2335.1
RefSeqiNP_001308547.1, NM_001321618.1
NP_001308548.1, NM_001321619.1
NP_001308550.1, NM_001321621.1
NP_001308551.1, NM_001321622.1
NP_001308556.1, NM_001321627.1
NP_776183.1, NM_173822.4
XP_016859370.1, XM_017003881.1
UniGeneiHs.24701

Genome annotation databases

EnsembliENST00000418596; ENSP00000393667; ENSG00000155744
GeneIDi285172
KEGGihsa:285172
UCSCiuc002uws.4 human

Similar proteinsi

Entry informationi

Entry nameiF126B_HUMAN
AccessioniPrimary (citable) accession number: Q8IXS8
Secondary accession number(s): B2RCG7, Q4ZG87, Q53TX6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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