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Protein

Protein FAM126B

Gene

FAM126B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM126B
Gene namesi
Name:FAM126B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:28593. FAM126B.

Subcellular locationi

  • Cytoplasmcytosol By similarity
  • Cell membrane By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162385879.

Polymorphism and mutation databases

BioMutaiFAM126B.
DMDMi74728235.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 530530Protein FAM126BPRO_0000278094Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei306 – 3061PhosphothreonineBy similarity
Modified residuei321 – 3211PhosphoserineCombined sources
Modified residuei341 – 3411PhosphoserineBy similarity
Modified residuei430 – 4301PhosphoserineBy similarity
Modified residuei442 – 4421PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8IXS8.
MaxQBiQ8IXS8.
PaxDbiQ8IXS8.
PRIDEiQ8IXS8.

PTM databases

iPTMnetiQ8IXS8.
PhosphoSiteiQ8IXS8.

Expressioni

Gene expression databases

BgeeiQ8IXS8.
CleanExiHS_FAM126B.
ExpressionAtlasiQ8IXS8. baseline and differential.
GenevisibleiQ8IXS8. HS.

Organism-specific databases

HPAiHPA036166.
HPA036167.

Interactioni

Subunit structurei

Component of a phosphatidylinositol 4-kinase (PI4K) complex, composed of PI4KA, EFR3 (EFR3A or EFR3B), TTC7 (TTC7A or TTC7B) and FAM126 (FAM126A or FAM126B).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
GOLGA2Q083793EBI-8787606,EBI-618309
TRIM27P143733EBI-8787606,EBI-719493

Protein-protein interaction databases

BioGridi130030. 3 interactions.
IntActiQ8IXS8. 3 interactions.
STRINGi9606.ENSP00000393667.

Structurei

3D structure databases

ProteinModelPortaliQ8IXS8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM126 family.Curated

Phylogenomic databases

eggNOGiKOG4688. Eukaryota.
ENOG410ZXRB. LUCA.
GeneTreeiENSGT00390000011295.
HOGENOMiHOG000252938.
HOVERGENiHBG057270.
InParanoidiQ8IXS8.
OMAiHRWRRED.
PhylomeDBiQ8IXS8.
TreeFamiTF317153.

Family and domain databases

InterProiIPR018619. Hyccin.
[Graphical view]
PfamiPF09790. Hyccin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IXS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGTDRCVVE EWLSEFKALP DTQITSYAAT LHRKKTLVPA LYKVIQDSNN
60 70 80 90 100
ELLEPVCHQL FELYRSSEVR LKRFTLQFLP ELMWVYLRLT VSRDRQSNGC
110 120 130 140 150
IEALLLGIYN LEIADKDGNN KVLSFTIPSL SKPSIYHEPS TIGSMALTEG
160 170 180 190 200
ALCQHDLIRV VYSDLHPQRE TFTAQNRFEV LSFLMLCYNS AIVYMPASSY
210 220 230 240 250
QSLCRMGSRV CVSGFPRQHE KHWKELCGRI VLDPEFMVQL LTGVYYAMYN
260 270 280 290 300
GQWDLGQEVL DDIIYRAQLE LFSQPLLVAN AMKNSLPFDA PDSTQEGQKV
310 320 330 340 350
LKVEVTPTVP RISRTAITTA SIRRHRWRRE GAEGVNGGEE SVNLNDADEG
360 370 380 390 400
FSSGASLSSQ PIGTKPSSSS QRGSLRKVAT GRSAKDKETA SAIKSSESPR
410 420 430 440 450
DSVVRKQYVQ QPTDLSVDSV ELTPMKKHLS LPAGQVVPKI NSLSLIRTAS
460 470 480 490 500
ASSSKSFDYV NGSQASTSIG VGTEGGTNLA ANNANRYSTV SLQEDRLGQA
510 520 530
GEGKELLSPG APLTKQSRSP SFNMQLISQV
Length:530
Mass (Da):58,647
Last modified:March 1, 2003 - v1
Checksum:iFD448E6AAB39D5AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315104 mRNA. Translation: BAG37564.1.
AL833403 mRNA. No translation available.
AC005037 Genomic DNA. Translation: AAY14726.1.
AC007272 Genomic DNA. Translation: AAX88971.1.
CH471063 Genomic DNA. Translation: EAW70232.1.
BC039295 mRNA. Translation: AAH39295.1.
CCDSiCCDS2335.1.
RefSeqiNP_776183.1. NM_173822.3.
UniGeneiHs.24701.

Genome annotation databases

EnsembliENST00000418596; ENSP00000393667; ENSG00000155744.
GeneIDi285172.
KEGGihsa:285172.
UCSCiuc002uws.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315104 mRNA. Translation: BAG37564.1.
AL833403 mRNA. No translation available.
AC005037 Genomic DNA. Translation: AAY14726.1.
AC007272 Genomic DNA. Translation: AAX88971.1.
CH471063 Genomic DNA. Translation: EAW70232.1.
BC039295 mRNA. Translation: AAH39295.1.
CCDSiCCDS2335.1.
RefSeqiNP_776183.1. NM_173822.3.
UniGeneiHs.24701.

3D structure databases

ProteinModelPortaliQ8IXS8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130030. 3 interactions.
IntActiQ8IXS8. 3 interactions.
STRINGi9606.ENSP00000393667.

PTM databases

iPTMnetiQ8IXS8.
PhosphoSiteiQ8IXS8.

Polymorphism and mutation databases

BioMutaiFAM126B.
DMDMi74728235.

Proteomic databases

EPDiQ8IXS8.
MaxQBiQ8IXS8.
PaxDbiQ8IXS8.
PRIDEiQ8IXS8.

Protocols and materials databases

DNASUi285172.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000418596; ENSP00000393667; ENSG00000155744.
GeneIDi285172.
KEGGihsa:285172.
UCSCiuc002uws.4. human.

Organism-specific databases

CTDi285172.
GeneCardsiFAM126B.
H-InvDBHIX0002732.
HGNCiHGNC:28593. FAM126B.
HPAiHPA036166.
HPA036167.
neXtProtiNX_Q8IXS8.
PharmGKBiPA162385879.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4688. Eukaryota.
ENOG410ZXRB. LUCA.
GeneTreeiENSGT00390000011295.
HOGENOMiHOG000252938.
HOVERGENiHBG057270.
InParanoidiQ8IXS8.
OMAiHRWRRED.
PhylomeDBiQ8IXS8.
TreeFamiTF317153.

Miscellaneous databases

ChiTaRSiFAM126B. human.
GenomeRNAii285172.
NextBioi95308.
PROiQ8IXS8.

Gene expression databases

BgeeiQ8IXS8.
CleanExiHS_FAM126B.
ExpressionAtlasiQ8IXS8. baseline and differential.
GenevisibleiQ8IXS8. HS.

Family and domain databases

InterProiIPR018619. Hyccin.
[Graphical view]
PfamiPF09790. Hyccin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fetal brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Adipose tissue.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-321, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  7. Cited for: IDENTIFICATION IN THE PI4K COMPLEX.

Entry informationi

Entry nameiF126B_HUMAN
AccessioniPrimary (citable) accession number: Q8IXS8
Secondary accession number(s): B2RCG7, Q4ZG87, Q53TX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: March 1, 2003
Last modified: April 13, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.