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Protein

Paralemmin-2

Gene

PALM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Paralemmin-2
Gene namesi
Name:PALM2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000243444.7
HGNCiHGNC:15845 PALM2
neXtProtiNX_Q8IXS6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi114299
OpenTargetsiENSG00000243444
PharmGKBiPA32924

Polymorphism and mutation databases

BioMutaiPALM2
DMDMi124015203

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002734461 – 376Paralemmin-2Add BLAST376
PropeptideiPRO_0000396693377 – 379Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei318PhosphoserineBy similarity1
Modified residuei358PhosphoserineCombined sources1
Lipidationi373S-palmitoyl cysteineSequence analysis1
Lipidationi375S-palmitoyl cysteineSequence analysis1
Modified residuei376Cysteine methyl esterSequence analysis1
Lipidationi376S-farnesyl cysteineSequence analysis1

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Phosphoprotein, Prenylation

Proteomic databases

EPDiQ8IXS6
PeptideAtlasiQ8IXS6
PRIDEiQ8IXS6

PTM databases

iPTMnetiQ8IXS6
PhosphoSitePlusiQ8IXS6
SwissPalmiQ8IXS6

Expressioni

Tissue specificityi

Expressed in infantile heart and muscle, and fibroblasts.1 Publication

Gene expression databases

BgeeiENSG00000243444
ExpressionAtlasiQ8IXS6 baseline and differential
GenevisibleiQ8IXS6 HS

Organism-specific databases

HPAiHPA074153

Interactioni

Protein-protein interaction databases

BioGridi125312, 18 interactors
IntActiQ8IXS6, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ8IXS6
SMRiQ8IXS6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili2 – 37Sequence analysisAdd BLAST36
Coiled coili69 – 110Sequence analysisAdd BLAST42

Sequence similaritiesi

Belongs to the paralemmin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG9A Eukaryota
ENOG410ZMFZ LUCA
GeneTreeiENSGT00530000063206
HOGENOMiHOG000043092
HOVERGENiHBG007431
InParanoidiQ8IXS6
KOiK16519
OrthoDBiEOG091G0713
PhylomeDBiQ8IXS6
TreeFamiTF105402

Family and domain databases

InterProiView protein in InterPro
IPR004965 Paralemmin
PfamiView protein in Pfam
PF03285 Paralemmin, 1 hit

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IXS6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEMAEAELHK ERLQAIAEKR KRQTEIEGKR QQLDEQILLL QHSKSKVLRE
60 70 80 90 100
KWLLQGIPAG TAEEEEARRR QSEEDEFRVK QLEDNIQRLE QEIQTLESEE
110 120 130 140 150
SQISAKEQII LEKLKETEKS FKDFQKGFSS TDGAVYAMEI NVEKDKQTGE
160 170 180 190 200
TKILSTSTIG PEGVHQKGVK VYDDGTKVVY EVRSGGTVVE NGVHKLSTKD
210 220 230 240 250
VEELIQKAGQ SSLGGGHVSE RTVIADGSLS HPKEHMLCKE AKLEMVHKSR
260 270 280 290 300
KDHSSGNPGQ QAQAPSAAGP EANLDQPVTM IFMGYQNIED EEETKKVLGY
310 320 330 340 350
DETIKAELVL IDEDDEKSLR EKTVTDVSTI DGNAAELVSG RPVSDTTEPS
360 370
SPEGKEESLA TEPAPGTQKK KRCQCCVVM
Length:379
Mass (Da):42,185
Last modified:January 23, 2007 - v3
Checksum:i5400EDC39ABE7298
GO
Isoform 2 (identifier: Q8IXS6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: Missing.
     133-133: G → GDAVNYISSQLPDLPILCSRTAEPSPGQDGTSRAA

Note: No experimental confirmation available.
Show »
Length:411
Mass (Da):45,438
Checksum:i9FFBBBAF9C6D9806
GO
Isoform 3 (identifier: Q9Y2D5-4) [UniParc]FASTAAdd to basket
Also known as: PALM2-AKAP2
The sequence of this isoform can be found in the external entry Q9Y2D5.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Based on a naturally occurring readthrough transcript which produces a PALM2-AKAP2 fusion protein.
Length:1,103
Mass (Da):122,071
GO
Isoform 4 (identifier: Q9Y2D5-6) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q9Y2D5.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Based on a naturally occurring readthrough transcript which produces a PALM2-AKAP2 fusion protein.
Length:1,090
Mass (Da):120,630
GO

Sequence cautioni

The sequence AAH39306 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti63 – 72Missing in BAC04472 (PubMed:14702039).Curated10
Sequence conflicti102Q → R in AAH39306 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0225661 – 2Missing in isoform 2. 1 Publication2
Alternative sequenceiVSP_022567133G → GDAVNYISSQLPDLPILCSR TAEPSPGQDGTSRAA in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ312216 mRNA Translation: CAC59693.1
AK095003 mRNA Translation: BAC04472.1
AL135789
, AL158829, AL353806, AL627225 Genomic DNA Translation: CAH73567.1
AL158829
, AL135789, AL353806, AL627225 Genomic DNA Translation: CAI13895.1
AL158829, AL353806, AL627225 Genomic DNA Translation: CAI13897.1
AL353806
, AL135789, AL158829, AL627225 Genomic DNA Translation: CAI12433.1
AL353806, AL158829, AL627225 Genomic DNA Translation: CAI12435.1
AL627225
, AL135789, AL158829, AL353806 Genomic DNA Translation: CAI10810.1
AL627225, AL158829, AL353806 Genomic DNA Translation: CAI10812.1
BC039306 mRNA Translation: AAH39306.2 Different initiation.
CCDSiCCDS35099.1 [Q8IXS6-1]
CCDS48002.2 [Q8IXS6-2]
RefSeqiNP_001032370.1, NM_001037293.2 [Q8IXS6-1]
NP_443749.5, NM_053016.5 [Q8IXS6-2]
UniGeneiHs.591908

Genome annotation databases

EnsembliENST00000314527; ENSP00000323805; ENSG00000243444 [Q8IXS6-2]
ENST00000374531; ENSP00000363656; ENSG00000243444 [Q8IXS6-1]
GeneIDi114299
KEGGihsa:114299
UCSCiuc004beg.4 human [Q8IXS6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPALM2_HUMAN
AccessioniPrimary (citable) accession number: Q8IXS6
Secondary accession number(s): A9Z1X9, Q8N9D5, Q96DU1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 106 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health