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Protein

Paralemmin-2

Gene

PALM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Paralemmin-2
Gene namesi
Name:PALM2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:15845. PALM2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32924.

Polymorphism and mutation databases

BioMutaiPALM2.
DMDMi124015203.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376Paralemmin-2PRO_0000273446Add
BLAST
Propeptidei377 – 3793Removed in mature formSequence analysisPRO_0000396693

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei318 – 3181PhosphoserineBy similarity
Modified residuei358 – 3581PhosphoserineCombined sources
Lipidationi373 – 3731S-palmitoyl cysteineSequence analysis
Lipidationi375 – 3751S-palmitoyl cysteineSequence analysis
Modified residuei376 – 3761Cysteine methyl esterSequence analysis
Lipidationi376 – 3761S-farnesyl cysteineSequence analysis

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Phosphoprotein, Prenylation

Proteomic databases

EPDiQ8IXS6.
MaxQBiQ8IXS6.
PaxDbiQ8IXS6.
PeptideAtlasiQ8IXS6.
PRIDEiQ8IXS6.

PTM databases

iPTMnetiQ8IXS6.
PhosphoSiteiQ8IXS6.
SwissPalmiQ8IXS6.

Expressioni

Tissue specificityi

Expressed in infantile heart and muscle, and fibroblasts.1 Publication

Gene expression databases

BgeeiENSG00000243444.
ExpressionAtlasiQ8IXS6. baseline and differential.
GenevisibleiQ8IXS6. HS.

Organism-specific databases

HPAiCAB021350.

Interactioni

Protein-protein interaction databases

BioGridi125312. 15 interactions.
STRINGi9606.ENSP00000451476.

Structurei

3D structure databases

ProteinModelPortaliQ8IXS6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili2 – 3736Sequence analysisAdd
BLAST
Coiled coili69 – 11042Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the paralemmin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG9A. Eukaryota.
ENOG410ZMFZ. LUCA.
GeneTreeiENSGT00530000063206.
HOGENOMiHOG000043092.
HOVERGENiHBG007431.
InParanoidiQ8IXS6.
KOiK16519.
OrthoDBiEOG091G0713.
PhylomeDBiQ8IXS6.
TreeFamiTF105402.

Family and domain databases

InterProiIPR004965. Paralemmin.
[Graphical view]
PfamiPF03285. Paralemmin. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IXS6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEMAEAELHK ERLQAIAEKR KRQTEIEGKR QQLDEQILLL QHSKSKVLRE
60 70 80 90 100
KWLLQGIPAG TAEEEEARRR QSEEDEFRVK QLEDNIQRLE QEIQTLESEE
110 120 130 140 150
SQISAKEQII LEKLKETEKS FKDFQKGFSS TDGAVYAMEI NVEKDKQTGE
160 170 180 190 200
TKILSTSTIG PEGVHQKGVK VYDDGTKVVY EVRSGGTVVE NGVHKLSTKD
210 220 230 240 250
VEELIQKAGQ SSLGGGHVSE RTVIADGSLS HPKEHMLCKE AKLEMVHKSR
260 270 280 290 300
KDHSSGNPGQ QAQAPSAAGP EANLDQPVTM IFMGYQNIED EEETKKVLGY
310 320 330 340 350
DETIKAELVL IDEDDEKSLR EKTVTDVSTI DGNAAELVSG RPVSDTTEPS
360 370
SPEGKEESLA TEPAPGTQKK KRCQCCVVM
Length:379
Mass (Da):42,185
Last modified:January 23, 2007 - v3
Checksum:i5400EDC39ABE7298
GO
Isoform 2 (identifier: Q8IXS6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: Missing.
     133-133: G → GDAVNYISSQLPDLPILCSRTAEPSPGQDGTSRAA

Note: No experimental confirmation available.
Show »
Length:411
Mass (Da):45,438
Checksum:i9FFBBBAF9C6D9806
GO
Isoform 3 (identifier: Q9Y2D5-4) [UniParc]FASTAAdd to basket
Also known as: PALM2-AKAP2
The sequence of this isoform can be found in the external entry Q9Y2D5.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Based on a naturally occurring readthrough transcript which produces a PALM2-AKAP2 fusion protein.
Length:1,103
Mass (Da):122,071
GO
Isoform 4 (identifier: Q9Y2D5-6) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q9Y2D5.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Based on a naturally occurring readthrough transcript which produces a PALM2-AKAP2 fusion protein.
Length:1,090
Mass (Da):120,630
GO

Sequence cautioni

The sequence AAH39306 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti63 – 7210Missing in BAC04472 (PubMed:14702039).Curated
Sequence conflicti102 – 1021Q → R in AAH39306 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 22Missing in isoform 2. 1 PublicationVSP_022566
Alternative sequencei133 – 1331G → GDAVNYISSQLPDLPILCSR TAEPSPGQDGTSRAA in isoform 2. 1 PublicationVSP_022567

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ312216 mRNA. Translation: CAC59693.1.
AK095003 mRNA. Translation: BAC04472.1.
AL135789
, AL158829, AL353806, AL627225 Genomic DNA. Translation: CAH73567.1.
AL158829
, AL135789, AL353806, AL627225 Genomic DNA. Translation: CAI13895.1.
AL158829, AL353806, AL627225 Genomic DNA. Translation: CAI13897.1.
AL353806
, AL135789, AL158829, AL627225 Genomic DNA. Translation: CAI12433.1.
AL353806, AL158829, AL627225 Genomic DNA. Translation: CAI12435.1.
AL627225
, AL135789, AL158829, AL353806 Genomic DNA. Translation: CAI10810.1.
AL627225, AL158829, AL353806 Genomic DNA. Translation: CAI10812.1.
BC039306 mRNA. Translation: AAH39306.2. Different initiation.
CCDSiCCDS35099.1. [Q8IXS6-1]
CCDS48002.2. [Q8IXS6-2]
RefSeqiNP_001032370.1. NM_001037293.2. [Q8IXS6-1]
NP_443749.5. NM_053016.5. [Q8IXS6-2]
UniGeneiHs.591908.

Genome annotation databases

EnsembliENST00000314527; ENSP00000323805; ENSG00000243444. [Q8IXS6-2]
ENST00000374531; ENSP00000363656; ENSG00000243444. [Q8IXS6-1]
GeneIDi114299.
KEGGihsa:114299.
UCSCiuc004beg.4. human. [Q8IXS6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ312216 mRNA. Translation: CAC59693.1.
AK095003 mRNA. Translation: BAC04472.1.
AL135789
, AL158829, AL353806, AL627225 Genomic DNA. Translation: CAH73567.1.
AL158829
, AL135789, AL353806, AL627225 Genomic DNA. Translation: CAI13895.1.
AL158829, AL353806, AL627225 Genomic DNA. Translation: CAI13897.1.
AL353806
, AL135789, AL158829, AL627225 Genomic DNA. Translation: CAI12433.1.
AL353806, AL158829, AL627225 Genomic DNA. Translation: CAI12435.1.
AL627225
, AL135789, AL158829, AL353806 Genomic DNA. Translation: CAI10810.1.
AL627225, AL158829, AL353806 Genomic DNA. Translation: CAI10812.1.
BC039306 mRNA. Translation: AAH39306.2. Different initiation.
CCDSiCCDS35099.1. [Q8IXS6-1]
CCDS48002.2. [Q8IXS6-2]
RefSeqiNP_001032370.1. NM_001037293.2. [Q8IXS6-1]
NP_443749.5. NM_053016.5. [Q8IXS6-2]
UniGeneiHs.591908.

3D structure databases

ProteinModelPortaliQ8IXS6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125312. 15 interactions.
STRINGi9606.ENSP00000451476.

PTM databases

iPTMnetiQ8IXS6.
PhosphoSiteiQ8IXS6.
SwissPalmiQ8IXS6.

Polymorphism and mutation databases

BioMutaiPALM2.
DMDMi124015203.

Proteomic databases

EPDiQ8IXS6.
MaxQBiQ8IXS6.
PaxDbiQ8IXS6.
PeptideAtlasiQ8IXS6.
PRIDEiQ8IXS6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314527; ENSP00000323805; ENSG00000243444. [Q8IXS6-2]
ENST00000374531; ENSP00000363656; ENSG00000243444. [Q8IXS6-1]
GeneIDi114299.
KEGGihsa:114299.
UCSCiuc004beg.4. human. [Q8IXS6-1]

Organism-specific databases

CTDi114299.
GeneCardsiPALM2.
HGNCiHGNC:15845. PALM2.
HPAiCAB021350.
neXtProtiNX_Q8IXS6.
PharmGKBiPA32924.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG9A. Eukaryota.
ENOG410ZMFZ. LUCA.
GeneTreeiENSGT00530000063206.
HOGENOMiHOG000043092.
HOVERGENiHBG007431.
InParanoidiQ8IXS6.
KOiK16519.
OrthoDBiEOG091G0713.
PhylomeDBiQ8IXS6.
TreeFamiTF105402.

Miscellaneous databases

ChiTaRSiPALM2. human.
GenomeRNAii114299.

Gene expression databases

BgeeiENSG00000243444.
ExpressionAtlasiQ8IXS6. baseline and differential.
GenevisibleiQ8IXS6. HS.

Family and domain databases

InterProiIPR004965. Paralemmin.
[Graphical view]
PfamiPF03285. Paralemmin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPALM2_HUMAN
AccessioniPrimary (citable) accession number: Q8IXS6
Secondary accession number(s): A9Z1X9, Q8N9D5, Q96DU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 96 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.