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Q8IXR9 (CL056_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uncharacterized protein C12orf56
Gene names
Name:C12orf56
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length622 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8IXR9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8IXR9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     164-323: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 622622Uncharacterized protein C12orf56
PRO_0000320926

Natural variations

Alternative sequence164 – 323160Missing in isoform 2.
VSP_031745

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 6, 2013. Version 3.
Checksum: 35E0DC70E2A6A354

FASTA62271,046
        10         20         30         40         50         60 
MASPLPSGFP ARRNSRLDVF LRRHLPPEVY DAVRAYEPCI VVSNSENHIL KYVVLSDRLV 

        70         80         90        100        110        120 
YLTENPPKSI RRVVALRDVV AIDLIDDYPE FLSSPDREIS QHIRIIYSST VLKKECKKSN 

       130        140        150        160        170        180 
SVRKFLFPFH HTKANNKKVK EEKNGLAFWR SKESRSLKES PLRDQQESST PSKDSTLCPR 

       190        200        210        220        230        240 
PGLKKLSLHG QGAFRPLPSP SRRSSQSAPT TGKAVSEPSC TTNTKEPQGL PDHNSISEIP 

       250        260        270        280        290        300 
FKCNGNGNEF YLGNSLLDSP SQSNSNLEKK ESELHLYVIS TTSSIFLHLK SSWNNYIIKA 

       310        320        330        340        350        360 
TLLQDPFYAS EFSPAIGSQK PYRSEEKIKH FSQLKSELFL KDNSLRRILS LLMELKVAAQ 

       370        380        390        400        410        420 
KNFILKRLFW KTSDLFYFIV NKLHEYLPES RDKNALQNQS QRVDELVACI EIIQTLVLMF 

       430        440        450        460        470        480 
RETETESSRL NTLAAKKGAL FNLLVILISE PQIPKSCPVF DIQLVADSAL VRMSFDAELQ 

       490        500        510        520        530        540 
KLILEYTNTA TALLYEILLV FQQGNLGLGS TKFAISWIMS FLQSCPPIIT FVASIVKQVV 

       550        560        570        580        590        600 
RGLSASFQLL SPCQAVLLYQ QFYILKSCLR HSRTLAEYIR NNYREEFRYF IHMPALQKRL 

       610        620 
PLCYPITQPT IQLFHEVLKL VE 

« Hide

Isoform 2 [UniParc].

Checksum: 725527381B2D26AF
Show »

FASTA46253,562

References

[1]"The finished DNA sequence of human chromosome 12."
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. expand/collapse author list , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 19-622 (ISOFORM 2).
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC012158 Genomic DNA. No translation available.
AC135279 Genomic DNA. No translation available.
BC039369 mRNA. Translation: AAH39369.1.
RefSeqNP_001093146.1. NM_001099676.2.
NP_001164104.1. NM_001170633.1.
UniGeneHs.535190.

3D structure databases

ProteinModelPortalQ8IXR9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000329698.

PTM databases

PhosphoSiteQ8IXR9.

Polymorphism databases

DMDM449081294.

Proteomic databases

PaxDbQ8IXR9.
PRIDEQ8IXR9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000333722; ENSP00000329698; ENSG00000185306. [Q8IXR9-2]
ENST00000543942; ENSP00000446101; ENSG00000185306. [Q8IXR9-1]
GeneID115749.
KEGGhsa:115749.
UCSCuc001ssa.4. human. [Q8IXR9-2]

Organism-specific databases

CTD115749.
GeneCardsGC12M064661.
HGNCHGNC:26967. C12orf56.
HPAHPA056986.
neXtProtNX_Q8IXR9.
PharmGKBPA143485385.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG47866.
HOGENOMHOG000057286.
HOVERGENHBG107709.
TreeFamTF331535.

Gene expression databases

ArrayExpressQ8IXR9.
BgeeQ8IXR9.
CleanExHS_C12orf56.
GenevestigatorQ8IXR9.

Family and domain databases

InterProIPR027878. DUF4551.
[Graphical view]
PfamPF15087. DUF4551. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi115749.
NextBio79666.

Entry information

Entry nameCL056_HUMAN
AccessionPrimary (citable) accession number: Q8IXR9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 6, 2013
Last modified: April 16, 2014
This is version 64 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM