Q8IXR9 (CL056_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized protein C12orf56

Gene names

Name:

C12orf56

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	622 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8IXR9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8IXR9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     164-323: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 622	622	Uncharacterized protein C12orf56		PRO_0000320926
Natural variations
	Alternative sequence	164 – 323	160	Missing in isoform 2.		VSP_031745

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 6, 2013. Version 3. Checksum: 35E0DC70E2A6A354	FASTA	622	71,046
	10 20 30 40 50 60 MASPLPSGFP ARRNSRLDVF LRRHLPPEVY DAVRAYEPCI VVSNSENHIL KYVVLSDRLV 70 80 90 100 110 120 YLTENPPKSI RRVVALRDVV AIDLIDDYPE FLSSPDREIS QHIRIIYSST VLKKECKKSN 130 140 150 160 170 180 SVRKFLFPFH HTKANNKKVK EEKNGLAFWR SKESRSLKES PLRDQQESST PSKDSTLCPR 190 200 210 220 230 240 PGLKKLSLHG QGAFRPLPSP SRRSSQSAPT TGKAVSEPSC TTNTKEPQGL PDHNSISEIP 250 260 270 280 290 300 FKCNGNGNEF YLGNSLLDSP SQSNSNLEKK ESELHLYVIS TTSSIFLHLK SSWNNYIIKA 310 320 330 340 350 360 TLLQDPFYAS EFSPAIGSQK PYRSEEKIKH FSQLKSELFL KDNSLRRILS LLMELKVAAQ 370 380 390 400 410 420 KNFILKRLFW KTSDLFYFIV NKLHEYLPES RDKNALQNQS QRVDELVACI EIIQTLVLMF 430 440 450 460 470 480 RETETESSRL NTLAAKKGAL FNLLVILISE PQIPKSCPVF DIQLVADSAL VRMSFDAELQ 490 500 510 520 530 540 KLILEYTNTA TALLYEILLV FQQGNLGLGS TKFAISWIMS FLQSCPPIIT FVASIVKQVV 550 560 570 580 590 600 RGLSASFQLL SPCQAVLLYQ QFYILKSCLR HSRTLAEYIR NNYREEFRYF IHMPALQKRL 610 620 PLCYPITQPT IQLFHEVLKL VE
	Isoform 2 [UniParc]. Checksum: 725527381B2D26AF	FASTA	462	53,562
	10 20 30 40 50 60 MASPLPSGFP ARRNSRLDVF LRRHLPPEVY DAVRAYEPCI VVSNSENHIL KYVVLSDRLV 70 80 90 100 110 120 YLTENPPKSI RRVVALRDVV AIDLIDDYPE FLSSPDREIS QHIRIIYSST VLKKECKKSN 130 140 150 160 170 180 SVRKFLFPFH HTKANNKKVK EEKNGLAFWR SKESRSLKES PLRSEEKIKH FSQLKSELFL 190 200 210 220 230 240 KDNSLRRILS LLMELKVAAQ KNFILKRLFW KTSDLFYFIV NKLHEYLPES RDKNALQNQS 250 260 270 280 290 300 QRVDELVACI EIIQTLVLMF RETETESSRL NTLAAKKGAL FNLLVILISE PQIPKSCPVF 310 320 330 340 350 360 DIQLVADSAL VRMSFDAELQ KLILEYTNTA TALLYEILLV FQQGNLGLGS TKFAISWIMS 370 380 390 400 410 420 FLQSCPPIIT FVASIVKQVV RGLSASFQLL SPCQAVLLYQ QFYILKSCLR HSRTLAEYIR 430 440 450 460 NNYREEFRYF IHMPALQKRL PLCYPITQPT IQLFHEVLKL VE

References

[1]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 19-622 (ISOFORM 2). Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC012158 Genomic DNA. No translation available. AC135279 Genomic DNA. No translation available. BC039369 mRNA. Translation: AAH39369.1.
IPI	IPI00217602. IPI00885072.
RefSeq	NP_001093146.1. NM_001099676.2. NP_001164104.1. NM_001170633.1.
UniGene	Hs.535190.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000329698.
PTM databases
PhosphoSite	Q8IXR9.
Polymorphism databases
DMDM	182637567.
Proteomic databases
PaxDb	Q8IXR9.
PRIDE	Q8IXR9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000333722; ENSP00000329698; ENSG00000185306.
GeneID	115749.
KEGG	hsa:115749.
UCSC	uc001ssa.4. human.
Organism-specific databases
CTD	115749.
GeneCards	GC12M064661.
HGNC	HGNC:26967. C12orf56.
HPA	HPA056986.
neXtProt	NX_Q8IXR9.
PharmGKB	PA143485385.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG47866.
HOGENOM	HOG000057286.
HOVERGEN	HBG107709.
OrthoDB	EOG4H464C.
Gene expression databases
ArrayExpress	Q8IXR9.
Bgee	Q8IXR9.
CleanEx	HS_C12orf56.
Genevestigator	Q8IXR9.
Family and domain databases
ProtoNet	Search...
Other
GenomeRNAi	115749.
NextBio	79666.

Entry information

Entry name

CL056_HUMAN

Accession

Primary (citable) accession number: Q8IXR9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	February 6, 2013
Last modified:	May 1, 2013
This is version 58 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.