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Q8IXR9

- CL056_HUMAN

UniProt

Q8IXR9 - CL056_HUMAN

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Protein

Uncharacterized protein C12orf56

Gene

C12orf56

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C12orf56
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:26967. C12orf56.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485385.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 622622Uncharacterized protein C12orf56PRO_0000320926Add
BLAST

Proteomic databases

MaxQBiQ8IXR9.
PaxDbiQ8IXR9.
PRIDEiQ8IXR9.

PTM databases

PhosphoSiteiQ8IXR9.

Expressioni

Gene expression databases

BgeeiQ8IXR9.
CleanExiHS_C12orf56.
ExpressionAtlasiQ8IXR9. baseline and differential.
GenevestigatoriQ8IXR9.

Organism-specific databases

HPAiHPA056986.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000329698.

Structurei

3D structure databases

ProteinModelPortaliQ8IXR9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG47866.
GeneTreeiENSGT00390000018424.
HOGENOMiHOG000057286.
HOVERGENiHBG107709.
InParanoidiQ8IXR9.
OMAiNEFYLGN.
TreeFamiTF331535.

Family and domain databases

InterProiIPR027878. DUF4551.
[Graphical view]
PfamiPF15087. DUF4551. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IXR9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASPLPSGFP ARRNSRLDVF LRRHLPPEVY DAVRAYEPCI VVSNSENHIL
60 70 80 90 100
KYVVLSDRLV YLTENPPKSI RRVVALRDVV AIDLIDDYPE FLSSPDREIS
110 120 130 140 150
QHIRIIYSST VLKKECKKSN SVRKFLFPFH HTKANNKKVK EEKNGLAFWR
160 170 180 190 200
SKESRSLKES PLRDQQESST PSKDSTLCPR PGLKKLSLHG QGAFRPLPSP
210 220 230 240 250
SRRSSQSAPT TGKAVSEPSC TTNTKEPQGL PDHNSISEIP FKCNGNGNEF
260 270 280 290 300
YLGNSLLDSP SQSNSNLEKK ESELHLYVIS TTSSIFLHLK SSWNNYIIKA
310 320 330 340 350
TLLQDPFYAS EFSPAIGSQK PYRSEEKIKH FSQLKSELFL KDNSLRRILS
360 370 380 390 400
LLMELKVAAQ KNFILKRLFW KTSDLFYFIV NKLHEYLPES RDKNALQNQS
410 420 430 440 450
QRVDELVACI EIIQTLVLMF RETETESSRL NTLAAKKGAL FNLLVILISE
460 470 480 490 500
PQIPKSCPVF DIQLVADSAL VRMSFDAELQ KLILEYTNTA TALLYEILLV
510 520 530 540 550
FQQGNLGLGS TKFAISWIMS FLQSCPPIIT FVASIVKQVV RGLSASFQLL
560 570 580 590 600
SPCQAVLLYQ QFYILKSCLR HSRTLAEYIR NNYREEFRYF IHMPALQKRL
610 620
PLCYPITQPT IQLFHEVLKL VE
Length:622
Mass (Da):71,046
Last modified:February 6, 2013 - v3
Checksum:i35E0DC70E2A6A354
GO
Isoform 2 (identifier: Q8IXR9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     164-323: Missing.

Note: No experimental confirmation available.

Show »
Length:462
Mass (Da):53,562
Checksum:i725527381B2D26AF
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei164 – 323160Missing in isoform 2. 1 PublicationVSP_031745Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC012158 Genomic DNA. No translation available.
AC135279 Genomic DNA. No translation available.
BC039369 mRNA. Translation: AAH39369.1.
CCDSiCCDS44935.1. [Q8IXR9-2]
CCDS61182.1. [Q8IXR9-1]
RefSeqiNP_001093146.1. NM_001099676.2. [Q8IXR9-2]
NP_001164104.1. NM_001170633.1. [Q8IXR9-1]
UniGeneiHs.535190.

Genome annotation databases

EnsembliENST00000333722; ENSP00000329698; ENSG00000185306. [Q8IXR9-2]
ENST00000543942; ENSP00000446101; ENSG00000185306. [Q8IXR9-1]
GeneIDi115749.
KEGGihsa:115749.
UCSCiuc001ssa.4. human. [Q8IXR9-2]

Polymorphism databases

DMDMi449081294.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC012158 Genomic DNA. No translation available.
AC135279 Genomic DNA. No translation available.
BC039369 mRNA. Translation: AAH39369.1 .
CCDSi CCDS44935.1. [Q8IXR9-2 ]
CCDS61182.1. [Q8IXR9-1 ]
RefSeqi NP_001093146.1. NM_001099676.2. [Q8IXR9-2 ]
NP_001164104.1. NM_001170633.1. [Q8IXR9-1 ]
UniGenei Hs.535190.

3D structure databases

ProteinModelPortali Q8IXR9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000329698.

PTM databases

PhosphoSitei Q8IXR9.

Polymorphism databases

DMDMi 449081294.

Proteomic databases

MaxQBi Q8IXR9.
PaxDbi Q8IXR9.
PRIDEi Q8IXR9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000333722 ; ENSP00000329698 ; ENSG00000185306 . [Q8IXR9-2 ]
ENST00000543942 ; ENSP00000446101 ; ENSG00000185306 . [Q8IXR9-1 ]
GeneIDi 115749.
KEGGi hsa:115749.
UCSCi uc001ssa.4. human. [Q8IXR9-2 ]

Organism-specific databases

CTDi 115749.
GeneCardsi GC12M064661.
HGNCi HGNC:26967. C12orf56.
HPAi HPA056986.
neXtProti NX_Q8IXR9.
PharmGKBi PA143485385.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG47866.
GeneTreei ENSGT00390000018424.
HOGENOMi HOG000057286.
HOVERGENi HBG107709.
InParanoidi Q8IXR9.
OMAi NEFYLGN.
TreeFami TF331535.

Miscellaneous databases

GenomeRNAii 115749.
NextBioi 79666.

Gene expression databases

Bgeei Q8IXR9.
CleanExi HS_C12orf56.
ExpressionAtlasi Q8IXR9. baseline and differential.
Genevestigatori Q8IXR9.

Family and domain databases

InterProi IPR027878. DUF4551.
[Graphical view ]
Pfami PF15087. DUF4551. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 19-622 (ISOFORM 2).
    Tissue: Testis.

Entry informationi

Entry nameiCL056_HUMAN
AccessioniPrimary (citable) accession number: Q8IXR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 6, 2013
Last modified: October 29, 2014
This is version 68 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM

External Data

Dasty 3