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Protein

Protein FAM178B

Gene

FAM178B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM178B
Gene namesi
Name:FAM178B
ORF Names:HSPC234
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:28036. FAM178B.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162387456.

Polymorphism and mutation databases

BioMutaiFAM178B.
DMDMi172045738.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 827827Protein FAM178BPRO_0000320193Add
BLAST

Proteomic databases

PaxDbiQ8IXR5.
PRIDEiQ8IXR5.

PTM databases

iPTMnetiQ8IXR5.
PhosphoSiteiQ8IXR5.

Expressioni

Gene expression databases

BgeeiQ8IXR5.
CleanExiHS_FAM178B.
GenevisibleiQ8IXR5. HS.

Organism-specific databases

HPAiHPA042516.

Interactioni

Protein-protein interaction databases

BioGridi119409. 1 interaction.
IntActiQ8IXR5. 2 interactions.
MINTiMINT-1400307.
STRINGi9606.ENSP00000429896.

Structurei

3D structure databases

ProteinModelPortaliQ8IXR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM178 family.Curated

Phylogenomic databases

eggNOGiENOG410IIBY. Eukaryota.
ENOG410YMV9. LUCA.
GeneTreeiENSGT00530000064017.
HOGENOMiHOG000050235.
HOVERGENiHBG107879.
InParanoidiQ8IXR5.
OMAiYVNSLDY.
PhylomeDBiQ8IXR5.
TreeFamiTF332216.

Family and domain databases

InterProiIPR026161. FAM178.
[Graphical view]
PANTHERiPTHR16046. PTHR16046. 1 hit.
PfamiPF14816. FAM178. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IXR5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAHEREILKG MYEELKEKSH KPDVELIQHR AWRIDMVSTE LESFRKASYI
60 70 80 90 100
ESGPEEFYQR FKKCFSATHI FISIKGKDSQ NTAHGYLILN RTLHQQLKIK
110 120 130 140 150
NPFLAPSSEA VRIPATLPHP GALPFPPYVA KASSDELLNL QKPLQSALGF
160 170 180 190 200
VILRSSQNWN SKNRQRWSRT KAGQMSHGLQ MAGPQETVLA LPLREGVQAA
210 220 230 240 250
ATVPILLYNL EDGLSDHPLD QGPRCPARRP CSPASAPAPT SPKKPKIQAP
260 270 280 290 300
GETFPTDWSP PPVEFLNPRV LQASREAPAQ RWVGVVGPQG LRRLAGELPE
310 320 330 340 350
ELEQEHLDLD PKRGLALPEK LFWNTSGLSQ QAAAPEFSWG GSGSYFNNLD
360 370 380 390 400
YLLQEKREQA LEQERERLLL QECLNLNSLD LDEEEVPLTP EHRMLVEKYS
410 420 430 440 450
VSLQTIPPVH PGETVFLPRC HPLPCILDSS LLKPRSHLEG LFLSSPPAQQ
460 470 480 490 500
LSFLRSGLLN ILYLHMPDCP VSLLQWLFQL LTWPPETSLG AFGLLWDLIV
510 520 530 540 550
DGIFLQPDED KHLWCPSLQE VREAFHSLGA HSPALYPLGP FWHGGRVLPG
560 570 580 590 600
EAGLNENEEQ DAPQEIALDI SLGHIYKFLA LCAQAQPGAY TDENLMGLIE
610 620 630 640 650
LLCRTSLDVG LRLLPKVDLQ QLLLLLLENI REWPGKLQEL CCTLSWVSDH
660 670 680 690 700
HHNLLALVQF FPDMTSRSRR LRSQLSLVVI ARMLGQQEML PLWQEKTQLS
710 720 730 740 750
SLSRLLGLMR PSSLRQYLDS VPLPPCQEQQ PKASAELDHK ACYLCHSLLM
760 770 780 790 800
LAGVVVSCQD ITPDQWGELQ LLCMQLDRHI STQIRESPQA MHRTMLKDLA
810 820
TQTYIRWQEL LTHCQPQAQY FSPWKDI
Length:827
Mass (Da):93,514
Last modified:February 26, 2008 - v2
Checksum:iE2C6664FB9D42A3F
GO
Isoform 2 (identifier: Q8IXR5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-708: Missing.

Show »
Length:119
Mass (Da):13,809
Checksum:i5E7010D9805BE57B
GO
Isoform 3 (identifier: Q8IXR5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-172: MAHEREILKG...NRQRWSRTKA → MWPRLPGAGLAPQLRRQDQRLHFT

Note: Gene prediction based on EST data.
Show »
Length:679
Mass (Da):76,515
Checksum:i8140A458F9026C22
GO

Sequence cautioni

The sequence AAF36154.1 differs from that shown. Reason: Frameshift at several positions. Curated
The sequence AAF36154.1 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti793 – 7931R → C.
Corresponds to variant rs34013660 [ dbSNP | Ensembl ].
VAR_039172

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 708708Missing in isoform 2. 2 PublicationsVSP_031636Add
BLAST
Alternative sequencei1 – 172172MAHER…SRTKA → MWPRLPGAGLAPQLRRQDQR LHFT in isoform 3. CuratedVSP_047162Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151068 mRNA. Translation: AAF36154.1. Sequence problems.
AC079395 Genomic DNA. No translation available.
AC092636 Genomic DNA. Translation: AAY14968.1.
BC038583 mRNA. Translation: AAH38583.3.
BC039488 mRNA. Translation: AAH39488.1.
BC051379 mRNA. Translation: AAH51379.1.
CCDSiCCDS33252.1. [Q8IXR5-2]
CCDS46366.2. [Q8IXR5-3]
RefSeqiNP_001116118.2. NM_001122646.2. [Q8IXR5-3]
NP_001166138.1. NM_001172667.1.
NP_057574.2. NM_016490.4. [Q8IXR5-2]
UniGeneiHs.107922.

Genome annotation databases

EnsembliENST00000393526; ENSP00000377160; ENSG00000168754. [Q8IXR5-2]
ENST00000490605; ENSP00000429896; ENSG00000168754. [Q8IXR5-3]
GeneIDi51252.
KEGGihsa:51252.
UCSCiuc002sxj.4. human. [Q8IXR5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151068 mRNA. Translation: AAF36154.1. Sequence problems.
AC079395 Genomic DNA. No translation available.
AC092636 Genomic DNA. Translation: AAY14968.1.
BC038583 mRNA. Translation: AAH38583.3.
BC039488 mRNA. Translation: AAH39488.1.
BC051379 mRNA. Translation: AAH51379.1.
CCDSiCCDS33252.1. [Q8IXR5-2]
CCDS46366.2. [Q8IXR5-3]
RefSeqiNP_001116118.2. NM_001122646.2. [Q8IXR5-3]
NP_001166138.1. NM_001172667.1.
NP_057574.2. NM_016490.4. [Q8IXR5-2]
UniGeneiHs.107922.

3D structure databases

ProteinModelPortaliQ8IXR5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119409. 1 interaction.
IntActiQ8IXR5. 2 interactions.
MINTiMINT-1400307.
STRINGi9606.ENSP00000429896.

PTM databases

iPTMnetiQ8IXR5.
PhosphoSiteiQ8IXR5.

Polymorphism and mutation databases

BioMutaiFAM178B.
DMDMi172045738.

Proteomic databases

PaxDbiQ8IXR5.
PRIDEiQ8IXR5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393526; ENSP00000377160; ENSG00000168754. [Q8IXR5-2]
ENST00000490605; ENSP00000429896; ENSG00000168754. [Q8IXR5-3]
GeneIDi51252.
KEGGihsa:51252.
UCSCiuc002sxj.4. human. [Q8IXR5-1]

Organism-specific databases

CTDi51252.
GeneCardsiFAM178B.
H-InvDBHIX0002285.
HGNCiHGNC:28036. FAM178B.
HPAiHPA042516.
neXtProtiNX_Q8IXR5.
PharmGKBiPA162387456.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIBY. Eukaryota.
ENOG410YMV9. LUCA.
GeneTreeiENSGT00530000064017.
HOGENOMiHOG000050235.
HOVERGENiHBG107879.
InParanoidiQ8IXR5.
OMAiYVNSLDY.
PhylomeDBiQ8IXR5.
TreeFamiTF332216.

Miscellaneous databases

ChiTaRSiFAM178B. human.
GenomeRNAii51252.
PROiQ8IXR5.

Gene expression databases

BgeeiQ8IXR5.
CleanExiHS_FAM178B.
GenevisibleiQ8IXR5. HS.

Family and domain databases

InterProiIPR026161. FAM178.
[Graphical view]
PANTHERiPTHR16046. PTHR16046. 1 hit.
PfamiPF14816. FAM178. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Umbilical cord blood.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 310-827 (ISOFORM 1).
    Tissue: Skin.

Entry informationi

Entry nameiF178B_HUMAN
AccessioniPrimary (citable) accession number: Q8IXR5
Secondary accession number(s): A8MXN2
, E9PD86, Q8IUY0, Q9P0P4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: June 8, 2016
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.