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Q8IXR5 (F178B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein FAM178B
Gene names
Name:FAM178B
ORF Names:HSPC234
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length827 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the FAM178 family.

Sequence caution

The sequence AAF36154.1 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.

The sequence AAF36154.1 differs from that shown. Reason: Frameshift at several positions.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8IXR5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8IXR5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-708: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 827827Protein FAM178B
PRO_0000320193

Natural variations

Alternative sequence1 – 708708Missing in isoform 2.
VSP_031636
Natural variant7931R → C.
Corresponds to variant rs34013660 [ dbSNP | Ensembl ].
VAR_039172

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 26, 2008. Version 2.
Checksum: E2C6664FB9D42A3F

FASTA82793,514
        10         20         30         40         50         60 
MAHEREILKG MYEELKEKSH KPDVELIQHR AWRIDMVSTE LESFRKASYI ESGPEEFYQR 

        70         80         90        100        110        120 
FKKCFSATHI FISIKGKDSQ NTAHGYLILN RTLHQQLKIK NPFLAPSSEA VRIPATLPHP 

       130        140        150        160        170        180 
GALPFPPYVA KASSDELLNL QKPLQSALGF VILRSSQNWN SKNRQRWSRT KAGQMSHGLQ 

       190        200        210        220        230        240 
MAGPQETVLA LPLREGVQAA ATVPILLYNL EDGLSDHPLD QGPRCPARRP CSPASAPAPT 

       250        260        270        280        290        300 
SPKKPKIQAP GETFPTDWSP PPVEFLNPRV LQASREAPAQ RWVGVVGPQG LRRLAGELPE 

       310        320        330        340        350        360 
ELEQEHLDLD PKRGLALPEK LFWNTSGLSQ QAAAPEFSWG GSGSYFNNLD YLLQEKREQA 

       370        380        390        400        410        420 
LEQERERLLL QECLNLNSLD LDEEEVPLTP EHRMLVEKYS VSLQTIPPVH PGETVFLPRC 

       430        440        450        460        470        480 
HPLPCILDSS LLKPRSHLEG LFLSSPPAQQ LSFLRSGLLN ILYLHMPDCP VSLLQWLFQL 

       490        500        510        520        530        540 
LTWPPETSLG AFGLLWDLIV DGIFLQPDED KHLWCPSLQE VREAFHSLGA HSPALYPLGP 

       550        560        570        580        590        600 
FWHGGRVLPG EAGLNENEEQ DAPQEIALDI SLGHIYKFLA LCAQAQPGAY TDENLMGLIE 

       610        620        630        640        650        660 
LLCRTSLDVG LRLLPKVDLQ QLLLLLLENI REWPGKLQEL CCTLSWVSDH HHNLLALVQF 

       670        680        690        700        710        720 
FPDMTSRSRR LRSQLSLVVI ARMLGQQEML PLWQEKTQLS SLSRLLGLMR PSSLRQYLDS 

       730        740        750        760        770        780 
VPLPPCQEQQ PKASAELDHK ACYLCHSLLM LAGVVVSCQD ITPDQWGELQ LLCMQLDRHI 

       790        800        810        820 
STQIRESPQA MHRTMLKDLA TQTYIRWQEL LTHCQPQAQY FSPWKDI

« Hide

Isoform 2 [UniParc].

Checksum: 5E7010D9805BE57B
Show »

FASTA11913,809

References

[1]"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. expand/collapse author list , Gu J., Chen S.-J., Chen Z.
Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Umbilical cord blood.
[2]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 310-827 (ISOFORM 1).
Tissue: Skin.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF151068 mRNA. Translation: AAF36154.1. Sequence problems.
AC079395 Genomic DNA. No translation available.
AC092636 Genomic DNA. Translation: AAY14968.1.
BC038583 mRNA. Translation: AAH38583.3.
BC039488 mRNA. Translation: AAH39488.1.
BC051379 mRNA. Translation: AAH51379.1.
IPIIPI00217597.
IPI00884898.
RefSeqNP_001116118.2. NM_001122646.2.
NP_001166138.1. NM_001172667.1.
NP_057574.2. NM_016490.4.
UniGeneHs.107922.

3D structure databases

ProteinModelPortalQ8IXR5.
ModBaseSearch...

Protein-protein interaction databases

IntActQ8IXR5. 2 interactions.
MINTMINT-1400307.

PTM databases

PhosphoSiteQ8IXR5.

Polymorphism databases

DMDM172045738.

Proteomic databases

PaxDbQ8IXR5.
PRIDEQ8IXR5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000393526; ENSP00000377160; ENSG00000168754.
ENST00000417561; ENSP00000413245; ENSG00000168754.
GeneID51252.
KEGGhsa:51252.
UCSCuc002sxi.4. human.

Organism-specific databases

CTD51252.
GeneCardsGC02M097541.
H-InvDBHIX0002285.
HGNCHGNC:28036. FAM178B.
HPAHPA042516.
neXtProtNX_Q8IXR5.
PharmGKBPA162387456.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG27278.
HOGENOMHOG000050235.
HOVERGENHBG107879.
OMAAFHSLGA.
OrthoDBEOG40GCS7.

Gene expression databases

ArrayExpressQ8IXR5.
BgeeQ8IXR5.
CleanExHS_FAM178B.
GenevestigatorQ8IXR5.

Family and domain databases

InterProIPR026161. FAM178.
[Graphical view]
PANTHERPTHR16046. PTHR16046. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi51252.
NextBio54399.

Entry information

Entry nameF178B_HUMAN
AccessionPrimary (citable) accession number: Q8IXR5
Secondary accession number(s): A8MXN2, Q8IUY0, Q9P0P4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: April 3, 2013
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

SIMILARITY comments

Index of protein domains and families

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