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Protein

Electron transfer flavoprotein beta subunit lysine methyltransferase

Gene

ETFBKMT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein-lysine methyltransferase that selectively trimethylates the flavoprotein ETFB in mitochondria (PubMed:25023281, PubMed:25416781). Thereby, may negatively regulate the function of ETFB in electron transfer from Acyl-CoA dehydrogenases to the main respiratory chain (PubMed:25416781).2 Publications

GO - Molecular functioni

  • heat shock protein binding Source: UniProtKB
  • protein-lysine N-methyltransferase activity Source: UniProtKB

GO - Biological processi

  • negative regulation of electron transfer activity Source: UniProtKB
  • negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase Source: UniProtKB
  • peptidyl-lysine methylation Source: UniProtKB
  • peptidyl-lysine trimethylation Source: UniProtKB
  • protein methylation Source: Reactome

Keywordsi

Molecular functionMethyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-HSA-8876725 Protein methylation

Names & Taxonomyi

Protein namesi
Recommended name:
Electron transfer flavoprotein beta subunit lysine methyltransferase1 Publication (EC:2.1.1.-2 Publications)
Alternative name(s):
ETFB lysine methyltransferase1 Publication
Short name:
ETFB-KMT1 Publication
Protein N-lysine methyltransferase METTL20
Gene namesi
Name:ETFBKMTImported
Synonyms:C12orf72, METTL20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000139160.13
HGNCiHGNC:28739 ETFBKMT
MIMi615256 gene
neXtProtiNX_Q8IXQ9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi121D → A: Loss of lysine methyltransferase activity. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000139160
PharmGKBiPA164716777

Polymorphism and mutation databases

BioMutaiMETTL20
DMDMi74759679

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 38MitochondrionSequence analysisAdd BLAST38
ChainiPRO_000031870939 – 262Electron transfer flavoprotein beta subunit lysine methyltransferaseAdd BLAST224

Proteomic databases

EPDiQ8IXQ9
PaxDbiQ8IXQ9
PeptideAtlasiQ8IXQ9
PRIDEiQ8IXQ9
ProteomicsDBi71049

PTM databases

iPTMnetiQ8IXQ9
PhosphoSitePlusiQ8IXQ9

Expressioni

Gene expression databases

BgeeiENSG00000139160
ExpressionAtlasiQ8IXQ9 baseline and differential
GenevisibleiQ8IXQ9 HS

Organism-specific databases

HPAiHPA039024

Interactioni

Subunit structurei

Interacts with HSPD1; this protein may possibly be a methylation substrate.1 Publication

GO - Molecular functioni

  • heat shock protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi129005, 12 interactors
STRINGi9606.ENSP00000350353

Structurei

3D structure databases

ProteinModelPortaliQ8IXQ9
SMRiQ8IXQ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IH4U Eukaryota
COG3897 LUCA
GeneTreeiENSGT00390000002528
HOGENOMiHOG000226047
HOVERGENiHBG107714
InParanoidiQ8IXQ9
OMAiCELNQLN
OrthoDBiEOG091G0J2A
PhylomeDBiQ8IXQ9
TreeFamiTF314934

Family and domain databases

InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
SUPFAMiSSF53335 SSF53335, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8IXQ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSLGWKAH RNHCGLLLQA LRSSGLLLFP CGQCPWRGAG SFLDPEIKAF
60 70 80 90 100
LEENTEVTSS GSLTPEIQLR LLTPRCKFWW ERADLWPHSD PYWAIYWPGG
110 120 130 140 150
QALSRYLLDN PDVVRGKSVL DLGSGCGATA IAAKMSGASR ILANDIDPIA
160 170 180 190 200
GMAITLNCEL NRLNPFPILI QNILNLEQDK WDLVVLGDMF YDEDLADSLH
210 220 230 240 250
QWLKKCFWTY RTRVLIGDPG RPQFSGHSIQ HHLHKVVEYS LLESTRQENS
260
GLTTSTVWGF QP
Length:262
Mass (Da):29,461
Last modified:March 1, 2003 - v1
Checksum:i4A784F2DFA6A4216
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290248 mRNA Translation: BAF82937.1
CH471116 Genomic DNA Translation: EAW88545.1
CH471116 Genomic DNA Translation: EAW88547.1
CH471116 Genomic DNA Translation: EAW88548.1
BC039107 mRNA Translation: AAH39107.1
BC039535 mRNA Translation: AAH39535.1
CCDSiCCDS8724.1
RefSeqiNP_001129335.1, NM_001135863.1
NP_001129336.1, NM_001135864.1
NP_776163.1, NM_173802.3
UniGeneiHs.740628

Genome annotation databases

EnsembliENST00000357721; ENSP00000350353; ENSG00000139160
ENST00000395763; ENSP00000379112; ENSG00000139160
ENST00000412352; ENSP00000396123; ENSG00000139160
ENST00000538463; ENSP00000441421; ENSG00000139160
GeneIDi254013
KEGGihsa:254013
UCSCiuc001rkl.4 human

Similar proteinsi

Entry informationi

Entry nameiETKMT_HUMAN
AccessioniPrimary (citable) accession number: Q8IXQ9
Secondary accession number(s): D3DUW3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2003
Last modified: June 20, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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