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Protein

Poly [ADP-ribose] polymerase 9

Gene

PARP9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

In concert with DTX3L plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. Involved in inducing the expression of IFN-gamma-responsive genes.2 Publications

Catalytic activityi

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.PROSITE-ProRule annotation

GO - Molecular functioni

  • NAD+ ADP-ribosyltransferase activity Source: UniProtKB

GO - Biological processi

  • cell migration Source: UniProtKB
  • double-strand break repair Source: UniProtKB
  • regulation of response to interferon-gamma Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Poly [ADP-ribose] polymerase 9 (EC:2.4.2.30)
Short name:
PARP-9
Alternative name(s):
ADP-ribosyltransferase diphtheria toxin-like 9
Short name:
ARTD9
B aggressive lymphoma protein
Gene namesi
Name:PARP9
Synonyms:BAL, BAL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:24118. PARP9.

Subcellular locationi

  • Cytoplasmcytosol
  • Nucleus

  • Note: Shuttles between the nucleus and the cytosol. Export to the cytosol depends on the interaction with DTX3L. Localizes at sites of DNA damage in a PARP1-dependent manner.

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: UniProtKB-SubCell
  • membrane Source: UniProtKB
  • mitochondrion Source: HPA
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Overexpressed at significantly higher levels in fatal high-risk diffuse large B-cell lymphomas (DLB-CL) compared to cured low-risk tumors. Overexpression in B-cell lymphoma transfectants may promote malignant B-cell migration. May therefore be involved in promoting B-cell migration and dissemination of high-risk DLB-CL tumors (PubMed:11110709).

Organism-specific databases

PharmGKBiPA134870403.

Polymorphism and mutation databases

BioMutaiPARP9.
DMDMi48474734.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 854854Poly [ADP-ribose] polymerase 9PRO_0000211339Add
BLAST

Proteomic databases

EPDiQ8IXQ6.
MaxQBiQ8IXQ6.
PaxDbiQ8IXQ6.
PRIDEiQ8IXQ6.

PTM databases

iPTMnetiQ8IXQ6.
PhosphoSiteiQ8IXQ6.

Expressioni

Tissue specificityi

Expressed in lymphocyte-rich tissues, spleen, lymph nodes, peripheral blood lymphocytes and colonic mucosa. Also expressed in nonhematopoietic tissues such as heart and skeletal muscle. Isoform 2 is the predominant form. Most abundantly expressed in lymphomas with a brisk host inflammatory response. In diffuse large B-cell lymphomas tumors, expressed specifically by malignant B-cells.2 Publications

Inductioni

Up-regulated by IFN-gamma in B-cell lymphoma cell lines.1 Publication

Gene expression databases

BgeeiQ8IXQ6.
CleanExiHS_PARP9.
ExpressionAtlasiQ8IXQ6. baseline and differential.
GenevisibleiQ8IXQ6. HS.

Interactioni

Subunit structurei

Interacts with DTX3L. Interacts with PARP1 (when poly-ADP-ribosylated).2 Publications

Protein-protein interaction databases

BioGridi123723. 8 interactions.
IntActiQ8IXQ6. 1 interaction.
STRINGi9606.ENSP00000353512.

Structurei

Secondary structure

1
854
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi311 – 3144Combined sources
Beta strandi317 – 3248Combined sources
Helixi326 – 3283Combined sources
Beta strandi330 – 33910Combined sources
Helixi347 – 35610Combined sources
Helixi358 – 37013Combined sources
Beta strandi378 – 3825Combined sources
Beta strandi386 – 39510Combined sources
Helixi402 – 41918Combined sources
Beta strandi423 – 4275Combined sources
Beta strandi433 – 4375Combined sources
Helixi439 – 45618Combined sources
Beta strandi462 – 4687Combined sources
Helixi473 – 49018Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5AILX-ray1.55A/B310-493[»]
ProteinModelPortaliQ8IXQ6.
SMRiQ8IXQ6. Positions 92-291, 308-493, 666-820.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini107 – 296190Macro 1PROSITE-ProRule annotationAdd
BLAST
Domaini306 – 487182Macro 2PROSITE-ProRule annotationAdd
BLAST
Domaini628 – 850223PARP catalyticPROSITE-ProRule annotationAdd
BLAST

Domaini

The domain macro 2 is required for recruitment to DNA damage sites.1 Publication

Sequence similaritiesi

Contains 2 Macro domains.PROSITE-ProRule annotation
Contains 1 PARP catalytic domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2633. Eukaryota.
COG2110. LUCA.
GeneTreeiENSGT00760000119084.
HOGENOMiHOG000115452.
HOVERGENiHBG045406.
InParanoidiQ8IXQ6.
KOiK15260.
OMAiSGIFQFP.
OrthoDBiEOG786H2D.
PhylomeDBiQ8IXQ6.
TreeFamiTF328965.

Family and domain databases

Gene3Di3.90.228.10. 1 hit.
InterProiIPR002589. Macro_dom.
IPR012317. Poly(ADP-ribose)pol_cat_dom.
[Graphical view]
PfamiPF01661. Macro. 2 hits.
[Graphical view]
SMARTiSM00506. A1pp. 2 hits.
[Graphical view]
PROSITEiPS51154. MACRO. 2 hits.
PS51059. PARP_CATALYTIC. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IXQ6-1) [UniParc]FASTAAdd to basket

Also known as: Long, L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDFSMVAGAA AYNEKSGRIT SLSLLFQKVF AQIFPQWRKG NTEECLPYKC
60 70 80 90 100
SETGALGENY SWQIPINHND FKILKNNERQ LCEVLQNKFG CISTLVSPVQ
110 120 130 140 150
EGNSKSLQVF RKMLTPRIEL SVWKDDLTTH AVDAVVNAAN EDLLHGGGLA
160 170 180 190 200
LALVKAGGFE IQEESKQFVA RYGKVSAGEI AVTGAGRLPC KQIIHAVGPR
210 220 230 240 250
WMEWDKQGCT GKLQRAIVSI LNYVIYKNTH IKTVAIPALS SGIFQFPLNL
260 270 280 290 300
CTKTIVETIR VSLQGKPMMS NLKEIHLVSN EDPTVAAFKA ASEFILGKSE
310 320 330 340 350
LGQETTPSFN AMVVNNLTLQ IVQGHIEWQT ADVIVNSVNP HDITVGPVAK
360 370 380 390 400
SILQQAGVEM KSEFLATKAK QFQRSQLVLV TKGFNLFCKY IYHVLWHSEF
410 420 430 440 450
PKPQILKHAM KECLEKCIEQ NITSISFPAL GTGNMEIKKE TAAEILFDEV
460 470 480 490 500
LTFAKDHVKH QLTVKFVIFP TDLEIYKAFS SEMAKRSKML SLNNYSVPQS
510 520 530 540 550
TREEKRENGL EARSPAINLM GFNVEEMYEA HAWIQRILSL QNHHIIENNH
560 570 580 590 600
ILYLGRKEHD ILSQLQKTSS VSITEIISPG RTELEIEGAR ADLIEVVMNI
610 620 630 640 650
EDMLCKVQEE MARKKERGLW RSLGQWTIQQ QKTQDEMKEN IIFLKCPVPP
660 670 680 690 700
TQELLDQKKQ FEKCGLQVLK VEKIDNEVLM AAFQRKKKMM EEKLHRQPVS
710 720 730 740 750
HRLFQQVPYQ FCNVVCRVGF QRMYSTPCDP KYGAGIYFTK NLKNLAEKAK
760 770 780 790 800
KISAADKLIY VFEAEVLTGF FCQGHPLNIV PPPLSPGAID GHDSVVDNVS
810 820 830 840 850
SPETFVIFSG MQAIPQYLWT CTQEYVQSQD YSSGPMRPFA QHPWRGFASG

SPVD
Length:854
Mass (Da):96,343
Last modified:October 10, 2003 - v2
Checksum:iCBBB3B4B7CA1CDA4
GO
Isoform 2 (identifier: Q8IXQ6-2) [UniParc]FASTAAdd to basket

Also known as: Short, S

The sequence of this isoform differs from the canonical sequence as follows:
     17-51: Missing.

Show »
Length:819
Mass (Da):92,271
Checksum:i110B81666B857940
GO
Isoform 3 (identifier: Q8IXQ6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     17-51: Missing.
     729-745: DPKYGAGIYFTKNLKNL → GRCQCLIIGATLWNLVS
     746-854: Missing.

Note: No experimental confirmation available.
Show »
Length:710
Mass (Da):80,291
Checksum:iE443D3E78BDF0E53
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti487 – 4871S → P in BAF85648 (PubMed:14702039).Curated
Sequence conflicti839 – 8391F → S in BAG36276 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti21 – 211S → L.
Corresponds to variant rs34006803 [ dbSNP | Ensembl ].
VAR_056654
Natural varianti517 – 5171I → V.1 Publication
Corresponds to variant rs28365795 [ dbSNP | Ensembl ].
VAR_056655
Natural varianti528 – 5281Y → C.3 Publications
Corresponds to variant rs9851180 [ dbSNP | Ensembl ].
VAR_056656
Natural varianti651 – 6511T → A.
Corresponds to variant rs6780543 [ dbSNP | Ensembl ].
VAR_056657

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei17 – 5135Missing in isoform 2 and isoform 3. 3 PublicationsVSP_008505Add
BLAST
Alternative sequencei729 – 74517DPKYG…NLKNL → GRCQCLIIGATLWNLVS in isoform 3. 1 PublicationVSP_046086Add
BLAST
Alternative sequencei746 – 854109Missing in isoform 3. 1 PublicationVSP_046087Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF307338 mRNA. Translation: AAK07558.1.
AF307339 mRNA. Translation: AAK07559.1.
AK292959 mRNA. Translation: BAF85648.1.
AK313494 mRNA. Translation: BAG36276.1.
AC092908 Genomic DNA. No translation available.
AC096861 Genomic DNA. No translation available.
BC017463 mRNA. No translation available.
BC039580 mRNA. Translation: AAH39580.1.
AL713679 mRNA. Translation: CAD28483.1.
CCDSiCCDS3014.1. [Q8IXQ6-1]
CCDS54633.1. [Q8IXQ6-3]
CCDS54634.1. [Q8IXQ6-2]
RefSeqiNP_001139574.1. NM_001146102.1. [Q8IXQ6-1]
NP_001139575.1. NM_001146103.1. [Q8IXQ6-2]
NP_001139576.1. NM_001146104.1. [Q8IXQ6-2]
NP_001139577.1. NM_001146105.1. [Q8IXQ6-2]
NP_113646.2. NM_031458.2. [Q8IXQ6-1]
XP_005247877.1. XM_005247820.1. [Q8IXQ6-1]
UniGeneiHs.518200.

Genome annotation databases

EnsembliENST00000360356; ENSP00000353512; ENSG00000138496. [Q8IXQ6-1]
ENST00000462315; ENSP00000418894; ENSG00000138496. [Q8IXQ6-3]
ENST00000471785; ENSP00000419001; ENSG00000138496. [Q8IXQ6-2]
ENST00000477522; ENSP00000419506; ENSG00000138496. [Q8IXQ6-2]
GeneIDi83666.
KEGGihsa:83666.
UCSCiuc003efh.5. human. [Q8IXQ6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF307338 mRNA. Translation: AAK07558.1.
AF307339 mRNA. Translation: AAK07559.1.
AK292959 mRNA. Translation: BAF85648.1.
AK313494 mRNA. Translation: BAG36276.1.
AC092908 Genomic DNA. No translation available.
AC096861 Genomic DNA. No translation available.
BC017463 mRNA. No translation available.
BC039580 mRNA. Translation: AAH39580.1.
AL713679 mRNA. Translation: CAD28483.1.
CCDSiCCDS3014.1. [Q8IXQ6-1]
CCDS54633.1. [Q8IXQ6-3]
CCDS54634.1. [Q8IXQ6-2]
RefSeqiNP_001139574.1. NM_001146102.1. [Q8IXQ6-1]
NP_001139575.1. NM_001146103.1. [Q8IXQ6-2]
NP_001139576.1. NM_001146104.1. [Q8IXQ6-2]
NP_001139577.1. NM_001146105.1. [Q8IXQ6-2]
NP_113646.2. NM_031458.2. [Q8IXQ6-1]
XP_005247877.1. XM_005247820.1. [Q8IXQ6-1]
UniGeneiHs.518200.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5AILX-ray1.55A/B310-493[»]
ProteinModelPortaliQ8IXQ6.
SMRiQ8IXQ6. Positions 92-291, 308-493, 666-820.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123723. 8 interactions.
IntActiQ8IXQ6. 1 interaction.
STRINGi9606.ENSP00000353512.

PTM databases

iPTMnetiQ8IXQ6.
PhosphoSiteiQ8IXQ6.

Polymorphism and mutation databases

BioMutaiPARP9.
DMDMi48474734.

Proteomic databases

EPDiQ8IXQ6.
MaxQBiQ8IXQ6.
PaxDbiQ8IXQ6.
PRIDEiQ8IXQ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360356; ENSP00000353512; ENSG00000138496. [Q8IXQ6-1]
ENST00000462315; ENSP00000418894; ENSG00000138496. [Q8IXQ6-3]
ENST00000471785; ENSP00000419001; ENSG00000138496. [Q8IXQ6-2]
ENST00000477522; ENSP00000419506; ENSG00000138496. [Q8IXQ6-2]
GeneIDi83666.
KEGGihsa:83666.
UCSCiuc003efh.5. human. [Q8IXQ6-1]

Organism-specific databases

CTDi83666.
GeneCardsiPARP9.
HGNCiHGNC:24118. PARP9.
MIMi612065. gene.
neXtProtiNX_Q8IXQ6.
PharmGKBiPA134870403.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2633. Eukaryota.
COG2110. LUCA.
GeneTreeiENSGT00760000119084.
HOGENOMiHOG000115452.
HOVERGENiHBG045406.
InParanoidiQ8IXQ6.
KOiK15260.
OMAiSGIFQFP.
OrthoDBiEOG786H2D.
PhylomeDBiQ8IXQ6.
TreeFamiTF328965.

Miscellaneous databases

GenomeRNAii83666.
NextBioi72639.
PROiQ8IXQ6.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IXQ6.
CleanExiHS_PARP9.
ExpressionAtlasiQ8IXQ6. baseline and differential.
GenevisibleiQ8IXQ6. HS.

Family and domain databases

Gene3Di3.90.228.10. 1 hit.
InterProiIPR002589. Macro_dom.
IPR012317. Poly(ADP-ribose)pol_cat_dom.
[Graphical view]
PfamiPF01661. Macro. 2 hits.
[Graphical view]
SMARTiSM00506. A1pp. 2 hits.
[Graphical view]
PROSITEiPS51154. MACRO. 2 hits.
PS51059. PARP_CATALYTIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "BAL is a novel risk-related gene in diffuse large B-cell lymphomas that enhances cellular migration."
    Aguiar R.C.T., Yakushijin Y., Kharbanda S., Salgia R., Fletcher J.A., Shipp M.A.
    Blood 96:4328-4334(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANT CYS-528, INVOLVEMENT IN B-CELL LYMPHOMAS.
    Tissue: B-cell.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT CYS-528.
    Tissue: Trachea and Umbilical cord blood.
  3. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANTS VAL-517 AND CYS-528.
    Tissue: Mammary gland and Melanoma.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 525-854.
    Tissue: Amygdala.
  6. "The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity."
    Takeyama K., Aguiar R.C.T., Gu L., He C., Freeman G.J., Kutok J.L., Aster J.C., Shipp M.A.
    J. Biol. Chem. 278:21930-21937(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DTX3L.
  7. "BAL1 and BBAP are regulated by a gamma interferon-responsive bidirectional promoter and are overexpressed in diffuse large B-cell lymphomas with a prominent inflammatory infiltrate."
    Juszczynski P., Kutok J.L., Li C., Mitra J., Aguiar R.C.T., Shipp M.A.
    Mol. Cell. Biol. 26:5348-5359(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.
  8. "Toward a unified nomenclature for mammalian ADP-ribosyltransferases."
    Hottiger M.O., Hassa P.O., Luscher B., Schuler H., Koch-Nolte F.
    Trends Biochem. Sci. 35:208-219(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE.
  9. "BAL1 and its partner E3 ligase, BBAP, link Poly(ADP-ribose) activation, ubiquitylation, and double-strand DNA repair independent of ATM, MDC1, and RNF8."
    Yan Q., Xu R., Zhu L., Cheng X., Wang Z., Manis J., Shipp M.A.
    Mol. Cell. Biol. 33:845-857(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH PARP1, DOMAIN MACRO 2.

Entry informationi

Entry nameiPARP9_HUMAN
AccessioniPrimary (citable) accession number: Q8IXQ6
Secondary accession number(s): A8KA94
, B2R8S9, E9PFM7, Q8TCP3, Q9BZL8, Q9BZL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: April 13, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.